WERAM Information

Tag Content
WERAM ID WERAM-Hos-0173
Ensembl Protein ID ENSP00000357442.2
Uniprot Accession Q9BRQ0; PYGO2_HUMAN; Q8WYZ4; Q96CY2
Genbank Protein ID NP_612157.1
Protein Name Pygopus homolog 2
Genbank Nucleotide ID NM_138300.3
Gene Name Pygo2;PP7910
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000163348.3 ENST00000368457.2 ENSP00000357442.2
ENSG00000163348.3 ENST00000368456.1 ENSP00000357441.1
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader PHD PHD-type H3K4me2/3 K 20637214
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader PHD 8.20e-08 34.6 329 383
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Involved in signal transduction through the Wnt pathway.
Domain Profile
  Me_Reader PHD
            PHD.txt   3 iClvCg.kddegekemvqCde.CddwfHlkCvklplsslpeg.......kswyCpsCk 51 
                         C +C+ ++++++  ++ C+  C++wfH +C++++  +  +g       + w C  C 
  ENSP00000357442.2 329 PCGACRsEVNDDQ-DAILCEAsCQKWFHRECTGMT--ESAYGlltteasAVWACDLCL 383
                        5****62555555.5********************..66666666665356******6 PP
Protein Sequence
(Fasta)		MAASAPPPPD KLEGGGGPAP PPAPPSTGRK QGKAGLQMKS PEKKRRKSNT QGPAYSHLTE 60
FAPPPTPMVD HLVASNPFED DFGAPKVGVA APPFLGSPVP FGGFRVQGGM AGQVPPGYST 120
GGGGGPQPLR RQPPPFPPNP MGPAFNMPPQ GPGYPPPGNM NFPSQPFNQP LGQNFSPPSG 180
QMMPGPVGGF GPMISPTMGQ PPRAELGPPS LSQRFAQPGA PFGPSPLQRP GQGLPSLPPN 240
TSPFPGPDPG FPGPGGEDGG KPLNPPASTA FPQEPHSGSP AAAVNGNQPS FPPNSSGRGG 300
GTPDANSLAP PGKAGGGSGP QPPPGLVYPC GACRSEVNDD QDAILCEASC QKWFHRECTG 360
MTESAYGLLT TEASAVWACD LCLKTKEIQS VYIREGMGQL VAANDG 406
Nucleotide Sequence
(Fasta)		GTCTGGAGAG AGCGCGCAGT TTGCGCGGCG GCTCGGCGCT TCCCTGTCGT CGCACTTTGT 60
GGTTGCTGCA GCTCGGGGGC CTGGGCTGCC CCTGACACCC CTTCTGGGCG ATGGTGCAGC 120
CCAAGGGCGC CTCCATCCCC CGCCGCTGCC GCTAACCCGG GTCCCCCACT CCATGGCCGC 180
CTCGGCGCCG CCCCCACCGG ACAAGCTGGA GGGAGGTGGC GGCCCCGCAC CGCCCCCTGC 240
GCCGCCCAGC ACCGGGAGGA AGCAGGGCAA GGCCGGTCTG CAAATGAAGA GTCCAGAAAA 300
GAAGCGAAGG AAGTCAAATA CTCAGGGCCC TGCATACTCA CATCTGACGG AGTTTGCACC 360
ACCCCCAACT CCCATGGTGG ATCACCTGGT TGCATCCAAC CCTTTTGAAG ATGACTTCGG 420
AGCCCCCAAA GTGGGGGTTG CAGCCCCTCC ATTCCTTGGC AGTCCTGTGC CCTTCGGAGG 480
CTTCCGTGTG CAGGGGGGCA TGGCGGGCCA GGTACCCCCA GGCTACAGCA CTGGAGGTGG 540
AGGGGGCCCC CAGCCACTCC GTCGACAGCC ACCCCCCTTC CCTCCCAATC CTATGGGCCC 600
TGCTTTCAAC ATGCCCCCCC AGGGTCCTGG CTACCCACCC CCAGGCAACA TGAACTTTCC 660
CAGCCAACCC TTCAACCAGC CTCTGGGTCA AAACTTTAGT CCTCCCAGTG GGCAGATGAT 720
GCCGGGCCCA GTGGGGGGAT TTGGTCCCAT GATCTCACCC ACCATGGGAC AGCCTCCCAG 780
AGCAGAGCTG GGCCCACCTT CTCTGTCCCA ACGATTTGCT CAGCCAGGGG CTCCTTTTGG 840
CCCTTCTCCT CTCCAGAGAC CTGGTCAGGG GCTCCCCAGC CTGCCGCCTA ACACAAGTCC 900
CTTTCCTGGT CCGGACCCTG GCTTTCCTGG CCCTGGTGGT GAGGATGGGG GGAAGCCCTT 960
GAATCCACCT GCTTCTACTG CTTTTCCCCA GGAGCCCCAC TCAGGCTCCC CGGCTGCTGC 1020
TGTTAATGGG AACCAGCCCA GTTTCCCCCC GAACAGCAGT GGGCGGGGTG GGGGCACTCC 1080
AGATGCCAAC AGCTTGGCAC CCCCTGGCAA GGCAGGTGGG GGCTCCGGGC CCCAGCCTCC 1140
CCCAGGCTTG GTGTACCCAT GTGGTGCCTG TCGGAGTGAG GTGAACGATG ACCAGGATGC 1200
CATTCTGTGT GAGGCCTCCT GCCAGAAATG GTTCCACCGT GAGTGCACAG GCATGACTGA 1260
GAGCGCCTAT GGGCTGCTGA CCACTGAAGC TTCTGCCGTC TGGGCCTGCG ATCTCTGCCT 1320
CAAGACCAAG GAGATCCAGT CTGTCTACAT CCGTGAGGGC ATGGGGCAGC TGGTGGCTGC 1380
TAACGATGGG TGACGCTGGT GAAGTGGCCC AGGGAAGTGC ACATGTCTCT CCCTGCTCTT 1440
CCAGGGTGAT TTTTTTGATG TTTGGCTCTT GGTCCTTGTT TCCACTGGCT TTCCATCCCC 1500
ATGGGGCAGA AACAGTGGCT CCTGGGAGCA GAAAAGGAAT TGAGGTGGGC AGGCAGAAGA 1560
GCCTGGATTG CTCACTGTTT TGGGAAACTT ACATGTTGAG ATCTACAGAG ATCCAGGAAA 1620
CCAAAGCCCT GCTGAGCAGA GCCATTTTGT GGCTATTTCT GGAGGCCCAG GAGTGTGGCT 1680
GCAAGAGAAA AGGGGCTGGA GGAAGATCCG GAGGGCAGGG GTGTTCCCTC TGCTGATGAT 1740
GGATGCCCCT AACACCTGTG CCTAACACCC CTACTGAACC CCACAGCTCC AGCCTTAGTT 1800
TTTGGAGTCA AGTGTTAAAG GTTTCTGGCC AGAGGAATTG GGGTCTTGCC ATCCCTGCAA 1860
TAGCCCTTTT ATGGGCTCTG GGAGACAGCT TTAGGGAATA AATGGGGATT TTCCCCTTTT 1920
TCTACCCACT CCTTTGCTTC CTCCAAGACT TACCCAACTC CTTCCCCCTC AGAGAACCAA 1980
ATAGCCTGAG GAAGCAGGAG AGTTCCTGGT TATGGCAGTT TCTTGGTGAT TTGGGGCTTC 2040
AAGACAGTAG GTGAGAGATG CTGTCAGGAC GTATCTTCTT CATACCAAAG TCACTGGTCC 2100
TTTCTCAGCC TCTCTCGTGC TTTTCTCCTA ATGACCATAT TTTTGCCAAA AATTGGGATA 2160
TGTTATCTGA CAGACCAGAA TATTTGAAGT TTGGGCTGTC CTGAAAGTCT GGACTTTGGT 2220
GGTACCCTCC TCCCCCAGCC CATCTGTTGC ACATTATACT CCGTGTGTTC TTCAACTTTC 2280
GGCGCCCTTA TTCCCCTGCC TTCCTGGCTT GATTGAAGGA AAGCTTGAAA AGGCGCAGAG 2340
CCCTATACCT CATTTCCTCC ATGATAAAAG GATCCAAGTG AGGCCCTGTC ACAGCCTGTG 2400
GGTAGGGGAT GCGGCGGGAT CCTCATTGCC ATGGTACTCA AAGGTAGAAG AGCCTGGAGT 2460
TTGTTGCTTC TCTTTGCTAT TCTTTCATAT CCTCTTGGGC CTGGTGATTA ATTAGCAATT 2520
CTCATTCCTC TCAGCCAAAG GCCTGCACTG GGCTTTATTT GTCTTTTTTT ATTTTTTAAG 2580
CACTGCCTGC CAGAGATGGG CCTGGGGCCT GATGAGGACC TTAGCGCTGC TCGTTCTCCT 2640
TTTCTGTTCA TGCACACATT CCTCCATGGG GTGGGGAAGG CAGGCATGGG GTGTGGCCCT 2700
CGGAGAAGTT AGGAGTCCCC CAGCTCAAGA TACAGTGGCA AAGACCTAGT GGTCCCCTAC 2760
CCCCACTTCT CTCAGTTCCT GGCATGAGGA GAGAAGACCC TGCTCTGGTG GAGCTGACAA 2820
CCTTTGAGGC TGGGAGGAGA GCAGCCTCTG GGCATCGTTC CCAGTGTCCC TCACACTAAA 2880
ACGGCGTAGA TGGCAACCCC CCACCCCCAC CCCGCTGCTC AACTCTTGTG TTTGTTGTTC 2940
TGTTTGCCCC ATTTATCTGT TGCTGTTTTT GTGTTGTCTT CCCCTGCTCC GCATTTTGTA 3000
AAATGGCCCC TGGGGGAGTG TTTTTGCTGG ATCTGCTCCC TCTCGCTCTC TCACTCCACT 3060
ACTTTTTGGA ACAAAGTGAT GGCAGAATGC GGTGGTGGTG GGGGTCTTTT GTACTGTTGG 3120
ATTAATAAAA TGATTTTAAA ATCCCA 3147
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0879--Wnt signaling pathway
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF00628--PHD
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0003682--F:chromatin binding
GO:0035034--F:histone acetyltransferase regulator activity
GO:0008270--F:zinc ion binding
GO:1904837--P:beta-catenin-TCF complex assembly
GO:0007420--P:brain development
GO:0060070--P:canonical Wnt signaling pathway
GO:0048589--P:developmental growth
GO:0001701--P:in utero embryonic development
GO:0001822--P:kidney development
GO:0002088--P:lens development in camera-type eye
GO:0030879--P:mammary gland development
GO:0060021--P:palate development
GO:0035563--P:positive regulation of chromatin binding
GO:0009791--P:post-embryonic development
GO:0051569--P:regulation of histone H3-K4 methylation
GO:0033599--P:regulation of mammary gland epithelial cell proliferation
GO:0007289--P:spermatid nucleus differentiation
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Gog-0142 ENSGGOP00000012538.2 Gorilla gorilla 100 3e-154 541
WERAM-Poa-0005 ENSPPYP00000000895.1 Pongo abelii 99 2e-153 539
WERAM-Pat-0012 ENSPTRP00000002348.2 Pan troglodytes 100 4e-152 535
WERAM-Tut-0184 ENSTTRP00000015334.1 Tursiops truncatus 98 2e-151 532
WERAM-Paa-0015 ENSPANP00000015103.1 Papio anubis 99 4e-151 531
WERAM-Chs-0020 ENSCSAP00000016064.1 Chlorocebus sabaeus 99 4e-151 531
WERAM-Mam-0047 ENSMMUP00000008655.2 Macaca mulatta 99 9e-151 530
WERAM-Dio-0032 ENSDORP00000003513.1 Dipodomys ordii 97 2e-150 529
WERAM-Sus-0044 ENSSSCP00000006969.2 Sus scrofa 97 4e-150 528
WERAM-Bot-0053 ENSBTAP00000005670.2 Bos taurus 98 8e-150 527
WERAM-Ict-0002 ENSSTOP00000000046.2 Ictidomys tridecemlineatus 96 3e-149 525
WERAM-Loa-0096 ENSLAFP00000008281.3 Loxodonta africana 97 9e-149 523
WERAM-Cap-0172 ENSCPOP00000015542.1 Cavia porcellus 96 4e-148 521
WERAM-Otg-0210 ENSOGAP00000015715.1 Otolemur garnettii 97 3e-146 515
WERAM-Eqc-0114 ENSECAP00000012702.1 Equus caballus 97 5e-146 514
WERAM-Mum-0184 ENSMUSP00000053672.4 Mus musculus 97 6e-146 514
WERAM-Caf-0224 ENSCAFP00000025271.1 Canis familiaris 97 7e-146 514
WERAM-Ran-0137 ENSRNOP00000028052.4 Rattus norvegicus 96 2e-145 513
WERAM-Ocp-0002 ENSOPRP00000000313.1 Ochotona princeps 95 3e-144 508
WERAM-Ptv-0005 ENSPVAP00000000761.1 Pteropus vampyrus 93 1e-142 503
WERAM-Aim-0134 ENSAMEP00000012137.1 Ailuropoda melanoleuca 95 2e-142 503
WERAM-Caj-0100 ENSCJAP00000017106.2 Callithrix jacchus 98 2e-138 489
WERAM-Myl-0030 ENSMLUP00000002172.2 Myotis lucifugus 95 8e-137 484
WERAM-Sah-0045 ENSSHAP00000005076.1 Sarcophilus harrisii 96 1e-136 483
WERAM-Mae-0007 ENSMEUP00000000587.1 Macropus eugenii 95 7e-136 481
WERAM-Mup-0070 ENSMPUP00000006277.1 Mustela putorius furo 96 7e-136 481
WERAM-Mod-0152 ENSMODP00000021391.2 Monodelphis domestica 96 8e-135 477
WERAM-Nol-0121 ENSNLEP00000013998.1 Nomascus leucogenys 94 3e-132 468
WERAM-Dan-0160 ENSDNOP00000018085.1 Dasypus novemcinctus 95 1e-129 460
WERAM-Ect-0101 ENSETEP00000011465.1 Echinops telfairi 98 2e-124 442
WERAM-Fec-0014 ENSFCAP00000024398.1 Felis catus 96 2e-96 350
WERAM-Fia-0172 ENSFALP00000015843.1 Ficedula albicollis 66 8e-95 344
WERAM-Gaga-0168 ENSGALP00000042398.1 Gallus gallus 78 6e-76 281
WERAM-Pes-0159 ENSPSIP00000018882.1 Pelodiscus sinensis 65 7e-62 235
WERAM-Lac-0088 ENSLACP00000011098.2 Latimeria chalumnae 61 2e-54 210
WERAM-Leo-0068 ENSLOCP00000008529.1 Lepisosteus oculatus 88 8e-41 165
WERAM-Gam-0111 ENSGMOP00000011639.1 Gadus morhua 77 2e-37 154
WERAM-Ora-0081 ENSOANP00000013587.3 Ornithorhynchus anatinus 69 8e-32 135
WERAM-Ova-0220 ENSOARP00000022458.1 Ovis aries 69 5e-31 132
WERAM-Chh-0069 ENSCHOP00000007311.1 Choloepus hoffmanni 69 6e-31 132
WERAM-Orc-0118 ENSOCUP00000010104.2 Oryctolagus cuniculus 74 2e-30 130
WERAM-Tub-0077 ENSTBEP00000009335.1 Tupaia belangeri 74 2e-30 130
WERAM-Tas-0051 ENSTSYP00000004621.1 Tarsius syrichta 74 2e-30 130
WERAM-Vip-0123 ENSVPAP00000011521.1 Vicugna pacos 74 2e-30 130
WERAM-Meg-0062 ENSMGAP00000005897.2 Meleagris gallopavo 70 2e-30 130
WERAM-Anp-0027 ENSAPLP00000003168.1 Anas platyrhynchos 70 3e-30 130
WERAM-Tag-0097 ENSTGUP00000006635.1 Taeniopygia guttata 75 3e-30 130
WERAM-Asm-0225 ENSAMXP00000021740.1 Astyanax mexicanus 66 3e-28 123
WERAM-Dar-0199 ENSDARP00000132493.1 Danio rerio 67 8e-27 119
WERAM-Xet-0168 ENSXETP00000057873.2 Xenopus tropicalis 58 7e-24 108
Created Date 25-Jun-2016