WERAM Information

Tag Content
WERAM ID WERAM-Sac-0011
Ensembl Protein ID YEL066W
Uniprot Accession P39979; HPA3_YEAST; D3DLI4
Genbank Protein ID NP_010848.1
Protein Name D-amino-acid N-acetyltransferase HPA3
Genbank Nucleotide ID NM_001178881.1
Gene Name HPA3;YEL066W
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YEL066W YEL066W YEL066W
Details
Type Family Domain Substrates AA References (PMIDs)
HAT HPA2 N-acetyltransferase H4K8 K 23775086
Status Reviewed
Classification
Type Family E-value Score Start End
HAT HPA2 3.30e-77 256.4 32 179
Organism Saccharomyces cerevisiae
NCBI Taxa ID 559292
Functional Description
(View)		 N-acetyltransferase that acetylates histone H4 at 'Lys-8'. Also acetylates polyamines like putrescine, spermidine and spermine (PubMed:23775086). Acts on a wide range of D-amino acids. Catalyzes the N-acetylation through an ordered bi-bi mechanism, in which acetyl-CoA is the first substrate to be bound and CoA is the last product to be liberated (PubMed:15375647). D-amino acids are toxic for the cell and their N-acetylation, preceding removal from cells, plays an important role in detoxification of D-amino acids (PubMed:10600387, PubMed:16362288).
Domain Profile
  HAT HPA2
  HPA2.txt   1 irvrsvikedkeavqklikeyqefekvedpvevaevafgrfidevvklaaavaiesesdkaiGlaiylnhlttWtvkekiyledlyvrerarvkGvGskll 101
               i+v++++++d+ea++kl+keyq+f+k+++p+eva+++f+rfid++vkl++a+a+++e+++aiG+a+ylnhlt+W+v+e++y++dlyv+erarvkGvG+kl+
   YEL066W  32 IVVKAIEPKDEEAWNKLWKEYQGFQKTVMPPEVATTTFARFIDPTVKLWGALAFDTETGDAIGFAHYLNHLTSWHVEEVVYMNDLYVTERARVKGVGRKLI 132
               79*************************************************************************************************** PP
  HPA2.txt 102 efvyreadklGtravyWvvddynhraqllyekvgykkkkllykrkGy 148
               efvy++ad+lGt+avyWv+d+ynhraqlly+kv+yk++k+lykr+Gy
   YEL066W 133 EFVYSRADELGTPAVYWVTDHYNHRAQLLYTKVAYKTDKVLYKRNGY 179
               **********************************************8 PP
Protein Sequence
(Fasta)		MKKTPDPSPP FASTKNVGMS NEEPEKMVND RIVVKAIEPK DEEAWNKLWK EYQGFQKTVM 60
PPEVATTTFA RFIDPTVKLW GALAFDTETG DAIGFAHYLN HLTSWHVEEV VYMNDLYVTE 120
RARVKGVGRK LIEFVYSRAD ELGTPAVYWV TDHYNHRAQL LYTKVAYKTD KVLYKRNGY 179
Nucleotide Sequence
(Fasta)		ATGAAAAAGA CCCCAGACCC ATCTCCACCT TTTGCAAGCA CGAAGAACGT AGGCATGTCA 60
AACGAAGAAC CGGAAAAAAT GGTTAACGAT CGAATTGTGG TGAAGGCCAT CGAGCCAAAA 120
GATGAGGAAG CCTGGAACAA ACTGTGGAAG GAGTATCAGG GTTTCCAAAA AACGGTTATG 180
CCTCCGGAAG TAGCCACCAC TACCTTCGCA AGGTTTATAG ACCCTACGGT CAAACTATGG 240
GGTGCTCTAG CCTTTGACAC CGAGACCGGC GATGCAATTG GCTTTGCACA CTACCTGAAC 300
CATTTGACGT CGTGGCATGT CGAAGAAGTT GTCTACATGA ATGACTTATA TGTCACTGAA 360
CGCGCAAGAG TCAAAGGCGT AGGTAGAAAG CTCATAGAAT TTGTATACAG CCGTGCCGAT 420
GAGCTCGGTA CGCCTGCAGT GTACTGGGTT ACAGACCATT ACAATCACCG CGCACAGTTG 480
CTGTACACCA AAGTGGCTTA CAAGACAGAT AAGGTTCTTT ACAAGAGAAA CGGATACTGA 540
541
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0012--Acyltransferase
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
--
Interpro

IPR016181--Acyl_CoA_acyltransferase
IPR000182--GNAT_dom
IPR032962--HPA2/HPA3
PROSITE

PS51186--GNAT
Pfam

PF00583--Acetyltransf_1
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0047812--F:D-amino-acid N-acetyltransferase activity
GO:0004402--F:histone acetyltransferase activity
GO:0070458--P:cellular detoxification of nitrogen compound
GO:0046416--P:D-amino acid metabolic process
Orthology
Created Date 25-Jun-2016