WERAM - Writers, Erasers & Readers of Histone Acetylation and Methylation Database

Protein
Gene
Details
Classification
Function
Domain Profile
Sequence
Keyword
GO
Orthology
TOP

WERAM Information

Tag

Content

WERAM ID

WERAM-Scp-0011

Ensembl Protein ID

SPAC23E2.02.1:pep

Uniprot Accession

Q10135; LSD2_SCHPO; Q9USA2

Genbank Protein ID

NP_592937.1

Protein Name

Lysine-specific histone demethylase 2

Genbank Nucleotide ID

NM_001018338.2

Gene Name

LSD2;Swm2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPAC23E2.02	SPAC23E2.02.1	SPAC23E2.02.1:pep

Details

Type	Family	Domain	Substrates	AA	References (PMIDs)
HDM	LSD1_KDM1	Demethylaseactivity	H3K4	K	17440621

Status

Reviewed

Classification

Type	Family	E-value	Score	Start	End
HDM	LSD1_KDM1	0	1046.8	542	1197

Organism

Schizosaccharomyces pombe

NCBI Taxa ID

284812

Functional Description
(View)

Catalytic component of the SWM histone demethylase complex that specifically demethylates H3K9me2, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Has a role in regulating heterochromatin propagation and euchromatic transcription. Also has a gene activating role.

Domain Profile

HDM LSD1_KDM1

           LSD1.txt    1 lppkvvilEAkeRvGGriyskavpvsdleasevsslasnsnavssksvnlelkkvkdkstlds..............dpLyelssqqlsl 76  
                         lppkv+ilEAkeR+GGriys+a+pvs+++a+++++++snsn++ss+s++l++k+v+d+s+++s              d+L++l+++ql++
  SPAC23E2.02.1:pep  542 LPPKVIILEAKERTGGRIYSRALPVSHTSATQINHHTSNSNSISSNSTSLNPKDVTDPSHIPSaidlgfqflfspmdDILLNLLNKQLGI 631 
                         79**************************************************************************************** PP
           LSD1.txt   77 ekvemverefvlheldtkvldvvevqklfvlfeklleyvkvvkskeelkelinkeeslkikileqiqlyisiEalpkslkkdLsellaes 166 
                         e++em+++++v++e+dtkvld+vev+kl++l+eklleyv+v+       ++in+ees++i++++q+ql+i+ E++p++l+k+Ls l+a++
  SPAC23E2.02.1:pep  632 EVTEMTGSDLVYDETDTKVLDMVEVKKLNILWEKLLEYVSVC-------FFINVEESVRISWISQFQLFID-EMFPDHLSKSLS-LNASH 712 
                         ******************************************.......**********************.************.***** PP
           LSD1.txt  167 enkleeklqllvaelksfvylssrdkkiLswslavael.envyPlstldldl..ellgekvavrrGlsdlpvaLastPspLdiklekavr 253 
                         e+++++++++l++e++s+++l++++kk+L+w+++vael +++yPl+t+d+d+  ++l++kva rrGls+lp+aL+s+PspL+i++ek+v+
  SPAC23E2.02.1:pep  713 EFSFKKTMLILIDEVSSYAKLGNSQKKFLIWCFKVAELdDTLYPLNTVDTDFskDILIPKVA-RRGLSQLPWALQSYPSPLNIHYEKFVS 801 
                         **************************************99**********************.*************************** PP
           LSD1.txt  254 kvkleddkvelsavnessykvDkvvialpldklksqlieFePpLpefktkaikridFknlkKviLifkaaFWepnislFGsvpkstarel 343 
                         kv++e+dk++l+++++ssy+vD+vvia+++++++s+ ieF+P+Lp+f+t++ik+idFk++kKviL+++aaFW++ni++FG++pks+++e+
  SPAC23E2.02.1:pep  802 KVTIENDKCTLDCKDNSSYEVDQVVIACSPSHFSSN-IEFSPGLPNFVTENIKSIDFKPGKKVILRYAAAFWRKNIRSFGIIPKSLSQEM 890 
                         ************************************.***************************************************** PP
           LSD1.txt  344 ifde.......vlrfwnllke...PiLlalvkveaidimenisddviqglvsailkvikgkse.aadpletvvsnWea....dsltsyss 418 
                         ++de       vlr+wn+l+e   PiL+a+++++++++++n+++++iq+l+s+i+++++++s+ +ad+l+++v+nW++    d+l+sy++
  SPAC23E2.02.1:pep  891 NNDEndgkscfVLRIWNMLPEtgvPILVADINPQMTSSSSNETSHLIQELHSLIVDHFQNDSNsSADLLDAWVTNWSRngvyDGLNSYPN 980 
                         ***************************************************************99*************999999****** PP
           LSD1.txt  419 yaidklflekdy..ailseplarlviagsyaysaagsrslrrafdsGllvardvldsliPislvieeileqsrkeydtklraskvlnkeg 506 
                         +a+dk+++ek++  ++ls++l+rl+iag+y++s++g+r+l+r+f+sGl+v+++++dsl+Pisl+i++i+e+srke+d++lr+skv+n+++
  SPAC23E2.02.1:pep  981 FANDKQQYEKRFrqSQLSYNLGRLHIAGDYIFSCVGCRTLQRSFLSGLSVCTGIIDSLAPISLTIPIIGETSRKELDQFLRNSKVNNFDP 1070
                         ****************************************************************************************** PP
           LSD1.txt  507 eaeaekrlsyqaeyllkkqkrldkekeeqelLvaellgpsPepPskPsanPyLlyqktqwhvckaladedkrrltGdstaratknevrak 596 
                         +aea+++lsyqa+y+lkkq+rld++keeqe+Lv+ellg++PepPskP+anP+Llyqk+qwhvc+aladedkrrltGdsta+at+ne+rak
  SPAC23E2.02.1:pep 1071 NAEAQRHLSYQARYRLKKQERLDEHKEEQEQLVTELLGYLPEPPSKPNANPFLLYQKMQWHVCRALADEDKRRLTGDSTAKATINETRAK 1160
                         ****************************************************************************************** PP
           LSD1.txt  597 LgktlReldslgkqplvdeiaarReayagklaeyqrs 633 
                         Lgkt+R+ld+lgk+p++deiaa+Reayagk+++yqr+
  SPAC23E2.02.1:pep 1161 LGKTWRQLDDLGKKPWIDEIAAQREAYAGKILRYQRL 1197
                         ***********************************97 PP

Protein Sequence
(Fasta)

MPLGRSSWIC CAKYFVNTKS RFNEILPPRF TLIVSFYSMN TSENDPDGHY DFPEMTEHHS 60
DRASSYANAN NVNSTQPQLV SSEQALLAIL GGGLQSITPN SVNQNAYSRS TYRTDGGLNS 120
QPVSSLNNQW GNYNPAFLPS RYDSSFHPYT ISQAANQPFP QHLLGNSNAG VAQQSGMRTI 180
GLPPTVGSSF PQQKSSTYEN FFDANSPSSQ QFPSTYPSRS QNPLSSSGDG STAIHAGPIQ 240
HQNSNAFSNY PYPLDASHLS SQQLLSMYRD QVSHGVTPST FRNHESFMPT QLVSATELSK 300
SVDNAVLPIP PTTAPAVVSP PASSFPLMSS AATSGNISSP ALFDSELGAR PEGSVAIEPS 360
RVLLQWSSQS SSHTIPSAGA SIPTSSLKSF FEHAAEAARK CNLDPRALES FEQHMLSDRL 420
HDPVVLFHYF QIRNSICWLW IKNPTHAISR VEAQGVCVDR CLFQLASLAY EFLVRYGYIN 480
YGCLSFDSSF TNETNTGTTS SSASKQKTIA VVGAGLTGLI CARQLTGLFS QYSSSFLSKN 540
ELPPKVIILE AKERTGGRIY SRALPVSHTS ATQINHHTSN SNSISSNSTS LNPKDVTDPS 600
HIPSAIDLGF QFLFSPMDDI LLNLLNKQLG IEVTEMTGSD LVYDETDTKV LDMVEVKKLN 660
ILWEKLLEYV SVCFFINVEE SVRISWISQF QLFIDEMFPD HLSKSLSLNA SHEFSFKKTM 720
LILIDEVSSY AKLGNSQKKF LIWCFKVAEL DDTLYPLNTV DTDFSKDILI PKVARRGLSQ 780
LPWALQSYPS PLNIHYEKFV SKVTIENDKC TLDCKDNSSY EVDQVVIACS PSHFSSNIEF 840
SPGLPNFVTE NIKSIDFKPG KKVILRYAAA FWRKNIRSFG IIPKSLSQEM NNDENDGKSC 900
FVLRIWNMLP ETGVPILVAD INPQMTSSSS NETSHLIQEL HSLIVDHFQN DSNSSADLLD 960
AWVTNWSRNG VYDGLNSYPN FANDKQQYEK RFRQSQLSYN LGRLHIAGDY IFSCVGCRTL 1020
QRSFLSGLSV CTGIIDSLAP ISLTIPIIGE TSRKELDQFL RNSKVNNFDP NAEAQRHLSY 1080
QARYRLKKQE RLDEHKEEQE QLVTELLGYL PEPPSKPNAN PFLLYQKMQW HVCRALADED 1140
KRRLTGDSTA KATINETRAK LGKTWRQLDD LGKKPWIDEI AAQREAYAGK ILRYQRLTKE 1200
YEMRAEQIRN DYAAKCQDEP IPDDEARLFM QAQREEEQRK QTQDDNISKS REASDEEYHD 1260
DGSSDSGYNG TRY 1273

Nucleotide Sequence
(Fasta)

ATGCCTCTCG GGCGTTCTTC ATGGATATGT TGCGCAAAGT ACTTTGTAAA CACCAAATCG 60
AGATTCAATG AGATTTTACC ACCTCGGTTC ACTTTGATTG TATCTTTTTA CTCTATGAAC 120
ACGAGCGAGA ATGATCCAGA TGGTCATTAT GACTTTCCAG AAATGACAGA GCATCATTCT 180
GACCGGGCTT CATCATATGC TAACGCCAAC AACGTTAATT CAACTCAACC TCAATTGGTG 240
AGTAGTGAAC AAGCGCTTTT AGCTATTTTA GGAGGTGGAT TACAGTCTAT CACACCTAAT 300
TCTGTTAATC AGAACGCGTA TTCAAGGTCA ACTTATCGTA CAGATGGCGG CTTAAATTCA 360
CAGCCAGTTA GCTCACTGAA CAATCAATGG GGAAACTATA ATCCAGCATT TTTACCTTCT 420
AGATATGATT CCTCTTTTCA CCCTTACACA ATTTCGCAAG CGGCTAATCA ACCATTTCCT 480
CAGCATCTTT TAGGCAATTC AAATGCAGGT GTCGCTCAGC AGTCTGGAAT GAGAACAATT 540
GGATTACCTC CAACTGTAGG TTCCTCTTTT CCTCAACAAA AGTCATCCAC ATACGAAAAC 600
TTTTTTGATG CAAACTCTCC GTCTTCTCAG CAATTTCCAT CTACATATCC TTCACGATCA 660
CAAAACCCGC TTTCTTCCAG TGGAGATGGT TCAACGGCAA TTCATGCAGG CCCCATTCAA 720
CACCAAAACT CAAATGCCTT TTCCAATTAT CCGTATCCAT TAGACGCTTC TCATTTATCT 780
TCTCAGCAAC TTTTGTCGAT GTATCGGGAT CAAGTTTCTC ATGGAGTTAC CCCATCTACA 840
TTCCGCAATC ATGAAAGTTT TATGCCTACA CAGTTGGTAT CAGCAACAGA ATTATCTAAA 900
AGTGTTGATA ACGCAGTTTT GCCAATACCA CCTACTACTG CACCGGCAGT TGTATCGCCT 960
CCTGCTTCAT CTTTCCCTTT AATGTCTTCA GCTGCTACAT CTGGTAATAT TAGTAGTCCT 1020
GCACTTTTTG ATTCAGAGTT AGGTGCTAGG CCTGAAGGTT CTGTTGCAAT TGAGCCGTCT 1080
AGAGTACTGC TACAATGGTC TAGTCAATCA TCATCTCATA CTATACCATC TGCAGGAGCC 1140
AGTATCCCTA CATCTTCTTT AAAGTCGTTT TTTGAGCATG CCGCTGAAGC AGCTCGTAAA 1200
TGCAATCTCG ATCCGAGGGC CTTAGAAAGT TTTGAACAAC ACATGCTTTC TGATCGTTTA 1260
CACGATCCCG TTGTATTATT TCATTATTTC CAAATTCGTA ACAGCATTTG TTGGCTTTGG 1320
ATTAAAAATC CTACGCATGC CATATCCAGA GTTGAAGCTC AGGGCGTATG TGTCGATCGA 1380
TGTTTGTTCC AATTAGCCTC TTTAGCTTAT GAATTCCTTG TAAGGTATGG ATATATAAAC 1440
TATGGATGCT TGTCCTTTGA TTCATCCTTT ACGAATGAAA CTAATACTGG CACAACATCC 1500
AGTTCTGCAT CGAAGCAGAA GACTATTGCT GTAGTAGGCG CTGGTCTTAC TGGTTTGATA 1560
TGTGCTAGAC AACTTACTGG CTTATTTTCT CAGTATTCTT CATCTTTTTT GTCAAAGAAT 1620
GAGCTTCCTC CTAAAGTTAT TATACTTGAA GCTAAAGAAA GGACAGGAGG TCGTATTTAC 1680
TCTCGAGCAT TGCCTGTTTC TCATACTTCG GCTACCCAAA TTAACCATCA TACATCTAAT 1740
TCGAATTCTA TTTCTAGTAA TTCCACTTCT TTAAACCCCA AGGATGTTAC TGACCCGTCC 1800
CATATTCCTT CAGCAATTGA TTTGGGATTT CAATTTTTAT TTTCGCCTAT GGACGATATT 1860
TTGCTTAACC TTTTAAATAA ACAATTGGGT ATTGAAGTTA CAGAGATGAC TGGCTCAGAT 1920
TTAGTTTACG ATGAGACCGA TACTAAAGTA TTAGACATGG TTGAGGTGAA AAAATTAAAC 1980
ATTTTATGGG AAAAACTTTT GGAATATGTT TCTGTTTGCT TTTTTATTAA CGTTGAGGAA 2040
TCTGTTCGTA TTTCTTGGAT ATCCCAATTT CAGTTGTTTA TAGATGAAAT GTTCCCTGAT 2100
CATTTGTCCA AATCACTCTC ATTAAATGCG TCACATGAAT TTTCCTTCAA AAAAACAATG 2160
CTAATACTAA TTGATGAAGT TTCTTCTTAT GCCAAACTCG GGAACAGTCA AAAGAAATTT 2220
CTGATATGGT GTTTTAAGGT CGCGGAATTG GACGATACTT TGTACCCTCT TAACACAGTT 2280
GATACAGACT TCTCCAAAGA TATTTTGATT CCAAAAGTTG CTAGAAGAGG TCTATCTCAA 2340
CTGCCATGGG CATTACAATC TTATCCATCT CCCTTAAATA TTCATTATGA GAAGTTTGTA 2400
TCTAAGGTAA CTATTGAAAA TGATAAATGT ACCCTTGATT GTAAGGACAA CTCTTCTTAT 2460
GAGGTTGACC AAGTTGTAAT TGCTTGCTCT CCTTCTCATT TTTCTTCAAA TATAGAGTTT 2520
TCACCAGGTC TTCCTAATTT CGTGACTGAA AACATAAAAA GTATAGATTT CAAACCCGGA 2580
AAAAAGGTTA TTCTTCGTTA TGCAGCTGCT TTTTGGCGAA AGAACATTAG ATCATTTGGT 2640
ATTATACCAA AATCATTAAG TCAAGAAATG AACAATGATG AGAATGATGG TAAATCTTGT 2700
TTTGTTTTGA GAATATGGAA TATGCTTCCT GAAACTGGTG TCCCAATATT AGTAGCGGAT 2760
ATCAATCCAC AAATGACAAG TTCTTCTTCT AACGAGACCT CCCACTTAAT TCAAGAATTA 2820
CACAGTCTAA TAGTAGATCA TTTTCAAAAT GATTCAAACA GCTCAGCTGA TTTATTAGAT 2880
GCTTGGGTCA CAAACTGGTC GAGAAATGGT GTCTATGACG GCTTAAATTC TTATCCAAAT 2940
TTTGCCAATG ATAAGCAGCA ATATGAAAAA AGATTTAGGC AAAGTCAGTT ATCGTATAAT 3000
TTGGGTCGCT TGCATATTGC TGGAGACTAT ATATTCAGTT GCGTAGGCTG TAGGACATTA 3060
CAAAGATCCT TTTTATCTGG CCTTTCCGTA TGTACAGGGA TTATTGATTC ATTGGCTCCA 3120
ATTTCCTTAA CCATACCTAT CATTGGAGAA ACCTCTCGCA AAGAATTGGA TCAGTTTTTG 3180
CGAAACTCTA AAGTTAATAA TTTTGATCCC AATGCTGAAG CACAGCGTCA CCTTTCTTAT 3240
CAGGCAAGAT ATAGGTTGAA AAAGCAGGAA AGACTTGACG AGCATAAGGA AGAACAGGAA 3300
CAGCTTGTAA CTGAACTTCT TGGTTATTTA CCTGAACCTC CTTCCAAGCC GAATGCAAAT 3360
CCCTTTTTAC TTTACCAAAA AATGCAGTGG CATGTATGCC GTGCACTTGC TGATGAAGAC 3420
AAGCGAAGGT TAACAGGAGA TAGTACAGCG AAGGCTACTA TTAATGAAAC ACGTGCCAAA 3480
CTAGGGAAAA CTTGGCGCCA GCTTGATGAT TTAGGTAAAA AACCTTGGAT TGATGAAATT 3540
GCAGCACAAA GAGAAGCTTA TGCTGGAAAA ATTCTTCGTT ATCAGCGCCT AACTAAAGAA 3600
TATGAAATGA GAGCCGAGCA AATACGAAAT GATTATGCGG CCAAATGCCA AGATGAACCT 3660
ATTCCCGATG ATGAAGCAAG ATTGTTTATG CAAGCTCAAC GAGAAGAAGA GCAAAGAAAA 3720
CAAACTCAGG ATGACAACAT TTCCAAAAGT CGAGAGGCTA GCGACGAAGA GTATCATGAC 3780
GATGGATCTT CTGATTCGGG TTATAATGGA ACACGATATT AAAAGAAAAA AAATCAAATC 3840
ACATATTGTT TTTTAAAAGT TTAGTTACTT CGCATCATTA CAAATACCCT TAAAATTTTA 3900
TGTACATATA TATTCTCGTC ATGCCCTAAA TGAAGCATTT TATCAAATTG CTAATTTCAG 3960
CAAATTGTTT AAGGAAAATC TAAAATACAT GTACACTTCT CGTTAGCCAG TAGCCAAC 4019

Nucleotide Fasta Sequence

>SPAC23E2.02.1:pep|LSD1_KDM1|Schizosaccharomyces pombe
ATGCCTCTCGGGCGTTCTTCATGGATATGTTGCGCAAAGTACTTTGTAAACACCAAATCGAGATTCAATGAGATTTTACCACCTCGGTTCACTTTGATTGTATCTTTTTACTCTATGAACACGAGCGAGAATGATCCAGATGGTCATTATGACTTTCCAGAAATGACAGAGCATCATTCTGACCGGGCTTCATCATATGCTAACGCCAACAACGTTAATTCAACTCAACCTCAATTGGTGAGTAGTGAACAAGCGCTTTTAGCTATTTTAGGAGGTGGATTACAGTCTATCACACCTAATTCTGTTAATCAGAACGCGTATTCAAGGTCAACTTATCGTACAGATGGCGGCTTAAATTCACAGCCAGTTAGCTCACTGAACAATCAATGGGGAAACTATAATCCAGCATTTTTACCTTCTAGATATGATTCCTCTTTTCACCCTTACACAATTTCGCAAGCGGCTAATCAACCATTTCCTCAGCATCTTTTAGGCAATTCAAATGCAGGTGTCGCTCAGCAGTCTGGAATGAGAACAATTGGATTACCTCCAACTGTAGGTTCCTCTTTTCCTCAACAAAAGTCATCCACATACGAAAACTTTTTTGATGCAAACTCTCCGTCTTCTCAGCAATTTCCATCTACATATCCTTCACGATCACAAAACCCGCTTTCTTCCAGTGGAGATGGTTCAACGGCAATTCATGCAGGCCCCATTCAACACCAAAACTCAAATGCCTTTTCCAATTATCCGTATCCATTAGACGCTTCTCATTTATCTTCTCAGCAACTTTTGTCGATGTATCGGGATCAAGTTTCTCATGGAGTTACCCCATCTACATTCCGCAATCATGAAAGTTTTATGCCTACACAGTTGGTATCAGCAACAGAATTATCTAAAAGTGTTGATAACGCAGTTTTGCCAATACCACCTACTACTGCACCGGCAGTTGTATCGCCTCCTGCTTCATCTTTCCCTTTAATGTCTTCAGCTGCTACATCTGGTAATATTAGTAGTCCTGCACTTTTTGATTCAGAGTTAGGTGCTAGGCCTGAAGGTTCTGTTGCAATTGAGCCGTCTAGAGTACTGCTACAATGGTCTAGTCAATCATCATCTCATACTATACCATCTGCAGGAGCCAGTATCCCTACATCTTCTTTAAAGTCGTTTTTTGAGCATGCCGCTGAAGCAGCTCGTAAATGCAATCTCGATCCGAGGGCCTTAGAAAGTTTTGAACAACACATGCTTTCTGATCGTTTACACGATCCCGTTGTATTATTTCATTATTTCCAAATTCGTAACAGCATTTGTTGGCTTTGGATTAAAAATCCTACGCATGCCATATCCAGAGTTGAAGCTCAGGGCGTATGTGTCGATCGATGTTTGTTCCAATTAGCCTCTTTAGCTTATGAATTCCTTGTAAGGTATGGATATATAAACTATGGATGCTTGTCCTTTGATTCATCCTTTACGAATGAAACTAATACTGGCACAACATCCAGTTCTGCATCGAAGCAGAAGACTATTGCTGTAGTAGGCGCTGGTCTTACTGGTTTGATATGTGCTAGACAACTTACTGGCTTATTTTCTCAGTATTCTTCATCTTTTTTGTCAAAGAATGAGCTTCCTCCTAAAGTTATTATACTTGAAGCTAAAGAAAGGACAGGAGGTCGTATTTACTCTCGAGCATTGCCTGTTTCTCATACTTCGGCTACCCAAATTAACCATCATACATCTAATTCGAATTCTATTTCTAGTAATTCCACTTCTTTAAACCCCAAGGATGTTACTGACCCGTCCCATATTCCTTCAGCAATTGATTTGGGATTTCAATTTTTATTTTCGCCTATGGACGATATTTTGCTTAACCTTTTAAATAAACAATTGGGTATTGAAGTTACAGAGATGACTGGCTCAGATTTAGTTTACGATGAGACCGATACTAAAGTATTAGACATGGTTGAGGTGAAAAAATTAAACATTTTATGGGAAAAACTTTTGGAATATGTTTCTGTTTGCTTTTTTATTAACGTTGAGGAATCTGTTCGTATTTCTTGGATATCCCAATTTCAGTTGTTTATAGATGAAATGTTCCCTGATCATTTGTCCAAATCACTCTCATTAAATGCGTCACATGAATTTTCCTTCAAAAAAACAATGCTAATACTAATTGATGAAGTTTCTTCTTATGCCAAACTCGGGAACAGTCAAAAGAAATTTCTGATATGGTGTTTTAAGGTCGCGGAATTGGACGATACTTTGTACCCTCTTAACACAGTTGATACAGACTTCTCCAAAGATATTTTGATTCCAAAAGTTGCTAGAAGAGGTCTATCTCAACTGCCATGGGCATTACAATCTTATCCATCTCCCTTAAATATTCATTATGAGAAGTTTGTATCTAAGGTAACTATTGAAAATGATAAATGTACCCTTGATTGTAAGGACAACTCTTCTTATGAGGTTGACCAAGTTGTAATTGCTTGCTCTCCTTCTCATTTTTCTTCAAATATAGAGTTTTCACCAGGTCTTCCTAATTTCGTGACTGAAAACATAAAAAGTATAGATTTCAAACCCGGAAAAAAGGTTATTCTTCGTTATGCAGCTGCTTTTTGGCGAAAGAACATTAGATCATTTGGTATTATACCAAAATCATTAAGTCAAGAAATGAACAATGATGAGAATGATGGTAAATCTTGTTTTGTTTTGAGAATATGGAATATGCTTCCTGAAACTGGTGTCCCAATATTAGTAGCGGATATCAATCCACAAATGACAAGTTCTTCTTCTAACGAGACCTCCCACTTAATTCAAGAATTACACAGTCTAATAGTAGATCATTTTCAAAATGATTCAAACAGCTCAGCTGATTTATTAGATGCTTGGGTCACAAACTGGTCGAGAAATGGTGTCTATGACGGCTTAAATTCTTATCCAAATTTTGCCAATGATAAGCAGCAATATGAAAAAAGATTTAGGCAAAGTCAGTTATCGTATAATTTGGGTCGCTTGCATATTGCTGGAGACTATATATTCAGTTGCGTAGGCTGTAGGACATTACAAAGATCCTTTTTATCTGGCCTTTCCGTATGTACAGGGATTATTGATTCATTGGCTCCAATTTCCTTAACCATACCTATCATTGGAGAAACCTCTCGCAAAGAATTGGATCAGTTTTTGCGAAACTCTAAAGTTAATAATTTTGATCCCAATGCTGAAGCACAGCGTCACCTTTCTTATCAGGCAAGATATAGGTTGAAAAAGCAGGAAAGACTTGACGAGCATAAGGAAGAACAGGAACAGCTTGTAACTGAACTTCTTGGTTATTTACCTGAACCTCCTTCCAAGCCGAATGCAAATCCCTTTTTACTTTACCAAAAAATGCAGTGGCATGTATGCCGTGCACTTGCTGATGAAGACAAGCGAAGGTTAACAGGAGATAGTACAGCGAAGGCTACTATTAATGAAACACGTGCCAAACTAGGGAAAACTTGGCGCCAGCTTGATGATTTAGGTAAAAAACCTTGGATTGATGAAATTGCAGCACAAAGAGAAGCTTATGCTGGAAAAATTCTTCGTTATCAGCGCCTAACTAAAGAATATGAAATGAGAGCCGAGCAAATACGAAATGATTATGCGGCCAAATGCCAAGATGAACCTATTCCCGATGATGAAGCAAGATTGTTTATGCAAGCTCAACGAGAAGAAGAGCAAAGAAAACAAACTCAGGATGACAACATTTCCAAAAGTCGAGAGGCTAGCGACGAAGAGTATCATGACGATGGATCTTCTGATTCGGGTTATAATGGAACACGATATTAAAAGAAAAAAAATCAAATCACATATTGTTTTTTAAAAGTTTAGTTACTTCGCATCATTACAAATACCCTTAAAATTTTATGTACATATATATTCTCGTCATGCCCTAAATGAAGCATTTTATCAAATTGCTAATTTCAGCAAATTGTTTAAGGAAAATCTAAAATACATGTACACTTCTCGTTAGCCAGTAGCCAAC

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0274--FAD
KW-0285--Flavoprotein
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
--

Interpro

IPR002937--Amino_oxidase
IPR023753--FAD/NAD-binding_dom
IPR009071--HMG_box_dom
IPR009057--Homeodomain-like
IPR007526--SWIRM
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50118--HMG_BOX_2
PS50934--SWIRM

Pfam

PF01593--Amino_oxidase
PF04433--SWIRM

Gene Ontology

GO:0005829--C:cytosol
GO:0033193--C:Lsd1/2 complex
GO:0000790--C:nuclear chromatin
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0016491--F:oxidoreductase activity
GO:0006338--P:chromatin remodeling
GO:0033169--P:histone H3-K9 demethylation
GO:0051445--P:regulation of meiotic cell cycle
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

Orthology

Created Date

25-Jun-2016

WERAM Information

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence