| Tag |
Content |
| WERAM ID |
WERAM-Hos-0108 |
| Ensembl Protein ID |
ENSP00000476228.1 |
| Uniprot Accession |
Q9NXA8; SIR5_HUMAN; B4DFM4; B4DYJ5; F5H5Z9; Q5T294; Q5T295; Q9Y6E6
|
| Genbank Protein ID |
NP_001180196.1; NP_001229756.1; NP_036373.1; NP_112534.1; XP_005249024.1; XP_005249025.1
|
| Protein Name |
NAD-dependent protein deacylase sirtuin-5, mitochondrial |
| Genbank Nucleotide ID |
NM_001193267.2; NM_001242827.1; NM_012241.4; NM_031244.3; XM_005248967.3; XM_005248968.3
|
| Gene Name |
SIRT5;SIR2L5 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDAC |
SIR2 |
Deacetylase sirtuin-type |
H3K9 |
K |
19698979; 22076378
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HDAC |
SIR2 |
2.90e-65 |
222.5 |
42 |
307 |
|
| Organism |
Homo sapiens |
| NCBI Taxa ID |
9606 |
Functional Description
(View)Functional Description
NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed:24140062). Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX. |
NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed:24140062). Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.
|
| Domain Profile |
HDAC SIR2
SIR2.txt 2 klakllkkskkivvltGAGiStsaGIPDFRsseGlysklkkeelpspeaifdldffrkdpkv..fyalakelyplgsakPtktHyflae... 88
+++k+++k+k+iv+++GAG+S+++G+P+FR++ G+++k+++++l++p a + ++ v fy++++e++ s +P++ H+++ae
ENSP00000476228.1 42 DFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNP---SR--VweFYHYRREVMG--SKEPNAGHRAIAEcet 126
68999*************************************999999944444...44..356********96..9**********99777 PP
SIR2.txt 89 .lekkgkllrlytQNiDgLerkaglkedklvelHGslatasCtkCk..kefpreeikeklkak..............ekvpkCek..Ckgvl 161
l k+g+ +++tQNiD+L+rkag+k +l+e+HGsl++++Ct+C+ +e ++ i+ +l+ k ek+p+Ce+ C+g+l
ENSP00000476228.1 127 rLGKQGRRVVVITQNIDELHRKAGTK--NLLEIHGSLFKTRCTSCGvvAENYKSPICPALSGKgapepgtqdasipvEKLPRCEEagCGGLL 216
7889*********************9..******************999999999*****999**********************9****** PP
SIR2.txt 162 kpdivffgenlpeefleeveedlkeadlllvlGtSlkvepvaslvkkavkkkvpvllvnleevkadkladlkllgdcdevveellkllgle 252
+p++v+fgenl+ + leev+++l+++dl+lv+GtS v+p+a+++ ++++++vpv+ +n+e+++a+++++++++g c++++ e l+++++e
ENSP00000476228.1 217 RPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFRFHFQGPCGTTLPEALACHENE 307
*********************************************************************************9998887765 PP
|
Protein Sequence
(Fasta) | MRPLQIVPSR LISQLYCGLK PPASTRNQIC LKMARPSSSM ADFRKFFAKA KHIVIISGAG 60
VSAESGVPTF RGAGGYWRKW QAQDLATPLA FAHNPSRVWE FYHYRREVMG SKEPNAGHRA 120
IAECETRLGK QGRRVVVITQ NIDELHRKAG TKNLLEIHGS LFKTRCTSCG VVAENYKSPI 180
CPALSGKGAP EPGTQDASIP VEKLPRCEEA GCGGLLRPHV VWFGENLDPA ILEEVDRELA 240
HCDLCLVVGT SSVVYPAAMF APQVAARGVP VAEFNTETTP ATNRFRFHFQ GPCGTTLPEA 300
LACHENETVS Protein Fasta Sequence
>ENSP00000476228.1|SIRT5;SIR2L5|Homo sapiens
MRPLQIVPSRLISQLYCGLKPPASTRNQICLKMARPSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFRFHFQGPCGTTLPEALACHENETVS |
Nucleotide Sequence
(Fasta) | CCGGAGCGCG GTCGGGACAC AGCGCCTCTA GGAGAAAGCC TGGAAGGCGC TCCGGGGGTA 60
CCCAGAGCTC TTAGCGGGCC GGCAGCATGT GCGGGGCCCA AGTAAATGGA AATGTTTTCT 120
AACATATAAA AACCTACAGA AGAAGAAAAT AATTTTCTGG ATCAAATTAG AAGTCTGTAT 180
TATATTGATG TCTCCAGATT CAAATATATT AGAAAGCAGC CGTGGAGACA ACCATCTTCA 240
TTTTGGGAGA AATAACTAAA GCCCGCCTCA AGCATTAGAA CTACAGACAA ACCCTGATGC 300
GACCTCTCCA GATTGTCCCA AGTCGATTGA TTTCCCAGCT ATATTGTGGC CTGAAGCCTC 360
CAGCGTCCAC ACGAAACCAG ATTTGCCTGA AAATGGCTCG GCCAAGTTCA AGTATGGCAG 420
ATTTTCGAAA GTTTTTTGCA AAAGCAAAGC ACATAGTCAT CATCTCAGGA GCTGGTGTTA 480
GTGCAGAAAG TGGTGTTCCG ACCTTCAGAG GAGCTGGAGG TTATTGGAGA AAATGGCAAG 540
CCCAGGACCT GGCGACTCCC CTGGCCTTTG CCCACAACCC GTCCCGGGTG TGGGAGTTCT 600
ACCACTACCG GCGGGAGGTC ATGGGGAGCA AGGAGCCCAA CGCCGGGCAC CGCGCCATAG 660
CCGAGTGTGA GACCCGGCTG GGCAAGCAGG GCCGGCGAGT CGTGGTCATC ACCCAGAACA 720
TCGATGAGCT GCACCGCAAG GCTGGCACCA AGAACCTTCT GGAGATCCAT GGTAGCTTAT 780
TTAAAACTCG ATGTACCTCT TGTGGAGTTG TGGCTGAGAA TTACAAGAGT CCAATTTGTC 840
CAGCTTTATC AGGAAAAGGT GCTCCAGAAC CTGGAACTCA AGATGCCAGC ATCCCAGTTG 900
AGAAACTTCC CCGGTGTGAA GAGGCAGGCT GCGGGGGCTT GCTGCGACCT CACGTCGTGT 960
GGTTTGGAGA AAACCTGGAT CCTGCCATTC TGGAGGAGGT TGACAGAGAG CTCGCCCACT 1020
GTGATTTATG TCTAGTGGTG GGCACTTCCT CTGTGGTGTA CCCAGCAGCC ATGTTTGCCC 1080
CCCAGGTGGC TGCCAGGGGC GTGCCAGTGG CTGAATTTAA CACGGAGACC ACCCCAGCTA 1140
CGAACAGATT CAGGTTTCAT TTCCAGGGAC CCTGTGGAAC GACTCTTCCT GAAGCCCTTG 1200
CCTGTCATGA AAATGAAACT GTTTCTTAAG TGTCCTGGGG AAGAAAGAAA TTACAGTATA 1260
TCTAAGAACT AGGCCACACG CAGAGGAGAA ATGGTCTTAT GGGTGGTGAG CTGAGTACTG 1320
AACAATCTAA AAATAGCCTC TGATTCCCTC GCTGGAATCC AACCTGTTGA TAAGTGATGG 1380
GGGTTTAGAA GTAGCAAAGA GCACCCACAT TCAAAAGTCA CAGAACTGGA AAGTTAATTC 1440
ATATTATTTG GTTTGAACTG AAACGTGAGG TATCTTTGAT GTGTATGGTT GGTTATTGGG 1500
AGGGAAAAAT TTTGTAAATT AGATTGTCTA AAAAAAATAG TTATTCTGAT TATATTTTTG 1560
TTATCTGGGC AAAGTAGAAG TCAAGGGGTA AAAACCCTAC TATTCTGATT TTTGCACAAG 1620
TTTTAGTGGA AAATAAAATC ACACTCTACA GTAGGTAATT TATTGTATAA AGACATTACC 1680
CCACGATATG GCTTTATTAG GGACTTTTTT TTTTTTTTTT TGAGACAGAG TTTCACTCTT 1740
GTTGCCCAGG CTGGAGTGCA GTGGTGCGAT CTCAGCTCAC AGCAACCTCC GCCTCCCGGG 1800
TTCAAGAGAT TCTCCTGCCT CAGCCTCATG AGTAGCTGGG ATTACAGGTA TGTACCACCA 1860
CACCCAGCTA ATTTTGTATT TTTAGTAGAG ACGGGGTTTC TCCATGTTGG TCAGGCTGGT 1920
CTTAAACTCT CGACCTCAGG TGATCTGCCC GCCTCGGCCT CCCAAAGTGC TGAGATTACG 1980
GGCATGAGCC ACCGCACCCG GCTTACTGGG GGCTTTTTAA CCTTGTTTGG CTACATTACC 2040
TCAGTGAACA AGGGGAAGCT CACAACAGGA ACTCACACAA AGAAGGAAGA GAACAGTACC 2100
AACAAGGTAG AACATCACGA TGAGAAGAAA GAATGATGCA AATATGTGGA CCCCCAGGAT 2160
AAACACAGCT GCCCAAAATT TAGCTCTGGC CCCCTTAGAT GGGGGAAGTC AACAGTGAAG 2220
TGTTTCTCAG CATCATAAAG GCAGAAGCTG TGGTTCCTGT GGGGCCTGCC AACCGTTCCC 2280
AGATGCTGAA CTCTGCTGGG AGTTTTTTCC ATGGGACTTT AAAAAATGAT GCCCTTAGGT 2340
TGGGCCAGAC CTCTGTTAAC TTCAGTAGGG ATGGCACCAG GTTCAAGAGG CCAAAGAAGA 2400
GACCTGGAGC TAGTGAAGGA AACATAGGGT TTATTTGGGG AACCTTACAG GGTGGTCCAG 2460
TGGCCGCGGG CTGGACAGAA CTGCAACCAC TTATAAAAAG CATGCAGTTT ACATAGCACT 2520
TTCACTCAGC ACCCTCCCCT CAGCAGCCTC CACGTGGCAA CCCTCACTTC TTAAGTTATT 2580
GCTGTCAGAT GCATCTGCCA TACAGGGTCA TTCTCAGGGG ATGCTTAAGT TATTTCTGTC 2640
AGGTACATCT TCCATACACT TTACTACCTT GGAGTAAAGT AGTAAGAATA CAGCTTTTTC 2700
CTTAACCTTT ACCAGCTAAC TCAGTGCTTA GGGGCCTTGG AATGCCTGCT GTCCAGCAGG 2760
TGTCACAGGC CTGACTGGGA GGCATGGCCA TTATCAACAG TGTATGAAGG TCACATATGG 2820
CTCCCTGAAG TGATTACATA CTTGGACCAC ATCACCTCAG CCCCTTGCAA AATTGCATTT 2880
AATGTTACAC CCTTGGCTTT TGTAGAAACA GGCAACAAGA CACTATCATA TAAAACTTTG 2940
TACTGCATTG CAAGGCATAA CCTTTAATAA ATCCCAGTGG TCCTTTGTGT AGGGAACGGG 3000
GATGCTCATA GCCTATGGGG CGGCTGGAGA ACCAGTCAGG GACCCTGAGG GCTCGATGTA 3060
CACTTTACAT GGGTGGGCCA AGGAGTTTAC ACTGAGGGCA CTGGTAATAC CTGTAATAGT 3120
CTTATAGTAC TTATAAAGCA GTTTTGCACA TAAAATACCA TCATGCACTT ATAAGTTTGT 3180
TCTTGGGCTG CTCCAAGTTA ACTTTATTCA TTTTCCTAGT GTTAGTGTCT CAGGGAGTCT 3240
GATTATATTT TTGATTTGTA ATTTCTATCT GACTAAGGCC TAGAGATTTC AAAACTGTTC 3300
TTTGCAATTC CTCTCATACT GAACCTCTGG TTCAGCAGCT TTTTTTGTTG TTGTTGTTTT 3360
CAAGTTTTAT CATTTTTGTT CCTATTTGGT TTTGTCGTTT TTAAATTGAG AATTGCTTCT 3420
AAAACAGAAG ACATGAAAAG AGAATTAAAA ATACAATATA TGTGTAAGAT AGAATTATTC 3480
AACTTAGCAT TTATTAAACA TCTACCAGAT GATAGACATT AGAAATAAAA TGACTAGCAA 3540
GACCTGGCCC TTCCCCTCAG GGGTTCACAG AATGGCTGGA GCAACTGTCA TATAAGCTGT 3600
TATGAAGTGC AGAAACTACA CAGACATTTG TGCGGGTTCA GACCAGCGCA ATTAGAGATG 3660
GGCAGAGTGG GATGGGGTAG GGGTAAGGTG CTTGAAATTT GCCTGGGTGG GAATTTTTGA 3720
AGTATAAAAA GGACTTCTAC CTGGGGGGCT GCGGCAGTAG AGGGAAGAGC ACGGTCGGTA 3780
CAAATGCATG GCAGGTGTGA AACAGTTTGA TTTGTTCAAA GAATGATGAA TCACTTAGTG 3840
TTGTATAATG GATGGGAGGA GAGAAACACA GCGATCACAA AGGGCCATGT TTGCCAAGAA 3900
ATAAAATATA CTTGGAAAAA AA
3923Nucleotide Fasta Sequence
>ENSP00000476228.1|SIR2|Homo sapiens
CCGGAGCGCGGTCGGGACACAGCGCCTCTAGGAGAAAGCCTGGAAGGCGCTCCGGGGGTACCCAGAGCTCTTAGCGGGCCGGCAGCATGTGCGGGGCCCAAGTAAATGGAAATGTTTTCTAACATATAAAAACCTACAGAAGAAGAAAATAATTTTCTGGATCAAATTAGAAGTCTGTATTATATTGATGTCTCCAGATTCAAATATATTAGAAAGCAGCCGTGGAGACAACCATCTTCATTTTGGGAGAAATAACTAAAGCCCGCCTCAAGCATTAGAACTACAGACAAACCCTGATGCGACCTCTCCAGATTGTCCCAAGTCGATTGATTTCCCAGCTATATTGTGGCCTGAAGCCTCCAGCGTCCACACGAAACCAGATTTGCCTGAAAATGGCTCGGCCAAGTTCAAGTATGGCAGATTTTCGAAAGTTTTTTGCAAAAGCAAAGCACATAGTCATCATCTCAGGAGCTGGTGTTAGTGCAGAAAGTGGTGTTCCGACCTTCAGAGGAGCTGGAGGTTATTGGAGAAAATGGCAAGCCCAGGACCTGGCGACTCCCCTGGCCTTTGCCCACAACCCGTCCCGGGTGTGGGAGTTCTACCACTACCGGCGGGAGGTCATGGGGAGCAAGGAGCCCAACGCCGGGCACCGCGCCATAGCCGAGTGTGAGACCCGGCTGGGCAAGCAGGGCCGGCGAGTCGTGGTCATCACCCAGAACATCGATGAGCTGCACCGCAAGGCTGGCACCAAGAACCTTCTGGAGATCCATGGTAGCTTATTTAAAACTCGATGTACCTCTTGTGGAGTTGTGGCTGAGAATTACAAGAGTCCAATTTGTCCAGCTTTATCAGGAAAAGGTGCTCCAGAACCTGGAACTCAAGATGCCAGCATCCCAGTTGAGAAACTTCCCCGGTGTGAAGAGGCAGGCTGCGGGGGCTTGCTGCGACCTCACGTCGTGTGGTTTGGAGAAAACCTGGATCCTGCCATTCTGGAGGAGGTTGACAGAGAGCTCGCCCACTGTGATTTATGTCTAGTGGTGGGCACTTCCTCTGTGGTGTACCCAGCAGCCATGTTTGCCCCCCAGGTGGCTGCCAGGGGCGTGCCAGTGGCTGAATTTAACACGGAGACCACCCCAGCTACGAACAGATTCAGGTTTCATTTCCAGGGACCCTGTGGAACGACTCTTCCTGAAGCCCTTGCCTGTCATGAAAATGAAACTGTTTCTTAAGTGTCCTGGGGAAGAAAGAAATTACAGTATATCTAAGAACTAGGCCACACGCAGAGGAGAAATGGTCTTATGGGTGGTGAGCTGAGTACTGAACAATCTAAAAATAGCCTCTGATTCCCTCGCTGGAATCCAACCTGTTGATAAGTGATGGGGGTTTAGAAGTAGCAAAGAGCACCCACATTCAAAAGTCACAGAACTGGAAAGTTAATTCATATTATTTGGTTTGAACTGAAACGTGAGGTATCTTTGATGTGTATGGTTGGTTATTGGGAGGGAAAAATTTTGTAAATTAGATTGTCTAAAAAAAATAGTTATTCTGATTATATTTTTGTTATCTGGGCAAAGTAGAAGTCAAGGGGTAAAAACCCTACTATTCTGATTTTTGCACAAGTTTTAGTGGAAAATAAAATCACACTCTACAGTAGGTAATTTATTGTATAAAGACATTACCCCACGATATGGCTTTATTAGGGACTTTTTTTTTTTTTTTTTGAGACAGAGTTTCACTCTTGTTGCCCAGGCTGGAGTGCAGTGGTGCGATCTCAGCTCACAGCAACCTCCGCCTCCCGGGTTCAAGAGATTCTCCTGCCTCAGCCTCATGAGTAGCTGGGATTACAGGTATGTACCACCACACCCAGCTAATTTTGTATTTTTAGTAGAGACGGGGTTTCTCCATGTTGGTCAGGCTGGTCTTAAACTCTCGACCTCAGGTGATCTGCCCGCCTCGGCCTCCCAAAGTGCTGAGATTACGGGCATGAGCCACCGCACCCGGCTTACTGGGGGCTTTTTAACCTTGTTTGGCTACATTACCTCAGTGAACAAGGGGAAGCTCACAACAGGAACTCACACAAAGAAGGAAGAGAACAGTACCAACAAGGTAGAACATCACGATGAGAAGAAAGAATGATGCAAATATGTGGACCCCCAGGATAAACACAGCTGCCCAAAATTTAGCTCTGGCCCCCTTAGATGGGGGAAGTCAACAGTGAAGTGTTTCTCAGCATCATAAAGGCAGAAGCTGTGGTTCCTGTGGGGCCTGCCAACCGTTCCCAGATGCTGAACTCTGCTGGGAGTTTTTTCCATGGGACTTTAAAAAATGATGCCCTTAGGTTGGGCCAGACCTCTGTTAACTTCAGTAGGGATGGCACCAGGTTCAAGAGGCCAAAGAAGAGACCTGGAGCTAGTGAAGGAAACATAGGGTTTATTTGGGGAACCTTACAGGGTGGTCCAGTGGCCGCGGGCTGGACAGAACTGCAACCACTTATAAAAAGCATGCAGTTTACATAGCACTTTCACTCAGCACCCTCCCCTCAGCAGCCTCCACGTGGCAACCCTCACTTCTTAAGTTATTGCTGTCAGATGCATCTGCCATACAGGGTCATTCTCAGGGGATGCTTAAGTTATTTCTGTCAGGTACATCTTCCATACACTTTACTACCTTGGAGTAAAGTAGTAAGAATACAGCTTTTTCCTTAACCTTTACCAGCTAACTCAGTGCTTAGGGGCCTTGGAATGCCTGCTGTCCAGCAGGTGTCACAGGCCTGACTGGGAGGCATGGCCATTATCAACAGTGTATGAAGGTCACATATGGCTCCCTGAAGTGATTACATACTTGGACCACATCACCTCAGCCCCTTGCAAAATTGCATTTAATGTTACACCCTTGGCTTTTGTAGAAACAGGCAACAAGACACTATCATATAAAACTTTGTACTGCATTGCAAGGCATAACCTTTAATAAATCCCAGTGGTCCTTTGTGTAGGGAACGGGGATGCTCATAGCCTATGGGGCGGCTGGAGAACCAGTCAGGGACCCTGAGGGCTCGATGTACACTTTACATGGGTGGGCCAAGGAGTTTACACTGAGGGCACTGGTAATACCTGTAATAGTCTTATAGTACTTATAAAGCAGTTTTGCACATAAAATACCATCATGCACTTATAAGTTTGTTCTTGGGCTGCTCCAAGTTAACTTTATTCATTTTCCTAGTGTTAGTGTCTCAGGGAGTCTGATTATATTTTTGATTTGTAATTTCTATCTGACTAAGGCCTAGAGATTTCAAAACTGTTCTTTGCAATTCCTCTCATACTGAACCTCTGGTTCAGCAGCTTTTTTTGTTGTTGTTGTTTTCAAGTTTTATCATTTTTGTTCCTATTTGGTTTTGTCGTTTTTAAATTGAGAATTGCTTCTAAAACAGAAGACATGAAAAGAGAATTAAAAATACAATATATGTGTAAGATAGAATTATTCAACTTAGCATTTATTAAACATCTACCAGATGATAGACATTAGAAATAAAATGACTAGCAAGACCTGGCCCTTCCCCTCAGGGGTTCACAGAATGGCTGGAGCAACTGTCATATAAGCTGTTATGAAGTGCAGAAACTACACAGACATTTGTGCGGGTTCAGACCAGCGCAATTAGAGATGGGCAGAGTGGGATGGGGTAGGGGTAAGGTGCTTGAAATTTGCCTGGGTGGGAATTTTTGAAGTATAAAAAGGACTTCTACCTGGGGGGCTGCGGCAGTAGAGGGAAGAGCACGGTCGGTACAAATGCATGGCAGGTGTGAAACAGTTTGATTTGTTCAAAGAATGATGAATCACTTAGTGTTGTATAATGGATGGGAGGAGAGAAACACAGCGATCACAAAGGGCCATGTTTGCCAAGAAATAAAATATACTTGGAAAAAAA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-0520--NAD
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0809--Transit peptide
KW-0862--Zinc
--
|
| Interpro |
IPR029035--DHS-like_NAD/FAD-binding_dom
IPR003000--Sirtuin
IPR026591--Sirtuin_cat_small_dom
IPR027546--Sirtuin_class_III
IPR026590--Ssirtuin_cat_dom
|
| PROSITE |
PS50305--SIRTUIN
|
| Pfam |
PF02146--SIR2
|
| Gene Ontology |
GO:0005829--C:cytosol
GO:0005743--C:mitochondrial inner membrane
GO:0005758--C:mitochondrial intermembrane space
GO:0005759--C:mitochondrial matrix
GO:0005739--C:mitochondrion
GO:0005634--C:nucleus
GO:0003950--F:NAD+ ADP-ribosyltransferase activity
GO:0070403--F:NAD+ binding
GO:0061697--F:protein-glutaryllysine deglutarylase activity
GO:0036054--F:protein-malonyllysine demalonylase activity
GO:0036055--F:protein-succinyllysine desuccinylase activity
GO:0008270--F:zinc ion binding
GO:0006342--P:chromatin silencing
GO:0010667--P:negative regulation of cardiac muscle cell apoptotic process
GO:2000378--P:negative regulation of reactive oxygen species metabolic process
GO:0061699--P:peptidyl-lysine deglutarylation
GO:0036047--P:peptidyl-lysine demalonylation
GO:0036049--P:peptidyl-lysine desuccinylation
GO:0006471--P:protein ADP-ribosylation
GO:0006476--P:protein deacetylation
GO:0061698--P:protein deglutarylation
GO:0036046--P:protein demalonylation
GO:0036048--P:protein desuccinylation
GO:0010566--P:regulation of ketone biosynthetic process
GO:0031667--P:response to nutrient levels
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
