WERAM Information

Tag Content
WERAM ID WERAM-Hos-0140
Ensembl Protein ID ENSP00000486001.1
Uniprot Accession Q9UJW3; DNM3L_HUMAN; E9PB42; Q9BUJ4
Genbank Protein ID NP_037501.2; NP_787063.1; XP_011527838.1
Protein Name DNA (cytosine-5)-methyltransferase 3-like
Genbank Nucleotide ID NM_013369.3; NM_175867.2; XM_011529536.1
Gene Name DNMT3L
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000142182.8 ENST00000628202.2 ENSP00000486001.1
ENSG00000142182.8 ENST00000270172.7 ENSP00000270172.3
ENSG00000142182.8 ENST00000431166.1 ENSP00000400242.1
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader ADD ADD H3K4me0; H4R3me2 R 17687327; 19234465
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader ADD 2.40e-61 207.9 41 172
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. Recognizes unmethylated histone H3 lysine 4 (H3K4) and induces de novo DNA methylation by recruitment or activation of DNMT3.
Domain Profile
  Me_Reader ADD
            ADD.txt   1 evkrnednlediciacGkkdsilrhPlleggicknckdkfleaaisydddGyqsycticaeGrelllcgndsctrafcvecvdrlvGrgeae 92 
                        evk+n++n+edici+cG+++++++hPl+eggic++ckdkfl+a ++ydddGyqsyc+ic++G++ll+cgn++ctr++c+ecvd+lvG+g++ 
  ENSP00000486001.1  41 EVKANQRNIEDICICCGSLQVHTQHPLFEGGICAPCKDKFLDALFLYDDDGYQSYCSICCSGETLLICGNPDCTRCYCFECVDSLVGPGTSG 132
                        89****************************************************************************************** PP
            ADD.txt  93 kikkeenWvcylclpesllgllrrrkdvkerleqllqqnk 132
                        k+++++nWvcylclp+s++gll+rr++++++l++++++++
  ENSP00000486001.1 133 KVHAMSNWVCYLCLPSSRSGLLQRRRKWRSQLKAFYDRES 172
                        *************************************997 PP
Protein Sequence
(Fasta)		MAAIPALDPE AEPSMDVILV GSSELSSSVS PGTGRDLIAY EVKANQRNIE DICICCGSLQ 60
VHTQHPLFEG GICAPCKDKF LDALFLYDDD GYQSYCSICC SGETLLICGN PDCTRCYCFE 120
CVDSLVGPGT SGKVHAMSNW VCYLCLPSSR SGLLQRRRKW RSQLKAFYDR ESENPLEMFE 180
TVPVWRRQPV RVLSLFEDIK KELTSLGFLE SGSDPGQLKH VVDVTDTVRK DVEEWGPFDL 240
VYGATPPLGH TCDRPPSWYL FQFHRLLQYA RPKPGSPRPF FWMFVDNLVL NKEDLDVASR 300
FLEMEPVTIP DVHGGSLQNA VRVWSNIPAI RSRHWALVSE EELSLLAQNK QSSKLAAKWP 360
TKLVKNCFLP LREYFKYFST ELTSSL 386
Nucleotide Sequence
(Fasta)		GTGGGCCTGG ATCCTTCCAG CTCATTCTTT GCCTGCGCCG TCCCTCGTTC CATGGCCCAG 60
TCCTCCCCGG GGACCCTGAG CCTGGAAGCC CCGGACCACT GGAACCTTGA ACCCACCAGC 120
TGGCTGTACC CGGAGCCGTG GCAGCAGCCC TCATCCCCAT GGCGGCCATC CCAGCCCTGG 180
ACCCAGAGGC CGAGCCCAGC ATGGACGTGA TTTTGGTGGG ATCCAGTGAG CTCTCAAGCT 240
CCGTTTCACC CGGGACAGGC AGAGATCTTA TTGCATATGA AGTCAAGGCT AACCAGCGAA 300
ATATAGAAGA CATCTGCATC TGCTGCGGAA GTCTCCAGGT TCACACACAG CACCCTCTGT 360
TTGAGGGAGG GATCTGCGCC CCATGTAAGG ACAAGTTCCT GGATGCCCTC TTCCTGTACG 420
ACGATGACGG GTACCAATCC TACTGCTCCA TCTGCTGCTC CGGAGAGACG CTGCTCATCT 480
GCGGAAACCC TGATTGCACC CGATGCTACT GCTTCGAGTG TGTGGATAGC CTGGTCGGCC 540
CCGGGACCTC GGGGAAGGTG CACGCCATGA GCAACTGGGT GTGCTACCTG TGCCTGCCGT 600
CCTCCCGAAG CGGGCTGCTG CAGCGTCGGA GGAAGTGGCG CAGCCAGCTC AAGGCCTTCT 660
ACGACCGAGA GTCGGAGAAT CCCCTTGAGA TGTTCGAAAC CGTGCCTGTG TGGAGGAGAC 720
AGCCAGTCCG GGTGCTGTCC CTTTTTGAAG ACATCAAGAA AGAGCTGACG AGTTTGGGCT 780
TTTTGGAAAG TGGTTCTGAC CCGGGACAAC TGAAGCATGT GGTTGATGTC ACAGACACAG 840
TGAGGAAGGA TGTGGAGGAG TGGGGACCCT TCGATCTTGT GTACGGCGCC ACACCTCCCC 900
TGGGCCACAC CTGTGACCGT CCTCCCAGCT GGTACCTGTT CCAGTTCCAC CGGCTCCTGC 960
AGTACGCACG GCCCAAGCCA GGCAGCCCCA GGCCCTTCTT CTGGATGTTC GTGGACAATC 1020
TGGTGCTGAA CAAGGAAGAC CTGGACGTCG CATCTCGCTT CCTGGAGATG GAGCCAGTCA 1080
CCATCCCAGA TGTCCACGGC GGATCCTTGC AGAATGCTGT CCGCGTGTGG AGCAACATCC 1140
CAGCCATAAG GAGCAGGCAC TGGGCTCTGG TTTCGGAAGA AGAATTGTCC CTGCTGGCCC 1200
AGAACAAGCA GAGCTCGAAG CTCGCGGCCA AGTGGCCCAC CAAGCTGGTG AAGAACTGCT 1260
TTCTCCCCCT AAGAGAATAT TTCAAGTATT TTTCAACAGA ACTCACTTCC TCTTTATAAA 1320
TGAGTCACTA TACTGTGAAG AAAAAGACTT TTCCTAGAAC AAAG 1365
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR025766--ADD
IPR030486--DNMT3L
IPR011011--Znf_FYVE_PHD
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51533--ADD
Pfam
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0008047--F:enzyme activator activity
GO:0019899--F:enzyme binding
GO:0046872--F:metal ion binding
GO:0006306--P:DNA methylation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0043085--P:positive regulation of catalytic activity
GO:0006349--P:regulation of gene expression by genetic imprinting
GO:0007283--P:spermatogenesis
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Pat-0114 ENSPTRP00000024048.3 Pan troglodytes 99 0.0 726
WERAM-Nol-0021 ENSNLEP00000002597.1 Nomascus leucogenys 96 0.0 706
WERAM-Paa-0142 ENSPANP00000012764.1 Papio anubis 94 0.0 696
WERAM-Gog-0139 ENSGGOP00000012133.2 Gorilla gorilla 96 0.0 694
WERAM-Chs-0093 ENSCSAP00000004106.1 Chlorocebus sabaeus 93 0.0 692
WERAM-Mam-0090 ENSMMUP00000013953.2 Macaca mulatta 94 0.0 692
WERAM-Caj-0037 ENSCJAP00000006474.1 Callithrix jacchus 82 5e-174 607
WERAM-Ova-0123 ENSOARP00000012622.1 Ovis aries 80 1e-169 593
WERAM-Bot-0138 ENSBTAP00000019812.4 Bos taurus 78 3e-167 585
WERAM-Aim-0123 ENSAMEP00000011430.1 Ailuropoda melanoleuca 77 7e-165 577
WERAM-Sus-0195 ENSSSCP00000026513.1 Sus scrofa 75 2e-159 559
WERAM-Mup-0111 ENSMPUP00000009928.1 Mustela putorius furo 75 1e-157 553
WERAM-Ict-0204 ENSSTOP00000017007.1 Ictidomys tridecemlineatus 75 2e-155 546
WERAM-Myl-0153 ENSMLUP00000012700.2 Myotis lucifugus 72 5e-153 537
WERAM-Otg-0162 ENSOGAP00000013760.2 Otolemur garnettii 76 7e-151 530
WERAM-Tub-0134 ENSTBEP00000014608.1 Tupaia belangeri 73 6e-88 321
WERAM-Mim-0063 ENSMICP00000006096.1 Microcebus murinus 40 2e-66 250
WERAM-Orla-0195 ENSORLP00000022087.1 Oryzias latipes 41 9e-66 248
WERAM-Tut-0163 ENSTTRP00000014038.1 Tursiops truncatus 39 1e-65 248
WERAM-Pof-0178 ENSPFOP00000015002.2 Poecilia formosa 41 1e-65 247
WERAM-Orn-0062 ENSONIP00000006964.1 Oreochromis niloticus 40 2e-65 247
WERAM-Tar-0037 ENSTRUP00000009049.1 Takifugu rubripes 41 4e-65 246
WERAM-Caf-0082 ENSCAFP00000010821.3 Canis familiaris 39 4e-65 245
WERAM-Tag-0096 ENSTGUP00000006612.1 Taeniopygia guttata 39 4e-65 245
WERAM-Mum-0086 ENSMUSP00000072761.3 Mus musculus 39 5e-65 245
WERAM-Dio-0128 ENSDORP00000012072.1 Dipodomys ordii 37 5e-65 245
WERAM-Ten-0221 ENSTNIP00000022331.1 Tetraodon nigroviridis 41 6e-65 245
WERAM-Eqc-0080 ENSECAP00000010703.1 Equus caballus 38 6e-65 245
WERAM-Tas-0015 ENSTSYP00000001852.1 Tarsius syrichta 38 7e-65 245
WERAM-Meg-0140 ENSMGAP00000014894.2 Meleagris gallopavo 41 8e-65 244
WERAM-Anc-0084 ENSACAP00000007951.3 Anolis carolinensis 41 8e-65 244
WERAM-Ran-0163 ENSRNOP00000046524.2 Rattus norvegicus 41 8e-65 244
WERAM-Cap-0181 ENSCPOP00000017608.1 Cavia porcellus 41 9e-65 244
WERAM-Poa-0091 ENSPPYP00000012188.1 Pongo abelii 39 9e-65 244
WERAM-Mod-0141 ENSMODP00000019777.2 Monodelphis domestica 41 9e-65 244
WERAM-Loa-0120 ENSLAFP00000011100.4 Loxodonta africana 41 1e-64 244
WERAM-Gaga-0042 ENSGALP00000006352.4 Gallus gallus 41 1e-64 244
WERAM-Fec-0041 ENSFCAP00000003373.3 Felis catus 41 1e-64 244
WERAM-Orc-0172 ENSOCUP00000015318.2 Oryctolagus cuniculus 38 1e-64 244
WERAM-Fia-0136 ENSFALP00000011094.1 Ficedula albicollis 41 1e-64 244
WERAM-Ocp-0080 ENSOPRP00000006902.2 Ochotona princeps 41 1e-64 244
WERAM-Dan-0082 ENSDNOP00000008153.3 Dasypus novemcinctus 41 2e-64 243
WERAM-Leo-0170 ENSLOCP00000020139.1 Lepisosteus oculatus 40 4e-64 242
WERAM-Xet-0006 ENSXETP00000002659.3 Xenopus tropicalis 40 1e-63 241
WERAM-Gaa-0071 ENSGACP00000009407.1 Gasterosteus aculeatus 40 3e-63 239
WERAM-Sah-0072 ENSSHAP00000008668.1 Sarcophilus harrisii 40 3e-63 239
WERAM-Gam-0205 ENSGMOP00000019846.1 Gadus morhua 41 3e-63 239
WERAM-Xim-0195 ENSXMAP00000015669.1 Xiphophorus maculatus 40 4e-63 239
WERAM-Dar-0012 ENSDARP00000091093.4 Danio rerio 40 4e-63 239
WERAM-Prc-0010 ENSPCAP00000000802.1 Procavia capensis 38 4e-63 239
WERAM-Asm-0010 ENSAMXP00000001710.1 Astyanax mexicanus 40 6e-63 238
WERAM-Ora-0103 ENSOANP00000019195.2 Ornithorhynchus anatinus 38 5e-62 235
WERAM-Ptv-0173 ENSPVAP00000014988.1 Pteropus vampyrus 37 3e-61 233
WERAM-Ect-0150 ENSETEP00000016503.1 Echinops telfairi 39 6e-61 232
WERAM-Soa-0100 ENSSARP00000009334.1 Sorex araneus 36 1e-60 231
WERAM-Ere-0054 ENSEEUP00000004702.1 Erinaceus europaeus 40 2e-59 227
WERAM-Anp-0024 ENSAPLP00000003099.1 Anas platyrhynchos 33 1e-58 224
WERAM-Lac-0124 ENSLACP00000014690.1 Latimeria chalumnae 36 1e-52 204
WERAM-Mae-0014 ENSMEUP00000001177.1 Macropus eugenii 38 6e-52 202
WERAM-Chh-0068 ENSCHOP00000007297.1 Choloepus hoffmanni 49 4e-41 166
WERAM-Vip-0102 ENSVPAP00000009529.1 Vicugna pacos 32 1e-23 107
Created Date 25-Jun-2016