Brassica oleracea      HMT      SET1

※ SET1 family introduction

    SET1: The SET1 gene in the budding yeast Saccharomyces cerevisiae was discovered by several laboratories as encoding the first known H3K4 methyltransferase, a catalytic function performed through its conserved SET domain. Yeast Set1, like its orthologs in higher eukaryotes (SET1A/B in humans), is recruited to chromatin by the serine 5-phosphorylated C-terminal domain of RNA polymerase II (pol II). This interaction with the initiating form of pol II results in the occupancy of Set1 near the 5’-end of active genes, which correlates closely with the peak of H3K4me3. (1)

    In metazoans, SET1A/B proteins seem to function analogously to yeast Set1 in performing the majority of transcription-coupled H3K4 methylation found at active genes, presumably through co-transcriptional recruitment. Unlike their yeast counterpart, human SET1A/B proteins are also recruited to chromatin via an interaction with non-methylated CpG island sequences, mediated by the SET1A/B-associated protein CFP1.

Reference
1. Ernst P, Vakoc CR.WRAD: enabler of the SET1-family of H3K4 methyltransferases. Brief Funct Genomics.2012;11(3):217-226. PMID: 22652693.



There are 24 genes.  Reviewed (0 or Unreviewed (24

No.StatusWERAM IDGene/Alias Name
1
WERAM-Bro-0011
2
WERAM-Bro-0025
3
WERAM-Bro-0040
4
WERAM-Bro-0047
5
WERAM-Bro-0063
ASHR3
6
WERAM-Bro-0064
ASHH3
7
WERAM-Bro-0078
CLF
8
WERAM-Bro-0079
9
WERAM-Bro-0082
ATX1
10
WERAM-Bro-0087
11
WERAM-Bro-0108
12
WERAM-Bro-0109
13
WERAM-Bro-0110
SDG14
14
WERAM-Bro-0118
SDG26
15
WERAM-Bro-0120
EFS
16
WERAM-Bro-0133
17
WERAM-Bro-0139
ATX4
18
WERAM-Bro-0156
ASHH4
19
WERAM-Bro-0163
ATX2
20
WERAM-Bro-0164
21
WERAM-Bro-0166
EZA1
22
WERAM-Bro-0175
ATXR7
23
WERAM-Bro-0182
ATXR5
24
WERAM-Bro-0184