WERAM Information


Tag Content
WERAM ID WERAM-Sac-0032
Ensembl Protein ID YLR442C
Uniprot Accession P06701; SIR3_YEAST; D6VZ77; E9P924
Genbank Protein ID NP_013547.3
Protein Name Regulatory protein SIR3
Genbank Nucleotide ID NM_001182330.3
Gene Name Sir3;CMT1;MAR2;STE8;YLR442C;L9753.10
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YLR442C YLR442C YLR442C
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader BAH BAH H3K79me K 24631869
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader BAH 1.50e-50 169.1 48 780
Organism Saccharomyces cerevisiae
NCBI Taxa ID 559292
Functional Description
(View)
The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR. The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure. Involves the compaction of chromatin fiber into a more condensed form.
Domain Profile
  Me_Reader BAH

  BAH.txt   1 lllkkgdsvllqdderktpdvyiikiieLfeneneveikkfarvrwf..........fRpseikesksrllykkkfanevfkselydtd..seinleevigv 90 
l+++kg+sv+++d++++t++vy+i++i+L++++n+vei++f+++rwf fRp++ike++++++yk+kf+nev+ksely+t+ sei+l+++i+v
YLR442C 48 LSFGKGESVIFNDNVTETYSVYLIHEIRLNTLNNVVEIWVFSYLRWFelkpklyyeqFRPDLIKEDHPLEFYKDKFFNEVNKSELYLTAelSEIWLKDFIAV 149
689**************************************************************************************9************ PP
BAH.txt 91 vqvlplaeynkesipktekeddvflvdlslekkaekflkie 131
+q+lp++++n++si+k+e++d flv++++e++aekf++i+
YLR442C 150 GQILPESQWNDSSIDKIEDRD--FLVRYACEPTAEKFVPID 188
*********************..****************97 PP
BAH.txt 26 iieLfenene.veikkfarvrwffRpseikesksrllykkkfanevfkselydtdseinleevi 88
+i+L++ +++ + + r++ +p +k++ ++++ + ++e ++ d+ i ++ +i
YLR442C 719 EIKLNKVDKNeLQQMIITRLKSLLKPFHVKVNDKKEMTIYNNIREGQNQKIP--DNVIVINHKI 780
6777775544034444556666677777777666666554333333333333..3444444444 PP

Protein Sequence
(Fasta)
MAKTLKDLDG WQVIITDDQG RVIDDNNRRR SRKRGGENVF LKRISDGLSF GKGESVIFND 60
NVTETYSVYL IHEIRLNTLN NVVEIWVFSY LRWFELKPKL YYEQFRPDLI KEDHPLEFYK 120
DKFFNEVNKS ELYLTAELSE IWLKDFIAVG QILPESQWND SSIDKIEDRD FLVRYACEPT 180
AEKFVPIDIF QIIRRVKEME PKQSDEYLKR VSVPVSGQKT NRQVMHKMGV ERSSKRLAKK 240
PSMKKIKIEP SADDDVNNGN IPSQRGTSTT HGSISPQEES VSPNISSASP SALTSPTDSS 300
KILQKRSISK ELIVSEEIPI NSSEQESDYE PNNETSVLSS KPGSKPEKTS TELVDGRENF 360
VYANNPEVSD DGGLEEETDE VSSESSDEAI IPVNKRRGAH GSELSSKIRK IHIQETQEFS 420
KNYTTETDNE MNGNGKPGIP RGNTKIHSMN ENPTPEKGNA KMIDFATLSK LKKKYQIILD 480
RFAPDNQVTD SSQLNKLTDE QSSLDVAGLE DKFRKACSSS GRETILSNFN ADINLEESIR 540
ESLQKRELLK SQVEDFTRIF LPIYDSLMSS QNKLFYITNA DDSTKFQLVN DVMDELITSS 600
ARKELPIFDY IHIDALELAG MDALYEKIWF AISKENLCGD ISLEALNFYI TNVPKAKKRK 660
TLILIQNPEN LLSEKILQYF EKWISSKNSK LSIICVGGHN VTIREQINIM PSLKAHFTEI 720
KLNKVDKNEL QQMIITRLKS LLKPFHVKVN DKKEMTIYNN IREGQNQKIP DNVIVINHKI 780
NNKITQLIAK NVANVSGSTE KAFKICEAAV EISKKDFVRK GGLQKGKLVV SQEMVPRYFS 840
EAINGFKDET ISKKIIGMSL LMRTFLYTLA QETEGTNRHT LALETVLIKM VKMLRDNPGY 900
KASKEIKKVI CGAWEPAITI EKLKQFSWIS VVNDLVGEKL VVVVLEEPSA SIMVELKLPL 960
EINYAFSMDE EFKNMDCI 978
Nucleotide Sequence
(Fasta)
ATGGCTAAAA CATTGAAAGA TTTGGACGGT TGGCAAGTTA TCATTACAGA TGATCAGGGG 60
AGGGTTATTG ACGACAACAA TAGAAGAAGA TCAAGAAAAA GAGGAGGAGA AAACGTATTT 120
CTGAAAAGAA TTTCTGATGG ATTGAGTTTT GGGAAGGGTG AGAGCGTGAT ATTTAATGAT 180
AATGTGACGG AAACATATTC TGTCTACTTG ATCCATGAGA TCAGACTCAA TACACTTAAT 240
AATGTTGTGG AGATTTGGGT TTTTTCTTAC TTGAGATGGT TTGAACTCAA ACCAAAACTG 300
TACTACGAAC AATTCAGGCC AGATCTAATA AAGGAAGATC ATCCTTTAGA ATTTTACAAA 360
GATAAATTTT TCAACGAAGT AAATAAGAGC GAGTTATATT TAACTGCTGA GCTATCAGAG 420
ATTTGGCTTA AGGATTTCAT TGCAGTTGGA CAGATACTGC CAGAGTCACA ATGGAATGAT 480
AGTAGTATCG ATAAAATAGA GGATAGAGAT TTTCTAGTAC GTTATGCATG CGAACCTACT 540
GCGGAAAAGT TTGTACCAAT TGATATTTTT CAAATCATAA GAAGAGTAAA GGAAATGGAA 600
CCCAAACAAT CTGATGAATA CTTGAAAAGA GTATCTGTAC CAGTGAGTGG GCAGAAGACA 660
AATAGACAGG TGATGCATAA GATGGGAGTT GAAAGATCTT CAAAAAGACT AGCAAAGAAA 720
CCTTCAATGA AAAAAATTAA AATCGAGCCC TCTGCAGATG ATGACGTAAA TAATGGAAAT 780
ATACCGTCTC AGCGAGGAAC GTCAACAACT CATGGTTCAA TTTCTCCCCA AGAAGAGTCT 840
GTTTCCCCTA ACATCTCATC GGCGTCCCCT TCTGCGCTCA CATCACCTAC AGATTCTTCG 900
AAAATTTTAC AAAAAAGATC TATATCAAAG GAACTAATTG TTTCAGAGGA AATACCAATA 960
AACTCTTCAG AACAGGAATC CGATTATGAG CCAAACAATG AAACATCTGT GCTTTCAAGT 1020
AAACCTGGGT CAAAGCCAGA GAAGACATCT ACAGAACTCG TTGACGGCCG AGAGAATTTT 1080
GTATATGCAA ATAATCCAGA AGTGAGTGAT GATGGTGGGC TTGAAGAGGA AACAGATGAA 1140
GTTAGTTCAG AAAGTTCTGA TGAAGCAATA ATACCAGTAA ATAAAAGACG TGGCGCTCAC 1200
GGAAGCGAAT TGAGCAGTAA AATTAGAAAA ATCCACATTC AAGAAACACA AGAATTTTCT 1260
AAAAATTACA CTACAGAAAC AGATAACGAA ATGAACGGAA ATGGAAAACC TGGAATTCCC 1320
AGGGGCAACA CCAAAATTCA TAGTATGAAC GAAAATCCTA CACCAGAAAA AGGTAATGCA 1380
AAGATGATTG ATTTCGCTAC TTTGTCAAAG TTGAAAAAAA AATATCAGAT AATTTTAGAC 1440
CGGTTTGCAC CAGATAATCA AGTAACAGAT TCCTCCCAAT TGAACAAATT AACAGACGAA 1500
CAGTCAAGCT TGGACGTTGC AGGCCTTGAG GATAAGTTTA GAAAAGCATG CTCTTCATCT 1560
GGAAGAGAAA CCATTCTGTC AAATTTTAAC GCTGATATAA ATTTAGAGGA ATCAATTAGA 1620
GAATCTTTAC AAAAGAGAGA ACTACTAAAA TCACAAGTGG AGGATTTTAC AAGAATATTC 1680
CTTCCGATTT ACGACAGTTT GATGTCTTCC CAAAATAAAC TATTTTATAT TACCAATGCA 1740
GATGATTCTA CTAAATTCCA GCTTGTGAAT GATGTAATGG ATGAGTTGAT CACCTCTTCG 1800
GCCCGAAAGG AACTACCTAT TTTCGATTAC ATTCATATTG ATGCCTTGGA ACTGGCAGGA 1860
ATGGATGCAT TATATGAGAA AATATGGTTC GCCATTTCTA AAGAAAATCT ATGCGGTGAT 1920
ATATCACTAG AGGCCTTAAA CTTCTATATT ACAAATGTCC CGAAAGCAAA AAAGAGAAAG 1980
ACACTAATAT TAATACAAAA TCCGGAAAAT CTATTGAGTG AGAAGATTTT ACAATATTTC 2040
GAGAAATGGA TTTCTTCGAA AAATTCAAAA TTGTCTATCA TTTGCGTTGG CGGACATAAT 2100
GTGACGATTA GAGAGCAAAT AAATATAATG CCCTCCCTCA AAGCACACTT TACCGAAATC 2160
AAACTTAATA AGGTGGACAA GAATGAATTG CAACAAATGA TCATCACGCG ACTCAAATCT 2220
TTATTGAAAC CTTTTCATGT CAAAGTAAAT GATAAGAAGG AAATGACTAT TTACAATAAT 2280
ATTCGCGAAG GACAGAACCA GAAAATACCA GATAATGTGA TAGTAATCAA TCATAAGATC 2340
AACAACAAAA TCACTCAACT TATTGCAAAG AACGTAGCCA ACGTAAGTGG TAGTACTGAA 2400
AAAGCATTCA AAATATGTGA AGCTGCCGTA GAAATTTCTA AAAAAGACTT CGTACGGAAA 2460
GGTGGTCTAC AAAAGGGTAA ATTGGTAGTG TCACAGGAGA TGGTACCACG CTATTTCTCA 2520
GAAGCTATTA ACGGATTCAA GGATGAAACT ATTTCAAAGA AGATTATAGG AATGTCTCTG 2580
TTGATGAGAA CATTTTTATA TACCCTGGCG CAAGAAACCG AAGGCACGAA TCGTCATACG 2640
CTTGCTCTGG AGACCGTCCT GATTAAGATG GTGAAGATGT TGCGGGACAA CCCAGGGTAC 2700
AAGGCGTCAA AAGAAATTAA GAAGGTCATA TGCGGTGCCT GGGAGCCCGC AATAACTATA 2760
GAGAAACTAA AGCAATTTTC TTGGATAAGT GTAGTGAATG ATTTAGTGGG AGAAAAATTA 2820
GTTGTTGTGG TGCTCGAGGA GCCCAGTGCA AGCATTATGG TAGAACTAAA ACTTCCTTTA 2880
GAAATAAATT ACGCCTTTTC GATGGATGAA GAATTCAAAA ATATGGACTG CATTTGA 2938
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
--

Interpro

IPR001025--BAH_dom

PROSITE

PS51038--BAH

Pfam

PF01426--BAH

Gene Ontology

GO:0005677--C:chromatin silencing complex
GO:0000781--C:chromosome, telomeric region
GO:0000784--C:nuclear chromosome, telomeric region
GO:0005720--C:nuclear heterochromatin
GO:0005724--C:nuclear telomeric heterochromatin
GO:0005730--C:nucleolus
GO:0003682--F:chromatin binding
GO:0003690--F:double-stranded DNA binding
GO:0042802--F:identical protein binding
GO:0031493--F:nucleosomal histone binding
GO:0031491--F:nucleosome binding
GO:0003697--F:single-stranded DNA binding
GO:0030466--P:chromatin silencing at silent mating-type cassette
GO:0031507--P:heterochromatin assembly
GO:0001308--P:negative regulation of chromatin silencing involved in replicative cell aging
GO:0070481--P:nuclear-transcribed mRNA catabolic process, non-stop decay
GO:0006351--P:transcription, DNA-templated

Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Tub-0063 ENSTBEP00000007929.1 Tupaia belangeri 19 6e-08 57.8
Created Date 25-Jun-2016