WERAM Information


Tag Content
WERAM ID WERAM-Hos-0157
Ensembl Protein ID ENSP00000392318.2
Uniprot Accession Q9H8E8; CSR2B_HUMAN; A2A2I5; Q96GW6; Q96IH3; Q9HBF0; Q9UIY5
Genbank Protein ID NP_065397.3
Protein Name Cysteine-rich protein 2-binding protein
Genbank Nucleotide ID NM_020536.4
Gene Name CSRP2BP;ATAC2;CSR2B
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000149474.13 ENST00000435364.7 ENSP00000392318.2
ENSG00000149474.13 ENST00000377681.7 ENSP00000366909.2
ENSG00000149474.13 ENST00000489634.2 ENSP00000425909.2
Details
Type Family Domain Substrates AA References (PMIDs)
HAT GNAT_other N-acetyltransferase K 22664638; 18838386
Status Reviewed
Classification
Type Family E-value Score Start End
HAT GNAT_other 2.50e-78 263.6 638 776
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)
Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle.
Domain Profile
  HAT GNAT_other

      GNATOTHER.txt   1 ldesfvrpvdirtindliqevlypgidlsecLdyddfsvvvlekkvviasgflvrdvgyneaeisllavrskyrraGiarilvyalietlms 92 
ld+++vrp++i+tin+++qe+++pgidlsecL+y+dfsvvvl+kkv+ia+gf+v+dv+ynea+is+l+v++++rraGia++++y+li+t+m+
ENSP00000392318.2 638 LDYCYVRPNHIPTINSMCQEFFWPGIDLSECLQYPDFSVVVLYKKVIIAFGFMVPDVKYNEAYISFLFVHPEWRRAGIATFMIYHLIQTCMG 729
79****************************************************************************************** PP
GNATOTHER.txt 93 kdvtllvsaanpalllyekfGfkmeeevlDfydkyfPlesllkktly 139
kdvtl+vsa+npa+lly+kfGfk+ee+vlDfydky+Ples+++k+++
ENSP00000392318.2 730 KDVTLHVSASNPAMLLYQKFGFKTEEYVLDFYDKYYPLESTECKHAF 776
*********************************************98 PP

Protein Sequence
(Fasta)
MDSSIHLSSL ISRHDDEATR TSTSEGLEEG EVEGETLLIV ESEDQASVDL SHDQSGDSLN 60
SDEGDVSWME EQLSYFCDKC QKWIPASQLR EQLSYLKGDN FFRFTCSDCS ADGKEQYERL 120
KLTWQQVVML AMYNLSLEGS GRQGYFRWKE DICAFIEKHW TFLLGNRKKT STWWSTVAGC 180
LSVGSPMYFR SGAQEFGEPG WWKLVHNKPP TMKPEGEKLS ASTLKIKAAS KPTLDPIITV 240
EGLRKRASRN PVESAMELKE KRSRTQEAKD IRRAQKEAAG FLDRSTSSTP VKFISRGRRP 300
DVILEKGEVI DFSSLSSSDR TPLTSPSPSP SLDFSAPGTP ASHSATPSLL SEADLIPDVM 360
PPQALFHDDD EMEGDGVIDP GMEYVPPPAG SVASGPVVGV RKKVRGPEQI KQEVESEEEK 420
PDRMDIDSED TDSNTSLQTR AREKRKPQLE KDTKPKEPRY TPVSIYEEKL LLKRLEACPG 480
AVAMTPEARR LKRKLIVRQA KRDRGLPLFD LDQVVNAALL LVDGIYGAKE GGISRLPAGQ 540
ATYRTTCQDF RILDRYQTSL PSRKGFRHQT TKFLYRLVGS EDMAVDQSIV SPYTSRILKP 600
YIRRDYETKP PKLQLLSQIR SHLHRSDPHW TPEPDAPLDY CYVRPNHIPT INSMCQEFFW 660
PGIDLSECLQ YPDFSVVVLY KKVIIAFGFM VPDVKYNEAY ISFLFVHPEW RRAGIATFMI 720
YHLIQTCMGK DVTLHVSASN PAMLLYQKFG FKTEEYVLDF YDKYYPLEST ECKHAFFLRL 780
RR 782
Nucleotide Sequence
(Fasta)
AGAAGATGTT ATTGGCAAAA GGATCTCAAA AATCATGACT TGAATGTGAA ATATCTGTTG 60
GACAGACAAC ACGAGTTTGT GTGTGTGTGT TGATGGAGAG TAGCTTAGTA GTATCTTCAT 120
CTTTTTTTTT GGTCACTGTC CTTTTAAACT TGATCAAATA AAGGACAGTG GGTCATATAA 180
GTTACTGCTT TCAGGGTCCC TTATATCTGA ATAAAGGAGT GTGGGCAGAC ACTTTTTGGA 240
AGAGTCTGTC TGGGTGATCC TGGTAGAAGC CCCATTAGGG TCACTGTCCA GTGCTTAGGG 300
TTGTTACTGA GAAGCACTGC CGAGCTTGTG AGAAGGAAGG GATGGATAGT AGCATCCACC 360
TGAGTAGTCT GATCAGTCGG CATGATGACG AAGCCACGAG AACATCGACC TCAGAAGGAC 420
TGGAGGAAGG TGAAGTGGAG GGAGAGACGC TCCTGATCGT CGAATCCGAG GATCAGGCAT 480
CAGTGGACTT ATCGCACGAC CAGAGTGGGG ATTCCCTCAA CAGTGATGAA GGAGACGTGT 540
CTTGGATGGA GGAGCAGCTG TCCTACTTCT GTGACAAGTG CCAAAAATGG ATACCAGCCA 600
GTCAGCTGAG GGAACAGCTC AGTTACCTTA AGGGTGATAA TTTTTTTAGG TTTACTTGTT 660
CGGATTGCTC AGCAGATGGC AAGGAGCAGT ATGAAAGGCT GAAGCTGACA TGGCAGCAAG 720
TCGTCATGTT GGCAATGTAC AACTTGTCTC TGGAAGGAAG TGGACGTCAA GGTTATTTCA 780
GGTGGAAAGA AGATATCTGT GCTTTTATTG AGAAACATTG GACTTTTTTA CTAGGGAATA 840
GGAAAAAGAC GTCTACCTGG TGGAGCACCG TGGCAGGTTG CCTCAGCGTG GGAAGTCCCA 900
TGTACTTCCG TTCAGGTGCT CAGGAATTTG GAGAGCCAGG ATGGTGGAAA CTTGTTCATA 960
ACAAGCCCCC AACGATGAAA CCTGAAGGAG AGAAGTTGTC TGCCTCTACT TTGAAAATAA 1020
AAGCAGCCTC AAAACCAACT TTAGATCCCA TCATTACTGT TGAGGGACTT AGAAAACGAG 1080
CAAGTCGGAA TCCTGTGGAA TCTGCCATGG AATTAAAAGA GAAAAGGTCT CGAACTCAGG 1140
AAGCAAAAGA CATTAGAAGA GCCCAGAAGG AGGCCGCTGG CTTTCTTGAC AGGAGCACAT 1200
CTTCTACCCC TGTAAAATTC ATAAGCCGAG GCCGCAGGCC AGATGTGATT CTGGAAAAAG 1260
GCGAAGTGAT TGACTTTTCC TCCTTGAGCT CCTCTGACCG CACCCCGCTG ACAAGCCCAT 1320
CTCCTTCTCC TTCTCTGGAT TTCTCTGCCC CTGGTACACC TGCCTCTCAT TCTGCCACAC 1380
CTAGCTTGCT TTCAGAAGCA GATCTGATTC CAGATGTGAT GCCCCCACAA GCCTTGTTTC 1440
ATGATGACGA TGAGATGGAA GGCGATGGAG TCATAGACCC AGGGATGGAG TACGTCCCAC 1500
CCCCTGCTGG GTCAGTAGCT TCTGGGCCAG TGGTTGGGGT CAGAAAGAAG GTCAGAGGCC 1560
CTGAACAGAT AAAGCAGGAG GTAGAGAGTG AGGAGGAAAA ACCCGACAGG ATGGATATTG 1620
ACAGTGAAGA CACAGATTCA AACACATCTT TGCAAACAAG GGCTAGAGAA AAGAGGAAGC 1680
CTCAGCTGGA GAAGGACACA AAGCCGAAAG AGCCCAGGTA TACTCCCGTG AGCATCTACG 1740
AGGAAAAGCT GCTGCTCAAG AGGCTGGAAG CTTGTCCCGG TGCTGTTGCC ATGACTCCGG 1800
AAGCTCGGAG ACTGAAACGC AAACTGATTG TCAGACAAGC GAAAAGGGAT AGGGGATTAC 1860
CACTTTTTGA CTTGGATCAA GTTGTTAATG CTGCTCTTTT GTTAGTTGAC GGGATTTATG 1920
GAGCCAAAGA AGGAGGAATT TCCAGACTTC CAGCTGGACA AGCCACGTAC AGAACCACCT 1980
GTCAGGACTT CAGAATCCTT GACCGATACC AGACTTCCTT GCCGTCCAGG AAGGGATTTC 2040
GACACCAGAC CACCAAGTTT TTGTATCGCT TGGTAGGATC AGAAGATATG GCTGTGGACC 2100
AGAGTATTGT CAGCCCTTAT ACCTCTCGGA TCTTGAAACC TTATATCAGG CGTGATTATG 2160
AAACAAAGCC ACCCAAACTG CAGCTCCTGT CACAGATTCG TTCCCACCTG CACAGGAGCG 2220
ACCCTCACTG GACGCCGGAG CCCGACGCAC CTCTCGATTA CTGTTATGTG CGGCCAAATC 2280
ACATCCCAAC GATCAACTCC ATGTGTCAGG AGTTTTTTTG GCCTGGCATT GACCTGTCTG 2340
AGTGTCTGCA GTACCCAGAC TTCAGTGTTG TTGTTCTTTA TAAAAAAGTC ATCATTGCCT 2400
TTGGCTTCAT GGTTCCTGAT GTGAAATACA ATGAAGCTTA CATTTCATTT CTGTTCGTCC 2460
ACCCTGAATG GAGAAGAGCA GGGATTGCAA CTTTCATGAT CTATCATCTG ATTCAGACCT 2520
GCATGGGCAA GGACGTAACC CTTCACGTCT CAGCAAGCAA CCCCGCTATG CTACTGTACC 2580
AGAAGTTTGG ATTCAAGACT GAAGAATATG TATTAGATTT CTATGATAAA TATTACCCAT 2640
TGGAGAGTAC AGAGTGTAAA CACGCATTCT TTCTGAGGCT CCGGCGCTGA TGCGAATACA 2700
GCTCACAGAG AAACGCATGT GCTATTGGAG AACAGGTCTT TGTGGAGATC TAAAGGCAGT 2760
GATTGATTTC ACAGGGAGCT CTAATCTCTG TGATTACATG GTCCTTCAAA CTCCCAACCA 2820
AAGTGAGAAA AGCGGCATGC AGTGAAATGA GCAGTGAGCA GCCCTTTAGC AAAATCGCCC 2880
TCCAGTCCTT CCTGGAGATG CCTTCAGCCA GCATCCCAGA CTCCACAGTT ATTTATGAAT 2940
GATGTCGTGA TTCTCCCTCC ACCTGACAGT TTGTAAGAGT GAAAGAGCAT CTAACCTGAT 3000
GCTCTTGGAG AGAGATAACC TGTCTGTCAT AACTTAAAGG ATGAGAAAAT GTGGTGTAGC 3060
TATTAAAGAT TCATGCAGTC CCAAAAGGCA CTGTCCTGGG ATGATGAGAG ATTATAAGGT 3120
GATTTCATAA AAGGAATCCA ACCCTGTGCC CGGCCATTGA TGTGTTGTCA TTGAATCCAG 3180
GAGGATTTCT AGGGCACTGA AGTTTTGTTG TTTCTTTTGC TGACTTTGGT TACAGTCAGA 3240
AAAAATAAAC TAGATGTTTG TGTCTACATG TTCTACCTGT TGTACCTATT AGCATCTTCC 3300
TGCAGGGACT TGGGCCCATG GCCTGGGAGG TTGGTTTGGG ATTGGGGTTG TTGGGCAGCC 3360
TGCCATTCAC CTGGCCTATC CTGGCCCTTC TCATGCCCAA GACAGTTGTT TCACAGGAGT 3420
GGAAGTGTGG GTGATGCAAG TAGAACCCTC TAGATGTACC CTGTGTGGTC TGCAGGACTG 3480
GACTGTTTGC TGTGTTTGTG GATGTTGGCG ATAGACTGTC AATTAGGTTG TTTGTGATCC 3540
AACAAGAACA TTTCCAAAAG TATCTAGGTG TTCTCAAATA AAAAGCTTTC TTTGCACAAC 3600
CCATGGCCAG AGCGTCAA 3619
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
--

Interpro

IPR016181--Acyl_CoA_acyltransferase
IPR000182--GNAT_dom

PROSITE

PS51186--GNAT

Pfam

PF13673--Acetyltransf_10

Gene Ontology

GO:0005671--C:Ada2/Gcn5/Ada3 transcription activator complex
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0004402--F:histone acetyltransferase activity
GO:0030274--F:LIM domain binding
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0043966--P:histone H3 acetylation

Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Pat-0106 ENSPTRP00000022781.4 Pan troglodytes 100 0.0 1397
WERAM-Poa-0090 ENSPPYP00000011998.2 Pongo abelii 99 0.0 1393
WERAM-Paa-0133 ENSPANP00000017109.1 Papio anubis 99 0.0 1389
WERAM-Chs-0142 ENSCSAP00000007739.1 Chlorocebus sabaeus 99 0.0 1389
WERAM-Ptv-0135 ENSPVAP00000011444.1 Pteropus vampyrus 98 0.0 1380
WERAM-Orc-0151 ENSOCUP00000013201.3 Oryctolagus cuniculus 95 0.0 1373
WERAM-Fec-0061 ENSFCAP00000005396.3 Felis catus 97 0.0 1373
WERAM-Caf-0065 ENSCAFP00000008130.3 Canis familiaris 97 0.0 1368
WERAM-Caj-0057 ENSCJAP00000009281.2 Callithrix jacchus 98 0.0 1368
WERAM-Nol-0102 ENSNLEP00000011864.1 Nomascus leucogenys 99 0.0 1367
WERAM-Eqc-0137 ENSECAP00000015220.1 Equus caballus 98 0.0 1367
WERAM-Mup-0013 ENSMPUP00000001281.1 Mustela putorius furo 97 0.0 1366
WERAM-Sus-0048 ENSSSCP00000007555.2 Sus scrofa 96 0.0 1358
WERAM-Myl-0082 ENSMLUP00000006635.2 Myotis lucifugus 97 0.0 1357
WERAM-Ova-0195 ENSOARP00000019685.1 Ovis aries 95 0.0 1357
WERAM-Aim-0065 ENSAMEP00000005555.1 Ailuropoda melanoleuca 95 0.0 1356
WERAM-Ran-0045 ENSRNOP00000009437.5 Rattus norvegicus 93 0.0 1352
WERAM-Dan-0066 ENSDNOP00000006490.3 Dasypus novemcinctus 96 0.0 1349
WERAM-Loa-0064 ENSLAFP00000004745.2 Loxodonta africana 96 0.0 1345
WERAM-Mum-0085 ENSMUSP00000028911.8 Mus musculus 93 0.0 1342
WERAM-Otg-0028 ENSOGAP00000001707.2 Otolemur garnettii 94 0.0 1306
WERAM-Soa-0107 ENSSARP00000010061.1 Sorex araneus 93 0.0 1302
WERAM-Sah-0199 ENSSHAP00000021647.1 Sarcophilus harrisii 91 0.0 1292
WERAM-Ora-0014 ENSOANP00000001992.1 Ornithorhynchus anatinus 91 0.0 1280
WERAM-Mod-0048 ENSMODP00000006860.2 Monodelphis domestica 89 0.0 1280
WERAM-Cap-0144 ENSCPOP00000011814.2 Cavia porcellus 91 0.0 1277
WERAM-Ect-0136 ENSETEP00000015380.1 Echinops telfairi 92 0.0 1265
WERAM-Tas-0003 ENSTSYP00000000350.1 Tarsius syrichta 91 0.0 1264
WERAM-Tut-0188 ENSTTRP00000015573.1 Tursiops truncatus 96 0.0 1261
WERAM-Mam-0212 ENSMMUP00000030461.2 Macaca mulatta 92 0.0 1254
WERAM-Anp-0156 ENSAPLP00000016062.1 Anas platyrhynchos 89 0.0 1241
WERAM-Gaga-0091 ENSGALP00000014153.2 Gallus gallus 89 0.0 1229
WERAM-Meg-0073 ENSMGAP00000006809.2 Meleagris gallopavo 89 0.0 1225
WERAM-Fia-0096 ENSFALP00000007927.1 Ficedula albicollis 88 0.0 1203
WERAM-Tag-0086 ENSTGUP00000006066.1 Taeniopygia guttata 88 0.0 1198
WERAM-Anc-0152 ENSACAP00000013990.2 Anolis carolinensis 80 0.0 1160
WERAM-Mae-0105 ENSMEUP00000010205.1 Macropus eugenii 84 0.0 1155
WERAM-Gog-0118 ENSGGOP00000009870.2 Gorilla gorilla 94 0.0 1123
WERAM-Ere-0075 ENSEEUP00000006314.1 Erinaceus europaeus 96 0.0 1102
WERAM-Dar-0094 ENSDARP00000122559.1 Danio rerio 72 0.0 1050
WERAM-Leo-0164 ENSLOCP00000019322.1 Lepisosteus oculatus 74 0.0 1045
WERAM-Xet-0093 ENSXETP00000030216.3 Xenopus tropicalis 76 0.0 1043
WERAM-Lac-0096 ENSLACP00000012192.1 Latimeria chalumnae 80 0.0 986
WERAM-Orn-0078 ENSONIP00000008648.1 Oreochromis niloticus 69 0.0 974
WERAM-Pof-0226 ENSPFOP00000018419.2 Poecilia formosa 67 0.0 966
WERAM-Tar-0140 ENSTRUP00000030432.1 Takifugu rubripes 67 0.0 947
WERAM-Gaa-0212 ENSGACP00000026301.1 Gasterosteus aculeatus 65 0.0 924
WERAM-Xim-0112 ENSXMAP00000009786.1 Xiphophorus maculatus 60 0.0 844
WERAM-Pes-0053 ENSPSIP00000007319.1 Pelodiscus sinensis 84 0.0 694
WERAM-Chh-0116 ENSCHOP00000012270.1 Choloepus hoffmanni 84 0.0 668
WERAM-Asm-0038 ENSAMXP00000004864.1 Astyanax mexicanus 62 6e-149 525
WERAM-Gam-0094 ENSGMOP00000009855.1 Gadus morhua 77 1e-141 501
WERAM-Pem-0022 ENSPMAP00000003104.1 Petromyzon marinus 69 5e-133 472
WERAM-Orla-0214 ENSORLP00000025874.1 Oryzias latipes 80 7e-94 342
WERAM-Drm-0047 FBpp0080629 Drosophila melanogaster 45 7e-75 279
WERAM-Ten-0083 ENSTNIP00000009767.1 Tetraodon nigroviridis 28 5e-10 64.3
WERAM-Mim-0032 ENSMICP00000003002.1 Microcebus murinus 41 1e-08 59.3
WERAM-Dio-0090 ENSDORP00000009372.1 Dipodomys ordii 41 2e-08 59.3
WERAM-Bot-0152 ENSBTAP00000022557.4 Bos taurus 41 2e-08 58.9
WERAM-Ict-0115 ENSSTOP00000011704.2 Ictidomys tridecemlineatus 41 3e-08 58.2
WERAM-Vip-0089 ENSVPAP00000008163.1 Vicugna pacos 34 2e-06 52.4
WERAM-Prc-0076 ENSPCAP00000006770.1 Procavia capensis 29 2e-06 52.4
Created Date 25-Jun-2016