WERAM Information

Tag Content
WERAM ID WERAM-Hos-0170
Ensembl Protein ID ENSP00000383333.1
Uniprot Accession Q14149; MORC3_HUMAN; A8KA92; Q9UEZ2
Genbank Protein ID NP_056173.1
Protein Name MORC family CW-type zinc finger protein 3
Genbank Nucleotide ID NM_015358.2
Gene Name MORC3;KIAA0136;NXP2;ZCWCC3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000159256.12 ENST00000400485.5 ENSP00000383333.1
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader ZF-CW CW-type H3K4me3 K 26933034
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader ZF-CW 7.90e-23 82.5 405 567
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism (PubMed:20501696). Sumoylated MORC3-NBs can also associate with PML-NBs (PubMed:20501696). Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity (PubMed:17332504). Binds RNA in vitro (PubMed:11927593). May be required for influenza A transcription during viral infection (PubMed:26202233).
Domain Profile
  Me_Reader ZF-CW
          ZF-CW.txt   2 geekvWvqCddClKWRrLpgevdasvlsekWiCinNsdvrynnCsvpeEsl 52 
                        +++++WvqCd+ClKWR+Lp+ +d+  l+ekW+C+nN+d++++nC+vpeE +
  ENSP00000383333.1 405 RPDQTWVQCDACLKWRKLPDGMDQ--LPEKWYCSNNPDPQFRNCEVPEEPE 453
                        689*********************..8**********************86 PP
          ZF-CW.txt  15 KWRrLpgevdasv 27 
                        K RrL+++ ++sv
  ENSP00000383333.1 555 KNRRLSSQFENSV 567
                        77****9998887 PP
Protein Sequence
(Fasta)		MAAQPPRGIR LSALCPKFLH TNSTSHTWPF SAVAELIDNA YDPDVNAKQI WIDKTVINDH 60
ICLTFTDNGN GMTSDKLHKM LSFGFSDKVT MNGHVPVGLY GNGFKSGSMR LGKDAIVFTK 120
NGESMSVGLL SQTYLEVIKA EHVVVPIVAF NKHRQMINLA ESKASLAAIL EHSLFSTEQK 180
LLAELDAIIG KKGTRIIIWN LRSYKNATEF DFEKDKYDIR IPEDLDEITG KKGYKKQERM 240
DQIAPESDYS LRAYCSILYL KPRMQIILRG QKVKTQLVSK SLAYIERDVY RPKFLSKTVR 300
ITFGFNCRNK DHYGIMMYHR NRLIKAYEKV GCQLRANNMG VGVVGIIECN FLKPTHNKQD 360
FDYTNEYRLT ITALGEKLND YWNEMKVKKN TEYPLNLPVE DIQKRPDQTW VQCDACLKWR 420
KLPDGMDQLP EKWYCSNNPD PQFRNCEVPE EPEDEDLVHP TYEKTYKKTN KEKFRIRQPE 480
MIPRINAELL FRPTALSTPS FSSPKESVPR RHLSEGTNSY ATRLLNNHQV PPQSEPESNS 540
LKRRLSTRSS ILNAKNRRLS SQFENSVYKG DDDDEDVIIL EENSTPKPAV DHDIDMKSEQ 600
SHVEQGGVQV EFVGDSEPCG QTGSTSTSSS RCDQGNTAAT QTEVPSLVVK KEETVEDEID 660
VRNDAVILPS CVEAEAKIHE TQETTDKSAD DAGCQLQELR NQLLLVTEEK ENYKRQCHMF 720
TDQIKVLQQR ILEMNDKYVK KETCHQSTET DAVFLLESIN GKSESPDHMV SQYQQALEEI 780
ERLKKQCSAL QHVKAECSQC SNNESKSEMD EMAVQLDDVF RQLDKCSIER DQYKSEVELL 840
EMEKSQIRSQ CEELKTEVEQ LKSTNQQTAT DVSTSSNIEE SVNHMDGESL KLRSLRVNVG 900
QLLAMIVPDL DLQQVNYDVD VVDEILGQVV EQMSEISST 939
Nucleotide Sequence
(Fasta)		AGGGCTCCAC AGTCGTTCCG CCACCTCCCA GTCGGGTTGC GGCGGAGGCC GTTCCTGGCT 60
TTGTAGCTCG CTCAAGATGG CGGCGCAGCC ACCCCGCGGG ATACGCCTCA GCGCGCTTTG 120
CCCGAAGTTT TTACATACAA ATTCTACTAG TCACACCTGG CCATTCAGTG CAGTTGCTGA 180
ATTAATAGAT AATGCTTATG ATCCTGATGT GAACGCTAAA CAAATATGGA TTGACAAAAC 240
AGTGATAAAT GACCATATAT GCTTGACATT CACCGACAAT GGGAATGGTA TGACTTCTGA 300
TAAATTACAT AAAATGCTAA GCTTTGGCTT CAGTGACAAA GTCACCATGA ATGGTCATGT 360
CCCAGTTGGA TTATATGGGA ATGGCTTCAA GTCGGGTTCT ATGCGTCTGG GTAAAGACGC 420
AATCGTTTTT ACCAAAAATG GAGAAAGCAT GAGCGTGGGC CTTTTGTCTC AGACCTACTT 480
GGAAGTCATA AAAGCGGAGC ATGTTGTTGT TCCAATAGTG GCATTCAACA AGCACCGACA 540
GATGATTAAT TTAGCAGAAT CAAAAGCCAG CCTTGCTGCA ATTCTGGAAC ATTCTCTGTT 600
TTCCACGGAA CAGAAGTTAC TGGCAGAACT TGATGCTATT ATAGGCAAGA AGGGGACGAG 660
GATCATCATT TGGAATCTTA GAAGCTACAA AAATGCAACA GAGTTCGATT TTGAAAAGGA 720
TAAATATGAT ATCAGAATTC CCGAGGATTT AGATGAGATA ACAGGGAAGA AGGGGTACAA 780
GAAGCAGGAA AGGATGGACC AGATTGCCCC TGAGAGTGAC TATTCCCTGA GGGCTTATTG 840
CAGTATATTA TATCTAAAGC CAAGAATGCA GATCATCCTA CGTGGACAGA AAGTGAAGAC 900
ACAGCTGGTT TCGAAGAGTC TTGCCTACAT CGAACGTGAT GTTTATCGAC CAAAATTTTT 960
ATCTAAAACA GTGAGAATTA CCTTTGGATT CAACTGCAGA AATAAAGATC ATTATGGGAT 1020
AATGATGTAT CACAGAAATA GACTCATCAA AGCTTATGAA AAAGTTGGAT GTCAGTTAAG 1080
GGCAAACAAC ATGGGTGTTG GAGTGGTTGG AATTATAGAG TGTAATTTCC TTAAGCCAAC 1140
TCATAATAAA CAAGATTTCG ACTATACTAA TGAGTACAGA CTTACAATAA CAGCACTAGG 1200
AGAAAAGCTG AATGATTACT GGAATGAAAT GAAAGTGAAG AAAAATACAG AATATCCTCT 1260
AAATTTGCCA GTTGAAGATA TACAGAAGCG TCCTGATCAG ACATGGGTTC AGTGTGATGC 1320
CTGTCTAAAG TGGCGGAAAT TACCTGATGG GATGGATCAA CTTCCTGAAA AATGGTATTG 1380
CTCCAATAAC CCTGACCCAC AGTTCAGAAA TTGTGAGGTT CCAGAAGAAC CTGAAGATGA 1440
GGATTTGGTA CATCCCACTT ATGAAAAAAC CTACAAAAAG ACCAACAAGG AAAAATTCAG 1500
GATCAGACAA CCGGAAATGA TCCCTCGGAT TAATGCTGAA CTGTTGTTTC GGCCAACTGC 1560
TCTTTCAACT CCAAGCTTTT CTTCTCCTAA GGAAAGTGTT CCAAGAAGAC ATCTTTCAGA 1620
AGGAACAAAT TCTTATGCGA CAAGACTTCT AAATAATCAT CAAGTTCCAC CTCAGTCTGA 1680
ACCTGAGAGC AACAGCTTGA AACGGAGACT TTCTACTCGT TCCTCAATTT TGAATGCAAA 1740
GAATCGGAGA TTGAGTAGTC AGTTTGAAAA TTCAGTTTAT AAAGGTGATG ATGATGATGA 1800
AGATGTCATC ATCTTAGAAG AAAACAGTAC CCCCAAACCT GCAGTAGATC ATGATATTGA 1860
CATGAAATCA GAACAGAGTC ACGTTGAGCA AGGTGGTGTT CAGGTTGAGT TTGTGGGTGA 1920
CAGTGAACCT TGTGGCCAGA CTGGTTCAAC AAGCACCTCA TCATCCCGAT GCGACCAGGG 1980
AAATACTGCA GCTACCCAGA CTGAAGTACC AAGTTTAGTT GTTAAAAAAG AAGAAACTGT 2040
TGAAGACGAG ATAGACGTAA GAAATGATGC AGTGATTCTG CCCTCCTGTG TAGAAGCTGA 2100
AGCAAAGATA CATGAAACCC AGGAAACCAC CGATAAATCT GCAGATGATG CAGGCTGCCA 2160
ATTACAAGAA CTGAGAAACC AGCTACTCCT TGTCACTGAG GAAAAAGAGA ATTATAAAAG 2220
ACAGTGTCAT ATGTTTACTG ATCAAATCAA AGTGTTACAA CAGAGGATAC TAGAAATGAA 2280
TGACAAGTAT GTTAAGAAAG AAACTTGCCA TCAGTCCACT GAAACCGATG CTGTATTTTT 2340
ACTTGAAAGT ATTAATGGCA AATCTGAAAG TCCAGACCAT ATGGTATCTC AGTATCAGCA 2400
AGCTTTGGAA GAAATAGAAA GGCTGAAAAA ACAATGTAGT GCTTTGCAAC ATGTAAAGGC 2460
TGAATGCAGC CAGTGTTCCA ATAATGAGAG TAAAAGTGAA ATGGATGAGA TGGCTGTGCA 2520
GCTTGACGAT GTGTTTAGAC AACTGGACAA ATGCAGTATT GAGAGGGACC AGTATAAAAG 2580
TGAGGTTGAA TTGCTGGAAA TGGAAAAGTC ACAAATCCGT TCACAGTGTG AAGAACTCAA 2640
AACTGAAGTA GAACAGTTAA AATCTACAAA TCAACAGACG GCAACAGATG TTTCAACATC 2700
AAGTAACATT GAGGAGTCTG TAAATCATAT GGATGGAGAA AGCCTCAAAC TCCGATCTCT 2760
TCGAGTTAAC GTAGGACAAC TGCTGGCTAT GATTGTGCCT GATCTTGATC TTCAGCAAGT 2820
GAATTACGAT GTTGATGTAG TTGATGAGAT TTTAGGACAA GTTGTTGAAC AAATGAGTGA 2880
AATCAGTAGT ACTTAAAGTA TATGTTATGT AAGATAAAAT ATTTGCTCAA TTCTTTTGGT 2940
TGTACAGCTT TCAAAATATA ATTAATTTTG TTTTATAGAT ATGATAGGCA ACAGACTGAA 3000
AACCATAATC TTTACTGTAT TCTATGCATT CAAATGTGGT CACAAATATT GTGGACACAT 3060
TATCTTATGT TTTGAAATAC CTGTGAATTG TTGGCATTGA GCAGCTGAAG CTAACTCATG 3120
ACTCTGTTTT GAATGTAAAT ATTTGTAATT AAGCCTGCAC ATATTTTTTT ATTGCCCTAG 3180
AGTACTCAAG TGTTTTTCAC CAAGAGCTTT TCAGGTTGCC CCTAAGCTTT GTGCAATTTT 3240
TTCTGGTTCC CCAAAGTGTA TTTTTCTCTA AGTCGAGGGC TATGCCATAA TACAAATGGA 3300
AATGTTACCT TTGATTTTCT TATAAAGGAG TTTAAATAGG ATTTTTAAAT AATGTAGTAA 3360
CACTCCTGAT ACAACTCTGG TTATAAGTGA ATTGAGCATT AATGTTTCTT TTGTATAAAT 3420
TCCTGTCCTG AAATATTTTA TTCATGAAAA TAAGGTAAGC AAAAACCAAC TCCATTTTGC 3480
CAGGATTTTG TTGTGCTGAG ATTGCCAATC ACGGTTAAAC ACAAAGTGTT TTTATAGAAT 3540
GAAGAAACAG TCTTTAACAG AAAAAAGGTA TTGAAATATT AAATGGCCAC CAAGTTTACT 3600
TTGAAGCCCA TTTTTGGCTG TTTAGTCAGC ATGAAGTGGG CATGATAATT TTTTAATATT 3660
TCTTTTTGTG AAATTTCCTG TACAGCCTTT TGTAGGATTA CTACAGGTTA ATGTGAGTTG 3720
AGGAAGACAG TCTTTCTCAA ACAATACTAC ATACCTTTTA TTATATTACA AACCTAAGTG 3780
TTTTATATCC TAGAGTCAAG GAACAAATTT CCTTAGGATT ATAGTATTAC ATGCCATAAA 3840
ATACTATGCT TTATTGGTCC CATGTTTTGT GCAATTTTAA AGAGATGGCT TTCTATTAAG 3900
TATAAACTAT GTATATATAA GAACCATATT TTCCACAACT AAAATGTGCA TTATTTTTTC 3960
CAAAGTTTTA TCATTGCTAT TTATTTTTAC CTTTGTTTTT GAACATTCAA TCCGTTCATT 4020
TTGTATGTAT GCTTAATACG TGTCGGTCAT ATACAGTATT GAATTTTTAC TGTATAGTAA 4080
TTCTGGAAAG AGCAAATAAA TGAAGATTGT TTTTATTTGC CTGATAAAGT AATTGAAAGT 4140
GTATTTTTGG TATGAAGCTG GTTTTCTGTC ACAATTGTAA TTTCCCAAAT TTTAAAATAT 4200
CTTATAATAA AATAAAAATA TATGATGGCT AACTGTTCAA ATGCTA 4247
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0945--Host-virus interaction
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0694--RNA-binding
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR003594--HATPase_C
IPR011124--Znf_CW
PROSITE

PS51050--ZF_CW
Pfam

PF07496--zf-CW
Gene Ontology

GO:0016363--C:nuclear matrix
GO:0005654--C:nucleoplasm
GO:0016605--C:PML body
GO:0003723--F:RNA binding
GO:0008270--F:zinc ion binding
GO:0007569--P:cell aging
GO:0051457--P:maintenance of protein location in nucleus
GO:0048147--P:negative regulation of fibroblast proliferation
GO:0018105--P:peptidyl-serine phosphorylation
GO:0009791--P:post-embryonic development
GO:0006468--P:protein phosphorylation
GO:0050821--P:protein stabilization
GO:0016032--P:viral process
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Pat-0112 ENSPTRP00000023905.4 Pan troglodytes 100 0.0 1836
WERAM-Gog-0137 ENSGGOP00000011690.2 Gorilla gorilla 99 0.0 1828
WERAM-Chs-0101 ENSCSAP00000004908.1 Chlorocebus sabaeus 99 0.0 1826
WERAM-Poa-0095 ENSPPYP00000012727.2 Pongo abelii 99 0.0 1821
WERAM-Mam-0186 ENSMMUP00000026364.2 Macaca mulatta 98 0.0 1811
WERAM-Paa-0068 ENSPANP00000013015.1 Papio anubis 96 0.0 1799
WERAM-Nol-0042 ENSNLEP00000005356.1 Nomascus leucogenys 97 0.0 1788
WERAM-Otg-0118 ENSOGAP00000010256.2 Otolemur garnettii 92 0.0 1679
WERAM-Caj-0024 ENSCJAP00000005071.2 Callithrix jacchus 93 0.0 1665
WERAM-Caf-0108 ENSCAFP00000014196.3 Canis familiaris 90 0.0 1660
WERAM-Orc-0198 ENSOCUP00000023881.2 Oryctolagus cuniculus 89 0.0 1650
WERAM-Aim-0068 ENSAMEP00000005857.1 Ailuropoda melanoleuca 90 0.0 1650
WERAM-Loa-0010 ENSLAFP00000000578.4 Loxodonta africana 89 0.0 1647
WERAM-Fec-0037 ENSFCAP00000002709.3 Felis catus 90 0.0 1633
WERAM-Dan-0031 ENSDNOP00000002822.3 Dasypus novemcinctus 90 0.0 1627
WERAM-Sus-0083 ENSSSCP00000012835.2 Sus scrofa 88 0.0 1619
WERAM-Eqc-0115 ENSECAP00000013094.1 Equus caballus 90 0.0 1599
WERAM-Soa-0043 ENSSARP00000004058.1 Sorex araneus 86 0.0 1564
WERAM-Cap-0078 ENSCPOP00000005697.2 Cavia porcellus 84 0.0 1545
WERAM-Ova-0150 ENSOARP00000014977.1 Ovis aries 86 0.0 1544
WERAM-Bot-0112 ENSBTAP00000015758.4 Bos taurus 86 0.0 1541
WERAM-Myl-0142 ENSMLUP00000011489.2 Myotis lucifugus 84 0.0 1539
WERAM-Mum-0163 ENSMUSP00000040152.6 Mus musculus 82 0.0 1511
WERAM-Ocp-0091 ENSOPRP00000008186.2 Ochotona princeps 83 0.0 1503
WERAM-Tub-0146 ENSTBEP00000015413.1 Tupaia belangeri 83 0.0 1476
WERAM-Ptv-0128 ENSPVAP00000011129.1 Pteropus vampyrus 80 0.0 1451
WERAM-Tut-0190 ENSTTRP00000015736.1 Tursiops truncatus 79 0.0 1353
WERAM-Mod-0189 ENSMODP00000026271.3 Monodelphis domestica 73 0.0 1311
WERAM-Mup-0086 ENSMPUP00000008153.1 Mustela putorius furo 88 0.0 1291
WERAM-Gaga-0145 ENSGALP00000025794.4 Gallus gallus 69 0.0 1226
WERAM-Meg-0146 ENSMGAP00000015395.1 Meleagris gallopavo 68 0.0 1217
WERAM-Ora-0087 ENSOANP00000015498.1 Ornithorhynchus anatinus 70 0.0 1213
WERAM-Anp-0132 ENSAPLP00000014493.1 Anas platyrhynchos 69 0.0 1202
WERAM-Tag-0069 ENSTGUP00000004962.1 Taeniopygia guttata 66 0.0 1144
WERAM-Anc-0135 ENSACAP00000012415.3 Anolis carolinensis 64 0.0 1117
WERAM-Prc-0152 ENSPCAP00000014486.1 Procavia capensis 76 0.0 1018
WERAM-Ran-0161 ENSRNOP00000059391.1 Rattus norvegicus 79 0.0 997
WERAM-Ict-0203 ENSSTOP00000018658.1 Ictidomys tridecemlineatus 86 0.0 981
WERAM-Tas-0014 ENSTSYP00000001575.1 Tarsius syrichta 96 0.0 956
WERAM-Fia-0132 ENSFALP00000010864.1 Ficedula albicollis 64 0.0 950
WERAM-Vip-0026 ENSVPAP00000002457.1 Vicugna pacos 85 0.0 944
WERAM-Pes-0144 ENSPSIP00000017186.1 Pelodiscus sinensis 66 0.0 933
WERAM-Xet-0087 ENSXETP00000028509.3 Xenopus tropicalis 55 0.0 926
WERAM-Ect-0103 ENSETEP00000011616.1 Echinops telfairi 80 0.0 882
WERAM-Leo-0063 ENSLOCP00000008264.1 Lepisosteus oculatus 50 0.0 833
WERAM-Chh-0109 ENSCHOP00000011938.1 Choloepus hoffmanni 77 0.0 719
WERAM-Ere-0125 ENSEEUP00000013432.1 Erinaceus europaeus 78 0.0 710
WERAM-Lac-0081 ENSLACP00000010352.1 Latimeria chalumnae 48 0.0 677
WERAM-Dar-0117 ENSDARP00000091859.3 Danio rerio 68 0.0 657
WERAM-Ten-0171 ENSTNIP00000016946.1 Tetraodon nigroviridis 43 0.0 644
WERAM-Pof-0008 ENSPFOP00000022200.1 Poecilia formosa 62 3e-177 619
WERAM-Xim-0044 ENSXMAP00000004148.1 Xiphophorus maculatus 62 1e-176 618
WERAM-Tar-0137 ENSTRUP00000029898.1 Takifugu rubripes 63 1e-170 598
WERAM-Orn-0194 ENSONIP00000020127.1 Oreochromis niloticus 61 2e-169 594
WERAM-Asm-0132 ENSAMXP00000012850.1 Astyanax mexicanus 64 2e-166 583
WERAM-Gaa-0029 ENSGACP00000004852.1 Gasterosteus aculeatus 58 1e-157 554
WERAM-Mae-0140 ENSMEUP00000014217.1 Macropus eugenii 78 6e-138 489
WERAM-Dio-0161 ENSDORP00000015212.1 Dipodomys ordii 51 2e-130 464
WERAM-Osl-0014 ABO99126 Ostreococcus lucimarinus 36 2e-49 195
WERAM-Pot-0026 POPTR_0002s07930.1 Populus trichocarpa 36 2e-06 52.8
Created Date 25-Jun-2016