WERAM Information

Tag Content
WERAM ID WERAM-Hos-0003
Ensembl Protein ID ENSP00000371502.3
Uniprot Accession Q92793; CBP_HUMAN; D3DUC9; O00147; Q16376; Q4LE28
Genbank Protein ID NP_001073315.1; NP_004371.2
Protein Name CREB-binding protein
Genbank Nucleotide ID NM_001079846.1; NM_004380.2
Gene Name CREBBP;CBP;KAT3A
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000005339.13 ENST00000382070.7 ENSP00000371502.3
ENSG00000005339.13 ENST00000262367.9 ENSP00000262367.5
ENSG00000005339.13 ENST00000570939.2 ENSP00000461002.2
Details
Type Family Domain Substrates AA References (PMIDs)
Ac_Reader Bromodomain Bromodomain H2AK15; H2BK85; H3K9; H3K14; H3K27; H3K36; H3K56; H3K122; H4K12; H4K20; H4K44 K 22464331; 24704920
HAT p300_CBP CBP/p300-type HAT H2AK15; H3K27; H3K56; H3K122; H4K20 K 26603525; 24704920
Status Reviewed
Classification
Type Family E-value Score Start End
HAT p300_CBP 1.10e-178 597.2 1285 1700
Ac_Reader Bromodomain 1.30e-25 91.5 1066 1137
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902).
Domain Profile
  HAT p300_CBP
            CBP.txt    1 klgakkLpetkLskfleqrlfkklkkerqerarlqgksyeevpeaeelvvrvvassdktlevkkrlkerfveen.fpeefpyrskalllf 89  
                         k++ak+L++t+L+++le+r++k+l+++++             pea+e++vrvvassdkt+evk+++k+rfv+++ ++e+fpyr+kal++f
  ENSP00000371502.3 1285 KFSAKRLQTTRLGNHLEDRVNKFLRRQNH-------------PEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGeMSESFPYRTKALFAF 1361
                         689*************************9.............************************************************ PP
            CBP.txt   90 ekidgvdvClfglyvqefGsecsaPnqrrvyisyLdsvkyfrPevrtvagealrtavyheiLiGyleyvkklGfttayiWaCPPseGddy 179 
                         e+idgvdvC+fg++vqe+Gs+c++Pn+rrvyisyLds+++frP       ++lrtavyheiLiGyleyvkklG++t++iWaCPPseGddy
  ENSP00000371502.3 1362 EEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDSIHFFRP-------RCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDY 1444
                         *******************************************.......**************************************** PP
            CBP.txt  180 ilychPedqkiPktkkLreWykkmLekavkerivvevtnlykdifkqaeedrlvtaarLPyfeGdfWpnvleelikeleqeeeerkkkek 269 
                         i++chP+dqkiPk+k+L+eWykkmL+ka++eri+++    ykdifkqa+edrl++a++LPyfeGdfWpnvlee+ikeleqeeeerkk+e+
  ENSP00000371502.3 1445 IFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHD----YKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKKEES 1530
                         ************************************....*********************************************99999 PP
            CBP.txt  270 kaaskkkvkkralkaegqldlsknakkklllmeklgetilpkkkdkilvelqksnkkksklvvsgnrwvcekcknlqlcdkcyeaeqerl 359 
                         +aas+++        eg++++sknakkk           ++kk++k++++++++nkkk+++++++n+                      l
  ENSP00000371502.3 1531 TAASETT--------EGSQGDSKNAKKK-----------NNKKTNKNKSSISRANKKKPSMPNVSND----------------------L 1579
                         9999888........99***********...........9***************************......................9 PP
            CBP.txt  360 seklyatmekekevlfvvrlkdvpa....aeiedkdellesdlldgrdafLtlardkhyefssLrrakhsslmllyeLhnqtk 438 
                         s+klyatmek+kev+fv++l++ p+    ++i+d+d+ll++dl+dgrdafLtlardkh+efssLrr+k+s+l++l+eLh+q++
  ENSP00000371502.3 1580 SQKLYATMEKHKEVFFVIHLHAGPVintlPPIVDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQ 1662
                         9***********************999999**************************************************975 PP
            CBP.txt  324 nkkksklvvsgnrwvcekcknlqlcdkcyeaeqe 357 
                         ++++   + +  rw c  c++++lc +cy+++ +
  ENSP00000371502.3 1669 CNECK--HHVETRWHCTVCEDYDLCINCYNTKSH 1700
                         44444..467889****************98765 PP
  Ac_Reader Bromodomain
          BROMO.txt    2 ehevsepFrepvdpq.leipdYydiikePmdLstikerleegnYsspeefvkDvrlifnNakaynenkssvq 72  
                         + ++s pFr+pvdpq l ipdY+di+k+PmdLstik++l++g+Y++p + v+Dv+l+fnNa  yn++ s v+
  ENSP00000371502.3 1066 QDPESLPFRQPVDPQlLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVY 1137
                         56899**************************************************************99887 PP
Protein Sequence
(Fasta)		MAENLLDGPP NPKRAKLSSP GFSANDSTDF GSLFDLENDL PDELIPNGGE LGLLNSGNLV 60
PDAASKHKQL SELLRGGSGS SINPGIGNVS ASSPVQQGLG GQAQGQPNSA NMASLSAMGK 120
SPLSQGDSSA PSLPKQAAST SGPTPAASQA LNPQAQKQVG LATSSPATSQ TGPGICMNAN 180
FNQTHPGLLN SNSGHSLINQ ASQGQAQVMN GSLGAAGRGR GAGMPYPTPA MQGASSSVLA 240
ETLTQVSPQM TGHAGLNTAQ AGGMAKMGIT GNTSPFGQPF SQAGGQPMGA TGVNPQLASK 300
QSMVNSLPTF PTDIKNTSVT NVPNMSQMQT SVGIVPTQAI ATGPTADPEK RKLIQQQLVL 360
LLHAHKCQRR EQANGEVRAC SLPHCRTMKN VLNHMTHCQA GKACQAILGS PASGIQNTIG 420
SVGTGQQNAT SLSNPNPIDP SSMQRAYAAL GLPYMNQPQT QLQPQVPGQQ PAQPQTHQQM 480
RTLNPLGNNP MNIPAGGITT DQQPPNLISE SALPTSLGAT NPLMNDGSNS GNIGTLSTIP 540
TAAPPSSTGV RKGWHEHVTQ DLRSHLVHKL VQAIFPTPDP AALKDRRMEN LVAYAKKVEG 600
DMYESANSRD EYYHLLAEKI YKIQKELEEK RRSRLHKQGI LGNQPALPAP GAQPPVIPQA 660
QPVRPPNGPL SLPVNRMQVS QGMNSFNPMS LGNVQLPQAP MGPRAASPMN HSVQMNSMGS 720
VPGMAISPSR MPQPPNMMGA HTNNMMAQAP AQSQFLPQNQ FPSSSGAMSV GMGQPPAQTG 780
VSQGQVPGAA LPNPLNMLGP QASQLPCPPV TQSPLHPTPP PASTAAGMPS LQHTTPPGMT 840
PPQPAAPTQP STPVSSSGQT PTPTPGSVPS ATQTQSTPTV QAAAQAQVTP QPQTPVQPPS 900
VATPQSSQQQ PTPVHAQPPG TPLSQAAASI DNRVPTPSSV ASAETNSQQP GPDVPVLEMK 960
TETQAEDTEP DPGESKGEPR SEMMEEDLQG ASQVKEETDI AEQKSEPMEV DEKKPEVKVE 1020
VKEEEESSSN GTASQSTSPS QPRKKIFKPE ELRQALMPTL EALYRQDPES LPFRQPVDPQ 1080
LLGIPDYFDI VKNPMDLSTI KRKLDTGQYQ EPWQYVDDVW LMFNNAWLYN RKTSRVYKFC 1140
SKLAEVFEQE IDPVMQSLGY CCGRKYEFSP QTLCCYGKQL CTIPRDAAYY SYQNRYHFCE 1200
KCFTEIQGEN VTLGDDPSQP QTTISKDQFE KKKNDTLDPE PFVDCKECGR KMHQICVLHY 1260
DIIWPSGFVC DNCLKKTGRP RKENKFSAKR LQTTRLGNHL EDRVNKFLRR QNHPEAGEVF 1320
VRVVASSDKT VEVKPGMKSR FVDSGEMSES FPYRTKALFA FEEIDGVDVC FFGMHVQEYG 1380
SDCPPPNTRR VYISYLDSIH FFRPRCLRTA VYHEILIGYL EYVKKLGYVT GHIWACPPSE 1440
GDDYIFHCHP PDQKIPKPKR LQEWYKKMLD KAFAERIIHD YKDIFKQATE DRLTSAKELP 1500
YFEGDFWPNV LEESIKELEQ EEEERKKEES TAASETTEGS QGDSKNAKKK NNKKTNKNKS 1560
SISRANKKKP SMPNVSNDLS QKLYATMEKH KEVFFVIHLH AGPVINTLPP IVDPDPLLSC 1620
DLMDGRDAFL TLARDKHWEF SSLRRSKWST LCMLVELHTQ GQDRFVYTCN ECKHHVETRW 1680
HCTVCEDYDL CINCYNTKSH AHKMVKWGLG LDDEGSSQGE PQSKSPQESR RLSIQRCIQS 1740
LVHACQCRNA NCSLPSCQKM KRVVQHTKGC KRKTNGGCPV CKQLIALCCY HAKHCQENKC 1800
PVPFCLNIKH KLRQQQIQHR LQQAQLMRRR MATMNTRNVP QQSLPSPTSA PPGTPTQQPS 1860
TPQTPQPPAQ PQPSPVSMSP AGFPSVARTQ PPTTVSTGKP TSQVPAPPPP AQPPPAAVEA 1920
ARQIEREAQQ QQHLYRVNIN NSMPPGRTGM GTPGSQMAPV SLNVPRPNQV SGPVMPSMPP 1980
GQWQQAPLPQ QQPMPGLPRP VISMQAQAAV AGPRMPSVQP PRSISPSALQ DLLRTLKSPS 2040
SPQQQQQVLN ILKSNPQLMA AFIKQRTAKY VANQPGMQPQ PGLQSQPGMQ PQPGMHQQPS 2100
LQNLNAMQAG VPRPGVPPQQ QAMGGLNPQG QALNIMNPGH NPNMASMNPQ YREMLRRQLL 2160
QQQQQQQQQQ QQQQQQQQGS AGMAGGMAGH GQFQQPQGPG GYPPAMQQQQ RMQQHLPLQG 2220
SSMGQMAAQM GQLGQMGQPG LGADSTPNIQ QALQQRILQQ QQMKQQIGSP GQPNPMSPQQ 2280
HMLSGQPQAS HLPGQQIATS LSNQVRSPAP VQSPRPQSQP PHSSPSPRIQ PQPSPHHVSP 2340
QTGSPHPGLA VTMASSIDQG HLGNPEQSAM LPQLNTPSRS ALSSELSLVG DTTGDTLEKF 2400
VEGL 2404
Nucleotide Sequence
(Fasta)		CTGCGGGGCG CTGTTGCTGT GGCTGAGATT TGGCCGCCGC CTCCCCCACC CGGCCTGCGC 60
CCTCCCTCTC CCTCGGCGCC CGCCCGCCCG CTCGCGGCCC GCGCTCGCTC CTCTCCCTCG 120
CAGCCGGCAG GGCCCCCGAC CCCCGTCCGG GCCCTCGCCG GCCCGGCCGC CCGTGCCCGG 180
GGCTGTTTTC GCGAGCAGGT GAAAATGGCT GAGAACTTGC TGGACGGACC GCCCAACCCC 240
AAAAGAGCCA AACTCAGCTC GCCCGGTTTC TCGGCGAATG ACAGCACAGA TTTTGGATCA 300
TTGTTTGACT TGGAAAATGA TCTTCCTGAT GAGCTGATAC CCAATGGAGG AGAATTAGGC 360
CTTTTAAACA GTGGGAACCT TGTTCCAGAT GCTGCTTCCA AACATAAACA ACTGTCGGAG 420
CTTCTACGAG GAGGCAGCGG CTCTAGTATC AACCCAGGAA TAGGAAATGT GAGCGCCAGC 480
AGCCCCGTGC AGCAGGGCCT GGGTGGCCAG GCTCAAGGGC AGCCGAACAG TGCTAACATG 540
GCCAGCCTCA GTGCCATGGG CAAGAGCCCT CTGAGCCAGG GAGATTCTTC AGCCCCCAGC 600
CTGCCTAAAC AGGCAGCCAG CACCTCTGGG CCCACCCCCG CTGCCTCCCA AGCACTGAAT 660
CCGCAAGCAC AAAAGCAAGT GGGGCTGGCG ACTAGCAGCC CTGCCACGTC ACAGACTGGA 720
CCTGGTATCT GCATGAATGC TAACTTTAAC CAGACCCACC CAGGCCTCCT CAATAGTAAC 780
TCTGGCCATA GCTTAATTAA TCAGGCTTCA CAAGGGCAGG CGCAAGTCAT GAATGGATCT 840
CTTGGGGCTG CTGGCAGAGG AAGGGGAGCT GGAATGCCGT ACCCTACTCC AGCCATGCAG 900
GGCGCCTCGA GCAGCGTGCT GGCTGAGACC CTAACGCAGG TTTCCCCGCA AATGACTGGT 960
CACGCGGGAC TGAACACCGC ACAGGCAGGA GGCATGGCCA AGATGGGAAT AACTGGGAAC 1020
ACAAGTCCAT TTGGACAGCC CTTTAGTCAA GCTGGAGGGC AGCCAATGGG AGCCACTGGA 1080
GTGAACCCCC AGTTAGCCAG CAAACAGAGC ATGGTCAACA GTTTGCCCAC CTTCCCTACA 1140
GATATCAAGA ATACTTCAGT CACCAACGTG CCAAATATGT CTCAGATGCA AACATCAGTG 1200
GGAATTGTAC CCACACAAGC AATTGCAACA GGCCCCACTG CAGATCCTGA AAAACGCAAA 1260
CTGATACAGC AGCAGCTGGT TCTACTGCTT CATGCTCATA AGTGTCAGAG ACGAGAGCAA 1320
GCAAACGGAG AGGTTCGGGC CTGCTCGCTC CCGCATTGTC GAACCATGAA AAACGTTTTG 1380
AATCACATGA CGCATTGTCA GGCTGGGAAA GCCTGCCAAG CCATCCTGGG GTCTCCAGCT 1440
AGTGGAATTC AAAACACAAT TGGTTCTGTT GGCACAGGGC AACAGAATGC CACTTCTTTA 1500
AGTAACCCAA ATCCCATAGA CCCCAGCTCC ATGCAGCGAG CCTATGCTGC TCTCGGACTC 1560
CCCTACATGA ACCAGCCCCA GACGCAGCTG CAGCCTCAGG TTCCTGGCCA GCAACCAGCA 1620
CAGCCTCAAA CCCACCAGCA GATGAGGACT CTCAACCCCC TGGGAAATAA TCCAATGAAC 1680
ATTCCAGCAG GAGGAATAAC AACAGATCAG CAGCCCCCAA ACTTGATTTC AGAATCAGCT 1740
CTTCCGACTT CCCTGGGGGC CACAAACCCA CTGATGAACG ATGGCTCCAA CTCTGGTAAC 1800
ATTGGAACCC TCAGCACTAT ACCAACAGCA GCTCCTCCTT CTAGCACCGG TGTAAGGAAA 1860
GGCTGGCACG AACATGTCAC TCAGGACCTG CGGAGCCATC TAGTGCATAA ACTCGTCCAA 1920
GCCATCTTCC CAACACCTGA TCCCGCAGCT CTAAAGGATC GCCGCATGGA AAACCTGGTA 1980
GCCTATGCTA AGAAAGTGGA AGGGGACATG TACGAGTCTG CCAACAGCAG GGATGAATAT 2040
TATCACTTAT TAGCAGAGAA AATCTACAAG ATACAAAAAG AACTAGAAGA AAAACGGAGG 2100
TCGCGTTTAC ATAAACAAGG CATCTTGGGG AACCAGCCAG CCTTACCAGC CCCGGGGGCT 2160
CAGCCCCCTG TGATTCCACA GGCACAACCT GTGAGACCTC CAAATGGACC CCTGTCCCTG 2220
CCAGTGAATC GCATGCAAGT TTCTCAAGGG ATGAATTCAT TTAACCCCAT GTCCTTGGGG 2280
AACGTCCAGT TGCCACAAGC ACCCATGGGA CCTCGTGCAG CCTCCCCAAT GAACCACTCT 2340
GTCCAGATGA ACAGCATGGG CTCAGTGCCA GGGATGGCCA TTTCTCCTTC CCGAATGCCT 2400
CAGCCTCCGA ACATGATGGG TGCACACACC AACAACATGA TGGCCCAGGC GCCCGCTCAG 2460
AGCCAGTTTC TGCCACAGAA CCAGTTCCCG TCATCCAGCG GGGCGATGAG TGTGGGCATG 2520
GGGCAGCCGC CAGCCCAAAC AGGCGTGTCA CAGGGACAGG TGCCTGGTGC TGCTCTTCCT 2580
AACCCTCTCA ACATGCTGGG GCCTCAGGCC AGCCAGCTAC CTTGCCCTCC AGTGACACAG 2640
TCACCACTGC ACCCAACACC GCCTCCTGCT TCCACGGCTG CTGGCATGCC ATCTCTCCAG 2700
CACACGACAC CACCTGGGAT GACTCCTCCC CAGCCAGCAG CTCCCACTCA GCCATCAACT 2760
CCTGTGTCGT CTTCCGGGCA GACTCCCACC CCGACTCCTG GCTCAGTGCC CAGTGCTACC 2820
CAAACCCAGA GCACCCCTAC AGTCCAGGCA GCAGCCCAGG CCCAGGTGAC CCCGCAGCCT 2880
CAAACCCCAG TTCAGCCCCC GTCTGTGGCT ACCCCTCAGT CATCGCAGCA ACAGCCGACG 2940
CCTGTGCACG CCCAGCCTCC TGGCACACCG CTTTCCCAGG CAGCAGCCAG CATTGATAAC 3000
AGAGTCCCTA CCCCCTCCTC GGTGGCCAGC GCAGAAACCA ATTCCCAGCA GCCAGGACCT 3060
GACGTACCTG TGCTGGAAAT GAAGACGGAG ACCCAAGCAG AGGACACTGA GCCCGATCCT 3120
GGTGAATCCA AAGGGGAGCC CAGGTCTGAG ATGATGGAGG AGGATTTGCA AGGAGCTTCC 3180
CAAGTTAAAG AAGAAACAGA CATAGCAGAG CAGAAATCAG AACCAATGGA AGTGGATGAA 3240
AAGAAACCTG AAGTGAAAGT AGAAGTTAAA GAGGAAGAAG AGAGTAGCAG TAACGGCACA 3300
GCCTCTCAGT CAACATCTCC TTCGCAGCCG CGCAAAAAAA TCTTTAAACC AGAGGAGTTA 3360
CGCCAGGCCC TCATGCCAAC CCTAGAAGCA CTGTATCGAC AGGACCCAGA GTCATTACCT 3420
TTCCGGCAGC CTGTAGATCC CCAGCTCCTC GGAATTCCAG ACTATTTTGA CATCGTAAAG 3480
AATCCCATGG ACCTCTCCAC CATCAAGCGG AAGCTGGACA CAGGGCAATA CCAAGAGCCC 3540
TGGCAGTACG TGGACGACGT CTGGCTCATG TTCAACAATG CCTGGCTCTA TAATCGCAAG 3600
ACATCCCGAG TCTATAAGTT TTGCAGTAAG CTTGCAGAGG TCTTTGAGCA GGAAATTGAC 3660
CCTGTCATGC AGTCCCTTGG ATATTGCTGT GGACGCAAGT ATGAGTTTTC CCCACAGACT 3720
TTGTGCTGCT ATGGGAAGCA GCTGTGTACC ATTCCTCGCG ATGCTGCCTA CTACAGCTAT 3780
CAGAATAGGT ATCATTTCTG TGAGAAGTGT TTCACAGAGA TCCAGGGCGA GAATGTGACC 3840
CTGGGTGACG ACCCTTCACA GCCCCAGACG ACAATTTCAA AGGATCAGTT TGAAAAGAAG 3900
AAAAATGATA CCTTAGACCC CGAACCTTTC GTTGATTGCA AGGAGTGTGG CCGGAAGATG 3960
CATCAGATTT GCGTTCTGCA CTATGACATC ATTTGGCCTT CAGGTTTTGT GTGCGACAAC 4020
TGCTTGAAGA AAACTGGCAG ACCTCGAAAA GAAAACAAAT TCAGTGCTAA GAGGCTGCAG 4080
ACCACAAGAC TGGGAAACCA CTTGGAAGAC CGAGTGAACA AATTTTTGCG GCGCCAGAAT 4140
CACCCTGAAG CCGGGGAGGT TTTTGTCCGA GTGGTGGCCA GCTCAGACAA GACGGTGGAG 4200
GTCAAGCCCG GGATGAAGTC ACGGTTTGTG GATTCTGGGG AAATGTCTGA ATCTTTCCCA 4260
TATCGAACCA AAGCTCTGTT TGCTTTTGAG GAAATTGACG GCGTGGATGT CTGCTTTTTT 4320
GGAATGCACG TCCAAGAATA CGGCTCTGAT TGCCCCCCTC CAAACACGAG GCGTGTGTAC 4380
ATTTCTTATC TGGATAGTAT TCATTTCTTC CGGCCACGTT GCCTCCGCAC AGCCGTTTAC 4440
CATGAGATCC TTATTGGATA TTTAGAGTAT GTGAAGAAAT TAGGGTATGT GACAGGGCAC 4500
ATCTGGGCCT GTCCTCCAAG TGAAGGAGAT GATTACATCT TCCATTGCCA CCCACCTGAT 4560
CAAAAAATAC CCAAGCCAAA ACGACTGCAG GAGTGGTACA AAAAGATGCT GGACAAGGCG 4620
TTTGCAGAGC GGATCATCCA TGACTACAAG GATATTTTCA AACAAGCAAC TGAAGACAGG 4680
CTCACCAGTG CCAAGGAACT GCCCTATTTT GAAGGTGATT TCTGGCCCAA TGTGTTAGAA 4740
GAGAGCATTA AGGAACTAGA ACAAGAAGAA GAGGAGAGGA AAAAGGAAGA GAGCACTGCA 4800
GCCAGTGAAA CCACTGAGGG CAGTCAGGGC GACAGCAAGA ATGCCAAGAA GAAGAACAAC 4860
AAGAAAACCA ACAAGAACAA AAGCAGCATC AGCCGCGCCA ACAAGAAGAA GCCCAGCATG 4920
CCCAACGTGT CCAATGACCT GTCCCAGAAG CTGTATGCCA CCATGGAGAA GCACAAGGAG 4980
GTCTTCTTCG TGATCCACCT GCACGCTGGG CCTGTCATCA ACACCCTGCC CCCCATCGTC 5040
GACCCCGACC CCCTGCTCAG CTGTGACCTC ATGGATGGGC GCGACGCCTT CCTCACCCTC 5100
GCCAGAGACA AGCACTGGGA GTTCTCCTCC TTGCGCCGCT CCAAGTGGTC CACGCTCTGC 5160
ATGCTGGTGG AGCTGCACAC CCAGGGCCAG GACCGCTTTG TCTACACCTG CAACGAGTGC 5220
AAGCACCACG TGGAGACGCG CTGGCACTGC ACTGTGTGCG AGGACTACGA CCTCTGCATC 5280
AACTGCTATA ACACGAAGAG CCATGCCCAT AAGATGGTGA AGTGGGGGCT GGGCCTGGAT 5340
GACGAGGGCA GCAGCCAGGG CGAGCCACAG TCAAAGAGCC CCCAGGAGTC ACGCCGGCTG 5400
AGCATCCAGC GCTGCATCCA GTCGCTGGTG CACGCGTGCC AGTGCCGCAA CGCCAACTGC 5460
TCGCTGCCAT CCTGCCAGAA GATGAAGCGG GTGGTGCAGC ACACCAAGGG CTGCAAACGC 5520
AAGACCAACG GGGGCTGCCC GGTGTGCAAG CAGCTCATCG CCCTCTGCTG CTACCACGCC 5580
AAGCACTGCC AAGAAAACAA ATGCCCCGTG CCCTTCTGCC TCAACATCAA ACACAAGCTC 5640
CGCCAGCAGC AGATCCAGCA CCGCCTGCAG CAGGCCCAGC TCATGCGCCG GCGGATGGCC 5700
ACCATGAACA CCCGCAACGT GCCTCAGCAG AGTCTGCCTT CTCCTACCTC AGCACCGCCC 5760
GGGACCCCCA CACAGCAGCC CAGCACACCC CAGACGCCGC AGCCCCCTGC CCAGCCCCAA 5820
CCCTCACCCG TGAGCATGTC ACCAGCTGGC TTCCCCAGCG TGGCCCGGAC TCAGCCCCCC 5880
ACCACGGTGT CCACAGGGAA GCCTACCAGC CAGGTGCCGG CCCCCCCACC CCCGGCCCAG 5940
CCCCCTCCTG CAGCGGTGGA AGCGGCTCGG CAGATCGAGC GTGAGGCCCA GCAGCAGCAG 6000
CACCTGTACC GGGTGAACAT CAACAACAGC ATGCCCCCAG GACGCACGGG CATGGGGACC 6060
CCGGGGAGCC AGATGGCCCC CGTGAGCCTG AATGTGCCCC GACCCAACCA GGTGAGCGGG 6120
CCCGTCATGC CCAGCATGCC TCCCGGGCAG TGGCAGCAGG CGCCCCTTCC CCAGCAGCAG 6180
CCCATGCCAG GCTTGCCCAG GCCTGTGATA TCCATGCAGG CCCAGGCGGC CGTGGCTGGG 6240
CCCCGGATGC CCAGCGTGCA GCCACCCAGG AGCATCTCAC CCAGCGCTCT GCAAGACCTG 6300
CTGCGGACCC TGAAGTCGCC CAGCTCCCCT CAGCAGCAAC AGCAGGTGCT GAACATTCTC 6360
AAATCAAACC CGCAGCTAAT GGCAGCTTTC ATCAAACAGC GCACAGCCAA GTACGTGGCC 6420
AATCAGCCCG GCATGCAGCC CCAGCCTGGC CTCCAGTCCC AGCCCGGCAT GCAACCCCAG 6480
CCTGGCATGC ACCAGCAGCC CAGCCTGCAG AACCTGAATG CCATGCAGGC TGGCGTGCCG 6540
CGGCCCGGTG TGCCTCCACA GCAGCAGGCG ATGGGAGGCC TGAACCCCCA GGGCCAGGCC 6600
TTGAACATCA TGAACCCAGG ACACAACCCC AACATGGCGA GTATGAATCC ACAGTACCGA 6660
GAAATGTTAC GGAGGCAGCT GCTGCAGCAG CAGCAGCAAC AGCAGCAGCA ACAACAGCAG 6720
CAACAGCAGC AGCAGCAAGG GAGTGCCGGC ATGGCTGGGG GCATGGCGGG GCACGGCCAG 6780
TTCCAGCAGC CTCAAGGACC CGGAGGCTAC CCACCGGCCA TGCAGCAGCA GCAGCGCATG 6840
CAGCAGCATC TCCCCCTCCA GGGCAGCTCC ATGGGCCAGA TGGCGGCTCA GATGGGACAG 6900
CTTGGCCAGA TGGGGCAGCC GGGGCTGGGG GCAGACAGCA CCCCCAACAT CCAGCAAGCC 6960
CTGCAGCAGC GGATTCTGCA GCAACAGCAG ATGAAGCAGC AGATTGGGTC CCCAGGCCAG 7020
CCGAACCCCA TGAGCCCCCA GCAACACATG CTCTCAGGAC AGCCACAGGC CTCGCATCTC 7080
CCTGGCCAGC AGATCGCCAC GTCCCTTAGT AACCAGGTGC GGTCTCCAGC CCCTGTCCAG 7140
TCTCCACGGC CCCAGTCCCA GCCTCCACAT TCCAGCCCGT CACCACGGAT ACAGCCCCAG 7200
CCTTCGCCAC ACCACGTCTC ACCCCAGACT GGTTCCCCCC ACCCCGGACT CGCAGTCACC 7260
ATGGCCAGCT CCATAGATCA GGGACACTTG GGGAACCCCG AACAGAGTGC AATGCTCCCC 7320
CAGCTGAACA CCCCCAGCAG GAGTGCGCTG TCCAGCGAAC TGTCCCTGGT CGGGGACACC 7380
ACGGGGGACA CGCTAGAGAA GTTTGTGGAG GGCTTGTAGC ATTGTGAGAG CATCACCTTT 7440
TCCCTTTCAT GTTCTTGGAC CTTTTGTACT GAAAATCCAG GCATCTAGGT TCTTTTTATT 7500
CCTAGATGGA ACTGCGACTT CCGAGCCATG GAAGGGTGGA TTGATGTTTA AAGAAACAAT 7560
ACAAAGAATA TATTTTTTTG TTAAAAACCA GTTGATTT 7599
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0010--Activator
KW-0012--Acyltransferase
KW-0025--Alternative splicing
KW-0090--Biological rhythms
KW-0103--Bromodomain
KW-0160--Chromosomal rearrangement
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0945--Host-virus interaction
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR031162--CBP_P300_HAT
IPR010303--DUF902_CREBbp
IPR013178--Histone_AcTrfase_Rtt109/CBP
IPR003101--KIX_dom
IPR009110--Nuc_rcpt_coact
IPR014744--Nuc_rcpt_coact_CREBbp
IPR000197--Znf_TAZ
IPR000433--Znf_ZZ
PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS51727--CBP_P300_HAT
PS50952--KIX
PS50134--ZF_TAZ
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2
Pfam

PF00439--Bromodomain
PF09030--Creb_binding
PF06001--DUF902
PF08214--HAT_KAT11
PF02172--KIX
PF02135--zf-TAZ
PF00569--ZZ
Gene Ontology

GO:0005737--C:cytoplasm
GO:0000123--C:histone acetyltransferase complex
GO:0016604--C:nuclear body
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005667--C:transcription factor complex
GO:0016407--F:acetyltransferase activity
GO:0003682--F:chromatin binding
GO:0000987--F:core promoter proximal region sequence-specific DNA binding
GO:0003684--F:damaged DNA binding
GO:0004402--F:histone acetyltransferase activity
GO:0043426--F:MRF binding
GO:0002039--F:p53 binding
GO:0034212--F:peptide N-acetyltransferase activity
GO:0001102--F:RNA polymerase II activating transcription factor binding
GO:0001105--F:RNA polymerase II transcription coactivator activity
GO:0001085--F:RNA polymerase II transcription factor binding
GO:0004871--F:signal transducer activity
GO:0003713--F:transcription coactivator activity
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008134--F:transcription factor binding
GO:0001078--F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001191--F:transcriptional repressor activity, RNA polymerase II transcription factor binding
GO:0008270--F:zinc ion binding
GO:1904837--P:beta-catenin-TCF complex assembly
GO:0008283--P:cell proliferation
GO:0098609--P:cell-cell adhesion
GO:0044255--P:cellular lipid metabolic process
GO:0034644--P:cellular response to UV
GO:0042733--P:embryonic digit morphogenesis
GO:0016573--P:histone acetylation
GO:0042592--P:homeostatic process
GO:0018076--P:N-terminal peptidyl-lysine acetylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0007219--P:Notch signaling pathway
GO:0060355--P:positive regulation of cell adhesion molecule production
GO:1900087--P:positive regulation of G1/S transition of mitotic cell cycle
GO:1901224--P:positive regulation of NIK/NF-kappaB signaling
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0032481--P:positive regulation of type I interferon production
GO:0006473--P:protein acetylation
GO:0006461--P:protein complex assembly
GO:0042981--P:regulation of apoptotic process
GO:1900034--P:regulation of cellular response to heat
GO:0008589--P:regulation of smoothened signaling pathway
GO:0061418--P:regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0006355--P:regulation of transcription, DNA-templated
GO:0001666--P:response to hypoxia
GO:0070555--P:response to interleukin-1
GO:0048511--P:rhythmic process
GO:0007165--P:signal transduction
GO:0002223--P:stimulatory C-type lectin receptor signaling pathway
GO:0006367--P:transcription initiation from RNA polymerase II promoter
GO:0016032--P:viral process
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Pat-0058 ENSPTRP00000013169.5 Pan troglodytes 100 0.0 2184
WERAM-Paa-0188 ENSPANP00000013793.1 Papio anubis 100 0.0 2177
WERAM-Mam-0016 ENSMMUP00000003058.2 Macaca mulatta 100 0.0 2177
WERAM-Nol-0103 ENSNLEP00000011912.1 Nomascus leucogenys 99 0.0 2174
WERAM-Gog-0070 ENSGGOP00000005899.2 Gorilla gorilla 99 0.0 2174
WERAM-Chs-0118 ENSCSAP00000005901.1 Chlorocebus sabaeus 97 0.0 2091
WERAM-Poa-0061 ENSPPYP00000007974.2 Pongo abelii 100 0.0 2013
WERAM-Otg-0033 ENSOGAP00000002066.2 Otolemur garnettii 97 0.0 1987
WERAM-Ran-0033 ENSRNOP00000007079.3 Rattus norvegicus 97 0.0 1973
WERAM-Mum-0047 ENSMUSP00000023165.6 Mus musculus 97 0.0 1966
WERAM-Mup-0171 ENSMPUP00000014925.1 Mustela putorius furo 96 0.0 1961
WERAM-Eqc-0206 ENSECAP00000022419.1 Equus caballus 96 0.0 1961
WERAM-Sus-0057 ENSSSCP00000008490.2 Sus scrofa 96 0.0 1960
WERAM-Caf-0199 ENSCAFP00000028407.4 Canis familiaris 96 0.0 1959
WERAM-Myl-0014 ENSMLUP00000001260.2 Myotis lucifugus 96 0.0 1957
WERAM-Tut-0196 ENSTTRP00000016110.1 Tursiops truncatus 96 0.0 1956
WERAM-Cap-0055 ENSCPOP00000004489.2 Cavia porcellus 91 0.0 1948
WERAM-Bot-0200 ENSBTAP00000005092.5 Bos taurus 95 0.0 1947
WERAM-Orc-0037 ENSOCUP00000003854.3 Oryctolagus cuniculus 96 0.0 1937
WERAM-Loa-0146 ENSLAFP00000013091.3 Loxodonta africana 94 0.0 1925
WERAM-Caj-0210 ENSCJAP00000036676.2 Callithrix jacchus 95 0.0 1918
WERAM-Mod-0143 ENSMODP00000020486.4 Monodelphis domestica 91 0.0 1915
WERAM-Sah-0155 ENSSHAP00000016296.1 Sarcophilus harrisii 91 0.0 1906
WERAM-Fec-0066 ENSFCAP00000005818.3 Felis catus 96 0.0 1891
WERAM-Ora-0059 ENSOANP00000009307.4 Ornithorhynchus anatinus 87 0.0 1843
WERAM-Anp-0146 ENSAPLP00000015529.1 Anas platyrhynchos 89 0.0 1843
WERAM-Fia-0062 ENSFALP00000004501.1 Ficedula albicollis 86 0.0 1834
WERAM-Gaga-0081 ENSGALP00000038776.2 Gallus gallus 88 0.0 1833
WERAM-Meg-0100 ENSMGAP00000009631.2 Meleagris gallopavo 89 0.0 1816
WERAM-Ptv-0059 ENSPVAP00000006213.1 Pteropus vampyrus 96 0.0 1814
WERAM-Lac-0104 ENSLACP00000012920.1 Latimeria chalumnae 81 0.0 1732
WERAM-Aim-0118 ENSAMEP00000011401.1 Ailuropoda melanoleuca 98 0.0 1732
WERAM-Ova-0015 ENSOARP00000002661.1 Ovis aries 97 0.0 1725
WERAM-Pes-0073 ENSPSIP00000009222.1 Pelodiscus sinensis 90 0.0 1712
WERAM-Dio-0142 ENSDORP00000013130.1 Dipodomys ordii 89 0.0 1697
WERAM-Tag-0058 ENSTGUP00000004146.1 Taeniopygia guttata 91 0.0 1695
WERAM-Xet-0068 ENSXETP00000022709.3 Xenopus tropicalis 79 0.0 1688
WERAM-Dan-0078 ENSDNOP00000007737.3 Dasypus novemcinctus 91 0.0 1657
WERAM-Ict-0052 ENSSTOP00000004511.2 Ictidomys tridecemlineatus 98 0.0 1568
WERAM-Leo-0017 ENSLOCP00000003190.1 Lepisosteus oculatus 88 0.0 1565
WERAM-Dar-0230 ENSDARP00000140135.1 Danio rerio 86 0.0 1542
WERAM-Anc-0132 ENSACAP00000012418.2 Anolis carolinensis 87 0.0 1540
WERAM-Orn-0056 ENSONIP00000006509.1 Oreochromis niloticus 83 0.0 1530
WERAM-Tar-0054 ENSTRUP00000012157.1 Takifugu rubripes 83 0.0 1519
WERAM-Ten-0085 ENSTNIP00000009829.1 Tetraodon nigroviridis 84 0.0 1516
WERAM-Ect-0128 ENSETEP00000014608.1 Echinops telfairi 85 0.0 1513
WERAM-Gaa-0114 ENSGACP00000014994.1 Gasterosteus aculeatus 83 0.0 1513
WERAM-Pof-0056 ENSPFOP00000005018.2 Poecilia formosa 82 0.0 1509
WERAM-Orla-0082 ENSORLP00000010434.1 Oryzias latipes 84 0.0 1508
WERAM-Ere-0006 ENSEEUP00000000252.1 Erinaceus europaeus 93 0.0 1505
WERAM-Xim-0049 ENSXMAP00000004610.1 Xiphophorus maculatus 85 0.0 1498
WERAM-Gam-0162 ENSGMOP00000016192.1 Gadus morhua 79 0.0 1462
WERAM-Prc-0144 ENSPCAP00000013530.1 Procavia capensis 89 0.0 1448
WERAM-Asm-0148 ENSAMXP00000014014.1 Astyanax mexicanus 86 0.0 1396
WERAM-Mae-0137 ENSMEUP00000013859.1 Macropus eugenii 77 0.0 1374
WERAM-Mim-0122 ENSMICP00000012659.1 Microcebus murinus 74 0.0 1321
WERAM-Vip-0014 ENSVPAP00000001514.1 Vicugna pacos 91 0.0 1190
WERAM-Tas-0111 ENSTSYP00000011311.1 Tarsius syrichta 89 0.0 1173
WERAM-Drm-0091 FBpp0291862 Drosophila melanogaster 68 0.0 1160
WERAM-Ocp-0065 ENSOPRP00000005776.1 Ochotona princeps 86 0.0 1091
WERAM-Cii-0047 ENSCINP00000018331.3 Ciona intestinalis 63 0.0 1050
WERAM-Chh-0071 ENSCHOP00000007796.1 Choloepus hoffmanni 78 0.0 1038
WERAM-Pem-0042 ENSPMAP00000005315.1 Petromyzon marinus 83 0.0 993
WERAM-Soa-0078 ENSSARP00000007495.1 Sorex araneus 80 0.0 788
WERAM-Cae-0001 R10E11.1b Caenorhabditis elegans 53 7e-165 580
WERAM-Mua-0017 GSMUA_Achr10P31040_001 Musa acuminata 34 8e-94 344
WERAM-Brd-0019 BRADI1G34530.1 Brachypodium distachyon 32 4e-88 325
WERAM-Brr-0197 Bra039359.1-P Brassica rapa 42 1e-73 277
WERAM-Sol-0005 Solyc01g008120.2.1 Solanum lycopersicum 41 1e-73 276
WERAM-Amt-0080 ERN03959 Amborella trichopoda 40 2e-73 276
WERAM-Bro-0018 Bo1g138720.1 Brassica oleracea 42 2e-73 276
WERAM-Glm-0074 GLYMA07G00230.1 Glycine max 40 4e-73 275
WERAM-Art-0069 AT3G12980.1 Arabidopsis thaliana 41 5e-73 275
WERAM-Viv-0063 VIT_09s0054g01780.t01 Vitis vinifera 41 2e-72 273
WERAM-Arl-0125 scaffold_301479.1 Arabidopsis lyrata 41 2e-72 273
WERAM-Orbr-0022 OB02G12780.1 Oryza brachyantha 41 5e-72 271
WERAM-Orgl-0019 OGLUM02G02970.1 Oryza glumaepatula 41 2e-71 270
WERAM-Sob-0064 Sb04g003020.1 Sorghum bicolor 41 4e-71 268
WERAM-Lep-0021 LPERR02G02770.1 Leersia perrieri 41 5e-71 268
WERAM-Tra-0249 Traes_6AS_0D50E58F7.2 Triticum aestivum 42 5e-71 268
WERAM-Orp-0019 OPUNC02G02380.1 Oryza punctata 40 7e-71 268
WERAM-Zem-0079 GRMZM2G139977_P01 Zea mays 41 7e-71 268
WERAM-Orm-0020 OMERI02G03750.1 Oryza meridionalis 40 7e-71 268
WERAM-Org-0018 ORGLA02G0029000.1 Oryza glaberrima 40 8e-71 267
WERAM-Orr-0017 ORUFI02G02990.1 Oryza rufipogon 40 8e-71 267
WERAM-Orni-0017 ONIVA02G02900.1 Oryza nivara 40 8e-71 267
WERAM-Orb-0018 OBART02G03080.1 Oryza barthii 40 8e-71 267
WERAM-Ori-0022 BGIOSGA007487-PA Oryza indica 40 1e-70 267
WERAM-Orl-0039 KN538877.1_FGP010 Oryza longistaminata 40 1e-70 266
WERAM-Tru-0059 TRIUR3_24220-P1 Triticum urartu 42 2e-70 266
WERAM-Prp-0017 EMJ16107 Prunus persica 39 3e-70 265
WERAM-Hov-0004 MLOC_11125.1 Hordeum vulgare 41 4e-70 265
WERAM-Aet-0052 EMT20273 Aegilops tauschii 41 4e-70 265
WERAM-Sei-0059 Si016078m Setaria italica 40 5e-70 265
WERAM-Thc-0074 EOY26177 Theobroma cacao 39 1e-69 264
WERAM-Php-0104 PP1S462_17V6.1 Physcomitrella patens 38 3e-68 259
WERAM-Sem-0084 EFJ15241 Selaginella moellendorffii 38 5e-68 258
WERAM-Pot-0140 POPTR_0014s00260.1 Populus trichocarpa 40 1e-67 257
WERAM-Sot-0043 PGSC0003DMT400040304 Solanum tuberosum 39 2e-65 250
WERAM-Met-0089 AES86305 Medicago truncatula 38 4e-65 248
WERAM-Ors-0061 OS06T0704800-00 Oryza sativa 43 5e-63 242
Created Date 25-Jun-2016