WERAM Information
Tag | Content | ||||||||||||||||||
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WERAM ID | WERAM-Hos-0011 | ||||||||||||||||||
Ensembl Protein ID | ENSP00000381053.3 | ||||||||||||||||||
Uniprot Accession | Q15326; ZMY11_HUMAN; B2R6G8; B7Z293; F6UH50; Q2LD45; Q2LD46; Q2LD47; Q2LD48; Q5VUI1; Q8N4B3 | ||||||||||||||||||
Genbank Protein ID | NP_001189393.1; NP_001189394.1; NP_001189396.1; NP_001189397.1; NP_006615.2; NP_997644.2; XP_005252416.1; XP_005252418.1; XP_005252419.1; XP_006717439.1 | ||||||||||||||||||
Protein Name | Zinc finger MYND domain-containing protein 11 | ||||||||||||||||||
Genbank Nucleotide ID | NM_001202464.1; NM_001202465.1; NM_001202467.1; NM_001202468.1; NM_006624.5; NM_212479.3; XM_005252359.3; XM_005252361.2; XM_005252362.1; XM_006717376.1 | ||||||||||||||||||
Gene Name | ZMYND11;BRAM1;BS69 | ||||||||||||||||||
Ensembl Information | |||||||||||||||||||
Details |
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Status | Reviewed | ||||||||||||||||||
Classification |
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Organism | Homo sapiens | ||||||||||||||||||
NCBI Taxa ID | 9606 | ||||||||||||||||||
Functional Description (View) |
Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth. | ||||||||||||||||||
Domain Profile | Ac_Reader Bromodomain BROMO.txt 11 epvdpqleipdYydiikePmdLstikerleegnYsspeefvkDvrlifnNakaynenkss 70 |
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Protein Sequence (Fasta) | MARLTKRRQA DTKAIQHLWA AIEIIRNQKQ IANIDRITKY MSRVHGMHPK ETTRQLSLAV 60 KDGLIVETLT VGCKGSKAGI EQEGYWLPGD EIDWETENHD WYCFECHLPG EVLICDLCFR 120 VYHSKCLSDE FRLRDSSSPW QCPVCRSIKK KNTNKQEMGT YLRFIVSRMK ERAIDLNKKG 180 KDNKHPMYRR LVHSAVDVPT IQEKVNEGKY RSYEEFKADA QLLLHNTVIF YGADSEQADI 240 ARMLYKDTCH ELDELQLCKN CFYLSNARPD NWFCYPCIPN HELVWAKMKG FGFWPAKVMQ 300 KEDNQVDVRF FGHHHQRAWI PSENIQDITV NIHRLHVKRS MGWKKACDEL ELHQRFLREG 360 RFWKSKNEDR GEEEAESSIS STSNEQLKVT QEPRAKKGRR NQSVEPKKEE PEPETEAVSS 420 SQEIPTMPQP IEKVSVSTQT KKLSASSPRM LHRSTQTTND GVCQSMCHDK YTKIFNDFKD 480 RMKSDHKRET ERVVREALEK LRSEMEEEKR QAVNKAVANM QGEMDRKCKQ VKEKCKEEFV 540 EEIKKLATQH KQLISQTKKK QWCYNCEEEA MYHCCWNTSY CSIKCQQEHW HAEHKRTCRR 600 KR 602 |
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Nucleotide Sequence (Fasta) | ACTTCTCGCG CAAATCTGCA GTGTTCTTGC AGGGCTGCTG ATGGGTGGTC CTGTTCTTTT 60 CGCGGTCCTG TTTGCGCAGA GATGAAACGG GGAACTTAGC GTATCCCTAC CGCTCTTTTT 120 GATGACAGGA GTAAAGGGCT GTTCAGACTA CCTAAACAAT GTTGTTAAGA GAAGCACTCG 180 TACTTCTCAG ACTTCGCTGT TCCGGACCCC GCGAGCCAGG GGCAGGCACC GGGTCCACCC 240 GGGGCTGAGC TGCGGCGGCG CCTGACAATG CCCCCTCGCG CCCCGGCCTC GGCGCCCGCT 300 CCCGGCTCCA GCGCGCCTGC ACCTAAAGAA GTAAACAGGT CATGGCACGT TTAACAAAAA 360 GACGACAGGC GGATACAAAA GCTATCCAGC ATCTTTGGGC AGCCATTGAG ATTATACGGA 420 ACCAGAAGCA GATTGCCAAC ATTGACCGTA TTACAAAGTA TATGTCTCGA GTCCACGGTA 480 TGCACCCTAA AGAGACCACC CGTCAGCTGA GCTTAGCTGT GAAAGATGGT CTTATTGTCG 540 AAACTCTAAC AGTGGGCTGC AAAGGTTCAA AAGCTGGTAT TGAACAAGAA GGATATTGGT 600 TGCCAGGAGA TGAGATTGAC TGGGAAACAG AAAATCATGA CTGGTATTGT TTTGAATGCC 660 ATTTGCCTGG AGAGGTGTTG ATATGTGACC TGTGTTTTCG TGTGTATCAT TCCAAGTGTT 720 TGTCTGATGA GTTCAGGCTT AGAGACAGCA GTAGTCCCTG GCAGTGCCCA GTTTGCAGGA 780 GCATTAAGAA GAAGAATACA AACAAACAGG AGATGGGCAC ATACCTCAGA TTCATTGTCT 840 CCCGCATGAA GGAGAGGGCT ATAGATCTTA ATAAAAAGGG GAAGGACAAT AAACACCCGA 900 TGTACAGGAG GCTGGTGCAC TCAGCTGTGG ACGTTCCCAC CATTCAAGAG AAAGTGAATG 960 AAGGGAAATA CCGAAGTTAT GAAGAGTTCA AAGCTGATGC CCAATTGCTT CTCCACAATA 1020 CCGTGATTTT CTATGGAGCA GACAGTGAGC AAGCTGACAT TGCGAGGATG CTATATAAAG 1080 ACACATGTCA TGAGCTGGAT GAACTGCAGC TTTGCAAGAA TTGCTTTTAC TTGTCAAATG 1140 CTCGTCCTGA CAACTGGTTC TGTTATCCTT GTATACCTAA TCATGAGCTG GTTTGGGCTA 1200 AAATGAAAGG TTTTGGGTTT TGGCCAGCCA AAGTCATGCA GAAAGAAGAC AATCAAGTCG 1260 ACGTTCGCTT CTTTGGCCAC CACCACCAGA GGGCCTGGAT TCCTTCTGAA AACATTCAAG 1320 ATATCACAGT CAACATTCAT CGGCTGCACG TGAAGCGCAG TATGGGTTGG AAAAAGGCCT 1380 GTGATGAGCT GGAGCTGCAT CAGCGTTTCC TACGAGAAGG GAGATTTTGG AAATCTAAGA 1440 ATGAGGACCG AGGTGAGGAA GAGGCAGAAT CCAGTATCTC CTCCACCAGT AATGAGCAGC 1500 TAAAGGTCAC TCAAGAACCA AGAGCAAAGA AAGGACGACG TAATCAAAGT GTGGAGCCCA 1560 AAAAGGAAGA ACCAGAGCCT GAAACAGAAG CAGTAAGTTC TAGCCAGGAA ATACCCACGA 1620 TGCCTCAGCC CATCGAAAAA GTCTCCGTGT CAACTCAGAC AAAGAAGTTA AGTGCCTCTT 1680 CACCAAGAAT GCTGCATCGG AGCACCCAGA CCACAAACGA CGGCGTGTGT CAGAGCATGT 1740 GCCATGACAA ATACACCAAG ATCTTCAATG ACTTCAAAGA CCGGATGAAG TCGGACCACA 1800 AGCGGGAGAC AGAGCGTGTT GTCCGAGAAG CTCTGGAGAA GCTGCGTTCT GAAATGGAAG 1860 AAGAAAAGAG ACAAGCTGTA AATAAAGCTG TAGCCAACAT GCAGGGTGAG ATGGACAGAA 1920 AATGTAAGCA AGTAAAGGAA AAGTGTAAGG AAGAATTTGT AGAAGAAATC AAGAAGCTGG 1980 CAACACAGCA CAAGCAACTG ATTTCTCAGA CCAAGAAGAA GCAGTGGTGC TACAACTGTG 2040 AGGAGGAGGC CATGTACCAC TGCTGCTGGA ACACATCCTA CTGCTCCATC AAGTGCCAGC 2100 AGGAGCACTG GCACGCGGAG CACAAGCGCA CCTGCCGCCG GAAAAGATGA AGCTGGCCCT 2160 TCCCGGAGTC ACCCCGATGA TTACTCTTTT CAGACACAGC GGTTTTTGTT TCCAAGAAGC 2220 CAAAATTGTT TAGAATTTGC TTCCCATTTT GCACCAGCCT TTAAACACTT TTCGTGAAGA 2280 AATTTTGCAC AGTAGTTTAA ATCTTTTGTT AATGCTCCTC CGAAGTTTTT CAGGGGGTAA 2340 AAGTAACATC AGTGGAGGGT ATTATTTTAA ATAAATTTTA ATTGAGAATT TGTTGCATTT 2400 TCAGCAAATT TTAAAACATT TTTAGGTTTT ACAGAGATTT TAACCTTTAA ACAACAGATC 2460 TTTAAAAAAC AGGTGAATAC AAGTGAGTTT AACAAAGAAA CATTTAGAAT AGATCTGAAT 2520 GTAAGAACTA CAGAACTGTT TCAGAAATAA AACATACTAC CTTGATGTGA CATTTTTTTC 2580 TTAACCTTGT TGAGCTGGTT TTGTTCAGCT TAATTTACTG TTCAAAGGCA TTATCTGTTG 2640 GTCACACCAG TGGGTATATG ATTGAATTTA GGGAACAGGG TTGACACAGC AGGGCTAGTC 2700 CTGCATATTT TTTCTTAAAT ATTTCCCAAT TGTGTTTTTC ATTATTTCTT TTCAATATAT 2760 AACTTTTATA ACAAATTATT AGCTTTGATC TTGTAGTTTA AAATTGCAGG GAACTGGGGT 2820 AATCTTTTAC TGAGCTGGAT CTTAGAGAAA ATGAATATTT AAATTTTAAA GTTTGCACAT 2880 TTCATCTTTG TCCTAACATG AGTGCTTGTA ACAAAATAAA CAACAAAAAC AAAGCCAAAA 2940 ACTACCTTTA TCCATATGTG AAATTATAGA TGAGGCATAC GAATTTGTTT AATGCTTCCC 3000 TTCCCTTCCC ACATATCATC TCACTGCCTA TTATCTGGTG TCACCTCATG TATCGTAAGT 3060 TAATACTAAA AGAAGAGAAA GCACTTAAGT TTCACAGAAG CCGTTATGTT TGTAGTAATG 3120 GGTCATTGCC TACTAATGAA CTCCATCACT GTACACAGAA TGAAGAATAA TGCATGTTAA 3180 TTTTCTTGTA TTAAAGATGC CGTGATTTGT AAAAAGTCTG TATTTTGCGG AATGTCTGGA 3240 TTAAGAAGCA TTACCAATAG GAATGGATCG ATAGTTGAAT AATGATTTTT TATACATAGA 3300 TATATAAAAT ACAGCCAGGA AAACTTAAAT TACTTTTCTT TTAAAATATC TCACAATTTA 3360 TGTGGTATTT TTAAAGACTG ATCTTAGACC AAGTCAAATT CCCATTTATC ATTTAGTTAT 3420 TTTTTGAGGT TAGAGAATAA TTTGTACATA TTTATTTAGA CCTTTGATAT TTATTAAAGC 3480 AATTACTCAC AATGGAAGTG AAAGAATCAG GAGAAAAGCC TTTTAAAAAG TATTCTCCAG 3540 GTTTGTCAGG GTCACTCTAA AGATAAAAAT GTAACTAAGT CTTCTGTGAA ATATCATCCA 3600 TCTAATCTTG ATGCTGTTGC AGATGGTGGT GACACAAGTT AATTGACAAA CTACTGCCAA 3660 ATGGTGCACA ATATTTTGTA AAAAGTACCC AGTAGCCCCA TTTCATACAA TGTACCTAAA 3720 TTATGCAGTA ACTTGGCATC ATCGTTCCCT CCTTGTTGCT GTGTAATTAG TCAGTGTTGC 3780 CACAGTGTGT GGCGCTGATG GAGATGTCAG AACCGAGAAC ACTTAACCTT CTTTGATTGT 3840 TTTTCAAGTT TTAAGACTTC GATCCACCCC TATGAGAGCA AGTAATTGTG GAAATATTTT 3900 TGGTGTAAAA TCATTCCAGA GTATGTAATA TTTAACTGAT AGCTGCATGA AAGTGAGATT 3960 CGTGTTACTT TGGCTTTTCT GTCTCTGTTG ACACGGTTGC ACATTTCCAA GTTACTACAG 4020 CGTGAAAACT GTGTGTTTAA AAAAAAACAA AATTAAAAAA AGAGATTGTG GCCTGGTTTT 4080 GTAAAAGTTT TAGGTAAAAT TACAATTGAT TGTTTTAGGA ATCATTATTA AAAATTTTCT 4140 GCAAATCATA AAGCTATATC GAGGTGTTGA GCTTAGCCAC TATGCACATT GTAATTATTC 4200 ATTGTGGCTG TCCAGTTCTA TGATGCATTC TGGCATTTTG TAAGCTGCTC TGACTAGCAA 4260 TATATAGATT CATTTAATGT GTTAACATTG GTTAATAAAT GTATTT 4307 |
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Sequence Source | Ensembl | ||||||||||||||||||
Keyword | KW-0002--3D-structure |
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Interpro | IPR001487--Bromodomain |
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PROSITE | PS50014--BROMODOMAIN_2 |
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Pfam | PF00439--Bromodomain |
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Gene Ontology | GO:0005694--C:chromosome |
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Orthology | |||||||||||||||||||
Created Date | 25-Jun-2016 |