WERAM Information

Tag Content
WERAM ID WERAM-Scp-0030
Ensembl Protein ID SPBC29A3.13.1:pep
Uniprot Accession O59676; PDP1_SCHPO; Q9USE8
Genbank Protein ID NP_595841.1
Protein Name PWWP domain-containing protein 1
Genbank Nucleotide ID NM_001021745.2
Gene Name Pdp1;SPBC29A3.13
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
SPBC29A3.13 SPBC29A3.13.1 SPBC29A3.13.1:pep
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader PWWP PWWP H4K20me K 19250904
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader PWWP 8.50e-20 68.8 52 282
Organism Schizosaccharomyces pombe
NCBI Taxa ID 284812
Functional Description
(View)		 Necessary for DNA damage checkpoint activation. Required for the association of set9 with chromatin and subsequent methylation of H4K20. Associates with H4K20me1 to increase the concentration of set9 on chromatin to perform H4K20me3. H4K20me3 is mainly enriched at heterochromatin and is required for proper heterochromatin assembly.
Domain Profile
  Me_Reader PWWP
           PWWP.txt   1 agdLVwaKlkgYpwWPalvisppleakklktqeaeenkylVlFFgnkherawvkrkklvpys 62 
                        +gd +++K  gYpwWPal++++++++++l+t+++ + +y+VlFF  + ++awvkr++++p+ 
  SPBC29A3.13.1:pep  52 FGDRILVKAPGYPWWPALLLRRKETKDSLNTNSSFNVLYKVLFFP-DFNFAWVKRNSVKPLL 112
                        69*******************************************.**************95 PP
           PWWP.txt  41 VlFFgnkherawvkrkkl 58 
                         lFF +k + a+++++ l
  SPBC29A3.13.1:pep 265 LLFFRHKLQKAFLSPDHL 282
                        589999999999998776 PP
Protein Sequence
(Fasta)		MNNARTNAKR RRLSSKQGGL SISEGKESNI PSVVEESKDN LEQASADDRL NFGDRILVKA 60
PGYPWWPALL LRRKETKDSL NTNSSFNVLY KVLFFPDFNF AWVKRNSVKP LLDSEIAKFL 120
GSSKRKSKEL IEAYEASKTP PDLKEESSTD EEMDSLSAAE EKPNFLQKRK YHWETSLDES 180
DAESISSGSL MSITSISEMY GPTVASTSRS STQLSDQRYP LSSNFDHRGE AKGKGKQPLK 240
NPQERGRISP SSPLNDQTKA LMQRLLFFRH KLQKAFLSPD HLIVEEDFYN ASKYLNAISD 300
IPFLNYELIT STKLAKVLKR IAFLEHLEND ELYDIRQKCK NLLYSWAMFL PNEPSIKGM 359
Nucleotide Sequence
(Fasta)		ACTAAGTATA GCTGACCCCC AAAGCAAGCA TACTATAGGA TTTCTAGTAA AGTAAAATTA 60
ATCTCGTTAT TAGTTTTGAT TGACTTGTCT TTATCCTTAT ACTTTTAAGA AAGATTGACA 120
GTGGTTGCTG ACTACTGCCC ACATGCCCAT TAAACGGGAG TGGTTAAACA TTAAAAGTAA 180
TACATGAGGC TAATCTCCTT TCATTTAGAA TAAGGAAAGT GGTTTTCTAT AATGAATAAT 240
GCCCGCACTA ATGCAAAAAG ACGAAGATTA TCTTCTAAAC AAGGGGGATT AAGCATATCC 300
GAAGGAAAAG AGAGTAATAT ACCCAGTGTT GTTGAAGAAA GCAAGGATAA TTTGGAACAA 360
GCTTCTGCAG ATGACAGGCT AAATTTTGGT GACCGAATTT TGGTAAAAGC CCCAGGTTAT 420
CCATGGTGGC CGGCCTTGCT ACTGAGACGA AAAGAAACTA AGGATAGTTT GAATACTAAT 480
AGCTCATTTA ATGTCTTATA TAAGGTTTTG TTTTTTCCTG ACTTCAATTT TGCATGGGTG 540
AAAAGAAATA GTGTTAAGCC ATTATTGGAT TCCGAAATAG CCAAATTTCT TGGTTCCTCA 600
AAGCGGAAGT CTAAAGAACT TATTGAAGCT TATGAGGCTT CAAAAACTCC TCCTGATTTA 660
AAGGAGGAAT CTTCCACCGA TGAGGAAATG GATAGCTTAT CAGCTGCTGA GGAGAAGCCT 720
AATTTTTTGC AAAAAAGAAA ATATCATTGG GAGACATCTC TTGATGAATC AGATGCGGAG 780
AGTATCTCCA GCGGATCCTT GATGTCAATA ACTTCTATTT CTGAAATGTA TGGTCCTACT 840
GTCGCTTCGA CTTCTCGTAG CTCTACGCAG TTAAGTGACC AAAGGTACCC ACTTTCAAGT 900
AATTTTGATC ATAGGGGAGA AGCAAAAGGA AAAGGAAAGC AACCTTTAAA AAACCCGCAA 960
GAGAGGGGCC GTATATCTCC TTCCTCACCT TTGAATGACC AGACGAAAGC ACTAATGCAG 1020
CGACTACTTT TTTTTCGCCA TAAGCTACAA AAAGCATTTC TTTCGCCGGA TCATTTGATA 1080
GTTGAAGAAG ATTTTTATAA CGCCAGTAAA TATCTAAACG CAATAAGTGA TATCCCGTTC 1140
CTGAACTACG AATTGATTAC TTCTACTAAA TTGGCAAAGG TCCTGAAGAG AATTGCTTTT 1200
TTGGAGCATT TAGAGAATGA CGAACTTTAT GATATTAGGC AGAAATGTAA AAATTTGCTT 1260
TACAGTTGGG CTATGTTTCT TCCAAACGAA CCATCGATAA AAGGCATGTA GTGTTTCTCA 1320
ACGTCAATAG AAGCTGATTT CCTATTACAC ACGACACCCT TTTACTTATG CTTTGGAGTA 1380
CCGGTATTGC ATACCAGATC GGTGGGAAGC AAGTTGTTAT CATGAATACT CTAAGTAAGA 1440
TGCGAAGCGC TAGTTTGCCG GTTGTTTAAA TTTAATGTTA TCATCTAGAT ACAATTTTTA 1500
CAGTGTATTT TAGCAGTTAA GTTTACGTTA AATTAGTATT TGTGGCTATT CACACAAGAA 1560
GGTAAAATTC ACATTTCTTT GGCAATATAC ATTGTTCAGT TGATGGTTCC TTTTTTTTTT 1620
GAAAGCGGCC TACAAGATAT ATTTCTAATT CACGTGCCTT TAGAAAATTG CCTCTATTTG 1680
TCTATATATT AATTAACGAA AAATATCAAA AACTTTAAGC AGCAAAAATT AAGTACTACA 1740
ATTTCATCCA ATACGACTAT ACCTTTAGTA TCTTCGTATT CTTTTTTTTT TGTCTCCTAA 1800
GTCAGTTTAT CTGTCTTCAC AATTTTTACG AAGCATTGGA TTCTTCAAAA ATCTATAAAA 1860
CGCTACAAGG CTTTAGTGCG CTAATTTAAT ACGAAGATGT AGACTTCAAA AAAAATGTAC 1920
GACAAAGAAC AGTTACCATA TGCATTGAGA TTATAAGCTA CATATACTAG TGAAATACAC 1980
AAGAAAGGAA TTTCATTTTC TACTCAGAGA TTAGGATTCA TTTTTACTAG TCAAAGAAAA 2040
GAATTACTCC TCTTCGGCTT CTTCACCTTC ACCACCCTCT TGTTGAGAGC GGAGACGCTT 2100
TCTCTTGCAG CGACCAGGGC GACCACCACC ATATGGAGAG GAAAGAGCAA AGTCGATATG 2160
CTTTTGGGCA TCCAAACGGA CAACGAAGGA AGGAACATTG ACAATTTGCT TACCAACACG 2220
GATGTGACGT TGGAAGATCA ACACACGTGC ATGATGGATG GACTTAGCCA AACCAAGCTT 2280
AAAGACTTGA GTTTGCAAAC GACGCTCCAA AAAGTCCTCG ATACGGAGAG CCAACACATA 2340
ATCAAGCTTC ATACGGGACT CATCCAAAAT GCCCAAACGA ACAAGACGAC GAATGATGGC 2400
ATTTCCCTCG AAAAGACGCT TAGGATCCTT CTCGTCAAGG GTCAAAAGCT CACGAGCAGC 2460
ACGACGGATT TTAGAAAGGG TAAGTGCTAC ACGCCAAATT TCATGCTTAT TTCTCAAACC 2520
ATATTCACCA GCAAGCTTGA GCTCGGCATC TAGACGGGCC GACTCGAAGG GACGACGAGG 2580
AACCTTGTAA GTCTTGGATT GCTTACGAGG AGCAGAAGGC ATTGTTTGTT TGGTGCTTTG 2640
CGCAACCTAC CTTTGCTATG TATTTTCAAG AAGGCACAAC AGTGACGGCT TTTTGAGATA 2700
CTGTAGTATT AGGTTAGGGT TTTGTCCCAT CACCATCCCG TACCGATATC CTTACTACAC 2760
ACTATTCCTA CTAACCCTC
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
--
Interpro

IPR000313--PWWP_dom
PROSITE

PS50812--PWWP
Pfam

PF00855--PWWP
Gene Ontology

GO:0000790--C:nuclear chromatin
GO:0005634--C:nucleus
GO:0003690--F:double-stranded DNA binding
GO:1990889--F:H4K20me3 modified histone binding
GO:0042393--F:histone binding
GO:0035064--F:methylated histone binding
GO:0031492--F:nucleosomal DNA binding
GO:0031493--F:nucleosomal histone binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006338--P:chromatin remodeling
GO:0070510--P:regulation of histone H4-K20 methylation
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
Orthology
Created Date 25-Jun-2016