| Tag |
Content |
| WERAM ID |
WERAM-Sac-0007 |
| Ensembl Protein ID |
YDR096W |
| Uniprot Accession |
Q03833; GIS1_YEAST; D6VS81
|
| Genbank Protein ID |
NP_010381.1
|
| Protein Name |
Transcriptional activator/repressor GIS1 |
| Genbank Nucleotide ID |
NM_001180404.1
|
| Gene Name |
GIS1 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDM |
JHDM3_JMJD2 |
Jmjc |
H3K36 |
K |
20868382
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HDM |
JHDM3_JMJD2 |
9.80e-62 |
206.3 |
171 |
324 |
|
| Organism |
Saccharomyces cerevisiae |
| NCBI Taxa ID |
559292 |
Functional Description
(View)Functional Description
Transcription factor involved in the regulation of gene expression upon nutrient starvation. Recognizes and binds to the post-diauxic-shift element 5'-T[AT]AGGGAT-3' in the promoter region. Can act as a transcriptional activator (e.g. of stress genes like SSA3, HSP12 and HSP26) as well as a repressor (e.g. of pyrophosphate phosphatase DPP1). GIS1 also acts as a DNA damage-responsive transcriptional repressor of photolyase PHR1. |
Transcription factor involved in the regulation of gene expression upon nutrient starvation. Recognizes and binds to the post-diauxic-shift element 5'-T[AT]AGGGAT-3' in the promoter region. Can act as a transcriptional activator (e.g. of stress genes like SSA3, HSP12 and HSP26) as well as a repressor (e.g. of pyrophosphate phosphatase DPP1). GIS1 also acts as a DNA damage-responsive transcriptional repressor of photolyase PHR1.
|
| Domain Profile |
HDM JHDM3_JMJD2
JHDM3.txt 2 edveeWnlnklktildsvekelkieieGvntpylyvgmlkttfaWhvedmdlysinylhfGapktWyavpseaakrlekllrkefsesakeceaflrhkt 101
+d++ Wnln+l+++++s++++ l++g++k++f+Wh+++++++sinylhfGapk+Wy++ps++++++ k+l+ke+s+++++c+af+rh++
YDR096W 171 YDLTLWNLNNLPDSINSSNRR------------LLTGQSKCIFPWHLDEQNKCSINYLHFGAPKQWYSIPSANTDQFLKILSKEPSSNKENCPAFIRHQN 258
57889*************999............9****************************************************************** PP
JHDM3.txt 102 tlisPellkkagipfnrivqeagefvitfPygyhaGfnhGfnlaestnfaterwievgkeaakcsc 167
+++sP++l+k++i+fnr+vq ++ef+itfPy++++Gfn+G+n++es++f+++++ v+k++ kc c
YDR096W 259 IITSPDFLRKNNIKFNRVVQFQHEFIITFPYCMYSGFNYGYNFGESIEFILDQQAVVRKQPLKCGC 324
****************************************************************99 PP
|
Protein Sequence
(Fasta) | MEIKPVEVID GVPVFKPSMM EFANFQYFID EITKFGIENG IVKVIPPKEW LELLEGSPPA 60
ESLKTIQLDS PIQQQAKRWD KHENGVFSIE NEYDNKSYNL TQWKNLAESL DSRISQGDFN 120
DKTLKENCRV DSQQDCYDLA QLQILESDFW KTIAFSKPFY AVDENSSIFP YDLTLWNLNN 180
LPDSINSSNR RLLTGQSKCI FPWHLDEQNK CSINYLHFGA PKQWYSIPSA NTDQFLKILS 240
KEPSSNKENC PAFIRHQNII TSPDFLRKNN IKFNRVVQFQ HEFIITFPYC MYSGFNYGYN 300
FGESIEFILD QQAVVRKQPL KCGCGNKKEE RKSGPFSNLS YDSNESEQRG SITDNDNDLF 360
QKVRSFDELL NHSSQELQNL EDNKNPLFSN INMNRPQSSS LRSTTPNGVN QFLNMNQTTI 420
SRISSPLLSR MMDLSNIVEP TLDDPGSKFK RKVLTPQLPQ MNIPSNSSNF GTPSLTNTNS 480
LLSNITATST NPSTTTNGSQ NHNNVNANGI NTSAAASINN NISSTNNSAN NSSSNNNVST 540
VPSSMMHSST LNGTSGLGGD NDDNMLALSL ATLANSATAS PRLTLPPLSS PMNPNGHTSY 600
NGNMMNNNSG NGSNGSNSYS NGVTTAAATT TSAPHNLSIV SPNPTYSPNP LSLYLTNSKN 660
PLNSGLAPLS PSTSNIPFLK RNNVVTLNIS REASKSPISS FVNDYRSPLG VSNPLMYSST 720
INDYSNGTGI RQNSNNINPL DAGPSFSPLH KKPKILNGND NSNLDSNNFD YSFTGNKQES 780
NPSILNNNTN NNDNYRTSSM NNNGNNYQAH SSKFGENEVI MSDHGKIYIC RECNRQFSSG 840
HHLTRHKKSV HSGEKPHSCP RCGKRFKRRD HVLQHLNKKI PCTQEMENTK LAES 894Protein Fasta Sequence
>YDR096W|GIS1|Saccharomyces cerevisiae
MEIKPVEVIDGVPVFKPSMMEFANFQYFIDEITKFGIENGIVKVIPPKEWLELLEGSPPAESLKTIQLDSPIQQQAKRWDKHENGVFSIENEYDNKSYNLTQWKNLAESLDSRISQGDFNDKTLKENCRVDSQQDCYDLAQLQILESDFWKTIAFSKPFYAVDENSSIFPYDLTLWNLNNLPDSINSSNRRLLTGQSKCIFPWHLDEQNKCSINYLHFGAPKQWYSIPSANTDQFLKILSKEPSSNKENCPAFIRHQNIITSPDFLRKNNIKFNRVVQFQHEFIITFPYCMYSGFNYGYNFGESIEFILDQQAVVRKQPLKCGCGNKKEERKSGPFSNLSYDSNESEQRGSITDNDNDLFQKVRSFDELLNHSSQELQNLEDNKNPLFSNINMNRPQSSSLRSTTPNGVNQFLNMNQTTISRISSPLLSRMMDLSNIVEPTLDDPGSKFKRKVLTPQLPQMNIPSNSSNFGTPSLTNTNSLLSNITATSTNPSTTTNGSQNHNNVNANGINTSAAASINNNISSTNNSANNSSSNNNVSTVPSSMMHSSTLNGTSGLGGDNDDNMLALSLATLANSATASPRLTLPPLSSPMNPNGHTSYNGNMMNNNSGNGSNGSNSYSNGVTTAAATTTSAPHNLSIVSPNPTYSPNPLSLYLTNSKNPLNSGLAPLSPSTSNIPFLKRNNVVTLNISREASKSPISSFVNDYRSPLGVSNPLMYSSTINDYSNGTGIRQNSNNINPLDAGPSFSPLHKKPKILNGNDNSNLDSNNFDYSFTGNKQESNPSILNNNTNNNDNYRTSSMNNNGNNYQAHSSKFGENEVIMSDHGKIYICRECNRQFSSGHHLTRHKKSVHSGEKPHSCPRCGKRFKRRDHVLQHLNKKIPCTQEMENTKLAES |
Nucleotide Sequence
(Fasta) | ATGGAAATCA AGCCAGTTGA GGTTATTGAT GGCGTTCCGG TTTTTAAGCC GTCTATGATG 60
GAGTTTGCAA ATTTCCAATA TTTCATTGAT GAAATTACTA AATTCGGAAT AGAAAATGGT 120
ATTGTCAAAG TCATTCCTCC CAAAGAATGG CTGGAGCTTT TAGAAGGCTC ACCTCCTGCG 180
GAAAGTTTAA AGACTATACA ACTAGACTCC CCGATTCAAC AACAAGCCAA GCGATGGGAC 240
AAACATGAAA ACGGTGTATT TAGCATCGAA AACGAGTATG ACAATAAGTC GTACAATTTA 300
ACACAGTGGA AGAACTTGGC CGAAAGTCTA GACTCTCGAA TAAGTCAAGG TGATTTTAAT 360
GATAAAACTT TAAAGGAAAA TTGCCGCGTA GATAGTCAGC AGGATTGTTA TGATTTGGCA 420
CAGTTACAAA TTTTAGAAAG TGATTTTTGG AAAACCATCG CTTTTTCGAA ACCTTTTTAT 480
GCAGTGGACG AAAACTCTTC AATTTTCCCC TATGATTTAA CTTTATGGAA TTTGAATAAT 540
TTGCCAGATT CTATAAACTC AAGTAACAGA CGGTTACTTA CTGGTCAGTC TAAATGCATT 600
TTTCCATGGC ATTTGGACGA ACAGAATAAA TGCTCTATAA ACTACTTGCA TTTCGGTGCT 660
CCCAAACAAT GGTATTCCAT ACCGTCCGCA AACACAGACC AATTTTTGAA AATTTTATCA 720
AAGGAACCAT CAAGTAATAA GGAAAATTGT CCAGCTTTTA TTAGACATCA AAACATCATA 780
ACTTCTCCCG ATTTCTTGCG AAAAAATAAT ATAAAATTTA ATAGAGTGGT GCAGTTCCAA 840
CATGAATTCA TCATTACTTT CCCTTATTGC ATGTACTCCG GATTCAATTA TGGTTACAAT 900
TTTGGCGAAT CTATTGAGTT CATATTAGAT CAGCAAGCTG TCGTTAGAAA GCAACCTTTA 960
AAATGCGGCT GTGGAAACAA GAAGGAAGAG CGAAAATCTG GTCCGTTTTC AAATTTATCT 1020
TATGATTCTA ATGAGTCGGA GCAACGAGGC TCCATTACTG ATAATGATAA CGATTTATTT 1080
CAAAAAGTTC GAAGTTTTGA TGAATTACTA AACCATTCCT CTCAAGAGTT ACAAAATTTA 1140
GAAGACAATA AGAACCCCTT GTTCTCCAAT ATTAATATGA ACAGACCGCA AAGTAGTTCT 1200
CTTCGGTCTA CTACCCCTAA TGGTGTAAAC CAGTTCCTGA ACATGAATCA AACTACCATA 1260
AGCAGAATTT CTTCCCCGTT GTTATCAAGG ATGATGGACT TATCAAATAT TGTGGAACCC 1320
ACTTTGGATG ATCCGGGTTC CAAGTTCAAA AGGAAAGTTT TAACTCCGCA ATTACCGCAG 1380
ATGAATATTC CGTCTAATTC TAGTAATTTT GGCACCCCTT CTCTAACTAA TACAAACTCC 1440
TTACTATCTA ATATAACGGC TACATCAACC AACCCATCGA CAACTACAAA TGGCAGCCAA 1500
AACCACAATA ATGTTAACGC CAATGGCATT AACACCTCTG CAGCCGCATC TATCAATAAT 1560
AACATTAGCA GTACCAATAA TAGCGCTAAT AATAGTAGTA GTAATAATAA CGTTTCCACT 1620
GTGCCTTCTT CAATGATGCA TTCGTCCACT TTAAATGGGA CTTCAGGTCT AGGCGGCGAT 1680
AACGATGACA ATATGTTAGC TTTAAGTTTA GCGACACTGG CTAACAGCGC TACTGCGTCA 1740
CCAAGATTGA CGTTACCGCC GCTGTCGTCA CCAATGAATC CGAACGGCCA CACCTCATAT 1800
AATGGCAATA TGATGAACAA CAACAGTGGT AATGGTAGCA ACGGTAGCAA CAGCTATTCT 1860
AACGGTGTGA CTACGGCTGC TGCCACAACT ACATCAGCGC CTCACAATCT ATCCATAGTG 1920
TCCCCTAATC CAACATACAG TCCGAATCCC CTATCTCTTT ATTTGACCAA CTCCAAAAAT 1980
CCATTAAATT CAGGTCTTGC ACCCTTATCA CCTTCAACAT CTAACATCCC ATTTCTCAAG 2040
AGGAATAATG TGGTTACATT AAATATTTCA AGAGAAGCTT CAAAGAGCCC TATATCTTCT 2100
TTTGTAAATG ACTATAGATC TCCGTTGGGT GTAAGCAATC CACTCATGTA TTCTTCCACA 2160
ATCAACGATT ATTCAAACGG TACTGGAATT CGCCAAAATA GTAATAATAT TAATCCCTTA 2220
GATGCAGGTC CATCTTTTTC TCCTCTCCAC AAAAAACCCA AAATACTCAA CGGTAATGAT 2280
AATAGCAATC TGGACAGTAA TAATTTTGAT TACAGTTTCA CGGGTAACAA GCAAGAATCT 2340
AATCCATCAA TCTTGAACAA TAATACTAAT AATAATGATA ACTATCGTAC ATCTTCAATG 2400
AACAATAACG GCAACAATTA TCAAGCGCAT TCTTCTAAGT TCGGTGAAAA TGAGGTCATT 2460
ATGTCAGATC ATGGTAAGAT TTACATTTGT CGGGAATGTA ATAGACAGTT TTCCTCTGGT 2520
CACCATCTAA CAAGACATAA AAAGTCAGTT CATTCCGGTG AGAAACCCCA TTCTTGCCCA 2580
AGATGCGGTA AAAGATTCAA GAGAAGAGAC CATGTTCTGC AACATTTAAA TAAAAAAATT 2640
CCATGCACTC AAGAAATGGA AAATACTAAA TTAGCTGAAT CATAG
2686Nucleotide Fasta Sequence
>YDR096W|JHDM3_JMJD2|Saccharomyces cerevisiae
ATGGAAATCAAGCCAGTTGAGGTTATTGATGGCGTTCCGGTTTTTAAGCCGTCTATGATGGAGTTTGCAAATTTCCAATATTTCATTGATGAAATTACTAAATTCGGAATAGAAAATGGTATTGTCAAAGTCATTCCTCCCAAAGAATGGCTGGAGCTTTTAGAAGGCTCACCTCCTGCGGAAAGTTTAAAGACTATACAACTAGACTCCCCGATTCAACAACAAGCCAAGCGATGGGACAAACATGAAAACGGTGTATTTAGCATCGAAAACGAGTATGACAATAAGTCGTACAATTTAACACAGTGGAAGAACTTGGCCGAAAGTCTAGACTCTCGAATAAGTCAAGGTGATTTTAATGATAAAACTTTAAAGGAAAATTGCCGCGTAGATAGTCAGCAGGATTGTTATGATTTGGCACAGTTACAAATTTTAGAAAGTGATTTTTGGAAAACCATCGCTTTTTCGAAACCTTTTTATGCAGTGGACGAAAACTCTTCAATTTTCCCCTATGATTTAACTTTATGGAATTTGAATAATTTGCCAGATTCTATAAACTCAAGTAACAGACGGTTACTTACTGGTCAGTCTAAATGCATTTTTCCATGGCATTTGGACGAACAGAATAAATGCTCTATAAACTACTTGCATTTCGGTGCTCCCAAACAATGGTATTCCATACCGTCCGCAAACACAGACCAATTTTTGAAAATTTTATCAAAGGAACCATCAAGTAATAAGGAAAATTGTCCAGCTTTTATTAGACATCAAAACATCATAACTTCTCCCGATTTCTTGCGAAAAAATAATATAAAATTTAATAGAGTGGTGCAGTTCCAACATGAATTCATCATTACTTTCCCTTATTGCATGTACTCCGGATTCAATTATGGTTACAATTTTGGCGAATCTATTGAGTTCATATTAGATCAGCAAGCTGTCGTTAGAAAGCAACCTTTAAAATGCGGCTGTGGAAACAAGAAGGAAGAGCGAAAATCTGGTCCGTTTTCAAATTTATCTTATGATTCTAATGAGTCGGAGCAACGAGGCTCCATTACTGATAATGATAACGATTTATTTCAAAAAGTTCGAAGTTTTGATGAATTACTAAACCATTCCTCTCAAGAGTTACAAAATTTAGAAGACAATAAGAACCCCTTGTTCTCCAATATTAATATGAACAGACCGCAAAGTAGTTCTCTTCGGTCTACTACCCCTAATGGTGTAAACCAGTTCCTGAACATGAATCAAACTACCATAAGCAGAATTTCTTCCCCGTTGTTATCAAGGATGATGGACTTATCAAATATTGTGGAACCCACTTTGGATGATCCGGGTTCCAAGTTCAAAAGGAAAGTTTTAACTCCGCAATTACCGCAGATGAATATTCCGTCTAATTCTAGTAATTTTGGCACCCCTTCTCTAACTAATACAAACTCCTTACTATCTAATATAACGGCTACATCAACCAACCCATCGACAACTACAAATGGCAGCCAAAACCACAATAATGTTAACGCCAATGGCATTAACACCTCTGCAGCCGCATCTATCAATAATAACATTAGCAGTACCAATAATAGCGCTAATAATAGTAGTAGTAATAATAACGTTTCCACTGTGCCTTCTTCAATGATGCATTCGTCCACTTTAAATGGGACTTCAGGTCTAGGCGGCGATAACGATGACAATATGTTAGCTTTAAGTTTAGCGACACTGGCTAACAGCGCTACTGCGTCACCAAGATTGACGTTACCGCCGCTGTCGTCACCAATGAATCCGAACGGCCACACCTCATATAATGGCAATATGATGAACAACAACAGTGGTAATGGTAGCAACGGTAGCAACAGCTATTCTAACGGTGTGACTACGGCTGCTGCCACAACTACATCAGCGCCTCACAATCTATCCATAGTGTCCCCTAATCCAACATACAGTCCGAATCCCCTATCTCTTTATTTGACCAACTCCAAAAATCCATTAAATTCAGGTCTTGCACCCTTATCACCTTCAACATCTAACATCCCATTTCTCAAGAGGAATAATGTGGTTACATTAAATATTTCAAGAGAAGCTTCAAAGAGCCCTATATCTTCTTTTGTAAATGACTATAGATCTCCGTTGGGTGTAAGCAATCCACTCATGTATTCTTCCACAATCAACGATTATTCAAACGGTACTGGAATTCGCCAAAATAGTAATAATATTAATCCCTTAGATGCAGGTCCATCTTTTTCTCCTCTCCACAAAAAACCCAAAATACTCAACGGTAATGATAATAGCAATCTGGACAGTAATAATTTTGATTACAGTTTCACGGGTAACAAGCAAGAATCTAATCCATCAATCTTGAACAATAATACTAATAATAATGATAACTATCGTACATCTTCAATGAACAATAACGGCAACAATTATCAAGCGCATTCTTCTAAGTTCGGTGAAAATGAGGTCATTATGTCAGATCATGGTAAGATTTACATTTGTCGGGAATGTAATAGACAGTTTTCCTCTGGTCACCATCTAACAAGACATAAAAAGTCAGTTCATTCCGGTGAGAAACCCCATTCTTGCCCAAGATGCGGTAAAAGATTCAAGAGAAGAGACCATGTTCTGCAACATTTAAATAAAAAAATTCCATGCACTCAAGAAATGGAAAATACTAAATTAGCTGAATCATAG
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0010--Activator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
--
|
| Interpro |
IPR003347--JmjC_dom
IPR003349--JmjN
IPR007087--Znf_C2H2
IPR015880--Znf_C2H2-like
IPR013087--Znf_C2H2/integrase_DNA-bd
|
| PROSITE |
PS51184--JMJC
PS51183--JMJN
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
|
| Pfam |
PF02373--JmjC
PF02375--JmjN
|
| Gene Ontology |
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0051864--F:histone demethylase activity (H3-K36 specific)
GO:0046872--F:metal ion binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001078--F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001300--P:chronological cell aging
GO:0016577--P:histone demethylation
GO:0070544--P:histone H3-K36 demethylation
GO:0060275--P:maintenance of stationary phase in response to starvation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0071071--P:regulation of phospholipid biosynthetic process
GO:0006366--P:transcription from RNA polymerase II promoter
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
