WERAM Information

Tag Content
WERAM ID WERAM-Hos-0231
Ensembl Protein ID ENSP00000351250.2
Uniprot Accession Q9UPN9; TRI33_HUMAN; O95855; Q5TG72; Q5TG73; Q5TG74; Q9C017; Q9UJ79
Genbank Protein ID NP_056990.3; NP_148980.2
Protein Name E3 ubiquitin-protein ligase TRIM33
Genbank Nucleotide ID NM_015906.3; NM_033020.2
Gene Name TRIM33;KIAA1113;RFG7;TIF1G;TRI33
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000197323.10 ENST00000358465.6 ENSP00000351250.2
ENSG00000197323.10 ENST00000369543.6 ENSP00000358556.2
ENSG00000197323.10 ENST00000448034.5 ENSP00000402333.1
ENSG00000197323.10 ENST00000450349.3 ENSP00000412077.3
Details
Type Family Domain Substrates AA References (PMIDs)
Ac_Reader Bromodomain Bromodomain H3K9; H3K14; H3K18; H3K23 K 22464331
Status Reviewed
Classification
Type Family E-value Score Start End
Ac_Reader Bromodomain 1.10e-22 82.2 974 1046
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).
Domain Profile
  Ac_Reader Bromodomain
          BROMO.txt    1 kehevsepFrepvdpqleipdYydiikePmdLstikerleegn...YsspeefvkDvrlifnNakaynenkssvq 72  
                         ++he+s  F+epv +  +ip+Yy+iik+PmdLst+k++l+++    Y+ p++fv+Dvrlif+N++ +ne  + vq
  ENSP00000351250.2  974 YCHELSIEFQEPVPA--SIPNYYKIIKKPMDLSTVKKKLQKKHsqhYQIPDDFVADVRLIFKNCERFNEMMKVVQ 1046
                         8**************..9***********************99999***********************988775 PP
Protein Sequence
(Fasta)		MAENKGGGEA ESGGGGSGSA PVTAGAAGPA AQEAEPPLTA VLVEEEEEEG GRAGAEGGAA 60
GPDDGGVAAA SSGSAQAASS PAASVGTGVA GGAVSTPAPA PASAPAPGPS AGPPPGPPAS 120
LLDTCAVCQQ SLQSRREAEP KLLPCLHSFC LRCLPEPERQ LSVPIPGGSN GDIQQVGVIR 180
CPVCRQECRQ IDLVDNYFVK DTSEAPSSSD EKSEQVCTSC EDNASAVGFC VECGEWLCKT 240
CIEAHQRVKF TKDHLIRKKE DVSESVGASG QRPVFCPVHK QEQLKLFCET CDRLTCRDCQ 300
LLEHKEHRYQ FLEEAFQNQK GAIENLLAKL LEKKNYVHFA ATQVQNRIKE VNETNKRVEQ 360
EIKVAIFTLI NEINKKGKSL LQQLENVTKE RQMKLLQQQN DITGLSRQVK HVMNFTNWAI 420
ASGSSTALLY SKRLITFQLR HILKARCDPV PAANGAIRFH CDPTFWAKNV VNLGNLVIES 480
KPAPGYTPNV VVGQVPPGTN HISKTPGQIN LAQLRLQHMQ QQVYAQKHQQ LQQMRMQQPP 540
APVPTTTTTT QQHPRQAAPQ MLQQQPPRLI SVQTMQRGNM NCGAFQAHQM RLAQNAARIP 600
GIPRHSGPQY SMMQPHLQRQ HSNPGHAGPF PVVSVHNTTI NPTSPTTATM ANANRGPTSP 660
SVTAIELIPS VTNPENLPSL PDIPPIQLED AGSSSLDNLL SRYISGSHLP PQPTSTMNPS 720
PGPSALSPGS SGLSNSHTPV RPPSTSSTGS RGSCGSSGRT AEKTSLSFKS DQVKVKQEPG 780
TEDEICSFSG GVKQEKTEDG RRSACMLSSP ESSLTPPLST NLHLESELDA LASLENHVKI 840
EPADMNESCK QSGLSSLVNG KSPIRSLMHR SARIGGDGNN KDDDPNEDWC AVCQNGGDLL 900
CCEKCPKVFH LTCHVPTLLS FPSGDWICTF CRDIGKPEVE YDCDNLQHSK KGKTAQGLSP 960
VDQRKCERLL LYLYCHELSI EFQEPVPASI PNYYKIIKKP MDLSTVKKKL QKKHSQHYQI 1020
PDDFVADVRL IFKNCERFNE MMKVVQVYAD TQEINLKADS EVAQAGKAVA LYFEDKLTEI 1080
YSDRTFAPLP EFEQEEDDGE VTEDSDEDFI QPRRKRLKSD ERPVHIK 1127
Nucleotide Sequence
(Fasta)		CTGCGGCTGG GGCTGGGGGC GGCGGCGGCG GCGACGCGGG CGGCGGGCGG CGCGGGGCGG 60
TCCGGCGGGT TCAAAGAGGA AAACATGGCG GAAAACAAAG GCGGCGGCGA GGCTGAGAGC 120
GGCGGCGGGG GCAGCGGCAG CGCGCCGGTA ACTGCCGGGG CCGCCGGGCC CGCCGCGCAG 180
GAGGCGGAGC CGCCTCTCAC CGCGGTGCTG GTGGAGGAGG AGGAGGAGGA AGGCGGCAGG 240
GCCGGCGCTG AGGGCGGCGC GGCCGGGCCC GACGACGGGG GGGTGGCCGC GGCCTCCTCG 300
GGCTCGGCCC AGGCTGCTTC ATCTCCTGCG GCCTCAGTGG GCACTGGAGT TGCCGGGGGC 360
GCAGTATCGA CGCCGGCTCC AGCTCCAGCC TCGGCTCCCG CTCCGGGTCC CTCGGCAGGG 420
CCGCCTCCTG GACCGCCAGC CTCGCTCCTG GACACCTGCG CCGTGTGTCA GCAGAGCTTG 480
CAGAGCCGGC GTGAGGCGGA GCCCAAGCTG CTGCCCTGTC TTCACTCCTT CTGCCTGCGC 540
TGCCTGCCCG AGCCGGAGCG CCAGCTCAGC GTGCCCATCC CGGGGGGCAG CAACGGCGAC 600
ATCCAGCAAG TTGGTGTAAT ACGGTGCCCA GTATGCCGCC AAGAATGCAG ACAGATAGAC 660
CTTGTGGATA ATTATTTTGT GAAAGACACA TCTGAAGCTC CTAGCAGTTC TGATGAAAAA 720
TCAGAACAGG TATGTACTAG TTGTGAAGAC AATGCAAGTG CAGTTGGCTT TTGTGTAGAA 780
TGTGGAGAGT GGCTATGTAA GACATGTATC GAAGCACATC AAAGAGTAAA ATTTACTAAA 840
GATCACTTGA TCAGGAAGAA AGAAGATGTC TCAGAGTCTG TTGGAGCATC TGGTCAACGC 900
CCTGTTTTCT GCCCTGTACA CAAACAAGAA CAGTTGAAAC TTTTCTGTGA AACATGTGAT 960
AGATTGACAT GTAGAGACTG TCAGCTATTG GAACACAAAG AACATAGGTA TCAGTTTTTG 1020
GAAGAAGCTT TTCAAAATCA GAAGGGTGCA ATTGAGAATC TACTGGCGAA ACTTCTTGAG 1080
AAGAAGAATT ATGTTCATTT TGCAGCTACT CAGGTGCAGA ATAGGATAAA AGAAGTAAAT 1140
GAGACTAACA AACGAGTAGA ACAGGAAATT AAAGTGGCCA TTTTCACCCT TATCAATGAA 1200
ATTAATAAGA AAGGAAAATC TCTCTTACAA CAGCTAGAGA ATGTTACAAA GGAAAGACAG 1260
ATGAAGTTAC TACAGCAGCA GAATGACATC ACAGGCCTTT CCCGGCAGGT GAAGCATGTT 1320
ATGAACTTCA CAAATTGGGC AATTGCAAGT GGCAGCAGCA CAGCACTACT ATACAGCAAG 1380
CGACTGATTA CTTTCCAGTT GCGTCATATT TTGAAAGCAC GGTGTGATCC TGTCCCTGCT 1440
GCTAATGGAG CAATACGTTT CCATTGTGAT CCCACCTTCT GGGCAAAGAA TGTAGTCAAT 1500
TTAGGTAATC TAGTAATAGA GAGTAAACCA GCTCCTGGTT ATACTCCTAA TGTTGTAGTT 1560
GGGCAAGTTC CTCCAGGGAC AAACCACATT AGTAAAACCC CTGGACAGAT TAACTTAGCA 1620
CAGCTTCGAC TCCAGCACAT GCAACAACAA GTATATGCAC AGAAACATCA GCAGTTGCAA 1680
CAGATGAGGA TGCAGCAACC ACCAGCACCT GTACCAACTA CAACAACAAC AACACAACAG 1740
CATCCTAGAC AAGCAGCCCC TCAGATGTTA CAACAACAGC CTCCTCGATT GATCAGTGTG 1800
CAAACAATGC AAAGAGGCAA CATGAACTGT GGAGCTTTTC AAGCCCATCA GATGAGACTG 1860
GCTCAGAATG CTGCCAGAAT ACCAGGGATA CCCAGGCACA GCGGCCCTCA ATATTCCATG 1920
ATGCAGCCAC ACCTCCAAAG ACAACACTCA AACCCAGGGC ATGCTGGACC CTTTCCCGTA 1980
GTATCGGTAC ACAACACCAC AATCAACCCA ACGAGCCCTA CTACAGCAAC TATGGCAAAT 2040
GCAAACCGAG GTCCCACCAG CCCATCTGTT ACAGCAATAG AGCTAATCCC CTCAGTTACC 2100
AATCCAGAAA ACCTTCCATC GCTGCCAGAT ATTCCACCCA TACAGTTGGA AGATGCTGGC 2160
TCAAGTAGTT TAGATAATCT ACTAAGTAGA TACATCTCAG GCAGTCACCT ACCCCCACAG 2220
CCTACAAGCA CCATGAATCC TTCTCCAGGT CCCTCTGCCC TTTCTCCGGG ATCATCAGGT 2280
TTATCCAATT CTCACACACC TGTGAGACCC CCAAGTACTT CTAGTACTGG CAGTCGAGGC 2340
AGCTGTGGGT CATCAGGAAG AACTGCTGAG AAGACAAGTC TTAGTTTCAA ATCTGATCAG 2400
GTGAAGGTCA AGCAAGAACC TGGGACTGAA GATGAAATAT GTAGCTTTTC AGGAGGTGTA 2460
AAACAAGAAA AAACAGAGGA TGGCAGGAGG AGTGCTTGCA TGTTGAGCAG TCCTGAGAGT 2520
AGCTTGACAC CACCTCTCTC AACCAACCTG CATCTAGAAA GTGAATTGGA TGCATTGGCA 2580
AGCCTGGAAA ACCATGTGAA AATTGAACCT GCAGATATGA ATGAAAGCTG CAAACAGTCA 2640
GGGCTCAGCA GCCTTGTTAA TGGAAAGTCC CCAATTCGAA GCCTCATGCA CAGGTCGGCA 2700
AGGATTGGAG GAGATGGCAA CAATAAAGAT GATGACCCAA ATGAAGACTG GTGTGCTGTC 2760
TGCCAAAACG GAGGAGATCT CTTGTGCTGC GAAAAATGTC CAAAGGTCTT TCATCTAACT 2820
TGTCATGTTC CAACACTACT TAGCTTTCCA AGTGGGGACT GGATATGCAC ATTTTGTAGA 2880
GATATTGGAA AGCCAGAAGT TGAATATGAT TGTGATAATT TGCAACATAG TAAGAAGGGG 2940
AAAACTGCGC AGGGGTTAAG CCCCGTGGAC CAAAGGAAAT GTGAACGTCT TCTGCTTTAC 3000
CTCTATTGCC ATGAATTAAG TATTGAATTC CAGGAGCCTG TTCCTGCTTC GATACCAAAC 3060
TACTATAAAA TTATAAAGAA ACCAATGGAT TTATCCACCG TGAAAAAGAA GCTTCAGAAA 3120
AAACATTCCC AACACTACCA AATCCCGGAT GACTTTGTGG CCGATGTCCG TTTGATCTTC 3180
AAGAACTGTG AAAGGTTTAA TGAAATGATG AAAGTTGTTC AAGTTTATGC AGACACACAA 3240
GAGATTAATT TGAAGGCTGA TTCAGAAGTA GCTCAGGCAG GGAAAGCAGT TGCATTGTAC 3300
TTTGAAGATA AACTCACAGA GATCTACTCA GACAGGACCT TCGCACCTTT GCCAGAGTTT 3360
GAGCAGGAAG AGGATGATGG TGAGGTAACT GAGGACTCTG ATGAAGACTT TATACAGCCC 3420
CGCAGAAAAC GCCTAAAGTC AGATGAGAGA CCAGTACATA TAAAGTAAAA TGACATGGAT 3480
TTAAATCAAT TGTTTAAAAA AAAAAAAACG AAAAAAAAAA AAAAAACACA AAAAACCCAG 3540
AAAACTTTTA AGTGTTGCTG GAATATCCTG CCTACAGTGG GCACCTCCTT GAAGAAGCTG 3600
ATAGCTTTTA CACAGTATTA GATTGAAATA ATGGACAGAA ACACATTCTT GTCAAGAAAG 3660
GGGGAGAGAA GTCTGTTTGC AAGTTTCAAA GCAAAAAGCA AAAGTGAAAT GATTTGAGGA 3720
TTTCTGTTCT AATGGAGATG ATTCTCTGAT TGTTAGAAAT GGCAAATATT GATGATTGTG 3780
TGCTATTGAT TGGTGCAGGA TACTTGGTAT ACGAGTAAAT ACTTGAGACT CGTGTCACTT 3840
GATAAATTTT CTTTTTGGAC TAGGTCGCAC AGTTATTAAA ACAACTTTTA ACCCTCCCCC 3900
TTCACACACA TACATATCAG GTTGTTTTCT AGTTAAAAAC CCAAGTAGCT CAGATTCTAC 3960
TTTAATGTCA GTGCAGATTT GCATTGAATC ATGCCATTAT GTTTTTTCTC ATTTTTATGC 4020
TGTTGGGTCT TAGTTTTTAA ATTGATATAA AGAACTCAGC AATGGTTTTA TTTTCTACTC 4080
ATACTTAGGG TTTAGGAAAC ACTACCACTA GTTATCATTT AATCAACTTC AATGGTCTAC 4140
TGAAACAAAA ATGGTAACTT TTCATTAGTG GATTATTTAG AGTTATAGTA GTTGTTTCCA 4200
GAAAACACTT CCTCACAATT GTACTTCCCA ATCAAATCAT GTGATCATAC AGTTATTCCC 4260
ATGAAAGGCA GAATGTTTGT TTCAAAATTA ATCTAGTTTT CTGTACATTT AAATTTGAGA 4320
AGGTGACAAC TGGCTCTTTT CCAGTCTTCC TTCATGTCAG TTTTCTGATA GACCACTATT 4380
GGCAAACAGT ATCTGTCAAC TACCAAATGT GTAAAATTTT CTGTATTTCA CTTTGTCTTA 4440
TTTGTAAATA GTGAACTAAA ACTTTTGGCA GATCAGCAAC ATTTGCTGAG CCTGTTTTTT 4500
AAGCTAATGT GTATTCTTAC TAATGTTCCT ATCAAGAATG GATTTGTAAT ATATGCTGTC 4560
TATTTCTAAT GTTCACATTC ATATTTTGAG GTTCTATCTT ATTTTAATAG AGAACAGACT 4620
TCTCAAAAAA TCTTCAGAAG CAGCTTATTA TTGAAATATC GAAATATTGA AATAAACCCG 4680
GTGGGGTTAG ATTACTCATC TGTCCACCAA GTGGGACATT TGCATGGACT GGGGGCTTAA 4740
AGGACTTAGA AGAGACCTGT AAGTAAATCC TGAAAATGAG CCAATCCCCA CTTGAATGGT 4800
TACTGGAGTA AACCCACCTT TACCACCCCA ATTACAGCAC CCGAGGCCGA TAAACCAACT 4860
TGGCTCTGGT TCATTTTTCT TTTCTTCATT TGTGATGCTC AGATTCAAAA TGTGTGTTCT 4920
ACACTGTTAC AGGCTTCTCT TTTGTTTGAT TAAAGATTTT AGTCCTACTT TTGTATGGAC 4980
ACATTAGAAT ATTCAGAGAC CAAAATAGAA GAATTTGCTG TTAGATATTT TTCAGAAGTC 5040
AGCAGATTTG TGGCAAATCA TTTATTTGCC TTTTTAAAAA TTCATTTAAG CAGTTCAGAG 5100
AGTAGACTAC TCAGAAAATT ATTTCACGTA ATTGTCTAAG AGGTCAATAT TTTTTAATGC 5160
ATATTGAATC AAATAAAGTG CTCTAAAGAA ATTATTATAC AAATTCCTTT GGGTTGTTTT 5220
TCTTTTCTTA ACAAGGGGTG GGGGTAAACA GGAATATGAT TCAGGCTTTC TGGTTGTGTA 5280
TTTAAAGAGT ATTGATTTTA TTATTACTAT TGATTTACTT TATTCCTGGC TTCCTTTTCA 5340
CTTTTCTTTC AATTTTTAAA AAATAATTTA AGCCGTTGAA AATATACCAA ACTGTTGAAA 5400
CATTTTACTC AAATTTTAAA TTCCTAAAAA TGTTTTTTAA TAAGAGGGAG AAAATTATTT 5460
AAAAATACTT ATGCCTATGC CAATTTCCCT CTTTTTTCAC AAAATCCATG ATTTCAGTTT 5520
GTAAGTAGAC ATATATCTAA GGGCACATTT TTGGAAAGTG AGGAATAGCA GCAGTATAAC 5580
TTCATTTTGT CAGGCCTTTG AGTTCTAATA TTTTGTATTG CTCTTCAAAT GGATCCTTTT 5640
AAAAAAATTG TAGATAATGA GTCATAAATA GATTCTGCCA ACTGAGGGGA GAAACATTTT 5700
AAGTAAATAT TTTTCAGTAT TTGGGGCCTT AAAAAATAAT TGTGTTTCCT TAAAATTACA 5760
TGTTAGATAG AGTTTTTAGG TTTTTTTGGT TTTAAGATTG GTTAAAGCAA TTTAAAAGCC 5820
ACTTTTTTGT CAACATTTAA TAGCCTCCAC TTCTGTTAAG ATAATGTATA CTGCTGAGGA 5880
ATTACTATTA ATAGCTATCA ACATACCACC ATTAAATTAA GGTATTCACT TTAGATTTTT 5940
TATTAAAGCT TTTTTCTTGC ACACTGATCG TTGTGTTTCT AAGCTGATTT TTTCAGCTCT 6000
AATATACCTA TGGTTAAAAA GTATAAAAAC TTAAATTGAT ATTTAGATAT ATGTTTTCCT 6060
ATTAGTTTAT GTTTTAAAAA GACAAAATTG TATCTGTCAG TCCCTGAAGG CAGTTTGTTT 6120
TTATACTCTC TCACATTTGT ATTTGTTTTT TAAATGGCAG TATTTTAGAA GATTTGGAGA 6180
AAAGTCCACA TAATAATGTT TTCTTAAAAG CTTTTAAAGT TTTTGCTGTA CTTCAATTTA 6240
CTTCTTCCAT CAGAAAACTA AGAACAAAGT GTTGCTCAGT CTGTTCCGCT GACCTAAATT 6300
TGTGTTTTCA GCACTTGGCT CAGCCAATTC ACTGAGTGAA GGAATTGCTT TATGAGGCAA 6360
AGCATGTGAA AGTTCTAAAG TATGGTTAGA TTGTAGGTCG TGCTCTATAT GGAAACATCA 6420
AACCATTACT ACAGAGAAAT GATAAGGCAT TGGATCCACT ATTGAAATTA TTATTTTTGG 6480
ATCAACAAGT TGGTACTTTC TGACTTCTGT ATCTTAACAT AAGGGAATTT TAGGTAATGC 6540
TAAGTCAGTT GTCTCATTTT TTGTGATAAG TTTTGGAATT TTTAGTTAAT TGAAATAAAT 6600
AATGCTTTTA AATAGAAGTA AAAGGTTTAT AAGTGTGCAA ATTGTAGATT TATCAATTAC 6660
CTCAGCAGGT ATCCTGCCAT GTAATTATTA GTGATTAGTG TTAATAAGAT AATAGATTCA 6720
GGTCTTCCAA CTATGCCCTT GGATTGTGGC CTACTGTATG TTATTAAATG GTCTCTTACT 6780
ATCCAAAATG GGAGTAGATG CTGTGGCCCC GTCTCCCTTG GCTTTTACGT CCCATATCCA 6840
CCCCCATTCA TGTACAACAT GTGAAATATA AAAATCTCAT TTCTTGTCAA AATCAGCACT 6900
GCTTATTTGC ATACTCAGCA TCGGATCAGT GAGTAGTTTT ATAAAAAATC CACGCACCCA 6960
ACTCCCTTAG TTAAAACAGA TTCTTAATTC ATACCATGAA TTCTTAATTT CTGTACCATC 7020
TATGTTAATG ATCTGCTGAA GGTGACTCAA GATTTTCAAG GTGTAATACA GTTTGATCAT 7080
GTACCGGACC TGGATATTTA ATTTTTTTTC CCTCACAGTT AATCTCCTCC TTGATAAAGC 7140
AATAACACTG CTTTGAGTCT GTTGCCTAAT AGCATGTCAG AATCCTCTCC TGGATGGTGA 7200
TTTTATAGGA AAGTTTGTAT GCATATCACC CAGTCTATCT TTTAAAAATT AAGAAATTTA 7260
AATGTATGCT GGAAGTAATG ACACTATATT GTGGCATTTT ATTTTAAAAA TTGGGGAAAG 7320
TTGCATATTT TTTTAAAAGT AAGTGTTTGA GTAAAAAAAT TGAAGGTACT TTTTTAAGGA 7380
AAAAAATTTA TATGCCACAG TTTACATAGA CATTTCAGAT TCAACACGTA CTCTTGAATA 7440
TAATGGTTTC TTTTACTTGG TCAAAATGCA TGTATAGCAT TTCTTTCATC TTAGTTCCTT 7500
GTGTTTGCCT ATGTGGTCCT TTATATATTT TTTATTGTAT CGAAGAAACA AAACTATCTT 7560
CAAAAATAAG TTAATTTGGA TATATTTGTC ATATCAAACT ACAAAGTGTA CAAAGTTAAG 7620
TTTAGCCCTT TTCTAGAAAG TGATCTTTAA AATTAAAAAT GCTCCTCTTT TAAATTCACC 7680
AAATTTATGT GTGGGAAGGC ACCAAAATGA TTTTGTAAGT GCCACTGCAA TATTCCCTTT 7740
CAAGTGTGGC CTAAATTTCA ATCTTAAGGA TGGAATGCAT GTCTGCTCCT TGTTCTGAAA 7800
AATGTAGGCA TCTACTACAT TTTAAAACAC AGTGAAACAT ATACATAAGC CTATAAAAAA 7860
AGATTTGTGC AATTTGAAAG CCTGTTAATT TTTTATGTAG ACATACCTAC ACACGAAAGG 7920
GTTAAATTCA CAGCCTTACT AGTTCCTTGC TTCCAGTATT TCAATTGGTC TCCTCCCCTC 7980
ATTATTATTA TTACTACTAG TACTATTATT TTTGCACATA GTTAACTGCC CTTCAATATG 8040
ATTCTTAAAA AGTGCTGTTT CTGTGGTATC GTATTCTCTA AATAATCATA TTTAATTTTT 8100
TAAAACAAGG TTGCAGTTTC TAATTGTTTC GTTCCTGTGT TTTTGCTGGT GTGTAATAAA 8160
AGCAAGTTTT TTCTTTTCAT GGTTATTTAA TACATTAGCT GCCTGTAAAT AATTCTTGTT 8220
ATAATGCTCT GGAATGTGTT GTAGAAGTTG TATTAGATTA GTTTTAAACC CTTGTTTGAA 8280
AGCCACATTG TTTTGGTTAT TTCTATTAAA TTAGAAAATT GAAAAAGTTT TCAAATGAA 8340
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0103--Bromodomain
KW-0160--Chromosomal rearrangement
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0436--Ligase
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR003649--Bbox_C
IPR001487--Bromodomain
IPR019786--Zinc_finger_PHD-type_CS
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50014--BROMODOMAIN_2
PS50119--ZF_BBOX
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00439--Bromodomain
PF00628--PHD
PF00643--zf-B_box
PF13445--zf-RING_UBOX
Gene Ontology

GO:0043231--C:intracellular membrane-bounded organelle
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0070410--F:co-SMAD binding
GO:0003677--F:DNA binding
GO:0016874--F:ligase activity
GO:0070412--F:R-SMAD binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0030514--P:negative regulation of BMP signaling pathway
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0016567--P:protein ubiquitination
GO:0017015--P:regulation of transforming growth factor beta receptor signaling pathway
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Pat-0010 ENSPTRP00000001947.2 Pan troglodytes 100 0.0 1724
WERAM-Chs-0018 ENSCSAP00000016377.1 Chlorocebus sabaeus 100 0.0 1722
WERAM-Poa-0007 ENSPPYP00000001169.2 Pongo abelii 100 0.0 1721
WERAM-Mam-0132 ENSMMUP00000019188.2 Macaca mulatta 100 0.0 1720
WERAM-Caj-0126 ENSCJAP00000022767.1 Callithrix jacchus 99 0.0 1717
WERAM-Nol-0047 ENSNLEP00000005733.1 Nomascus leucogenys 100 0.0 1715
WERAM-Paa-0113 ENSPANP00000006336.1 Papio anubis 97 0.0 1715
WERAM-Tut-0035 ENSTTRP00000002542.1 Tursiops truncatus 98 0.0 1710
WERAM-Ova-0213 ENSOARP00000021430.1 Ovis aries 98 0.0 1707
WERAM-Cap-0115 ENSCPOP00000009104.2 Cavia porcellus 98 0.0 1704
WERAM-Dan-0058 ENSDNOP00000005475.2 Dasypus novemcinctus 98 0.0 1704
WERAM-Mup-0062 ENSMPUP00000005374.1 Mustela putorius furo 99 0.0 1702
WERAM-Otg-0096 ENSOGAP00000008438.2 Otolemur garnettii 98 0.0 1694
WERAM-Aim-0012 ENSAMEP00000000723.1 Ailuropoda melanoleuca 98 0.0 1689
WERAM-Bot-0013 ENSBTAP00000001967.5 Bos taurus 98 0.0 1689
WERAM-Caf-0106 ENSCAFP00000013912.3 Canis familiaris 99 0.0 1688
WERAM-Eqc-0171 ENSECAP00000019025.1 Equus caballus 98 0.0 1687
WERAM-Mum-0130 ENSMUSP00000029444.6 Mus musculus 97 0.0 1683
WERAM-Mod-0002 ENSMODP00000000527.3 Monodelphis domestica 96 0.0 1677
WERAM-Ran-0121 ENSRNOP00000025600.5 Rattus norvegicus 96 0.0 1652
WERAM-Fia-0050 ENSFALP00000003601.1 Ficedula albicollis 91 0.0 1603
WERAM-Fec-0195 ENSFCAP00000022996.1 Felis catus 99 0.0 1596
WERAM-Loa-0024 ENSLAFP00000001389.3 Loxodonta africana 98 0.0 1588
WERAM-Myl-0151 ENSMLUP00000012441.2 Myotis lucifugus 98 0.0 1583
WERAM-Orc-0160 ENSOCUP00000014126.3 Oryctolagus cuniculus 96 0.0 1583
WERAM-Sah-0059 ENSSHAP00000006896.1 Sarcophilus harrisii 95 0.0 1560
WERAM-Gaga-0021 ENSGALP00000003066.4 Gallus gallus 91 0.0 1540
WERAM-Anp-0085 ENSAPLP00000010241.1 Anas platyrhynchos 91 0.0 1525
WERAM-Chh-0017 ENSCHOP00000001525.1 Choloepus hoffmanni 95 0.0 1524
WERAM-Ptv-0083 ENSPVAP00000007765.1 Pteropus vampyrus 94 0.0 1507
WERAM-Anc-0023 ENSACAP00000002604.2 Anolis carolinensis 90 0.0 1497
WERAM-Xet-0134 ENSXETP00000046394.3 Xenopus tropicalis 85 0.0 1483
WERAM-Sus-0170 ENSSSCP00000021501.1 Sus scrofa 87 0.0 1432
WERAM-Ora-0046 ENSOANP00000007156.1 Ornithorhynchus anatinus 95 0.0 1412
WERAM-Pes-0015 ENSPSIP00000003979.1 Pelodiscus sinensis 91 0.0 1370
WERAM-Gog-0183 ENSGGOP00000016037.2 Gorilla gorilla 99 0.0 1338
WERAM-Lac-0178 ENSLACP00000020861.1 Latimeria chalumnae 82 0.0 1307
WERAM-Tag-0017 ENSTGUP00000001056.1 Taeniopygia guttata 76 0.0 1220
WERAM-Ocp-0060 ENSOPRP00000005161.1 Ochotona princeps 87 0.0 1198
WERAM-Vip-0008 ENSVPAP00000000669.1 Vicugna pacos 92 0.0 1077
WERAM-Tas-0025 ENSTSYP00000002916.1 Tarsius syrichta 99 0.0 1024
WERAM-Asm-0128 ENSAMXP00000012606.1 Astyanax mexicanus 60 0.0 983
WERAM-Xim-0152 ENSXMAP00000012685.1 Xiphophorus maculatus 55 0.0 977
WERAM-Ect-0052 ENSETEP00000005302.1 Echinops telfairi 96 0.0 844
WERAM-Leo-0095 ENSLOCP00000012853.1 Lepisosteus oculatus 76 0.0 837
WERAM-Ere-0055 ENSEEUP00000004806.1 Erinaceus europaeus 86 0.0 831
WERAM-Ict-0156 ENSSTOP00000017434.1 Ictidomys tridecemlineatus 98 0.0 694
WERAM-Tar-0093 ENSTRUP00000018722.1 Takifugu rubripes 59 0.0 682
WERAM-Gam-0174 ENSGMOP00000017205.1 Gadus morhua 63 0.0 675
WERAM-Dar-0038 ENSDARP00000025140.8 Danio rerio 73 5e-171 599
WERAM-Tub-0017 ENSTBEP00000001699.1 Tupaia belangeri 85 9e-168 588
WERAM-Orn-0109 ENSONIP00000011616.1 Oreochromis niloticus 70 1e-165 581
WERAM-Pof-0192 ENSPFOP00000016145.2 Poecilia formosa 69 2e-165 581
WERAM-Gaa-0050 ENSGACP00000006576.1 Gasterosteus aculeatus 71 2e-164 577
WERAM-Orla-0005 ENSORLP00000000400.1 Oryzias latipes 68 1e-159 561
WERAM-Meg-0058 ENSMGAP00000005321.2 Meleagris gallopavo 91 6e-149 526
WERAM-Mim-0057 ENSMICP00000005746.1 Microcebus murinus 100 1e-138 491
WERAM-Prc-0095 ENSPCAP00000008532.1 Procavia capensis 59 2e-119 427
WERAM-Ten-0081 ENSTNIP00000009576.1 Tetraodon nigroviridis 47 9e-99 359
WERAM-Soa-0121 ENSSARP00000011616.1 Sorex araneus 64 5e-94 343
WERAM-Dio-0037 ENSDORP00000004316.1 Dipodomys ordii 58 4e-80 297
WERAM-Mae-0121 ENSMEUP00000012357.1 Macropus eugenii 40 2e-65 248
WERAM-Drm-0020 FBpp0083320 Drosophila melanogaster 32 2e-49 195
WERAM-Cii-0027 ENSCINP00000010542.3 Ciona intestinalis 43 1e-39 163
Created Date 25-Jun-2016