WERAM Information

Tag Content
WERAM ID WERAM-Hos-0244
Ensembl Protein ID ENSP00000373278.2
Uniprot Accession Q504Y3; ZCPW2_HUMAN
Genbank Protein ID NP_001035522.1
Protein Name Zinc finger CW-type PWWP domain protein 2
Genbank Nucleotide ID NM_001040432.2
Gene Name ZCWPW2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000206559.7 ENST00000383768.6 ENSP00000373278.2
ENSG00000206559.7 ENST00000428875.1 ENSP00000393521.1
ENSG00000206559.7 ENST00000420223.5 ENSP00000395930.1
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader PWWP PWWP H3K4me3 K 26933034
Me_Reader ZF-CW CW-type H3K4me3 K 26933034
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader ZF-CW 8.90e-23 82.4 24 174
Me_Reader PWWP 2.30e-17 65.1 99 161
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)
Domain Profile
  Me_Reader ZF-CW
          ZF-CW.txt  1 kgeekvWvqCd..dClKWRrLpgevdasv.lsekWiCinNsdvrynnCsvpeEsl 52
                       ++++kvWvqC+  +ClKWR L++e++a+v ++e+W+C++N+d+rynnCs++eE++
  ENSP00000373278.2 24 MYVNKVWVQCEneNCLKWRLLSSEDSAKVdHDEPWYCFMNTDSRYNNCSISEEDF 78
                       6789*******99****************************************97 PP
          ZF-CW.txt  10 CddClKW 16 
                        C +  KW
  ENSP00000373278.2 168 CKNKKKW 174
                        7777888 PP
  Me_Reader PWWP
           PWWP.txt   2 gdLVwaKlkgYpwWPalvisppleakkl.ktqeaeenkylVlFFgnkherawvkrkklvpyse 63 
                        g+LV++Kl+++p+WP++++ +++++k++ ++ + + ++y+++F+g+ h+r+w+k++ + +ys 
  ENSP00000373278.2  99 GSLVLVKLQNWPSWPGILCPDRFKGKYVtYDPDGNVEEYHIEFLGDPHSRSWIKATFVGHYSI 161
                        89***********************************************************85 PP
Protein Sequence
(Fasta)		MDKEKLDVKI EYCNYAMDSS VENMYVNKVW VQCENENCLK WRLLSSEDSA KVDHDEPWYC 60
FMNTDSRYNN CSISEEDFPE ESQLHQCGFK IVYSQLPLGS LVLVKLQNWP SWPGILCPDR 120
FKGKYVTYDP DGNVEEYHIE FLGDPHSRSW IKATFVGHYS ITLKPEKCKN KKKWYKSALQ 180
EACLLYGYSH EQRLEMCCLS KLQDKSETHD KVAALVKKRK QTSKNNIEKK KPKFRKRKRK 240
AILKCSFENV YSDDALSKEN RVVCETEVLL KELEQMLQQA LQPTATPDES EEGHGEEINM 300
GEKLSKCSPE APAGSLFENH YEEDYLVIDG IKLKAGECIE DITNKFKEID ALMSEF 356
Nucleotide Sequence
(Fasta)		GGCGGGACGG GGCGGGGCCG CGGGACGCCA GGAGGCGGAG GCGGAGTGGA GTTAGATTCA 60
TCCCAGTAGA ACGCCTGCCT CTTTAGTGAC TACAGACCTC ACTTCCCTTC TCTGGAGTTT 120
TGGAGTCTAT TTTCTTCATG GAATTTTGCT AGGAACAAAA GAAAAGTCTA ACTCCATTAA 180
ATGCCTTAAT GGATAAAGAA AAATTGGATG TTAAGATTGA ATATTGTAAC TATGCAATGG 240
ATTCCTCAGT GGAAAACATG TATGTAAACA AAGTGTGGGT TCAATGTGAG AATGAAAATT 300
GTTTGAAATG GAGATTGTTA TCAAGTGAGG ATTCAGCCAA GGTTGATCAT GATGAACCAT 360
GGTACTGCTT CATGAACACT GATTCAAGAT ATAATAACTG CTCAATTTCT GAAGAAGACT 420
TCCCTGAAGA GTCTCAGCTT CATCAGTGTG GATTTAAGAT TGTCTATTCA CAGCTCCCTC 480
TTGGAAGCCT GGTTTTGGTA AAATTACAGA ATTGGCCAAG TTGGCCAGGA ATACTTTGCC 540
CTGACCGTTT TAAAGGGAAA TATGTAACTT ATGACCCGGA TGGAAATGTT GAAGAGTATC 600
ACATAGAATT CCTGGGCGAT CCCCATTCAA GATCATGGAT AAAGGCAACA TTCGTTGGAC 660
ATTATAGTAT CACATTAAAG CCAGAAAAGT GTAAGAATAA AAAGAAGTGG TATAAAAGTG 720
CACTACAAGA AGCATGTCTA CTCTATGGAT ATTCTCATGA GCAAAGACTG GAAATGTGCT 780
GCCTATCAAA ACTACAAGAT AAATCCGAAA CACATGACAA AGTTGCTGCA CTGGTCAAGA 840
AAAGGAAGCA GACTTCTAAA AATAATATTG AAAAGAAGAA GCCCAAATTT AGAAAAAGGA 900
AAAGGAAAGC AATTTTAAAA TGCTCTTTTG AAAATGTTTA TTCTGATGAT GCCTTATCAA 960
AGGAGAACAG GGTTGTCTGT GAGACGGAAG TTTTACTAAA AGAGCTGGAG CAAATGCTGC 1020
AGCAAGCACT GCAACCCACA GCCACACCTG ATGAATCAGA AGAAGGACAT GGAGAGGAAA 1080
TAAATATGGG AGAAAAGTTA TCTAAATGCA GCCCAGAAGC TCCTGCAGGC AGTCTGTTTG 1140
AAAACCACTA TGAAGAGGAC TATCTTGTAA TTGATGGGAT AAAATTAAAA GCTGGAGAAT 1200
GTATTGAGGA TATAACTAAT AAATTTAAAG AAATAGATGC TTTGATGTCT GAGTTTTAGA 1260
ACATTATACA TTTTTCAAAT TAATTATAAA AATATTGGCA TCTTTATATT TATCCAAAGT 1320
TAAAACTTTA AAAATGTTTA GTGAAATAGG TATAAATTAT ACCAAAGTTT ATATTTGCGG 1380
TAACTTTCTA CTTCATATTT TGAGAATGGC CATGATTTTT AGAGCCAGTC AAATGGTATT 1440
TAAGTTAGTG TTAAAAATTT AGAATTAAAA AACCCTGATA TTTGTATTTA TATATTTCTT 1500
GTTTGCCTTA ATTTTTAAAT GGTTTGTGAA ATTTGCCTAA CAAACATATG TTTTACAATG 1560
ATTGTTTAGG CCCTTTGTTC AAAAATGGAT AACTTAAAAT GGCTGGCCAA GCTATTATAA 1620
TTCTCAGAGG TAATTCAAAT CTAATAAACT TAGAGAATGT ATATTTGCAG TGGAATCAAA 1680
CTATTACAAA ATAAAAGGAA ATAATTTTTT AAATAA 1717
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR000313--PWWP_dom
IPR011124--Znf_CW
PROSITE

PS50812--PWWP
PS51050--ZF_CW
Pfam

PF00855--PWWP
PF07496--zf-CW
Gene Ontology

GO:0008270--F:zinc ion binding
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Pat-0204 ENSPTRP00000051508.1 Pan troglodytes 97 0.0 657
WERAM-Poa-0126 ENSPPYP00000015722.1 Pongo abelii 97 0.0 647
WERAM-Paa-0038 ENSPANP00000010051.1 Papio anubis 94 7e-180 627
WERAM-Mam-0222 ENSMMUP00000038332.1 Macaca mulatta 94 4e-179 624
WERAM-Nol-0040 ENSNLEP00000004983.1 Nomascus leucogenys 95 2e-176 615
WERAM-Caj-0049 ENSCJAP00000007787.1 Callithrix jacchus 90 5e-166 580
WERAM-Ict-0094 ENSSTOP00000009920.2 Ictidomys tridecemlineatus 83 1e-161 566
WERAM-Tas-0002 ENSTSYP00000000260.1 Tarsius syrichta 82 9e-159 556
WERAM-Loa-0075 ENSLAFP00000005674.2 Loxodonta africana 83 7e-158 553
WERAM-Eqc-0163 ENSECAP00000017428.1 Equus caballus 85 7e-157 550
WERAM-Orc-0171 ENSOCUP00000015216.3 Oryctolagus cuniculus 84 1e-152 536
WERAM-Caf-0066 ENSCAFP00000008197.3 Canis familiaris 82 8e-152 533
WERAM-Bot-0190 ENSBTAP00000046618.3 Bos taurus 78 1e-148 523
WERAM-Dan-0027 ENSDNOP00000002581.2 Dasypus novemcinctus 81 3e-147 518
WERAM-Mup-0134 ENSMPUP00000011872.1 Mustela putorius furo 80 5e-145 511
WERAM-Myl-0073 ENSMLUP00000005934.2 Myotis lucifugus 75 2e-144 509
WERAM-Ova-0158 ENSOARP00000015677.1 Ovis aries 77 3e-142 502
WERAM-Soa-0059 ENSSARP00000005629.1 Sorex araneus 76 4e-136 481
WERAM-Ptv-0029 ENSPVAP00000003502.1 Pteropus vampyrus 74 9e-128 453
WERAM-Ect-0097 ENSETEP00000011224.1 Echinops telfairi 71 3e-125 445
WERAM-Prc-0047 ENSPCAP00000004181.1 Procavia capensis 71 8e-117 417
WERAM-Mim-0151 ENSMICP00000015867.1 Microcebus murinus 72 1e-113 407
WERAM-Fec-0102 ENSFCAP00000008755.3 Felis catus 79 7e-110 394
WERAM-Mod-0200 ENSMODP00000032422.2 Monodelphis domestica 63 3e-109 392
WERAM-Vip-0111 ENSVPAP00000010397.1 Vicugna pacos 60 2e-99 359
WERAM-Dio-0135 ENSDORP00000012704.1 Dipodomys ordii 51 7e-87 318
WERAM-Ocp-0122 ENSOPRP00000012511.1 Ochotona princeps 82 1e-76 284
WERAM-Cap-0075 ENSCPOP00000005523.2 Cavia porcellus 81 4e-72 269
WERAM-Lac-0192 ENSLACP00000022969.1 Latimeria chalumnae 41 7e-68 254
WERAM-Mae-0116 ENSMEUP00000011219.1 Macropus eugenii 62 2e-49 193
WERAM-Anc-0121 ENSACAP00000011361.3 Anolis carolinensis 35 9e-18 88.6
WERAM-Sah-0006 ENSSHAP00000000215.1 Sarcophilus harrisii 32 1e-16 85.1
WERAM-Sus-0051 ENSSSCP00000008180.2 Sus scrofa 35 3e-16 83.6
WERAM-Mum-0145 ENSMUSP00000048730.7 Mus musculus 30 9e-16 81.6
WERAM-Ran-0217 ENSRNOP00000062266.3 Rattus norvegicus 34 2e-15 80.5
WERAM-Pem-0067 ENSPMAP00000007319.1 Petromyzon marinus 39 2e-15 80.5
WERAM-Aim-0168 ENSAMEP00000015870.1 Ailuropoda melanoleuca 35 4e-15 79.7
WERAM-Gog-0058 ENSGGOP00000005254.2 Gorilla gorilla 33 2e-14 77.4
WERAM-Otg-0112 ENSOGAP00000009858.2 Otolemur garnettii 32 2e-14 77.0
WERAM-Chs-0210 ENSCSAP00000013911.1 Chlorocebus sabaeus 33 5e-13 72.8
WERAM-Asm-0212 ENSAMXP00000020465.1 Astyanax mexicanus 31 1e-10 65.1
WERAM-Leo-0137 ENSLOCP00000016746.1 Lepisosteus oculatus 30 4e-09 59.7
WERAM-Chr-0042 EDP03990 Chlamydomonas reinhardtii 46 2e-06 51.2
WERAM-Ere-0046 ENSEEUP00000003988.1 Erinaceus europaeus 31 2e-06 51.2
WERAM-Xet-0087 ENSXETP00000028509.3 Xenopus tropicalis 47 3e-06 50.1
Created Date 25-Jun-2016