WERAM Information


Tag Content
WERAM ID WERAM-Cae-0020
Ensembl Protein ID T26A5.7a
Uniprot Accession Q22795; SET1_CAEEL
Genbank Protein ID NP_001022796.1
Protein Name Probable histone-lysine N-methyltransferase set-1
Genbank Nucleotide ID NM_001027625.3
Gene Name SET1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00004781 T26A5.7a T26A5.7a
Details
Type Family Domain Substrates AA References (PMIDs)
HMT SET1 SET H3K4 K 20236312
Status Reviewed
Classification
Type Family E-value Score Start End
HMT HMT_other 1.00e-40 164
HMT SET1 2.50e-36 125 106 225
HMT HMT_other 4.00e-36 148
Organism Caenorhabditis elegans
NCBI Taxa ID 6239
Functional Description
(View)
Probable histone methyltransferase involved in chromatin modification and/or regulation.
Domain Profile
  HMT HMT_other

Query: 55  RKGVSVKDVSNHKITEFFQVRRSNRKTSKQISDEAKHALRDTVLKGTNERLLEVYKDVV- 113
RK K N K+T+F+ VRRS+RK+ ++ E + + D +++ E +++ D++
Sbjct: 168 RKKAQGKTQQNRKLTDFYPVRRSSRKSKAELQSEERKRI-DELIESGKEEGMKI--DLID 224
Query: 114 -KGRGIRTKVNFEKGDFVVEYRGVMMEYSEAKVIEEQYSNDEEIGSYMYFFEHNNKKWCI 172
KGRG+ F +GDFVVEY G ++E ++AK E Y+ D G YMY+F++ +K +C+
Sbjct: 225 GKGRGVIATKQFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCV 284
Query: 173 DATKESPWKGRLINHSVLRPNLKTKVVEIDGSHHLILVARRQIAQGEELLYDYGDRSAET 232
DAT+E+ GRLINHS N +TK+ +IDG HLIL+A R IA GEELLYDYGDRS +
Sbjct: 285 DATRETNRLGRLINHSKCG-NCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDRSKAS 343
Query: 233 IAKNPWL 239
I +PWL
Sbjct: 344 IEAHPWL 350

  HMT SET1

  SET1.txt   3 levakskikglglvakkeiekeelviEYvGevirsevadkrekeyekkeig.vylfrldedae.vvvdatkkgn.iarfinhsce.pNceakvvavdgekk 99 
lev+k+ +kg+g+++k ++ek+++v+EY+G ++++++a+ e++y+++e + +y++ ++++++ +++datk++ + r+inhs+ pN+++kvv++dg+++
T26A5.7a 106 LEVYKDVVKGRGIRTKVNFEKGDFVVEYRGVMMEYSEAKVIEEQYSNDEEIgSYMYFFEHNNKkWCIDATKESPwKGRLINHSVLrPNLKTKVVEIDGSHH 206
899*******************************************998777****99998777*********9899******977*************** PP
SET1.txt 100 iviyakraIekgeeltydY 118
++++a+r+I++geel+ydY
T26A5.7a 207 LILVARRQIAQGEELLYDY 225
******************* PP

  HMT HMT_other

Query: 65  NHKITEFFQVRRSNRKTSKQISDEAKHALRDTVLKGTNERL--LEVYKDVVKGRGIRTKV 122
N ++T+FF VRRS RKT + +E L VL+ ER L+V + KGRG+
Sbjct: 517 NREMTDFFPVRRSVRKTKTAVKEEWMRGLEQAVLE---ERCDGLQVRHFMGKGRGVVADR 573
Query: 123 NFEKGDFVVEYRGVMMEYSEAKVIEEQYSNDEEIGSYMYFFEHNNKKWCIDATKESPWKG 182
F++ +FVVEY G ++ EA E++Y+ DE G YMY+F+H ++++CIDAT ++ G
Sbjct: 574 PFKRNEFVVEYVGDLISIGEAAEREKRYALDENAGCYMYYFKHKSQQYCIDATVDTGKLG 633
Query: 183 RLINHSVLRPNLKTKVVEIDGSHHLILVARRQIAQGEELLYDYGDRSAETIAKNPWLV 240
RLINHS NL TKVV I HL+L+A+ I GEEL YDYGDRS E++ +PWL
Sbjct: 634 RLINHSRAG-NLMTKVVLIKQRPHLVLLAKDDIEPGEELTYDYGDRSKESLLHHPWLA 690

Protein Sequence
(Fasta)
MKVAAKKLAT SRMRKDRAAA ASPSSDIENS ENPSSLASHS SSSGRMTPSK NTRSRKGVSV 60
KDVSNHKITE FFQVRRSNRK TSKQISDEAK HALRDTVLKG TNERLLEVYK DVVKGRGIRT 120
KVNFEKGDFV VEYRGVMMEY SEAKVIEEQY SNDEEIGSYM YFFEHNNKKW CIDATKESPW 180
KGRLINHSVL RPNLKTKVVE IDGSHHLILV ARRQIAQGEE LLYDYGDRSA ETIAKNPWLV 240
NT 242
Nucleotide Sequence
(Fasta)
CGGTGTCACT CGAAGGATGA AAGTTGCCGC GAAGAAGCTG GCAACGAGTA GAATGCGAAA 60
GGATCGTGCC GCAGCAGCGT CACCATCTAG TGATATTGAG AACTCCGAAA ATCCATCGTC 120
TTTGGCTTCA CACTCTTCAT CTTCAGGAAG AATGACACCG TCGAAAAACA CAAGGAGCAG 180
AAAAGGAGTG TCGGTGAAAG ATGTCTCAAA CCATAAAATC ACAGAATTCT TCCAAGTGCG 240
GCGAAGTAAT CGGAAGACGA GCAAGCAAAT TAGCGATGAA GCTAAACATG CTCTTCGCGA 300
TACCGTACTC AAGGGGACTA ATGAACGACT TCTTGAAGTG TACAAAGATG TTGTGAAGGG 360
GCGAGGAATT CGAACGAAAG TTAACTTTGA AAAAGGAGAC TTTGTTGTCG AATACAGAGG 420
TGTTATGATG GAGTACTCGG AAGCAAAAGT GATAGAAGAA CAATATTCGA ATGATGAGGA 480
AATCGGATCC TACATGTACT TTTTTGAGCA CAACAATAAA AAATGGTGTA TCGATGCGAC 540
AAAAGAATCT CCATGGAAAG GACGACTCAT CAATCATTCC GTGTTAAGGC CGAATCTCAA 600
AACGAAAGTG GTGGAAATCG ATGGGTCGCA TCACCTGATT CTCGTCGCCA GGCGTCAAAT 660
CGCACAAGGA GAAGAGCTTC TCTACGATTA TGGAGATCGT TCAGCAGAGA CGATTGCCAA 720
GAATCCATGG CTTGTGAACA CATAATATGT TGCTCCACAA CATCTCTTCG ATCTGCTCAA 780
TCCATTTCAA ATGTTCATTT ACCTTCACGA GTATACTACT GTAATTCCCT TCATTTTCTC 840
ATATTTTCCA CGGCACTCGT GCCCAATCCT CTCATTACTT CGTCTCTTTC AACCGCCTTT 900
TCTCATTCTC ACAGCGAATC AAACCTGAAA CAAATCTCAA TAACGAGCCG TAATAACGTG 960
CTCATTTATG ATAATCTGGA TCTCGTGAGT ATCCAATTCT GTACCTTTCC TGTTGACTTT 1020
TGAAAAGTCC CTTGTTCTTT CCTTTCATTG AAACCTGAAA ATCTCCTCAC TTGTTCCACT 1080
ACGAAATGCC TTTAATATCT TTAATTCTTC TGTAAATTTC TCGTTGATCG CCCATTTTTT 1140
CCTGAATTAT TCATTTTTGT GGTGTACATG AGGTGCGAGT TGGAAACCTA CTTTAATGAC 1200
TGGTTAACGC TAAAATCGTT TCCATCCCTA TCGGAAAACA TTATCAGCGT GCAAATCTCA 1260
ATTTTTCATT TTGAAAACAA TTAAAATCCA T 1292
Sequence Source Ensembl
Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
--

Interpro

IPR016858--Hist_H4-K20_MeTrfase
IPR001214--SET_dom

PROSITE

PS51571--SAM_MT43_PR_SET
PS50280--SET

Pfam

PF00856--SET

Gene Ontology

GO:0005634--C:nucleus
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0009792--P:embryo development ending in birth or egg hatching
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Pof-0135 ENSPFOP00000011379.1 Poecilia formosa 48 2e-44 176
WERAM-Xim-0218 ENSXMAP00000017730.1 Xiphophorus maculatus 50 1e-43 173
WERAM-Tar-0115 ENSTRUP00000024193.1 Takifugu rubripes 51 5e-43 171
WERAM-Ten-0166 ENSTNIP00000016502.1 Tetraodon nigroviridis 46 1e-42 170
WERAM-Dar-0229 ENSDARP00000136245.1 Danio rerio 45 3e-42 168
WERAM-Orla-0057 ENSORLP00000007720.1 Oryzias latipes 49 5e-42 168
WERAM-Orc-0205 ENSOCUP00000022542.1 Oryctolagus cuniculus 44 7e-42 167
WERAM-Leo-0051 ENSLOCP00000006933.1 Lepisosteus oculatus 44 2e-41 166
WERAM-Pat-0047 ENSPTRP00000009519.4 Pan troglodytes 45 6e-41 164
WERAM-Hos-0217 ENSP00000384629.3 Homo sapiens 45 6e-41 164
WERAM-Ict-0158 ENSSTOP00000023966.1 Ictidomys tridecemlineatus 44 6e-41 164
WERAM-Paa-0154 ENSPANP00000008801.1 Papio anubis 45 6e-41 164
WERAM-Chs-0023 ENSCSAP00000015972.1 Chlorocebus sabaeus 45 7e-41 164
WERAM-Poa-0049 ENSPPYP00000005792.2 Pongo abelii 45 8e-41 164
WERAM-Mam-0117 ENSMMUP00000017774.2 Macaca mulatta 45 9e-41 164
WERAM-Ocp-0106 ENSOPRP00000010131.1 Ochotona princeps 44 1e-40 164
WERAM-Gaa-0167 ENSGACP00000020612.1 Gasterosteus aculeatus 46 1e-40 163
WERAM-Mum-0187 ENSMUSP00000052953.4 Mus musculus 45 2e-40 163
WERAM-Tub-0097 ENSTBEP00000011336.1 Tupaia belangeri 44 2e-40 162
WERAM-Anp-0148 ENSAPLP00000015527.1 Anas platyrhynchos 46 2e-40 162
WERAM-Ran-0009 ENSRNOP00000062763.2 Rattus norvegicus 45 3e-40 162
WERAM-Otg-0208 ENSOGAP00000021371.1 Otolemur garnettii 43 3e-40 162
WERAM-Orn-0186 ENSONIP00000019310.1 Oreochromis niloticus 44 3e-40 162
WERAM-Sah-0176 ENSSHAP00000018113.1 Sarcophilus harrisii 43 4e-40 162
WERAM-Ora-0125 ENSOANP00000024129.1 Ornithorhynchus anatinus 44 6e-40 161
WERAM-Gog-0125 ENSGGOP00000010534.2 Gorilla gorilla 44 7e-40 160
WERAM-Tag-0075 ENSTGUP00000005528.1 Taeniopygia guttata 45 8e-40 160
WERAM-Mod-0104 ENSMODP00000015612.3 Monodelphis domestica 42 8e-40 160
WERAM-Meg-0034 ENSMGAP00000002945.1 Meleagris gallopavo 45 8e-40 160
WERAM-Mim-0060 ENSMICP00000006018.1 Microcebus murinus 44 8e-40 160
WERAM-Eqc-0169 ENSECAP00000018549.1 Equus caballus 44 9e-40 160
WERAM-Gaga-0036 ENSGALP00000005256.4 Gallus gallus 43 1e-39 160
WERAM-Cap-0061 ENSCPOP00000004895.2 Cavia porcellus 45 1e-39 160
WERAM-Myl-0188 ENSMLUP00000015654.2 Myotis lucifugus 45 1e-39 160
WERAM-Prc-0120 ENSPCAP00000010599.1 Procavia capensis 44 1e-39 160
WERAM-Caj-0175 ENSCJAP00000030718.1 Callithrix jacchus 45 2e-39 159
WERAM-Lac-0163 ENSLACP00000019549.1 Latimeria chalumnae 44 2e-39 159
WERAM-Tut-0178 ENSTTRP00000015051.1 Tursiops truncatus 44 2e-39 159
WERAM-Gam-0203 ENSGMOP00000019601.1 Gadus morhua 46 2e-39 159
WERAM-Dio-0014 ENSDORP00000001741.1 Dipodomys ordii 45 3e-39 159
WERAM-Fec-0198 ENSFCAP00000024833.1 Felis catus 44 3e-39 159
WERAM-Caf-0085 ENSCAFP00000011125.3 Canis familiaris 44 3e-39 159
WERAM-Bot-0003 ENSBTAP00000000160.5 Bos taurus 44 3e-39 159
WERAM-Mup-0016 ENSMPUP00000001614.1 Mustela putorius furo 44 3e-39 158
WERAM-Asm-0210 ENSAMXP00000020029.1 Astyanax mexicanus 44 4e-39 158
WERAM-Ova-0028 ENSOARP00000004029.1 Ovis aries 44 5e-39 158
WERAM-Sus-0069 ENSSSCP00000010440.2 Sus scrofa 44 5e-39 158
WERAM-Aim-0171 ENSAMEP00000016053.1 Ailuropoda melanoleuca 44 5e-39 158
WERAM-Loa-0119 ENSLAFP00000010602.2 Loxodonta africana 45 7e-39 157
WERAM-Ere-0036 ENSEEUP00000002745.1 Erinaceus europaeus 43 1e-38 157
WERAM-Dan-0081 ENSDNOP00000008024.3 Dasypus novemcinctus 43 2e-38 156
WERAM-Anc-0163 ENSACAP00000015161.3 Anolis carolinensis 43 6e-38 154
WERAM-Xet-0039 ENSXETP00000012803.3 Xenopus tropicalis 43 3e-37 152
WERAM-Ptv-0168 ENSPVAP00000014436.1 Pteropus vampyrus 42 8e-37 150
WERAM-Drm-0015 FBpp0082389 Drosophila melanogaster 46 4e-36 148
WERAM-Cii-0056 ENSCINP00000025690.2 Ciona intestinalis 41 1e-35 146
WERAM-Pes-0087 ENSPSIP00000010443.1 Pelodiscus sinensis 53 9e-33 137
WERAM-Ect-0102 ENSETEP00000011488.1 Echinops telfairi 42 2e-32 136
WERAM-Fia-0114 ENSFALP00000009670.1 Ficedula albicollis 42 2e-29 126
WERAM-Pem-0049 ENSPMAP00000005510.1 Petromyzon marinus 46 4e-28 122
WERAM-Cis-0084 ENSCSAVP00000018916.1 Ciona savignyi 42 4e-26 115
WERAM-Soa-0016 ENSSARP00000001796.1 Sorex araneus 34 3e-17 85.9
WERAM-Mae-0133 ENSMEUP00000013331.1 Macropus eugenii 35 3e-17 85.9
WERAM-Nol-0118 ENSNLEP00000013752.1 Nomascus leucogenys 34 6e-17 84.7
WERAM-Vip-0069 ENSVPAP00000006534.1 Vicugna pacos 57 7e-15 78.2
WERAM-Tas-0109 ENSTSYP00000011196.1 Tarsius syrichta 35 2e-14 76.3
WERAM-Amt-0059 ERN13661 Amborella trichopoda 35 4e-14 75.5
WERAM-Chh-0055 ENSCHOP00000006343.1 Choloepus hoffmanni 32 1e-13 73.6
WERAM-Ved-0007 EGY17741 Verticillium dahliae 29 2e-13 72.8
WERAM-Mua-0036 GSMUA_Achr1P18360_001 Musa acuminata 35 3e-13 72.4
WERAM-Art-0004 AT1G05830.1 Arabidopsis thaliana 31 3e-13 72.4
WERAM-Bro-0082 Bo4g176210.1 Brassica oleracea 32 6e-13 71.6
WERAM-Arl-0029 fgenesh1_pm.C_scaffold_1000445 Arabidopsis lyrata 31 7e-13 71.6
WERAM-Brr-0112 Bra021721.1-P Brassica rapa 33 1e-12 70.9
WERAM-Nec-0021 EFNCRP00000004417 Neurospora crassa 29 2e-12 69.7
WERAM-Brd-0096 BRADI4G08510.1 Brachypodium distachyon 35 2e-12 69.7
WERAM-Map-0034 MAPG_11216T0 Magnaporthe poae 32 3e-12 69.3
WERAM-Mao-0038 MGG_15053T0 Magnaporthe oryzae 30 3e-12 68.9
WERAM-Trv-0023 EHK27489 Trichoderma virens 28 4e-12 68.9
WERAM-Gag-0022 GGTG_06874T0 Gaeumannomyces graminis 39 4e-12 68.9
WERAM-Fuo-0006 FOXG_01447P0 Fusarium oxysporum 28 4e-12 68.9
WERAM-Sem-0044 EFJ23651 Selaginella moellendorffii 35 5e-12 68.6
WERAM-Trr-0040 EGR44940 Trichoderma reesei 28 5e-12 68.6
WERAM-Glm-0241 GLYMA18G51890.2 Glycine max 34 5e-12 68.6
WERAM-Sob-0033 Sb02g032470.1 Sorghum bicolor 35 6e-12 68.6
WERAM-Chg-0032 EAQ86448 Chaetomium globosum 32 6e-12 68.2
WERAM-Orbr-0103 OB09G11020.1 Oryza brachyantha 34 8e-12 67.8
WERAM-Zem-0147 GRMZM2G473138_P01 Zea mays 29 9e-12 67.8
WERAM-Tru-0051 TRIUR3_21779-P1 Triticum urartu 33 9e-12 67.8
WERAM-Lep-0095 LPERR09G00060.1 Leersia perrieri 34 1e-11 67.0
WERAM-Orr-0101 ORUFI09G01680.1 Oryza rufipogon 34 1e-11 67.0
WERAM-Ors-0087 OS09T0134500-02 Oryza sativa 34 2e-11 67.0
WERAM-Orni-0097 ONIVA09G01640.1 Oryza nivara 34 2e-11 67.0
WERAM-Org-0095 ORGLA09G0014000.1 Oryza glaberrima 34 2e-11 67.0
WERAM-Orgl-0094 OGLUM09G02000.1 Oryza glumaepatula 34 2e-11 67.0
WERAM-Orb-0098 OBART09G01600.1 Oryza barthii 34 2e-11 67.0
WERAM-Thc-0051 EOY04911 Theobroma cacao 35 2e-11 66.6
WERAM-Orp-0092 OPUNC09G01430.1 Oryza punctata 34 2e-11 66.6
WERAM-Sei-0103 Si028792m Setaria italica 29 2e-11 66.6
WERAM-Met-0147 KEH21862 Medicago truncatula 34 2e-11 66.6
Created Date 25-Jun-2016