| Tag |
Content |
| WERAM ID |
WERAM-Cae-0057 |
| Ensembl Protein ID |
F29B9.2a |
| Uniprot Accession |
Q9GYI0; KDM7_CAEEL; Q9BI67
|
| Genbank Protein ID |
NP_500610.1; NP_500611.1
|
| Protein Name |
Lysine-specific demethylase 7 homolog |
| Genbank Nucleotide ID |
NM_068209.4; NM_068210.3
|
| Gene Name |
JMJD1.2;PHF8;KDM7;ceKDM7A |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDM |
PHF2_PHF8 |
Jmjc |
H3K4me3; H3K23me2; H3K9me2; H3K27me2 |
K |
26476455; 20346720; 20567262
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HDM |
PHF2_PHF8 |
7.20e-78 |
260.4 |
442 |
612 |
|
| Organism |
Caenorhabditis elegans |
| NCBI Taxa ID |
6239 |
Functional Description
(View)Functional Description
Histone demethylase required for nervous system development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3, thereby playing a central role in histone code. |
Histone demethylase required for nervous system development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3, thereby playing a central role in histone code.
|
| Domain Profile |
HDM PHF2_PHF8
PHF2.txt 2 sdtklselveppdivkklslvenlwpd............eavle...kpkvekycligvkdsytdfhidfggasvyyhvlkgekifylirpteanlalyea 87
++++++e+++pp++v+++s+v++lwpd e++l+ +pkve++cl+g+++sytdfh+dfgg+svyyh+lkgekify+++pte+n+a+y+a
F29B9.2a 442 DNNEMKEIAKPPRFVQEISMVNRLWPDvsgaeyikllqrEEYLPedqRPKVEQFCLAGMAGSYTDFHVDFGGSSVYYHILKGEKIFYIAAPTEQNFAAYQA 542
89*************************************99999899****************************************************** PP
PHF2.txt 88 wesssdqsevffgdkvdkayk.vvvkqgqtllipagwihavltpvdclafggnflhslniemqlrayelek 157
+e+s+d++ ++fgd++++a+k vv+k+gqtllipagwihavltpvd+l+fggnflh +n+emq+r+y+le+
F29B9.2a 543 HETSPDTT-TWFGDIANGAVKrVVIKEGQTLLIPAGWIHAVLTPVDSLVFGGNFLHLGNLEMQMRVYHLEN 612
******99.************99**********************************************96 PP
|
Protein Sequence
(Fasta) | MDGNDINIQK NEFSRDQSAL LMMDQHSDHK NHESAIGEPG MSYTASQPAL SSTEHQTPLV 60
SEASVAAPQN HLNGNSHESV SEMDRNSVDF AIESVLMKAR AYNKMGAPKD PRRKQHNPKS 120
EPKIEPHVTD SSDNQAAMSN KMEAEAPKME SNQNYVSNGS EPPFRFVSIS NFDEMKTKKK 180
EVQEELKLEV DSDSEEDDVP EQKTPKESDR CGGCGKFTHE DDLIALEEEK KKEKEKPLMS 240
KKKSHHHKKN DFQWIGCDSC QTWYHFLCSG LEQFEYYLYE KFFCPKCVPH TGHSIRYKVV 300
APHRYRWYSP NEKHLGIEVG SKTWIEDFIT RENTVPSPTD DEVCIVEDGY EFRREFEKLG 360
GADNWGKVFM VKDMDGLNMT MPKPGFDLED VVKIMGSDYE VDTIDVYNQS TYSMKLDTFR 420
KLFRDTKNRP LLYNFLSLEF SDNNEMKEIA KPPRFVQEIS MVNRLWPDVS GAEYIKLLQR 480
EEYLPEDQRP KVEQFCLAGM AGSYTDFHVD FGGSSVYYHI LKGEKIFYIA APTEQNFAAY 540
QAHETSPDTT TWFGDIANGA VKRVVIKEGQ TLLIPAGWIH AVLTPVDSLV FGGNFLHLGN 600
LEMQMRVYHL ENAIRKEIRS EEKFYFPNFE LLHWMYMRNV LLEKITEANQ EGSDMREQEK 660
NIWTASQIMK AEMERWMDRE LRLGPEKNAI LPTDDKNKIM ISVRKQIEIQ TKIQNAKNKP 720
MGLKQKRKSR ESAERDDEDY CPSSSTAYKK KYTKKAKKDN DDAPKVKKAK KEEVPEEKVP 780
VPEAAGPSEV TAPLTIKIGM GPTEDQKGVV QIFNNQCTSS GRKVKLNQNV ADYCGSHLEA 840
RVEEIPEKAT KSFRELDNEL ERCEAVHSGE KIKKVKEPKP PKQPKEKKEK PPPKKKEMSS 900
RDRLMKKLKM Protein Fasta Sequence
>F29B9.2a|JMJD1.2;PHF8;KDM7;ceKDM7A|Caenorhabditis elegans
MDGNDINIQKNEFSRDQSALLMMDQHSDHKNHESAIGEPGMSYTASQPALSSTEHQTPLVSEASVAAPQNHLNGNSHESVSEMDRNSVDFAIESVLMKARAYNKMGAPKDPRRKQHNPKSEPKIEPHVTDSSDNQAAMSNKMEAEAPKMESNQNYVSNGSEPPFRFVSISNFDEMKTKKKEVQEELKLEVDSDSEEDDVPEQKTPKESDRCGGCGKFTHEDDLIALEEEKKKEKEKPLMSKKKSHHHKKNDFQWIGCDSCQTWYHFLCSGLEQFEYYLYEKFFCPKCVPHTGHSIRYKVVAPHRYRWYSPNEKHLGIEVGSKTWIEDFITRENTVPSPTDDEVCIVEDGYEFRREFEKLGGADNWGKVFMVKDMDGLNMTMPKPGFDLEDVVKIMGSDYEVDTIDVYNQSTYSMKLDTFRKLFRDTKNRPLLYNFLSLEFSDNNEMKEIAKPPRFVQEISMVNRLWPDVSGAEYIKLLQREEYLPEDQRPKVEQFCLAGMAGSYTDFHVDFGGSSVYYHILKGEKIFYIAAPTEQNFAAYQAHETSPDTTTWFGDIANGAVKRVVIKEGQTLLIPAGWIHAVLTPVDSLVFGGNFLHLGNLEMQMRVYHLENAIRKEIRSEEKFYFPNFELLHWMYMRNVLLEKITEANQEGSDMREQEKNIWTASQIMKAEMERWMDRELRLGPEKNAILPTDDKNKIMISVRKQIEIQTKIQNAKNKPMGLKQKRKSRESAERDDEDYCPSSSTAYKKKYTKKAKKDNDDAPKVKKAKKEEVPEEKVPVPEAAGPSEVTAPLTIKIGMGPTEDQKGVVQIFNNQCTSSGRKVKLNQNVADYCGSHLEARVEEIPEKATKSFRELDNELERCEAVHSGEKIKKVKEPKPPKQPKEKKEKPPPKKKEMSSRDRLMKKLKM |
Nucleotide Sequence
(Fasta) | AATCTACACA TTCCAAATGG ATGGTAATGA TATAAATATA CAAAAAAACG AGTTTTCTCG 60
AGACCAATCA GCACTTCTAA TGATGGATCA GCATTCCGAC CATAAGAATC ACGAATCGGC 120
AATCGGCGAG CCAGGAATGT CATACACAGC CTCTCAACCG GCTCTTTCCT CTACTGAGCA 180
TCAAACGCCA TTAGTTTCTG AAGCAAGCGT CGCAGCTCCT CAAAATCATT TGAATGGCAA 240
TTCCCATGAA TCGGTTTCCG AAATGGATAG AAATTCGGTT GATTTTGCGA TAGAATCAGT 300
GCTCATGAAA GCGAGAGCTT ACAACAAGAT GGGCGCTCCA AAAGATCCGA GGAGAAAGCA 360
GCACAATCCG AAGAGCGAGC CTAAAATCGA GCCACATGTG ACAGATTCAT CGGATAATCA 420
GGCTGCAATG AGCAACAAGA TGGAAGCGGA AGCGCCGAAG ATGGAGTCAA ATCAGAACTA 480
CGTCAGCAAC GGATCTGAGC CTCCATTCCG TTTCGTTTCA ATTTCGAATT TCGACGAAAT 540
GAAAACAAAA AAGAAAGAAG TTCAAGAAGA ATTGAAGCTT GAGGTGGACT CGGACAGTGA 600
AGAAGATGAT GTCCCAGAGC AGAAAACTCC AAAGGAATCG GATCGATGTG GAGGATGCGG 660
AAAATTTACT CATGAAGATG ATCTAATTGC TCTTGAAGAG GAAAAGAAGA AGGAAAAGGA 720
AAAGCCACTG ATGAGCAAGA AGAAATCTCA CCATCACAAG AAAAATGACT TCCAATGGAT 780
TGGCTGTGAC TCTTGCCAAA CCTGGTACCA TTTTCTGTGC TCAGGCCTCG AGCAATTTGA 840
GTATTACCTG TATGAGAAAT TTTTCTGCCC CAAATGCGTT CCACATACCG GACATAGCAT 900
TCGATACAAA GTCGTCGCCC CACATCGTTA TCGCTGGTAC AGTCCGAACG AGAAGCATCT 960
CGGAATTGAA GTTGGCTCAA AAACTTGGAT TGAGGATTTC ATCACCAGAG AAAATACTGT 1020
TCCCTCACCA ACCGACGATG AGGTTTGCAT TGTCGAAGAT GGCTACGAAT TCCGCAGAGA 1080
ATTCGAAAAA CTCGGAGGAG CTGACAACTG GGGAAAAGTT TTTATGGTCA AAGACATGGA 1140
CGGCCTCAAT ATGACAATGC CGAAGCCTGG ATTCGATTTG GAGGATGTTG TGAAAATTAT 1200
GGGATCGGAT TATGAAGTGG ACACGATCGA TGTCTATAAT CAGAGCACCT ATTCGATGAA 1260
GCTTGATACG TTCAGAAAAC TTTTTCGCGA CACTAAAAAC AGACCACTCT TGTACAATTT 1320
TCTGTCCCTT GAATTCTCGG ACAATAATGA GATGAAAGAA ATCGCTAAGC CGCCAAGATT 1380
TGTCCAGGAA ATCTCAATGG TCAACCGCCT GTGGCCTGAT GTCAGTGGAG CGGAGTACAT 1440
TAAACTCCTC CAGAGAGAAG AATATCTTCC AGAAGATCAG CGACCAAAAG TGGAACAGTT 1500
TTGTCTCGCA GGAATGGCTG GATCTTATAC GGATTTCCAC GTGGACTTTG GTGGTAGTAG 1560
CGTCTACTAT CACATTTTGA AGGGCGAGAA AATCTTCTAC ATCGCCGCGC CAACGGAGCA 1620
GAACTTTGCA GCTTATCAAG CACACGAGAC ATCTCCGGAC ACCACTACAT GGTTCGGTGA 1680
CATTGCCAAC GGAGCTGTTA AGCGAGTTGT GATCAAGGAA GGTCAGACAC TGCTCATCCC 1740
GGCTGGTTGG ATTCACGCGG TTCTCACTCC AGTCGATTCG CTCGTTTTTG GAGGAAACTT 1800
CTTGCATTTG GGAAATCTTG AGATGCAAAT GCGCGTGTAC CATCTCGAAA ACGCGATTCG 1860
TAAGGAAATT AGAAGCGAGG AGAAGTTCTA CTTTCCGAAT TTCGAACTTC TTCATTGGAT 1920
GTACATGCGA AACGTCTTGC TTGAGAAGAT TACAGAAGCC AATCAGGAAG GTTCTGACAT 1980
GCGTGAGCAG GAGAAGAATA TTTGGACGGC GTCACAAATC ATGAAGGCCG AAATGGAGCG 2040
CTGGATGGAT CGAGAGTTGA GATTGGGTCC CGAGAAGAAC GCGATCCTGC CCACTGACGA 2100
CAAGAATAAG ATTATGATCT CGGTGAGGAA GCAGATTGAG ATTCAGACGA AGATTCAGAA 2160
TGCCAAGAAT AAGCCGATGG GGTTGAAGCA GAAACGTAAA AGTCGAGAAT CCGCGGAGCG 2220
GGATGATGAG GACTATTGCC CGTCCAGCTC GACTGCCTAC AAGAAGAAGT ATACGAAAAA 2280
GGCTAAGAAG GACAATGATG ATGCTCCGAA GGTGAAGAAG GCGAAGAAAG AGGAAGTTCC 2340
CGAGGAGAAG GTTCCGGTTC CTGAAGCAGC AGGTCCTTCC GAAGTTACAG CTCCATTGAC 2400
CATCAAGATT GGAATGGGAC CGACTGAAGA TCAGAAGGGC GTTGTCCAGA TATTCAATAA 2460
TCAATGCACG TCGTCTGGAA GAAAAGTAAA GTTGAATCAG AACGTGGCCG ACTATTGTGG 2520
ATCCCATCTC GAAGCACGCG TCGAAGAGAT TCCGGAAAAG GCGACGAAAA GCTTCCGCGA 2580
GCTTGACAAC GAACTGGAGC GCTGTGAAGC TGTTCATTCC GGAGAGAAAA TCAAGAAGGT 2640
TAAAGAGCCA AAGCCACCGA AGCAACCAAA AGAGAAAAAG GAGAAACCAC CACCAAAGAA 2700
AAAGGAAATG AGTTCCAGAG ATCGCCTCAT GAAGAAGCTC AAAATGTGAA CGTCCTCTAC 2760
CTCAAGATAT GTGTGCACTT TGACGAAATA TAAATCTCGT ACAATTATAA AGTGCCCCCC 2820
GATCTTAATA GTAATTTCCC CGTATTTTTG ACTAATTTTT ACATTCGTTT TATTGTTTTA 2880
TTCACACAAT CCCATATTCT TTCACGCGGT TCTTTTGCAT CCAAAAATTT GTACAAGACG 2940
ATCTCCCGAA TTTACTGACG GGGATTTTTT TGTAGTTTGA AAATACACAC GCACAATAAA 3000
GCGTTGATTA TGTTAA
3017Nucleotide Fasta Sequence
>F29B9.2a|PHF2_PHF8|Caenorhabditis elegans
AATCTACACATTCCAAATGGATGGTAATGATATAAATATACAAAAAAACGAGTTTTCTCGAGACCAATCAGCACTTCTAATGATGGATCAGCATTCCGACCATAAGAATCACGAATCGGCAATCGGCGAGCCAGGAATGTCATACACAGCCTCTCAACCGGCTCTTTCCTCTACTGAGCATCAAACGCCATTAGTTTCTGAAGCAAGCGTCGCAGCTCCTCAAAATCATTTGAATGGCAATTCCCATGAATCGGTTTCCGAAATGGATAGAAATTCGGTTGATTTTGCGATAGAATCAGTGCTCATGAAAGCGAGAGCTTACAACAAGATGGGCGCTCCAAAAGATCCGAGGAGAAAGCAGCACAATCCGAAGAGCGAGCCTAAAATCGAGCCACATGTGACAGATTCATCGGATAATCAGGCTGCAATGAGCAACAAGATGGAAGCGGAAGCGCCGAAGATGGAGTCAAATCAGAACTACGTCAGCAACGGATCTGAGCCTCCATTCCGTTTCGTTTCAATTTCGAATTTCGACGAAATGAAAACAAAAAAGAAAGAAGTTCAAGAAGAATTGAAGCTTGAGGTGGACTCGGACAGTGAAGAAGATGATGTCCCAGAGCAGAAAACTCCAAAGGAATCGGATCGATGTGGAGGATGCGGAAAATTTACTCATGAAGATGATCTAATTGCTCTTGAAGAGGAAAAGAAGAAGGAAAAGGAAAAGCCACTGATGAGCAAGAAGAAATCTCACCATCACAAGAAAAATGACTTCCAATGGATTGGCTGTGACTCTTGCCAAACCTGGTACCATTTTCTGTGCTCAGGCCTCGAGCAATTTGAGTATTACCTGTATGAGAAATTTTTCTGCCCCAAATGCGTTCCACATACCGGACATAGCATTCGATACAAAGTCGTCGCCCCACATCGTTATCGCTGGTACAGTCCGAACGAGAAGCATCTCGGAATTGAAGTTGGCTCAAAAACTTGGATTGAGGATTTCATCACCAGAGAAAATACTGTTCCCTCACCAACCGACGATGAGGTTTGCATTGTCGAAGATGGCTACGAATTCCGCAGAGAATTCGAAAAACTCGGAGGAGCTGACAACTGGGGAAAAGTTTTTATGGTCAAAGACATGGACGGCCTCAATATGACAATGCCGAAGCCTGGATTCGATTTGGAGGATGTTGTGAAAATTATGGGATCGGATTATGAAGTGGACACGATCGATGTCTATAATCAGAGCACCTATTCGATGAAGCTTGATACGTTCAGAAAACTTTTTCGCGACACTAAAAACAGACCACTCTTGTACAATTTTCTGTCCCTTGAATTCTCGGACAATAATGAGATGAAAGAAATCGCTAAGCCGCCAAGATTTGTCCAGGAAATCTCAATGGTCAACCGCCTGTGGCCTGATGTCAGTGGAGCGGAGTACATTAAACTCCTCCAGAGAGAAGAATATCTTCCAGAAGATCAGCGACCAAAAGTGGAACAGTTTTGTCTCGCAGGAATGGCTGGATCTTATACGGATTTCCACGTGGACTTTGGTGGTAGTAGCGTCTACTATCACATTTTGAAGGGCGAGAAAATCTTCTACATCGCCGCGCCAACGGAGCAGAACTTTGCAGCTTATCAAGCACACGAGACATCTCCGGACACCACTACATGGTTCGGTGACATTGCCAACGGAGCTGTTAAGCGAGTTGTGATCAAGGAAGGTCAGACACTGCTCATCCCGGCTGGTTGGATTCACGCGGTTCTCACTCCAGTCGATTCGCTCGTTTTTGGAGGAAACTTCTTGCATTTGGGAAATCTTGAGATGCAAATGCGCGTGTACCATCTCGAAAACGCGATTCGTAAGGAAATTAGAAGCGAGGAGAAGTTCTACTTTCCGAATTTCGAACTTCTTCATTGGATGTACATGCGAAACGTCTTGCTTGAGAAGATTACAGAAGCCAATCAGGAAGGTTCTGACATGCGTGAGCAGGAGAAGAATATTTGGACGGCGTCACAAATCATGAAGGCCGAAATGGAGCGCTGGATGGATCGAGAGTTGAGATTGGGTCCCGAGAAGAACGCGATCCTGCCCACTGACGACAAGAATAAGATTATGATCTCGGTGAGGAAGCAGATTGAGATTCAGACGAAGATTCAGAATGCCAAGAATAAGCCGATGGGGTTGAAGCAGAAACGTAAAAGTCGAGAATCCGCGGAGCGGGATGATGAGGACTATTGCCCGTCCAGCTCGACTGCCTACAAGAAGAAGTATACGAAAAAGGCTAAGAAGGACAATGATGATGCTCCGAAGGTGAAGAAGGCGAAGAAAGAGGAAGTTCCCGAGGAGAAGGTTCCGGTTCCTGAAGCAGCAGGTCCTTCCGAAGTTACAGCTCCATTGACCATCAAGATTGGAATGGGACCGACTGAAGATCAGAAGGGCGTTGTCCAGATATTCAATAATCAATGCACGTCGTCTGGAAGAAAAGTAAAGTTGAATCAGAACGTGGCCGACTATTGTGGATCCCATCTCGAAGCACGCGTCGAAGAGATTCCGGAAAAGGCGACGAAAAGCTTCCGCGAGCTTGACAACGAACTGGAGCGCTGTGAAGCTGTTCATTCCGGAGAGAAAATCAAGAAGGTTAAAGAGCCAAAGCCACCGAAGCAACCAAAAGAGAAAAAGGAGAAACCACCACCAAAGAAAAAGGAAATGAGTTCCAGAGATCGCCTCATGAAGAAGCTCAAAATGTGAACGTCCTCTACCTCAAGATATGTGTGCACTTTGACGAAATATAAATCTCGTACAATTATAAAGTGCCCCCCGATCTTAATAGTAATTTCCCCGTATTTTTGACTAATTTTTACATTCGTTTTATTGTTTTATTCACACAATCCCATATTCTTTCACGCGGTTCTTTTGCATCCAAAAATTTGTACAAGACGATCTCCCGAATTTACTGACGGGGATTTTTTTGTAGTTTGAAAATACACACGCACAATAAAGCGTTGATTATGTTAA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0408--Iron
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
--
|
| Interpro |
IPR003347--JmjC_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR013083--Znf_RING/FYVE/PHD
|
| PROSITE |
PS51184--JMJC
PS01359--ZF_PHD_1
|
| Pfam |
PF02373--JmjC
|
| Gene Ontology |
GO:0005634--C:nucleus
GO:0051213--F:dioxygenase activity
GO:0042393--F:histone binding
GO:0071558--F:histone demethylase activity (H3-K27 specific)
GO:0032454--F:histone demethylase activity (H3-K9 specific)
GO:0008270--F:zinc ion binding
GO:0071557--P:histone H3-K27 demethylation
GO:0033169--P:histone H3-K9 demethylation
GO:0040012--P:regulation of locomotion
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
