WERAM Information

Tag Content
WERAM ID WERAM-Cae-0015
Ensembl Protein ID Y2H9A.1
Uniprot Accession Q9NH52; MES4_CAEEL; Q9XXS4
Genbank Protein ID NP_506333.1
Protein Name Histone-lysine N-methyltransferase mes-4
Genbank Nucleotide ID NM_073932.4
Gene Name MES4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00003222 Y2H9A.1 Y2H9A.1
Details
Type Family Domain Substrates AA References (PMIDs)
HMT SET2 SET H3K27; H3K36 K 20236312; 16968818; 12077420
Status Reviewed
Classification
Type Family E-value Score Start End
HMT SET2 1.90e-42 144.7 514 665
Organism Caenorhabditis elegans
NCBI Taxa ID 6239
Functional Description
(View)		 Histone methyltransferase. Dimethylates 'Lys-36' of histone H3, a specific tag for epigenetic transcriptional activation. Plays a central role in early development and is responsible for all H3 'Lys-36' dimethylation until about the 40-cell stage. Indirectly involved in the global inactivation of the X chromosomes in germline cells, possibly by excluding the mes-2-mes-3-mes-6 repressive Polycomb complex from the autosomes. Not related to transcription elongation.
Domain Profile
  HMT SET2
  SET2.txt  81 sCePncetqkwtvegelrvglf 102
                C P c  +    + ++ +g+ 
   Y2H9A.1 514 ECPPSCSKKGVCHNRQVSMGIV 535
               5999999999999999998886 PP
  SET2.txt   2 kveliktekkGyGlrakeeikkdefileYvGevidekeakkRlk..eyeeekvkdfYlleldkdeviDatkkGnlaRfinhsCePncet......qkwtve 94 
               k++l++t +kGyG++ak +i+kde+i+eYvGe+id++e+k+Rl+  +++++ ++++Y++el+k+ ++Da+++Gn++R+inhsC+Pn+++       k+t+e
   Y2H9A.1 538 KIKLAATLCKGYGVFAKGQIEKDEYICEYVGEIIDKAEKKRRLDsvSISRDFQANHYMMELHKGLTVDAARYGNISRYINHSCDPNAASfvtkvfVKKTKE 638
               89*****************************************9667899**************************************9999999899999 PP
  SET2.txt  95 g...elrvglfakkkikkgeeltfdYn 118
               g   ++r++++a+++i++g+e+tf+Yn
   Y2H9A.1 639 GslyDTRSYIRAIRTIDDGDEITFSYN 665
               999999********************8 PP
Protein Sequence
(Fasta)		MLPSSGDSSK ENCAPQDGIV EKEGPNKPFK KKNVKQRNAT PQGAGSETSS NAEDKQEEAP 60
ILTNAPKDII SMQIQETKAF LSEYEEFVDT DYPKTTFTHV PRKFLSVSPF TPIEADAEGE 120
FLPDADSKCV ICHEEKDKTG KSDLITCHGY INGEMDDGKR LLGNIPMFPC RSKFHASCMI 180
NYNSGGFHFQ YAARLECQAR LLCPLHCCNS CNLDHHKQSA YVGDIAECAL CLRAFHLTSC 240
YPSGGRDLNV SITIGGKVEK FEMIICPAHY LPGADVQFYN KHKKRKNAVT VVPKADVTMK 300
SHIKACCVIG CEKSSNSKTI MCKTCCRSFH SGCREVETLN GKPIPDDQCE SCVCGDPIPQ 360
NTLILAKWTD NSFWLALTLD WYKYPTGNRG NINFERLGYT VVQWLIPQEN DKEKQPLMSI 420
VPVSDIARLT KNYFSLAKNS TLRNLWEEKY EEQADTALKR CPYVCKTVFG RLRTSVYYKC 480
EPKLEEYHNN EVCNCEGADR CTKLSCQYLA DDYECPPSCS KKGVCHNRQV SMGIVSEKIK 540
LAATLCKGYG VFAKGQIEKD EYICEYVGEI IDKAEKKRRL DSVSISRDFQ ANHYMMELHK 600
GLTVDAARYG NISRYINHSC DPNAASFVTK VFVKKTKEGS LYDTRSYIRA IRTIDDGDEI 660
TFSYNMNNEE NLPDCECGAE NCMGTMGKAK REKPEVADSS EKAAKKNKSS KKKSVKNQNR 720
KSQEAGKNGT ASKKSEISPS KPSTSSASST SFVQQASWPI SQNKKNLKKN SNQPVADTGS 780
TLSTSTELNF HEKPQELLSP VSSRSRAASS STPRAQKSKS RRDDVESEAP PVKRATPSLQ 840
TIQETGKAIE FPATKSAITK ARALSTQSVP SPHTVEVKVR AISTRGRVQK ETKRFEPI 898
Nucleotide Sequence
(Fasta)		AGTTGCTTAC TTCTCGCGCT TGGTGCCAAA TTATGCTGCC GAGCTCTGGT GACTCCAGCA 60
AAGAGAACTG TGCTCCACAG GACGGTATCG TTGAGAAAGA AGGACCAAAT AAACCTTTTA 120
AAAAGAAGAA CGTTAAACAA CGGAATGCTA CTCCACAAGG CGCGGGTTCC GAAACCTCAT 180
CCAATGCAGA AGACAAGCAA GAAGAAGCAC CGATTCTAAC GAATGCTCCC AAAGACATTA 240
TTTCGATGCA AATACAGGAA ACGAAGGCAT TTCTTAGTGA ATATGAGGAG TTCGTTGACA 300
CAGATTATCC AAAAACTACC TTCACCCACG TGCCACGAAA GTTTCTGAGT GTTTCGCCAT 360
TCACCCCGAT TGAAGCCGAC GCGGAAGGAG AGTTTCTTCC AGATGCTGAC TCAAAATGCG 420
TGATTTGCCA CGAAGAGAAG GATAAAACCG GAAAATCTGA TTTGATCACA TGTCATGGAT 480
ACATCAATGG AGAAATGGAC GACGGCAAGC GTCTCTTGGG AAATATACCA ATGTTTCCTT 540
GTCGTAGTAA ATTTCACGCG AGTTGTATGA TCAATTACAA CAGTGGCGGC TTTCACTTTC 600
AATATGCAGC CCGACTCGAA TGCCAAGCAA GACTTCTGTG CCCTCTTCAT TGCTGCAATA 660
GTTGCAATTT GGACCATCAC AAGCAATCGG CTTATGTTGG AGATATTGCA GAATGTGCTC 720
TCTGTCTCCG CGCTTTCCAT TTGACGTCGT GTTATCCATC AGGTGGCCGA GATTTGAATG 780
TTTCGATAAC AATTGGTGGG AAAGTGGAGA AGTTCGAAAT GATAATTTGT CCAGCACACT 840
ATCTACCTGG TGCTGATGTT CAATTCTACA ATAAACATAA AAAAAGAAAA AACGCCGTCA 900
CTGTTGTTCC GAAAGCGGAT GTTACAATGA AATCCCATAT CAAAGCGTGT TGCGTAATTG 960
GATGTGAGAA ATCTTCGAAT TCAAAAACAA TCATGTGCAA GACTTGTTGC CGATCGTTTC 1020
ATTCTGGATG TCGAGAAGTG GAAACGCTGA ATGGAAAACC GATACCAGAC GATCAATGCG 1080
AATCGTGTGT TTGTGGAGAT CCGATTCCGC AAAATACATT GATTCTCGCG AAGTGGACGG 1140
ACAATTCATT CTGGCTAGCA TTAACACTCG ATTGGTACAA GTACCCTACT GGAAATCGTG 1200
GTAATATCAA CTTTGAACGT CTTGGATATA CTGTTGTCCA GTGGCTGATA CCCCAAGAAA 1260
ATGATAAAGA GAAACAACCT CTCATGTCAA TTGTGCCGGT CTCGGATATC GCCCGTCTTA 1320
CCAAGAATTA CTTTTCGTTG GCAAAGAATT CGACGCTTAG AAACTTGTGG GAAGAGAAAT 1380
ATGAGGAACA AGCAGATACT GCGTTGAAGA GATGCCCGTA CGTGTGTAAA ACTGTATTTG 1440
GAAGACTGAG AACATCTGTG TACTACAAAT GCGAACCAAA ACTGGAAGAG TATCACAACA 1500
ACGAAGTTTG CAATTGTGAA GGAGCTGACC GCTGTACAAA GCTGTCGTGT CAATATCTCG 1560
CCGATGATTA TGAATGTCCC CCGAGTTGTT CGAAAAAGGG CGTTTGTCAT AATCGTCAAG 1620
TTTCCATGGG AATAGTTAGC GAGAAAATCA AACTGGCAGC CACTTTGTGT AAAGGATACG 1680
GTGTCTTTGC GAAAGGTCAA ATCGAAAAAG ACGAATACAT ATGCGAGTAC GTTGGAGAAA 1740
TAATCGATAA AGCTGAAAAG AAGAGGCGCT TGGATTCGGT TTCAATTTCG CGAGATTTCC 1800
AGGCGAACCA TTATATGATG GAATTGCACA AAGGATTAAC CGTGGACGCT GCCAGATACG 1860
GTAACATCTC CAGATACATC AATCATTCTT GCGATCCCAA CGCTGCATCT TTCGTTACAA 1920
AAGTGTTCGT TAAGAAAACC AAAGAAGGCA GTTTATATGA TACTCGCAGT TATATTCGGG 1980
CAATTCGCAC TATTGACGAC GGCGACGAGA TCACGTTCAG TTACAATATG AACAATGAGG 2040
AGAACTTACC AGACTGTGAA TGTGGAGCTG AAAACTGTAT GGGTACAATG GGAAAAGCGA 2100
AACGCGAGAA ACCGGAAGTG GCTGATAGTT CCGAGAAAGC TGCTAAAAAG AACAAATCGT 2160
CCAAGAAGAA ATCTGTAAAA AATCAGAATA GAAAGAGCCA GGAGGCCGGA AAGAACGGAA 2220
CCGCATCTAA GAAATCAGAA ATTTCTCCTT CGAAACCATC CACAAGCTCC GCGTCGAGCA 2280
CTTCCTTCGT CCAACAAGCA TCATGGCCAA TTTCCCAGAA TAAGAAAAAT TTAAAGAAGA 2340
ATTCCAATCA ACCTGTAGCC GACACCGGAT CAACATTGAG TACATCTACA GAGTTGAATT 2400
TCCACGAAAA ACCGCAAGAA CTCTTGAGCC CTGTTTCATC GCGATCGCGC GCAGCTTCAT 2460
CTTCAACACC ACGGGCACAA AAATCAAAGA GCCGTCGAGA TGATGTGGAA AGTGAAGCGC 2520
CACCTGTGAA ACGAGCTACG CCATCATTGC AAACAATTCA AGAAACCGGA AAAGCGATAG 2580
AGTTTCCTGC AACCAAGTCG GCTATCACAA AAGCACGAGC GTTGTCGACA CAATCAGTTC 2640
CATCACCTCA TACTGTGGAG GTCAAAGTTA GAGCAATATC TACTCGTGGA CGAGTTCAAA 2700
AAGAGACAAA ACGGTTTGAA CCGATTTGAA AAGTGAAATA ATATGCTGTC TCGCCCAATT 2760
GAACTCTTTC CAATAGTCTT CCAAGTACTA AATTATGATT TTACTTCAAT TAGTTTCAAT 2820
CAACAGTGCC CTCATTCTTT TTAATCGTAC TATGAGTTTT TCCTGGACTG TCGACACAAT 2880
TTTTGGAAAC GCTGAAATTC ATTTGACCAA CGTTCAAAGA ATAACGAAGA CTTTCCTATT 2940
CATCTTTTTT GAAAATTATT TTCACACTAA ACTAGGGGTT TTATTATTGC TTTAACCATT 3000
GCTTTCATTC ACTTGTCATT TTTTTTTCCC TATGTGTTCT TTCGTTCTTG TTACTGCGTC 3060
CCATCATATC GATAAATACG ACTTTTTTTT CTCATCTGTA ATAAATACCT TTGCAAA 3118
Sequence Source Ensembl
Keyword

KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR003616--Post-SET_dom
IPR001214--SET_dom
PROSITE

PS50868--POST_SET
PS50280--SET
Pfam

PF00856--SET
Gene Ontology

GO:0030849--C:autosome
GO:0005694--C:chromosome
GO:0000228--C:nuclear chromosome
GO:0000805--C:X chromosome
GO:0042054--F:histone methyltransferase activity
GO:0046975--F:histone methyltransferase activity (H3-K36 specific)
GO:0046872--F:metal ion binding
GO:0016458--P:gene silencing
GO:0018992--P:germ-line sex determination
GO:0010452--P:histone H3-K36 methylation
GO:0016571--P:histone methylation
GO:0040029--P:regulation of gene expression, epigenetic
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Drm-0072 FBpp0084636 Drosophila melanogaster 26 1e-27 123
WERAM-Leo-0066 ENSLOCP00000008456.1 Lepisosteus oculatus 26 9e-26 116
WERAM-Pof-0148 ENSPFOP00000012106.2 Poecilia formosa 24 2e-25 115
WERAM-Xet-0100 ENSXETP00000054753.2 Xenopus tropicalis 25 3e-25 114
WERAM-Mup-0106 ENSMPUP00000009598.1 Mustela putorius furo 24 7e-25 114
WERAM-Orn-0179 ENSONIP00000018125.1 Oreochromis niloticus 25 7e-25 113
WERAM-Gaa-0041 ENSGACP00000006025.1 Gasterosteus aculeatus 25 1e-24 112
WERAM-Tar-0201 ENSTRUP00000042261.1 Takifugu rubripes 24 1e-24 112
WERAM-Ict-0015 ENSSTOP00000001032.2 Ictidomys tridecemlineatus 23 2e-24 112
WERAM-Sus-0116 ENSSSCP00000016766.2 Sus scrofa 24 2e-24 112
WERAM-Ova-0008 ENSOARP00000001509.1 Ovis aries 24 2e-24 112
WERAM-Cap-0159 ENSCPOP00000013130.2 Cavia porcellus 24 2e-24 112
WERAM-Hos-0155 ENSP00000313983.7 Homo sapiens 24 2e-24 112
WERAM-Pat-0171 ENSPTRP00000045907.3 Pan troglodytes 24 2e-24 112
WERAM-Gog-0135 ENSGGOP00000011612.2 Gorilla gorilla 24 3e-24 111
WERAM-Gam-0039 ENSGMOP00000004113.1 Gadus morhua 26 3e-24 111
WERAM-Anc-0184 ENSACAP00000017722.2 Anolis carolinensis 24 4e-24 111
WERAM-Chs-0185 ENSCSAP00000011515.1 Chlorocebus sabaeus 24 4e-24 111
WERAM-Ten-0192 ENSTNIP00000019016.1 Tetraodon nigroviridis 24 4e-24 110
WERAM-Ran-0107 ENSRNOP00000057648.2 Rattus norvegicus 24 5e-24 110
WERAM-Xim-0090 ENSXMAP00000008149.1 Xiphophorus maculatus 26 5e-24 110
WERAM-Poa-0173 ENSPPYP00000020764.2 Pongo abelii 24 6e-24 110
WERAM-Tas-0004 ENSTSYP00000000493.1 Tarsius syrichta 24 9e-24 110
WERAM-Mum-0196 ENSMUSP00000081040.5 Mus musculus 23 1e-23 109
WERAM-Fia-0085 ENSFALP00000006989.1 Ficedula albicollis 24 1e-23 109
WERAM-Caj-0014 ENSCJAP00000003436.2 Callithrix jacchus 26 1e-23 109
WERAM-Pem-0013 ENSPMAP00000002102.1 Petromyzon marinus 25 2e-23 108
WERAM-Ora-0032 ENSOANP00000005155.1 Ornithorhynchus anatinus 24 2e-23 108
WERAM-Dan-0070 ENSDNOP00000007225.3 Dasypus novemcinctus 24 2e-23 108
WERAM-Bot-0197 ENSBTAP00000034104.4 Bos taurus 24 2e-23 108
WERAM-Mam-0074 ENSMMUP00000011851.2 Macaca mulatta 24 3e-23 108
WERAM-Ptv-0053 ENSPVAP00000005699.1 Pteropus vampyrus 23 3e-23 108
WERAM-Otg-0116 ENSOGAP00000010251.2 Otolemur garnettii 24 3e-23 108
WERAM-Paa-0116 ENSPANP00000000470.1 Papio anubis 24 3e-23 108
WERAM-Nol-0141 ENSNLEP00000015392.2 Nomascus leucogenys 24 3e-23 108
WERAM-Sah-0142 ENSSHAP00000014900.1 Sarcophilus harrisii 24 4e-23 107
WERAM-Tag-0070 ENSTGUP00000004993.1 Taeniopygia guttata 24 4e-23 107
WERAM-Orla-0025 ENSORLP00000003502.1 Oryzias latipes 24 5e-23 107
WERAM-Sei-0068 Si016710m Setaria italica 31 5e-23 107
WERAM-Pes-0094 ENSPSIP00000011454.1 Pelodiscus sinensis 24 5e-23 107
WERAM-Asm-0131 ENSAMXP00000012840.1 Astyanax mexicanus 24 6e-23 107
WERAM-Eqc-0202 ENSECAP00000021664.1 Equus caballus 23 6e-23 107
WERAM-Tut-0052 ENSTTRP00000004261.1 Tursiops truncatus 23 7e-23 107
WERAM-Orc-0022 ENSOCUP00000002408.2 Oryctolagus cuniculus 24 7e-23 107
WERAM-Mod-0087 ENSMODP00000013395.2 Monodelphis domestica 25 8e-23 106
WERAM-Loa-0134 ENSLAFP00000012330.4 Loxodonta africana 23 8e-23 106
WERAM-Fec-0136 ENSFCAP00000012620.3 Felis catus 24 9e-23 106
WERAM-Caf-0170 ENSCAFP00000024244.3 Canis familiaris 24 9e-23 106
WERAM-Myl-0080 ENSMLUP00000006392.2 Myotis lucifugus 24 1e-22 106
WERAM-Aim-0211 ENSAMEP00000019234.1 Ailuropoda melanoleuca 24 1e-22 106
WERAM-Anp-0119 ENSAPLP00000013578.1 Anas platyrhynchos 24 1e-22 106
WERAM-Dar-0147 ENSDARP00000085548.5 Danio rerio 25 1e-22 106
WERAM-Soa-0071 ENSSARP00000007016.1 Sorex araneus 23 1e-22 106
WERAM-Prc-0065 ENSPCAP00000006170.1 Procavia capensis 25 1e-22 106
WERAM-Lac-0095 ENSLACP00000012148.1 Latimeria chalumnae 25 2e-22 105
WERAM-Mua-0098 GSMUA_Achr6P30890_001 Musa acuminata 33 3e-22 105
WERAM-Gaga-0035 ENSGALP00000005219.3 Gallus gallus 24 3e-22 105
WERAM-Ere-0029 ENSEEUP00000002285.1 Erinaceus europaeus 23 2e-21 102
WERAM-Meg-0020 ENSMGAP00000001588.2 Meleagris gallopavo 24 2e-21 102
WERAM-Php-0121 PP1S76_183V6.2 Physcomitrella patens 32 3e-21 101
WERAM-Tra-0270 Traes_6DL_CCA52705A.2 Triticum aestivum 30 1e-20 99.8
WERAM-Brd-0088 BRADI3G48497.1 Brachypodium distachyon 32 2e-20 99.0
WERAM-Orbr-0104 OB09G13220.1 Oryza brachyantha 35 3e-20 98.6
WERAM-Sob-0074 Sb04g025725.1 Sorghum bicolor 34 3e-20 98.2
WERAM-Bro-0063 Bo3g175360.1 Brassica oleracea 34 5e-20 97.8
WERAM-Art-0109 AT4G30860.1 Arabidopsis thaliana 34 6e-20 97.4
WERAM-Viv-0070 VIT_11s0037g00880.t01 Vitis vinifera 37 7e-20 97.1
WERAM-Brr-0056 Bra010270.1-P Brassica rapa 34 7e-20 97.1
WERAM-Sol-0087 Solyc07g006060.2.1 Solanum lycopersicum 35 8e-20 97.1
WERAM-Cii-0053 ENSCINP00000025830.2 Ciona intestinalis 37 1e-19 95.9
WERAM-Ors-0088 OS09T0307800-01 Oryza sativa 36 2e-19 95.5
WERAM-Hov-0080 MLOC_61642.1 Hordeum vulgare 34 2e-19 95.5
WERAM-Ori-0107 BGIOSGA030025-PA Oryza indica 36 2e-19 95.5
WERAM-Org-0102 ORGLA10G0160100.1 Oryza glaberrima 36 2e-19 95.5
WERAM-Glm-0067 GLYMA06G29960.2 Glycine max 36 2e-19 95.5
WERAM-Orni-0090 ONIVA08G08400.1 Oryza nivara 36 2e-19 95.5
WERAM-Thc-0107 EOY31523 Theobroma cacao 34 3e-19 95.1
WERAM-Tub-0091 ENSTBEP00000010577.1 Tupaia belangeri 33 3e-19 95.1
WERAM-Ect-0087 ENSETEP00000010123.1 Echinops telfairi 36 3e-19 94.7
WERAM-Orl-0068 KN539433.1_FGP002 Oryza longistaminata 34 3e-19 94.7
WERAM-Prp-0057 EMJ26894 Prunus persica 36 4e-19 94.7
WERAM-Sem-0009 EFJ19814 Selaginella moellendorffii 31 5e-19 94.4
WERAM-Orgl-0027 OGLUM02G24130.1 Oryza glumaepatula 35 5e-19 94.4
WERAM-Orr-0102 ORUFI09G05410.1 Oryza rufipogon 38 1e-18 92.8
WERAM-Arl-0143 scaffold_701130.1 Arabidopsis lyrata 32 1e-18 92.8
WERAM-Zem-0023 GRMZM2G033694_P01 Zea mays 33 2e-18 92.4
WERAM-Orp-0093 OPUNC09G04270.1 Oryza punctata 37 2e-18 92.4
WERAM-Ocp-0029 ENSOPRP00000002509.2 Ochotona princeps 36 2e-18 92.0
WERAM-Vip-0117 ENSVPAP00000010795.1 Vicugna pacos 23 2e-18 92.0
WERAM-Tru-0071 TRIUR3_26983-P1 Triticum urartu 36 3e-18 91.7
WERAM-Orb-0099 OBART09G04760.1 Oryza barthii 38 4e-18 91.7
WERAM-Met-0003 KEH16902 Medicago truncatula 36 5e-18 90.9
WERAM-Trr-0038 EGR45981 Trichoderma reesei 32 6e-18 90.9
WERAM-Pot-0091 POPTR_0007s12130.1 Populus trichocarpa 35 7e-18 90.5
WERAM-Lep-0096 LPERR09G03460.1 Leersia perrieri 38 8e-18 90.1
WERAM-Cis-0029 ENSCSAVP00000005982.1 Ciona savignyi 37 1e-17 89.4
WERAM-Caa-0013 KGT70398 Candida albicans 36 2e-17 89.4
WERAM-Dio-0131 ENSDORP00000012311.1 Dipodomys ordii 34 2e-17 89.4
Created Date 25-Jun-2016