WERAM Information

Tag Content
WERAM ID WERAM-Hos-0135
Ensembl Protein ID ENSP00000322716.6
Uniprot Accession Q49A26; GLYR1_HUMAN; B4DL47; C9JJ40; C9JJ60; Q5U632; Q6P1Q2; Q6V3W7; Q9BTI1; Q9BXK2
Genbank Protein ID NP_001295025.1; NP_115958.2; XP_011521019.1
Protein Name Putative oxidoreductase GLYR1
Genbank Nucleotide ID NM_001308096.1; NM_032569.3; XM_011522717.1
Gene Name N-PAC;GLYR1HIBDL;NP60
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000140632.16 ENST00000321919.13 ENSP00000322716.6
ENSG00000140632.16 ENST00000436648.9 ENSP00000390276.4
ENSG00000140632.16 ENST00000588297.5 ENSP00000467751.1
ENSG00000140632.16 ENST00000591451.5 ENSP00000468328.1
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader PWWP PWWP H3K36me3 K 20850016
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader PWWP 6.50e-19 70.1 9 65
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 May have oxidoreductase activity. Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6. Recruited on chromatin, recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3).
Domain Profile
  Me_Reader PWWP
           PWWP.txt  2 gdLVwaKlkgYpwWPalvisppleakklktqeaeenkylVlFFgnkherawvkrkklvpyse 63
                       gdLVw+Kl++Yp WP+++++pp++ kk+    + ++++ V+FFg ++++aw+k+++l+py+ 
  ENSP00000322716.6  9 GDLVWGKLGRYPPWPGKIVNPPKDLKKP----RGKKCFFVKFFG-TEDHAWIKVEQLKPYHA 65
                       9***************************....************.***************86 PP
Protein Sequence
(Fasta)		MAAVSLRLGD LVWGKLGRYP PWPGKIVNPP KDLKKPRGKK CFFVKFFGTE DHAWIKVEQL 60
KPYHAHKEEM IKINKGKRFQ QAVDAVEEFL RRAKGKDQTS SHNSSDDKNR RNSSEERSRP 120
NSGDEKRKLS LSEGKVKKNM GEGKKRVSSG SSERGSKSPL KRAQEQSPRK RGRPPKDEKD 180
LTIPESSTVK GMMAGPMAAF KWQPTASEPV KDADPHFHHF LLSQTEKPAV CYQAITKKLK 240
ICEEETGSTS IQAADSTAVN GSITPTDKKI GFLGLGLMGS GIVSNLLKMG HTVTVWNRTA 300
EKCDLFIQEG ARLGRTPAEV VSTCDITFAC VSDPKAAKDL VLGPSGVLQG IRPGKCYVDM 360
STVDADTVTE LAQVIVSRGG RFLEAPVSGN QQLSNDGMLV ILAAGDRGLY EDCSSCFQAM 420
GKTSFFLGEV GNAAKMMLIV NMVQGSFMAT IAEGLTLAQV TGQSQQTLLD ILNQGQLASI 480
FLDQKCQNIL QGNFKPDFYL KYIQKDLRLA IALGDAVNHP TPMAAAANEV YKRAKALDQS 540
DNDMSAVYRA YIH 553
Nucleotide Sequence
(Fasta)		GGCCCACTCC AATGGGCGGC GCCGGGGCGA CTTGCTGTTC CCGGCGGCCC GTGCGTCGGC 60
GGTGGTTGGG TGGTAAGATG GCGGCTGTGA GTCTGCGGCT CGGCGACTTG GTGTGGGGGA 120
AACTCGGCCG ATATCCTCCT TGGCCAGGAA AGATTGTTAA TCCACCAAAG GACTTGAAGA 180
AACCTCGCGG AAAGAAATGC TTCTTTGTGA AATTTTTTGG AACAGAAGAT CATGCCTGGA 240
TCAAAGTGGA ACAGCTGAAG CCATATCATG CTCATAAAGA GGAAATGATA AAAATTAACA 300
AGGGTAAACG ATTCCAGCAA GCGGTAGATG CTGTCGAAGA GTTCCTCAGG AGAGCCAAAG 360
GGAAAGACCA GACGTCATCC CACAATTCTT CTGATGACAA GAATCGACGT AATTCCAGTG 420
AGGAGAGAAG TAGGCCAAAC TCAGGTGATG AGAAGCGCAA ACTTAGCCTG TCTGAAGGGA 480
AGGTGAAGAA GAACATGGGA GAAGGAAAGA AGAGGGTGTC TTCAGGCTCT TCAGAGAGAG 540
GCTCCAAATC CCCTCTGAAA AGAGCCCAAG AGCAAAGTCC CCGGAAGCGG GGTCGGCCCC 600
CAAAGGATGA GAAGGATCTC ACCATCCCGG AGTCTAGTAC CGTGAAGGGG ATGATGGCCG 660
GACCGATGGC CGCGTTTAAA TGGCAGCCAA CCGCAAGCGA GCCTGTTAAA GATGCAGATC 720
CTCATTTCCA TCATTTCCTG CTAAGCCAAA CAGAGAAGCC AGCTGTCTGT TACCAGGCAA 780
TCACGAAGAA GTTGAAAATA TGTGAAGAGG AAACTGGCTC CACCTCCATC CAGGCAGCTG 840
ACAGCACAGC CGTGAATGGC AGCATCACAC CCACAGACAA AAAGATAGGA TTTTTGGGCC 900
TTGGTCTCAT GGGAAGTGGA ATCGTCTCCA ACTTGCTAAA AATGGGTCAC ACAGTGACTG 960
TCTGGAACCG CACTGCAGAG AAATGTGATT TGTTCATCCA GGAGGGGGCC CGTCTGGGAA 1020
GAACCCCCGC TGAAGTCGTC TCAACCTGCG ACATCACTTT CGCCTGCGTG TCGGATCCCA 1080
AGGCGGCCAA GGACCTGGTG CTGGGCCCCA GTGGTGTGCT GCAAGGGATC CGCCCTGGGA 1140
AGTGCTACGT GGACATGTCA ACAGTGGACG CTGACACCGT CACTGAGCTG GCCCAGGTGA 1200
TTGTGTCCAG GGGGGGGCGC TTTCTGGAAG CCCCCGTCTC AGGGAATCAG CAGCTGTCTA 1260
ATGACGGGAT GTTGGTGATC TTAGCGGCTG GAGACAGGGG CTTATATGAG GACTGCAGCA 1320
GCTGCTTCCA GGCGATGGGG AAGACCTCCT TCTTCCTAGG TGAAGTGGGC AATGCAGCCA 1380
AGATGATGCT GATCGTGAAC ATGGTCCAAG GGAGCTTCAT GGCCACTATT GCCGAGGGGC 1440
TGACCCTGGC CCAGGTGACA GGCCAGTCCC AGCAGACACT CTTGGACATC CTCAATCAGG 1500
GACAGTTGGC CAGCATCTTC CTGGACCAGA AGTGCCAAAA TATCCTGCAA GGAAACTTTA 1560
AGCCTGATTT CTACCTGAAA TACATTCAGA AGGATCTCCG CTTAGCCATT GCGCTGGGTG 1620
ATGCGGTCAA CCATCCGACT CCCATGGCAG CTGCAGCAAA TGAGGTGTAC AAAAGAGCCA 1680
AGGCGCTGGA CCAGTCTGAC AACGATATGT CCGCCGTGTA CCGAGCCTAC ATACACTAAG 1740
CTGTCGACAC CCCGCCCTCA CCCCTCCAAT CCCCCCTCTG ACCCCCTCTT CCTCACATGG 1800
GGTCGGGGGC CTGGGAGTTC ATTCTGGACC AGCCCACCTA TCTCCATTTC CTTTTATACA 1860
GACTTTGAGA CTTGCCATCA GCACAGCACA CAGCAGCACC CTTCCCCTGA GGCCGGTGGG 1920
GAGGGGACAA GTGTCAGCAG GATTGGCGTG TGGGAAAGCT CTTGAGCTGG GCACTGGCCC 1980
CCCGGACGAG GTGGCTGTGT GTTCACACAC ACACACACAC ACACACACAC ACACACACAC 2040
AGGCTCTCGC CCCAGGATAG AAGCTGCCCA GAAACTGCTG CCTGGCTTTT TTTCTTCCGA 2100
GCTTGTCTTA TCTCAAACCC CTTCCAGTCA AGGAACTAGA ATCAGCAACG AGAGTTGGAA 2160
GCCTTCCCAC AGCTTCCCCC AGAGCGAAGA GGCTGTAGTC ATGTCCCCAT CCCCCACTGG 2220
ATTCCCTACA AGGAGAGGCC TTGGGCCCAG ATGAGCCAGT ACAGACTCCA GACAGAGGGG 2280
CCCTTGGGGC CCTCCAACCT CAGGTGATGA GCTGAGAAAG ATGTTCACGT CTAAGCGTCC 2340
AGTGTGCACC CAGCGCTCCA TAGACGCCTT TGTGAACTGA AAAGAGACTG GCAGAGTCCC 2400
GAGAAGATGG GGCCCTGGCT TTCCAGGGAG TGCAGCAAGC AGCCGGCCTG CAGGTGAGCA 2460
TGGAGGCCCG GCCCTCACCG CCTCGAAGCC ATGCCCCAGA TGCCACTGCC ACAGCGGGCG 2520
CTCGCTCCTC CCTAGGCTGT TTTAGTATTT GGATTTGCAT TCCATCCCTT GGGAGGGAGT 2580
CCTCAGGGCC ACTAGTGATG AGCCAAGAGG AGTGGGGGTT GGGGGCGCTC CTTTCTGTTT 2640
CCGTTAGGCC ACAGACTCTT CACCTGGCTC TGAAGAGCCA CTCTTACCTC GGTCCCCTCC 2700
CAGTGGTCCC ACCTTCTCCA CCCTGCCCTG CCAAGTCCCC TGCATGCCCA CCGCTCTCCA 2760
TCCTCCCTCC TCTCCCTCTT CCTCCCGTGG AGACAGTATT TCTTTCTGTC TGTCCCTTTG 2820
GCCCAGACCC AGCCTGACCA ACGATGAGCA TTTCTTAGGC TCAGCTCTTG ATACGGAAAC 2880
GAGTGTCTTC ACTCCAGCCA GCATCATGGT CTTCGGTGCT TCCCGGGCCC GGGGTCTGTC 2940
GGGAGGGAAG AGAACTGGGC CTGACCTACC TGAACTGACT GGCCCTCCGA GGTGGGTCTG 3000
GGACATCCTA GAGGCCCTAC ATTTGTCCTT GGATAGGGGA CCGGGGGGGG CTTGGAATGT 3060
TGCAAAAAAA AAAGTTACCC AAGGGATGTC AGTTTTTTAT CCCTCTGCAT GGGTTGGATT 3120
TTCCAAAATC ATAATTTGCA GAAGGAAGGC CAGCATTTAC GATGCAATAT GTAATTATAT 3180
ATAGGGTGGC CACACTAGGG CGGGGTCCTT CCCCCCTCAC AGCTTTGGCC CCTTTCAGAG 3240
ATTAGAAACT GGGTTAGAGG ATTGCAGAAG ACGAGTGGGG GGAGGGCAGG GAAGATGCCT 3300
GTCGGGTTTT TAGCACAGTT CATTTCACTG GGATTTTGAA GCATTTCTGT CTGAACACAA 3360
AGCCTGTTCT AGTCCTGGCG GAACACACTG GGGGTGGGGG CGGGGGAAGA TGCGGTAATG 3420
AAACCGGTTA GTCAATTTTG TCTTAATATT GTTGACAATT CTGTAAAGTT CCTTTTTATG 3480
AATATTTCTG TTTAAGCTAT TTCACCTTTC TTTTGAAATC CTTCCCTTTT AAGGAGAAAA 3540
TGTGACACTT GTGAAAAAGC TTGTAAGAAA GCCCCTCCCT TTTTTCTTTA AACCTTTAAA 3600
TGACAAATCT AGGTAATTAA GGTTGTGAAT TTTTATTTTT GCTTTGTTTT TAATGAACAT 3660
TTGTCTTTCA GAATAGGATT GTGTGATAAT GTTTAAATGG CAAAAACAAA ACATGATTTT 3720
GTGCAATTAA CAAAGCTACT GCAAGAAAAA TAAAACACTT CTTGGTAACA CA 3773
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0520--NAD
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0832--Ubl conjugation
--
Interpro

IPR008927--6-PGluconate_DH_C-like
IPR013328--6PGD_dom_2
IPR006115--6PGDH_NADP-bd
IPR016040--NAD(P)-bd_dom
IPR029154--NADP-bd
IPR000313--PWWP_dom
PROSITE

PS50812--PWWP
Pfam

PF14833--NAD_binding_11
PF03446--NAD_binding_2
PF00855--PWWP
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005794--C:Golgi apparatus
GO:0005654--C:nucleoplasm
GO:0003677--F:DNA binding
GO:0035064--F:methylated histone binding
GO:0051287--F:NAD binding
GO:0004616--F:phosphogluconate dehydrogenase (decarboxylating) activity
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Gog-0180 ENSGGOP00000015862.2 Gorilla gorilla 100 0.0 1055
WERAM-Loa-0039 ENSLAFP00000002682.3 Loxodonta africana 99 0.0 1055
WERAM-Cap-0129 ENSCPOP00000010428.2 Cavia porcellus 99 0.0 1054
WERAM-Tut-0069 ENSTTRP00000005198.1 Tursiops truncatus 99 0.0 1053
WERAM-Nol-0106 ENSNLEP00000012138.1 Nomascus leucogenys 100 0.0 1053
WERAM-Orc-0107 ENSOCUP00000009038.2 Oryctolagus cuniculus 99 0.0 1052
WERAM-Mup-0170 ENSMPUP00000014774.1 Mustela putorius furo 99 0.0 1051
WERAM-Fec-0190 ENSFCAP00000020433.1 Felis catus 99 0.0 1051
WERAM-Chs-0106 ENSCSAP00000005198.1 Chlorocebus sabaeus 100 0.0 1050
WERAM-Caf-0198 ENSCAFP00000028259.3 Canis familiaris 99 0.0 1050
WERAM-Sus-0056 ENSSSCP00000008469.2 Sus scrofa 99 0.0 1050
WERAM-Myl-0146 ENSMLUP00000011845.2 Myotis lucifugus 99 0.0 1049
WERAM-Bot-0019 ENSBTAP00000002268.5 Bos taurus 98 0.0 1046
WERAM-Ran-0023 ENSRNOP00000004159.4 Rattus norvegicus 99 0.0 1046
WERAM-Aim-0024 ENSAMEP00000001782.1 Ailuropoda melanoleuca 99 0.0 1044
WERAM-Prc-0012 ENSPCAP00000000806.1 Procavia capensis 98 0.0 1043
WERAM-Paa-0088 ENSPANP00000013833.1 Papio anubis 99 0.0 1041
WERAM-Poa-0062 ENSPPYP00000007997.1 Pongo abelii 99 0.0 1040
WERAM-Mam-0078 ENSMMUP00000032666.1 Macaca mulatta 99 0.0 1033
WERAM-Dan-0170 ENSDNOP00000031463.1 Dasypus novemcinctus 95 0.0 1031
WERAM-Mum-0048 ENSMUSP00000023189.7 Mus musculus 97 0.0 1025
WERAM-Mod-0054 ENSMODP00000007612.2 Monodelphis domestica 93 0.0 1024
WERAM-Sah-0063 ENSSHAP00000007314.1 Sarcophilus harrisii 95 0.0 1023
WERAM-Fia-0072 ENSFALP00000005352.1 Ficedula albicollis 95 0.0 1016
WERAM-Gaga-0020 ENSGALP00000002822.4 Gallus gallus 95 0.0 1010
WERAM-Tag-0049 ENSTGUP00000003237.1 Taeniopygia guttata 94 0.0 1010
WERAM-Dio-0116 ENSDORP00000011264.1 Dipodomys ordii 98 0.0 996
WERAM-Anc-0063 ENSACAP00000006188.3 Anolis carolinensis 90 0.0 988
WERAM-Leo-0007 ENSLOCP00000001247.1 Lepisosteus oculatus 77 0.0 873
WERAM-Xim-0187 ENSXMAP00000015055.1 Xiphophorus maculatus 75 0.0 841
WERAM-Orn-0041 ENSONIP00000004324.1 Oreochromis niloticus 75 0.0 839
WERAM-Asm-0111 ENSAMXP00000010900.1 Astyanax mexicanus 75 0.0 839
WERAM-Gaa-0040 ENSGACP00000005850.1 Gasterosteus aculeatus 75 0.0 836
WERAM-Orla-0191 ENSORLP00000021806.1 Oryzias latipes 75 0.0 832
WERAM-Pof-0177 ENSPFOP00000023950.1 Poecilia formosa 75 0.0 829
WERAM-Tar-0139 ENSTRUP00000030305.1 Takifugu rubripes 75 0.0 827
WERAM-Pat-0059 ENSPTRP00000013200.4 Pan troglodytes 100 0.0 815
WERAM-Caj-0213 ENSCJAP00000037064.2 Callithrix jacchus 98 0.0 770
WERAM-Xet-0062 ENSXETP00000020070.2 Xenopus tropicalis 78 2e-179 626
WERAM-Dar-0203 ENSDARP00000137468.1 Danio rerio 87 7e-172 601
WERAM-Gam-0082 ENSGMOP00000008531.1 Gadus morhua 63 8e-101 365
WERAM-Cii-0024 ENSCINP00000009181.3 Ciona intestinalis 55 3e-92 336
WERAM-Drm-0081 FBpp0079520 Drosophila melanogaster 40 4e-67 253
WERAM-Cis-0031 ENSCSAVP00000006479.1 Ciona savignyi 42 2e-15 81.6
WERAM-Chg-0021 EAQ87835 Chaetomium globosum 26 3e-13 74.3
WERAM-Sei-0090 Si024584m Setaria italica 40 2e-10 65.1
WERAM-Orp-0052 OPUNC05G17170.1 Oryza punctata 35 9e-10 62.8
WERAM-Orgl-0056 OGLUM05G20570.1 Oryza glumaepatula 35 1e-09 62.8
WERAM-Orb-0054 OBART05G19470.1 Oryza barthii 35 1e-09 62.8
WERAM-Orr-0056 ORUFI05G20700.1 Oryza rufipogon 35 1e-09 62.4
WERAM-Orni-0052 ONIVA05G20360.1 Oryza nivara 35 1e-09 62.4
WERAM-Lep-0056 LPERR05G15370.1 Leersia perrieri 34 8e-08 56.2
WERAM-Ptv-0053 ENSPVAP00000005699.1 Pteropus vampyrus 34 9e-07 52.8
WERAM-Vip-0117 ENSVPAP00000010795.1 Vicugna pacos 34 1e-06 52.4
WERAM-Ova-0008 ENSOARP00000001509.1 Ovis aries 34 1e-06 52.4
WERAM-Pes-0059 ENSPSIP00000007870.1 Pelodiscus sinensis 35 2e-06 52.0
WERAM-Lac-0169 ENSLACP00000019994.1 Latimeria chalumnae 35 2e-06 51.6
WERAM-Orbr-0103 OB09G11020.1 Oryza brachyantha 36 2e-06 51.6
WERAM-Anp-0119 ENSAPLP00000013578.1 Anas platyrhynchos 34 2e-06 51.2
WERAM-Ocp-0003 ENSOPRP00000000331.2 Ochotona princeps 33 3e-06 51.2
WERAM-Eqc-0202 ENSECAP00000021664.1 Equus caballus 33 3e-06 51.2
WERAM-Ict-0015 ENSSTOP00000001032.2 Ictidomys tridecemlineatus 32 3e-06 50.8
WERAM-Ten-0211 ENSTNIP00000021181.1 Tetraodon nigroviridis 34 3e-06 50.8
WERAM-Tas-0004 ENSTSYP00000000493.1 Tarsius syrichta 33 3e-06 50.8
WERAM-Mae-0114 ENSMEUP00000010800.1 Macropus eugenii 33 4e-06 50.8
WERAM-Ora-0032 ENSOANP00000005155.1 Ornithorhynchus anatinus 33 4e-06 50.4
WERAM-Mua-0036 GSMUA_Achr1P18360_001 Musa acuminata 34 6e-06 50.1
WERAM-Otg-0202 ENSOGAP00000021038.1 Otolemur garnettii 37 8e-06 49.7
Created Date 25-Jun-2016