WERAM Information


Tag Content
WERAM ID WERAM-Hos-0103
Ensembl Protein ID ENSP00000379670.2
Uniprot Accession Q13185; CBX3_HUMAN; Q96CD7; Q99409; Q9BVS3; Q9P0Z6
Genbank Protein ID NP_009207.2; NP_057671.2; XP_005249668.1
Protein Name Chromobox protein homolog 3
Genbank Nucleotide ID NM_007276.4; NM_016587.3; XM_005249611.2
Gene Name Cbx3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000122565.18 ENST00000396386.6 ENSP00000379670.2
ENSG00000122565.18 ENST00000337620.8 ENSP00000336687.4
ENSG00000122565.18 ENST00000462165.2 ENSP00000473748.1
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader DCD Chromo1 H1.4K25me2; H3K9me3 K 22514736
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader Chromodomain 8.50e-18 66.5 30 169
Me_Reader DCD 2.40e-35 107.5 32 81
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)
Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1.
Domain Profile
  Me_Reader Chromodomain

   Chromodomain.txt  1 FeverivdkkelrkgeveYlVrWkGynksddtWepeenLlckelleefekkkek 54
F ve+++ ++++ +g+veY+ +WkG+++ d+tWepeenL c+el+e+f + ++
ENSP00000379670.2 30 FVVEKVL-DRRVVNGKVEYFLKWKGFTDADNTWEPEENLDCPELIEAFLNSQKA 82
78*****.9**************************************9765544 PP
Chromodomain.txt 13 rkgeveYlVrWkGynksddtWepeenLlckelleefek 50
ge +l +Wk ++ d e n++c++++ +f +
ENSP00000379670.2 132 SSGELMFLMKWKDSDEADLVLAKEANMKCPQIVIAFYE 169
56788899999988877777778888889888888866 PP

  Me_Reader DCD

       Chromo-2.txt  3 verIinhsvdkkGelhyLikWkdlpYdeaswesatvenkkypqlvqsfyeere 55
ve++++ +G+++y++kWk+ a+ + +en ++p+l+++f ++++
ENSP00000379670.2 32 VEKVLDRR-VVNGKVEYFLKWKGF--TDADNTWEPEENLDCPELIEAFLNSQK 81
67777777.679***********7..77777777789***********99876 PP
Chromo-2.txt 2 mverIinhsvdkkGelhyLikWkdlpYdeaswesatvenkkypqlvqsfyeeresmrgee 61
+erIi+++ d++Gel++L+kWkd+ dea+++ a+++n+k+pq+v++fyeer+++++++
ENSP00000379670.2 122 DPERIIGAT-DSSGELMFLMKWKDS--DEADLVLAKEANMKCPQIVIAFYEERLTWHSCP 178
69*******.***************..******************************987 PP

Protein Sequence
(Fasta)
MASNKTTLQK MGKKQNGKSK KVEEAEPEEF VVEKVLDRRV VNGKVEYFLK WKGFTDADNT 60
WEPEENLDCP ELIEAFLNSQ KAGKEKDGTK RKSLSDSESD DSKSKKKRDA ADKPRGFARG 120
LDPERIIGAT DSSGELMFLM KWKDSDEADL VLAKEANMKC PQIVIAFYEE RLTWHSCPED 180
EAQ 183
Nucleotide Sequence
(Fasta)
GGTGCCACCC CTCCCCCCGG CGGCCCCGCG CGCAGCTCCC GGCTCCCTCC CCCTTCGGAT 60
GTGGCTTGAG CTGTAGGCGC GGAGGGCCGG AGACGCTGCA GACCCGCGAC CCGGAGCAGC 120
TCGGAGGCGG TGAATAATAG CTCTTCAAGT CTGCAATAAA AAATGGCCTC CAACAAAACT 180
ACATTGCAAA AAATGGGAAA AAAACAGAAT GGAAAGAGTA AAAAAGTTGA AGAGGCAGAG 240
CCTGAAGAAT TTGTCGTGGA AAAAGTACTA GATCGACGTG TAGTGAATGG GAAAGTGGAA 300
TATTTCCTGA AGTGGAAGGG ATTTACAGAT GCTGACAATA CTTGGGAACC TGAAGAAAAT 360
TTAGATTGTC CAGAATTGAT TGAAGCGTTT CTTAACTCTC AGAAAGCTGG CAAAGAAAAA 420
GATGGTACAA AAAGAAAATC TTTATCTGAC AGTGAATCTG ATGACAGCAA ATCAAAGAAG 480
AAAAGAGATG CTGCTGACAA ACCAAGAGGA TTTGCCAGAG GTCTTGATCC TGAAAGAATA 540
ATTGGTGCCA CAGACAGCAG TGGAGAATTG ATGTTTCTCA TGAAATGGAA AGATTCAGAT 600
GAGGCAGACT TGGTGCTGGC GAAAGAGGCA AATATGAAGT GTCCTCAAAT TGTAATTGCT 660
TTTTATGAAG AGAGACTAAC TTGGCATTCT TGTCCAGAAG ATGAAGCTCA ATAATTGTTC 720
ACATTGTTCT TTTATATATA TTTATATATA TATATAAAAA TTGGGTCTTA GATTTTGATT 780
TACTAGTGTG ACAAAATAAC TACATCCTAA TGAAAATCAA GTTTGATATG TTTGTTTTGA 840
AAGTAGCGTT GGAAGAGTTG TTGGGGGTTT TTTGCATCCA TAGCACTGGT TACTTTGAAC 900
AAATAAATAA AAGCTTTCTG TAGTTGCTTC CTTTATCAGA AAAGAACATT TGATACCATG 960
GTATATCATT TCCTCTTCAT TAAAGAACAG CTTTTCTAAA TGTTGGGGGA AATGTCCATA 1020
GTCATTACTC AGTCAAAACT TGTGTTCTCA TGAGCCTAAG GACCATTCTA GATTTATTAC 1080
GTGTTTTTTG TGTGTGTGTG TGTGTGTGTG TGTGTGTGTA TCCATAAAAT GCATATGTAA 1140
ATTTTTTTTT GTTTTTAAGC ATTCACCCAA ACAAAAAAAT CACAGGTAAA CCCATGTTTC 1200
TGAGATGCCA TTATTCCAAG CAAAATAAGA GATAATCCCT TCAAGTTAAA TTGAAAATTT 1260
TCCTGAAACC ATACATTTCA AGTGAAATAA GTAATTCTAG ATAGGACAAT TTAAATTGGA 1320
TAATTTTAAA GTGTCTATAA TTGCAGTGGT TTATTTGCAA AATTCCTAAA AGGAAAAATT 1380
TTATCACTGC CATCACAGCA GGTTTCCTCA TCCAGATGAG GAAACTAGAC AAATGCTAGT 1440
GTGTTTTAAC TAGCTAAACA AAACTAAGTT AAATGAACAT TTAAAAGTTT CCCTAGCGGG 1500
CCATTCCTTA GCAAAATGTT GGAATCCCTG TTGCTACATT GACTAAAAGG TCATGATGAA 1560
TGGAATATGT AAGACTTGGC TCATAGAAAC CTAATCAGAT GGTTAGAGGT GTTGGCAGTT 1620
TAGGACCTGC TGTCATAAAT GTGTGAACAA CCTTTTGTAA CCTAACCTAT TGACCTGCAT 1680
GTTTTTTCTT TACCCCAATT CATTACATGG AGGCTCAATC TTGAGTTTGC TTTACTGGTT 1740
CAGCAAAAGC CAGGAAGAAC AACTTTGTAG TAATCAAAAT GTTATCCAAC TGTATATTGT 1800
TTACTTTATT GTAAATACTG GTGAACAGTG GTTAATAAAT AGTTTTATAT TCCTTTA 1858
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0090--Biological rhythms
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
--

Interpro

IPR000953--Chromo/shadow_dom
IPR017984--Chromo_dom_subgr
IPR023780--Chromo_domain
IPR008251--Chromo_shadow_dom
IPR016197--Chromodomain-like
IPR023779--Chromodomain_CS

PROSITE

PS00598--CHROMO_1
PS50013--CHROMO_2

Pfam

PF00385--Chromo
PF01393--Chromo_shadow

Gene Ontology

GO:0000785--C:chromatin
GO:0000775--C:chromosome, centromeric region
GO:0000779--C:condensed chromosome, centromeric region
GO:0000784--C:nuclear chromosome, telomeric region
GO:0005635--C:nuclear envelope
GO:0005719--C:nuclear euchromatin
GO:0005720--C:nuclear heterochromatin
GO:0005637--C:nuclear inner membrane
GO:0031618--C:nuclear pericentric heterochromatin
GO:0005634--C:nucleus
GO:0035985--C:senescence-associated heterochromatin focus
GO:0005819--C:spindle
GO:0019899--F:enzyme binding
GO:1990226--F:histone methyltransferase binding
GO:0042802--F:identical protein binding
GO:0019904--F:protein domain specific binding
GO:0071549--P:cellular response to dexamethasone stimulus
GO:0006338--P:chromatin remodeling
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0048511--P:rhythmic process
GO:0006351--P:transcription, DNA-templated

Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Mod-0004 ENSMODP00000000687.1 Monodelphis domestica 99 5e-70 260
WERAM-Orc-0181 ENSOCUP00000018528.2 Oryctolagus cuniculus 100 6e-70 260
WERAM-Ran-0076 ENSRNOP00000015828.5 Rattus norvegicus 100 8e-70 259
WERAM-Poa-0161 ENSPPYP00000019856.2 Pongo abelii 100 8e-70 259
WERAM-Pat-0159 ENSPTRP00000032477.4 Pan troglodytes 100 8e-70 259
WERAM-Otg-0188 ENSOGAP00000016528.1 Otolemur garnettii 100 8e-70 259
WERAM-Nol-0164 ENSNLEP00000018163.1 Nomascus leucogenys 100 8e-70 259
WERAM-Myl-0086 ENSMLUP00000006919.2 Myotis lucifugus 100 8e-70 259
WERAM-Mum-0104 ENSMUSP00000031862.7 Mus musculus 100 8e-70 259
WERAM-Ict-0062 ENSSTOP00000005562.2 Ictidomys tridecemlineatus 100 8e-70 259
WERAM-Gog-0213 ENSGGOP00000019678.1 Gorilla gorilla 100 8e-70 259
WERAM-Fec-0151 ENSFCAP00000014123.2 Felis catus 100 8e-70 259
WERAM-Eqc-0087 ENSECAP00000010494.1 Equus caballus 99 8e-70 259
WERAM-Dio-0056 ENSDORP00000005131.1 Dipodomys ordii 99 8e-70 259
WERAM-Chh-0115 ENSCHOP00000012258.1 Choloepus hoffmanni 100 8e-70 259
WERAM-Cap-0200 ENSCPOP00000019328.1 Cavia porcellus 100 8e-70 259
WERAM-Caf-0036 ENSCAFP00000004286.3 Canis familiaris 100 8e-70 259
WERAM-Caj-0087 ENSCJAP00000014705.1 Callithrix jacchus 100 8e-70 259
WERAM-Prc-0049 ENSPCAP00000004565.1 Procavia capensis 99 8e-70 259
WERAM-Loa-0077 ENSLAFP00000005800.3 Loxodonta africana 99 8e-70 259
WERAM-Soa-0076 ENSSARP00000007237.1 Sorex araneus 99 9e-70 259
WERAM-Tut-0010 ENSTTRP00000000670.1 Tursiops truncatus 99 1e-69 258
WERAM-Sah-0195 ENSSHAP00000021126.1 Sarcophilus harrisii 98 2e-69 258
WERAM-Sus-0125 ENSSSCP00000017701.2 Sus scrofa 99 3e-69 258
WERAM-Mam-0052 ENSMMUP00000008960.2 Macaca mulatta 99 3e-69 258
WERAM-Dan-0199 ENSDNOP00000027320.1 Dasypus novemcinctus 99 3e-69 257
WERAM-Mim-0066 ENSMICP00000006372.1 Microcebus murinus 100 4e-69 257
WERAM-Aim-0219 ENSAMEP00000020568.1 Ailuropoda melanoleuca 99 5e-69 257
WERAM-Vip-0106 ENSVPAP00000009695.1 Vicugna pacos 95 2e-68 255
WERAM-Chs-0175 ENSCSAP00000010317.1 Chlorocebus sabaeus 98 2e-68 254
WERAM-Ora-0086 ENSOANP00000014578.2 Ornithorhynchus anatinus 96 6e-68 253
WERAM-Ova-0106 ENSOARP00000010784.1 Ovis aries 98 6e-68 253
WERAM-Mup-0215 ENSMPUP00000018538.1 Mustela putorius furo 98 6e-68 253
WERAM-Ptv-0057 ENSPVAP00000005952.1 Pteropus vampyrus 100 1e-67 253
WERAM-Tas-0077 ENSTSYP00000007470.1 Tarsius syrichta 100 1e-67 253
WERAM-Ocp-0110 ENSOPRP00000010669.1 Ochotona princeps 99 3e-67 251
WERAM-Pes-0009 ENSPSIP00000002734.1 Pelodiscus sinensis 97 5e-67 250
WERAM-Anc-0137 ENSACAP00000012734.2 Anolis carolinensis 93 2e-66 248
WERAM-Tag-0045 ENSTGUP00000002967.1 Taeniopygia guttata 96 3e-66 248
WERAM-Meg-0109 ENSMGAP00000011085.1 Meleagris gallopavo 96 3e-66 248
WERAM-Anp-0098 ENSAPLP00000011741.1 Anas platyrhynchos 96 3e-66 248
WERAM-Gaga-0108 ENSGALP00000017958.3 Gallus gallus 96 1e-64 242
WERAM-Fia-0115 ENSFALP00000009927.1 Ficedula albicollis 96 1e-64 242
WERAM-Xet-0081 ENSXETP00000026572.3 Xenopus tropicalis 91 6e-63 236
WERAM-Bot-0058 ENSBTAP00000007283.4 Bos taurus 90 2e-62 234
WERAM-Leo-0115 ENSLOCP00000014443.1 Lepisosteus oculatus 83 3e-58 221
WERAM-Pof-0032 ENSPFOP00000002567.2 Poecilia formosa 73 3e-57 218
WERAM-Orn-0050 ENSONIP00000005779.1 Oreochromis niloticus 74 7e-57 216
WERAM-Xim-0006 ENSXMAP00000001021.1 Xiphophorus maculatus 72 8e-57 216
WERAM-Gam-0140 ENSGMOP00000014229.1 Gadus morhua 74 1e-56 216
WERAM-Dar-0007 ENSDARP00000009789.7 Danio rerio 76 2e-56 215
WERAM-Gaa-0070 ENSGACP00000009362.1 Gasterosteus aculeatus 73 3e-56 214
WERAM-Tar-0197 ENSTRUP00000040634.1 Takifugu rubripes 74 1e-55 212
WERAM-Paa-0176 ENSPANP00000020092.1 Papio anubis 67 5e-52 200
WERAM-Asm-0160 ENSAMXP00000015994.1 Astyanax mexicanus 67 6e-52 200
WERAM-Lac-0097 ENSLACP00000012217.1 Latimeria chalumnae 65 4e-51 197
WERAM-Tub-0117 ENSTBEP00000012952.1 Tupaia belangeri 70 2e-50 195
WERAM-Ect-0002 ENSETEP00000000152.1 Echinops telfairi 70 6e-50 194
WERAM-Orla-0051 ENSORLP00000006270.1 Oryzias latipes 69 1e-49 192
WERAM-Ere-0053 ENSEEUP00000004419.1 Erinaceus europaeus 70 3e-49 191
WERAM-Ten-0119 ENSTNIP00000002974.1 Tetraodon nigroviridis 65 6e-49 190
WERAM-Pem-0087 ENSPMAP00000009118.1 Petromyzon marinus 63 5e-48 187
WERAM-Mae-0074 ENSMEUP00000007510.1 Macropus eugenii 59 3e-41 165
WERAM-Cii-0080 ENSCINP00000030026.1 Ciona intestinalis 49 1e-39 159
WERAM-Drm-0034 FBpp0071221 Drosophila melanogaster 55 1e-37 153
WERAM-Cis-0006 ENSCSAVP00000000838.1 Ciona savignyi 68 4e-24 107
Created Date 25-Jun-2016