WERAM Information

Tag Content
WERAM ID WERAM-Hos-0025
Ensembl Protein ID ENSP00000264606.3
Uniprot Accession P56524; HDAC4_HUMAN; E9PGB9; F5GX36; Q86YH7; Q9UND6
Genbank Protein ID NP_006028.2
Protein Name Histone deacetylase 4
Genbank Nucleotide ID NM_006037.3
Gene Name HDAC4;KIAA0288
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000068024.16 ENST00000345617.7 ENSP00000264606.3
ENSG00000068024.16 ENST00000543185.5 ENSP00000440481.2
Details
Type Family Domain Substrates AA References (PMIDs)
HDAC Class-II Histone deacetylase H2A; H2B; H3; H4 K 18292778
Status Reviewed
Classification
Type Family E-value Score Start End
HDAC Class-II 2.90e-154 515.3 94 994
HDAC Class-I 9.40e-30 106.6 114 959
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
Domain Profile
  HDAC Class-II
        class-2.txt  10 mlkhqale.enkekhpEkpeRiqailsrlqeagllekleelkarkatkeelqlvHseehvelletaeklekeelesltvd 88 
                        + +h+ l+ +++++  E+ +  q++l + ++++lle+  +l+ r+ +++el++ H e+ +++l+++ek +++ ++s++v+
  ENSP00000264606.3  94 QRQHEQLSrQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLE-RHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVK 172
                        455555440445557889999999999999999999988886.66778899999*9999999999998888888775444 PP
        class-2.txt   2 aglvydekmlkhqaleenkekhpEkpeRiqailsrlqeagllekleelkarkatkeelqlvHseehvelletaeklekeeles......... 84 
                        +glvyd+ mlkhq++++++++hpE+++Riq+i+srlqe+gl++k+e++++rkat+eelq+vHse+h+ l++t+ +l++++l+s         
  ENSP00000264606.3 654 TGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTN-PLNRQKLDSkkllgslas 744
                        79***********************************************************************.****************** PP
        class-2.txt  85 .........ltvdsdsiylesksikaarlavGavlelvdkvlkgelkngfavvRPPGHHaeestamGFClfnnvavaakllqqklkvkkili 167
                                 ++vdsd+i++e++s+ aarlavG+v+elv+kv++gelkngfavvRPPGHHaeest+mGFC+fn+vavaakllqq+l+v+kili
  ENSP00000264606.3 745 vfvrlpcggVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILI 836
                        ******************************************************************************************** PP
        class-2.txt 168 vDwDvHhGnGtqeifykdpkvlylSlHRydkgsffpesgsgavdevgegkgegfnvNvawnggl...mgdaeylaafrevvlpiakeFkPdl 256
                        vDwDvHhGnGtq++fy+dp+vly+SlHRyd+g+ffp  gsga+devg+g+g+gfnvN+a++ggl   mgdaeylaafr+vv+pia+eF+Pd+
  ENSP00000264606.3 837 VDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFP--GSGAPDEVGTGPGVGFNVNMAFTGGLdppMGDAEYLAAFRTVVMPIASEFAPDV 926
                        ************************************..****************************************************** PP
        class-2.txt 257 vlvsaGfDaaeg..dplgglsvtakcyatltkqllklaggrvvlvlEGGynlkaiaeaveavvkaLlg 322
                        vlvs+GfDa+eg  +plgg++++a+c+++ltkql++laggr+vl+lEGG++l+ai++a+ea+v+aLlg
  ENSP00000264606.3 927 VLVSSGFDAVEGhpTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLG 994
                        ************9*****************************************************96 PP
  HDAC Class-I
        class-1.txt  29 ltheLvlnyglskkleivk..pkkasaeellkfhseeyieflkkvepenae.....elskelkkfnvg 89 
                          +e++   + ++ le  +   ++ + +el k h+e+ ++ lk+ e+ +++     e++ +l++f ++
  ENSP00000264606.3 114 QQQEMLAMKHQQELLEHQRklERHRQEQELEKQHREQKLQQLKNKEKGKESavastEVKMKLQEFVLN 181
                        33332222222222222220134556789999999999999999988877733333333455666555 PP
        class-1.txt  18 qkhpmkpkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyi.....eflkkvepenae...elskelkkf...nvgedc.Pvfdg 97 
                        ++hp    r++ + + + + gl  k e ++ +ka+ eel+++hse++      + l++ + ++++   +l++ + +    +vg d+  + ++
  ENSP00000264606.3 673 SSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTllygtNPLNRQKLDSKKllgSLASVFVRLpcgGVGVDSdTIWNE 764
                        56666777777777777777777777777777777777777777655311111334444444444444222222222111444454134555 PP
        class-1.txt  98 lfey..cqlitGasleaakkLnkkead..iainwaGGlhhakkseasGfcyvnDivlailellk..khkrvlyididlhhGDgveeafyttd 183
                        +++   ++l  G  +e + k+ ++e +   a+      hha  s   Gfcy n + +a   l++  + +++l +d d+hhG+g ++afy   
  ENSP00000264606.3 765 VHSAgaARLAVGCVVELVFKVATGELKngFAVVRPP-GHHAEESTPMGFCYFNSVAVAAKLLQQrlSVSKILIVDWDVHHGNGTQQAFYSDP 855
                        554311456667777777777776655114444444.4*****************99987776645789*********************** PP
        class-1.txt 184 rvmtvsfhkyge.effPgtGdlsdvgaekgkyyavnvPlkdgid....DesyekifksviskvieafePeavvlqcGaDslagD..rlgefn 268
                         v+ +s+h+y++ +ffPg+G  ++vg++ g  + vn+ ++ g+d    D +y + f++v+ ++ + f P++v++  G D++ g   +lg +n
  ENSP00000264606.3 856 SVLYMSLHRYDDgNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDppmgDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHptPLGGYN 947
                        **********9746************************99998766669********************************9963369**** PP
        class-1.txt 269 lsikghaecvkf 280
                        ls + ++   k 
  ENSP00000264606.3 948 LSARCFGYLTKQ 959
                        **9998876655 PP
Protein Sequence
(Fasta)		MSSQSHPDGL SGRDQPVELL NPARVNHMPS TVDVATALPL QVAPSAVPMD LRLDHQFSLP 60
VAEPALREQQ LQQELLALKQ KQQIQRQILI AEFQRQHEQL SRQHEAQLHE HIKQQQEMLA 120
MKHQQELLEH QRKLERHRQE QELEKQHREQ KLQQLKNKEK GKESAVASTE VKMKLQEFVL 180
NKKKALAHRN LNHCISSDPR YWYGKTQHSS LDQSSPPQSG VSTSYNHPVL GMYDAKDDFP 240
LRKTASEPNL KLRSRLKQKV AERRSSPLLR RKDGPVVTAL KKRPLDVTDS ACSSAPGSGP 300
SSPNNSSGSV SAENGIAPAV PSIPAETSLA HRLVAREGSA APLPLYTSPS LPNITLGLPA 360
TGPSAGTAGQ QDAERLTLPA LQQRLSLFPG THLTPYLSTS PLERDGGAAH SPLLQHMVLL 420
EQPPAQAPLV TGLGALPLHA QSLVGADRVS PSIHKLRQHR PLGRTQSAPL PQNAQALQHL 480
VIQQQHQQFL EKHKQQFQQQ QLQMNKIIPK PSEPARQPES HPEETEEELR EHQALLDEPY 540
LDRLPGQKEA HAQAGVQVKQ EPIESDEEEA EPPREVEPGQ RQPSEQELLF RQQALLLEQQ 600
RIHQLRNYQA SMEAAGIPVS FGGHRPLSRA QSSPASATFP VSVQEPPTKP RFTTGLVYDT 660
LMLKHQCTCG SSSSHPEHAG RIQSIWSRLQ ETGLRGKCEC IRGRKATLEE LQTVHSEAHT 720
LLYGTNPLNR QKLDSKKLLG SLASVFVRLP CGGVGVDSDT IWNEVHSAGA ARLAVGCVVE 780
LVFKVATGEL KNGFAVVRPP GHHAEESTPM GFCYFNSVAV AAKLLQQRLS VSKILIVDWD 840
VHHGNGTQQA FYSDPSVLYM SLHRYDDGNF FPGSGAPDEV GTGPGVGFNV NMAFTGGLDP 900
PMGDAEYLAA FRTVVMPIAS EFAPDVVLVS SGFDAVEGHP TPLGGYNLSA RCFGYLTKQL 960
MGLAGGRIVL ALEGGHDLTA ICDASEACVS ALLGNELDPL PEKVLQQRPN ANAVRSMEKV 1020
MEIHSKYWRC LQRTTSTAGR SLIEAQTCEN EEAETVTAMA SLSVGVKPAE KRPDEEPMEE 1080
EPPL 1084
Nucleotide Sequence
(Fasta)		GGAGGTTGTG GGGCCGCCGC CGCGGAGCAC CGTCCCCGCC GCCGCCCGAG CCCGAGCCCG 60
AGCCCGCGCA CCCGCCCGCG CCGCCGCCGC CGCCGCCCGA ACAGCCTCCC AGCCTGGGCC 120
CCCGGCGGCG CCGTGGCCGC GTCCCGGCTG TCGCCGCCCG AGCCCGAGCC CGCGCGCCGG 180
CGGGTGGCGG CGCAGGCTGA GGAGATGCGG CGCGGAGCGC CGGAGCAGGG CTAGAGCCGG 240
CCGCCGCCGC CCGCCGCGGT AAGCGCAGCC CCGGCCCGGC GCCCGCGGGC CATTGTCCGC 300
CGCCCGCCCC GCGCCCCGCG CAGCCTGCAG GCCTTGGAGC CCGCGGCAGG TGGACGCCGC 360
CGGTCCACAC CCGCCCCGCG CGCGGCCGTG GGAGGCGGGG GCCAGCGCTG GCCGCGCGCC 420
GTGGGACCCG CCGGTCCCCA GGGCCGCCCG GCCCCTTCTG GACCTTTCCA CCCGCGCCGC 480
GAGGCGGCTT CGCCCGCCGG GGCGGGGGCG CGGGGGTGGG CACGGCAGGC AGCGGCGCCG 540
TCTCCCGGTG CGGGGCCCGC GCCCCCCGAG CAGGTTCATC TGCAGAAGCC AGCGGACGCC 600
TCTGTTCAAC TTGTGGGTTA CCTGGCTCAT GAGACCTTGC CGGCGAGGCT CGGCGCTTGA 660
ACGTCTGTGA CCCAGCCCTC ACCGTCCCGG TACTTGTATG TGTTGGTGGG AGTTTGGAGC 720
TCGTTGGAGC TATCGTTTCC GTGGAAATTT TGAGCCATTT CGAATCACTT AAAGGAGTGG 780
ACATTGCTAG CAATGAGCTC CCAAAGCCAT CCAGATGGAC TTTCTGGCCG AGACCAGCCA 840
GTGGAGCTGC TGAATCCTGC CCGCGTGAAC CACATGCCCA GCACGGTGGA TGTGGCCACG 900
GCGCTGCCTC TGCAAGTGGC CCCCTCGGCA GTGCCCATGG ACCTGCGCCT GGACCACCAG 960
TTCTCACTGC CTGTGGCAGA GCCGGCCCTG CGGGAGCAGC AGCTGCAGCA GGAGCTCCTG 1020
GCGCTCAAGC AGAAGCAGCA GATCCAGAGG CAGATCCTCA TCGCTGAGTT CCAGAGGCAG 1080
CACGAGCAGC TCTCCCGGCA GCACGAGGCG CAGCTCCACG AGCACATCAA GCAACAACAG 1140
GAGATGCTGG CCATGAAGCA CCAGCAGGAG CTGCTGGAAC ACCAGCGGAA GCTGGAGAGG 1200
CACCGCCAGG AGCAGGAGCT GGAGAAGCAG CACCGGGAGC AGAAGCTGCA GCAGCTCAAG 1260
AACAAGGAGA AGGGCAAAGA GAGTGCCGTG GCCAGCACAG AAGTGAAGAT GAAGTTACAA 1320
GAATTTGTCC TCAATAAAAA GAAGGCGCTG GCCCACCGGA ATCTGAACCA CTGCATTTCC 1380
AGCGACCCTC GCTACTGGTA CGGGAAAACG CAGCACAGTT CCCTTGACCA GAGTTCTCCA 1440
CCCCAGAGCG GAGTGTCGAC CTCCTATAAC CACCCGGTCC TGGGAATGTA CGACGCCAAA 1500
GATGACTTCC CTCTTAGGAA AACAGCTTCT GAACCGAATC TGAAATTACG GTCCAGGCTA 1560
AAGCAGAAAG TGGCCGAAAG ACGGAGCAGC CCCCTGTTAC GCAGGAAAGA CGGGCCAGTG 1620
GTCACTGCTC TAAAAAAGCG TCCGTTGGAT GTCACAGACT CCGCGTGCAG CAGCGCCCCA 1680
GGCTCCGGAC CCAGCTCACC CAACAACAGC TCCGGGAGCG TCAGCGCGGA GAACGGTATC 1740
GCGCCCGCCG TCCCCAGCAT CCCGGCGGAG ACGAGTTTGG CGCACAGACT TGTGGCACGA 1800
GAAGGCTCGG CCGCTCCACT TCCCCTCTAC ACATCGCCAT CCTTGCCCAA CATCACGCTG 1860
GGCCTGCCTG CCACCGGCCC CTCTGCGGGC ACGGCGGGCC AGCAGGACGC CGAGAGACTC 1920
ACCCTTCCCG CCCTCCAGCA GAGGCTCTCC CTTTTCCCCG GCACCCACCT CACTCCCTAC 1980
CTGAGCACCT CGCCCTTGGA GCGGGACGGA GGGGCAGCGC ACAGCCCTCT TCTGCAGCAC 2040
ATGGTCTTAC TGGAGCAGCC GCCGGCACAA GCACCCCTCG TCACAGGCCT GGGAGCACTG 2100
CCCCTCCACG CACAGTCCTT GGTTGGTGCA GACCGGGTGT CCCCCTCCAT CCACAAGCTG 2160
CGGCAGCACC GCCCACTGGG GCGGACCCAG TCGGCCCCGC TGCCCCAGAA CGCCCAGGCT 2220
CTGCAGCACC TGGTCATCCA GCAGCAGCAT CAGCAGTTTC TGGAGAAACA CAAGCAGCAG 2280
TTCCAGCAGC AGCAACTGCA GATGAACAAG ATCATCCCCA AGCCAAGCGA GCCAGCCCGG 2340
CAGCCGGAGA GCCACCCGGA GGAGACGGAG GAGGAGCTCC GTGAGCACCA GGCTCTGCTG 2400
GACGAGCCCT ACCTGGACCG GCTGCCGGGG CAGAAGGAGG CGCACGCACA GGCCGGCGTG 2460
CAGGTGAAGC AGGAGCCCAT TGAGAGCGAT GAGGAAGAGG CAGAGCCCCC ACGGGAGGTG 2520
GAGCCGGGCC AGCGCCAGCC CAGTGAGCAG GAGCTGCTCT TCAGACAGCA AGCCCTCCTG 2580
CTGGAGCAGC AGCGGATCCA CCAGCTGAGG AACTACCAGG CGTCCATGGA GGCCGCCGGC 2640
ATCCCCGTGT CCTTCGGCGG CCACAGGCCT CTGTCCCGGG CGCAGTCCTC ACCCGCGTCT 2700
GCCACCTTCC CCGTGTCTGT GCAGGAGCCC CCCACCAAGC CGAGGTTCAC GACAGGCCTC 2760
GTGTATGACA CGCTGATGCT GAAGCACCAG TGCACCTGCG GGAGTAGCAG CAGCCACCCC 2820
GAGCACGCCG GGAGGATCCA GAGCATCTGG TCCCGCCTGC AGGAGACGGG CCTCCGGGGC 2880
AAATGCGAGT GCATCCGCGG ACGCAAGGCC ACCCTGGAGG AGCTACAGAC GGTGCACTCG 2940
GAAGCCCACA CCCTCCTGTA TGGCACGAAC CCCCTCAACC GGCAGAAACT GGACAGTAAG 3000
AAACTTCTAG GCTCGCTCGC CTCCGTGTTC GTCCGGCTCC CTTGCGGTGG TGTTGGGGTG 3060
GACAGTGACA CCATATGGAA CGAGGTGCAC TCGGCGGGGG CAGCCCGCCT GGCTGTGGGC 3120
TGCGTGGTAG AGCTGGTCTT CAAGGTGGCC ACAGGGGAGC TGAAGAATGG CTTTGCTGTG 3180
GTCCGCCCCC CTGGACACCA TGCGGAGGAG AGCACGCCCA TGGGCTTTTG CTACTTCAAC 3240
TCCGTGGCCG TGGCAGCCAA GCTTCTGCAG CAGAGGTTGA GCGTGAGCAA GATCCTCATC 3300
GTGGACTGGG ACGTGCACCA TGGAAACGGG ACCCAGCAGG CTTTCTACAG CGACCCCAGC 3360
GTCCTGTACA TGTCCCTCCA CCGCTACGAC GATGGGAACT TCTTCCCAGG CAGCGGGGCT 3420
CCTGATGAGG TGGGCACAGG GCCCGGCGTG GGTTTCAACG TCAACATGGC TTTCACCGGC 3480
GGCCTGGACC CCCCCATGGG AGACGCTGAG TACTTGGCGG CCTTCAGAAC GGTGGTCATG 3540
CCGATCGCCA GCGAGTTTGC CCCGGATGTG GTGCTGGTGT CATCAGGCTT CGATGCCGTG 3600
GAGGGCCACC CCACCCCTCT TGGGGGCTAC AACCTCTCCG CCAGATGCTT CGGGTACCTG 3660
ACGAAGCAGC TGATGGGCCT GGCTGGCGGC CGGATTGTCC TGGCCCTCGA GGGAGGCCAC 3720
GACCTGACCG CCATTTGCGA CGCCTCGGAA GCATGTGTTT CTGCCTTGCT GGGAAACGAG 3780
CTTGATCCTC TCCCAGAAAA GGTTTTACAG CAAAGACCCA ATGCAAACGC TGTCCGTTCC 3840
ATGGAGAAAG TCATGGAGAT CCACAGCAAG TACTGGCGCT GCCTGCAGCG CACAACCTCC 3900
ACAGCGGGGC GTTCTCTGAT CGAGGCTCAG ACTTGCGAGA ACGAAGAAGC CGAGACGGTC 3960
ACCGCCATGG CCTCGCTGTC CGTGGGCGTG AAGCCCGCCG AAAAGAGACC AGATGAGGAG 4020
CCCATGGAAG AGGAGCCGCC CCTGTAGCAC TCCCTCGAAG CTGCTGTTCT CTTGTCTGTC 4080
TGTCTCTGTC TTGAAGCTCA GCCAAGAAAC TTTCCCGTGT CACGCCTGCG TCCCACCGTG 4140
GGGCTCTCTT GGAGCACCCA GGGACACCCA GCGTGCAACA GCCACGGGAA GCCTTTCTGC 4200
CGCCCAGGCC CACAGGTCTC GAGACGCACA TGCACGCCTG GGCGTGGCAG CCTCACAGGG 4260
AACACGGGAC AGACGCCGGC GACGCGCAGA CACACGGACA CGCGGAAGCC AAGCACACTC 4320
TGGCGGGTCC CGCAAGGGAC GCCGTGGAAG AAAGGAGCCT GTGGCAACAG GCGGCCGAGC 4380
TGCCGAATTC AGTTGACACG AGGCACAGAA AACAAATATC AAAGATCTAA TAATACAAAA 4440
CAAACTTGAT TAAAACTGGT GCTTAAAGTT TATTACCCAC AACTCCACAG TCTCTGTGTA 4500
AACCACTCGA CTCATCTTGT AGCTTATTTT TTTTTAAAGA GGACGTTTTC TACGGCTGTG 4560
GCCCGCCTCT GTGAACCATA GCGGTGTGCG GCGGGGGGTC TGCACCCGGG TGGGGGACAG 4620
AGGGACCTTT AAAGAAAACA AAACTGGACA GAAACAGGAA TGTGAGCTGG GGGAGCTGGC 4680
TTGAGTTTCT CAAAAGCCAT CGGAAGATGC GAGTTTGTGC CTTTTTTTTT ATTGCTCTGG 4740
TGGATTTTTG TGGCTGGGTT TTCTGAAGTC TGAGGAACAA TGCCTTAAGA AAAAACAAAC 4800
AGCAGGAATC GGTGGGACAG TTTCCTGTGG CCAGCCGAGC CTGGCAGTGC TGGCACCGCG 4860
AGCTGGCCTG ACGCCTCAAG CACGGGCACC AGCCGTCATC TCCGGGGCCA GGGGCTGCAG 4920
CCCGGCGGTC CCTGTTTTGC TTTATTGCTG TTTAAGAAAA ATGGAGGTAG TTCCAAAAAA 4980
GTGGCAAATC CCGTTGGAGG TTTTGAAGTC CAACAAATTT TAAACGAATC CAAAGTGTTC 5040
TCACACGTCA CATACGATTG AGCATCTCCA TCTGGTCGTG AAGCATGTGG TAGGCACACT 5100
TGCAGTGTTA CGATCGGAAT GCTTTTTATT AAAAGCAAGT AGCATGAAGT ATTGCTTAAA 5160
TTTTAGGTAT AAATAAATAT ATATATGTAT AATATATATT CCAATGTATT CCAAGCTAAG 5220
AAACTTACTT GATTCTTATG AAATCTTGAT AAAATATTTA TAATGCATTT ATAGAAAAAG 5280
TATATATATA TATATAAAAT GAATGCAGAT TGCGAAGGTC CCTGCAAATG GATGGCTTGT 5340
GAATTTGCTC TCAAGGTGCT TATGGAAAGG GATCCTGATT GATTGAAATT CATGTTTTCT 5400
CAAGCTCCAG ATTGGCTAGA TTTCAGATCG CCAACACATT CGCCACTGGG CAACTACCCT 5460
ACAAGTTTGT ACTTTCATTT TAATTATTTT CTAACAGAAC CGCTCCCGTC TCCAAGCCTT 5520
CATGCACATA TGTACCTAAT GAGTTTTTAT AGCAAAGAAT ATAAATTTGC TGTTGATTTT 5580
TGTATGAATT TTTTCACAAA AAGATCCTGA ATAAGCATTG TTTTATGAAT TTTACATTTT 5640
TCCTCACCAT TTAGCAATTT TCTGAATGGT AATAATGTCT AAATCTTTTT CCTTTCTGAA 5700
TTCTTGCTTG TACATTTTTT TTTACCTTTC AAAGGTTTTT AATTATTTTT GTTTTTATTT 5760
TTGTACGATG AGTTTTCTGC AGCGTACAGA ATTGTTGCTG TCAGATTCTA TTTTCAGAAA 5820
GTGAGAGGAG GGACCGTAGG TCTTTTCGGA GTGACACCAA CGATTGTGTC TTTCCTGGTC 5880
TGTCCTAGGA GCTGTATAAA GAAGCCCAGG GGCTCTTTTT AACTTTCAAC ACTAGTAGTA 5940
TTACGAGGGG TGGTGTGTTT TTCCCCTCCG TGGCAAGGGC AGGGAGGGTT GCTTAGGATG 6000
CCCGGCCACC CTGGGAGGCT TGCCAGATGC CGGGGGCAGT CAGCATTAAT GAAACTCATG 6060
TTTAAACTTC TCTGACCACA TCGTCAGGAT AGAATTCTAA CTTGAGTTTT CCAAAGACCT 6120
TTTGAGCATG TCAGCAATGC ATGGGGCACA CGTGGGGCTC TTTACCCACT TGGGTTTTTC 6180
CACTGCAGCC ACGTGGCCAG CCCTGGATTT TGGAGCCTGT GGCTGCAAGG AACCCAGGGA 6240
CCCTTGTTGC CTGGTGAACC TGCAGGGAGG GTATGATTGC CTGACCAGGA CAGCCAGTCT 6300
TTACTCTTTT TCTCTTCAAC AGTAACTGAC AGTCACGTTT TACTGGTAAC TTATTTTCCA 6360
GCACATGAAG CCACCAGTTT CATTCCAAAG TGTATATTGG GTTCAGACTT GGGGGCAGAA 6420
GTTCAGACAC ACCGTGCTCA GGAGGGACCC AGAGCCGAGT TTCGGAGTTT GGTAAAGTTT 6480
ACAGGGTAGC TTCTGAAATT AACTCAAACT TTTGACCAAA TGAGTGCAGA TTCTTGGATT 6540
CACTTGGTCA CTGGGCTGCT GATGGTCAGC TCTGAGACAG TGGTTTGAGA GCAGGCAGAA 6600
CGGTCTTGGG ACTTGTTTGA CTTTCCCCTC CCTGGTGGCC ACTCTTTGCT CTGAAGCCCA 6660
GATTGGCAAG AGGAGCTGGT CCATTCCCCA TTCATGGCAC AGAGCAGTGG CAGGGCCCAG 6720
CTAGCAGGCT CTTCTGGCCT CCTTGGCCTC ATTCTCTGCA TAGCCCTCTG GGGATCCTGC 6780
CACCTGCCCT CTTACCCCGC CGTGGCTTAT GGGGAGGAAT GCATCATCTC ACTTTTTTTT 6840
TTTAAGCAGA TGATGGGATA ACATGGACTG CTCAGTGGCC AGGTTATCAG TGGGGGGACT 6900
TAATTCTAAT CTCATTCAAA TGGAGACGCC CTCTGCAAAG GCCTGGCAGG GGGAGGCACG 6960
TTTCATCTGT CAGCTCACTC CAGCTTCACA AATGTGCTGA GAGCATTACT GTGTAGCCTT 7020
TTCTTTGAAG ACACACTCGG CTCTTCTCCA CAGCAAGCGT CCAGGGCAGA TGGCAGAGGA 7080
TCTGCCTCGG CGTCTGCAGG CGGGACCACG TCAGGGAGGG TTCCTTCATG TGTTCTCCCT 7140
GTGGGTCCTT GGACCTTTAG CCTTTTTCTT CCTTTGCAAA GGCCTTGGGG GCACTGGCTG 7200
GGAGTCAGCA AGCGAGCACT TTATATCCCT TTGAGGGAAA CCCTGATGAC GCCACTGGGC 7260
CTCTTGGCGT CTGCCCTGCC CTCGCGGCTT CCCGCCGTGC CGCAGCGTGC CCACGTGCCC 7320
ACGCCCCACC AGCAGGCGGC TGTCCCGGAG GCCGTGGCCC GCTGGGACTG GCCGCCCCTC 7380
CCCAGCGTCC CAGGGCTCTG GTTCTGGAGG GCCACTTTGT CAAGGTGTTT CAGTTTTTCT 7440
TTACTTCTTT TGAAAATCTG TTTGCAAGGG GAAGGACCAT TTCGTAATGG TCTGACACAA 7500
AAGCAAGTTT GATTTTTGCA GCACTAGCAA TGGACTTTGT TGTTTTTCTT TTTGATCAGA 7560
ACATTCCTTC TTTACTGGTC ACAGCCACGT GCTCATTCCA TTCTTCTTTT TGTAGACTTT 7620
GGGCCCACGT GTTTTATGGG CATTGATACA TATATAAATA TATAGATATA AATATATATG 7680
AATATATTTT TTTAAGTTTC CTACACCTGG AGGTTGCATG GACTGTACGA CCGGCATGAC 7740
TTTATATTGT ATACAGATTT TGCACGCCAA ACTCGGCAGC TTTGGGGAAG AAGAAAAATG 7800
CCTTTCTGTT CCCCTCTCAT GACATTTGCA GATACAAAAG ATGGAAATTT TTCTGTAAAA 7860
CAAAACCTTG AAGGAGAGGA GGGCGGGGAA GTTTGCGTCT TATTGAACTT ATTCTTAAGA 7920
AATTGTACTT TTTATTGTAA GAAAAATAAA AAGGACTACT TAAACATTTG TCATATTAAG 7980
AAAAAAAGTT TATCTAGCAC TTGTGACATA CCAATAATAG AGTTTATTGT ATTTATGTGG 8040
AAACAGTGTT TTAGGGAAAC TACTCAGAAT TCACAGTGAA CTGCCTGTCT CTCTCGAGTT 8100
GATTTGGAGG AATTTTGTTT TGTTTTGTTT TGTTTGTTTC CTTTTATCTC CTTCCACGGG 8160
CCAGGCGAGC GCCGCCCGCC CTCACTGGCC TTGTGACGGT TTATTCTGAT TGAGAACTGG 8220
GCGGACTCGA AAGAGTCCCC TTTTCCGCAC AGCTGTGTTG ACTTTTTAAT TACTTTTAGG 8280
TGATGTATGG CTAAGATTTC ACTTTAAGCA GTCGTGAACT GTGCGAGCAC TGTGGTTTAC 8340
AATTATACTT TGCATCGAAA GGAAACCATT TCTTCATTGT AACGAAGCTG AGCGTGTTCT 8400
TAGCTCGGCC TCACTTTGTC TCTGGCATTG ATTAAAAGTC TGCTATTGAA AGAAAAAGAA 8460
AGCGAACAGT TTTTGTTTGT TTTTTTTGCC GTGTGTGCTC CATAGTGGAG GCGCTATTTT 8520
CCAATTGATG AGAATGACAA ACATATATAA TCTATCTATC TATCTATCTA TCTATCTATC 8580
TATACAGGGG GCTTGAACCT TACTCACCCA AGAGCTTCTT ACGGAATGTG GTAGAAAACC 8640
AAGTTGTAAC GACACTGTAA CCTACCTGAT GCCTGTTCGC GCCCGCCGTG AGCTGCGCAC 8700
TGGCCGTGGC CACCATTCAC CTCTGTAATT TAATCCGTTT CTCTTGGATT GTCTGGACGT 8760
GCCCGATGGT TCTTTCTTTT GCTCAGTGGA GTTGGAGGTT TTGTGTTTGG TTTTCTCATT 8820
CTTGTCTTGT TTTGTGTGGG TGGATTTTCA CCGACCAATG ATATCCTCTT CTGACGGTCA 8880
CCTTCTTTCC ACTTCACTGG AGTCCAGTAT TCTGTACCAC ATCACGCAAC GTGTTATCTT 8940
GTGGTGTAAA TAAAGACTGC GTTACTTGCC CTCCCA 8977
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-1268--Autism spectrum disorder
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-1017--Isopeptide bond
KW-0991--Mental retardation
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
--
Interpro

IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
IPR024643--Hist_deacetylase_Gln_rich_N
IPR017320--Histone_deAcase_II_euk
PROSITE
Pfam

PF12203--HDAC4_Gln
PF00850--Hist_deacetyl
Gene Ontology

GO:0031672--C:A band
GO:0042641--C:actomyosin
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0000118--C:histone deacetylase complex
GO:0031594--C:neuromuscular junction
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0017053--C:transcriptional repressor complex
GO:0030018--C:Z disc
GO:0033613--F:activating transcription factor binding
GO:0003682--F:chromatin binding
GO:0001047--F:core promoter binding
GO:0004407--F:histone deacetylase activity
GO:0042826--F:histone deacetylase binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0030955--F:potassium ion binding
GO:0033558--F:protein deacetylase activity
GO:0070491--F:repressing transcription factor binding
GO:0001025--F:RNA polymerase III transcription factor binding
GO:0003714--F:transcription corepressor activity
GO:0008134--F:transcription factor binding
GO:0008270--F:zinc ion binding
GO:0042113--P:B cell activation
GO:0030183--P:B cell differentiation
GO:0014898--P:cardiac muscle hypertrophy in response to stress
GO:0071260--P:cellular response to mechanical stimulus
GO:0071374--P:cellular response to parathyroid hormone stimulus
GO:0071356--P:cellular response to tumor necrosis factor
GO:0006338--P:chromatin remodeling
GO:0016575--P:histone deacetylation
GO:0070932--P:histone H3 deacetylation
GO:0070933--P:histone H4 deacetylation
GO:0006954--P:inflammatory response
GO:0008285--P:negative regulation of cell proliferation
GO:0045820--P:negative regulation of glycolytic process
GO:0010832--P:negative regulation of myotube differentiation
GO:0045668--P:negative regulation of osteoblast differentiation
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0007399--P:nervous system development
GO:0002076--P:osteoblast development
GO:0034983--P:peptidyl-lysine deacetylation
GO:0008284--P:positive regulation of cell proliferation
GO:0010592--P:positive regulation of lamellipodium assembly
GO:0043525--P:positive regulation of neuron apoptotic process
GO:0033235--P:positive regulation of protein sumoylation
GO:1903428--P:positive regulation of reactive oxygen species biosynthetic process
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0014911--P:positive regulation of smooth muscle cell migration
GO:0048661--P:positive regulation of smooth muscle cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0010882--P:regulation of cardiac muscle contraction by calcium ion signaling
GO:0040029--P:regulation of gene expression, epigenetic
GO:0043393--P:regulation of protein binding
GO:0048742--P:regulation of skeletal muscle fiber development
GO:0014894--P:response to denervation involved in regulation of muscle adaptation
GO:0042493--P:response to drug
GO:0070555--P:response to interleukin-1
GO:0001501--P:skeletal system development
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Pat-0104 ENSPTRP00000022412.3 Pan troglodytes 100 0.0 1883
WERAM-Chs-0068 ENSCSAP00000002314.1 Chlorocebus sabaeus 99 0.0 1862
WERAM-Mup-0001 ENSMPUP00000000123.1 Mustela putorius furo 93 0.0 1777
WERAM-Aim-0131 ENSAMEP00000011965.1 Ailuropoda melanoleuca 93 0.0 1777
WERAM-Poa-0116 ENSPPYP00000014905.2 Pongo abelii 96 0.0 1773
WERAM-Cap-0143 ENSCPOP00000011770.2 Cavia porcellus 93 0.0 1769
WERAM-Bot-0159 ENSBTAP00000023621.5 Bos taurus 93 0.0 1768
WERAM-Mam-0041 ENSMMUP00000007984.2 Macaca mulatta 95 0.0 1758
WERAM-Caf-0133 ENSCAFP00000018541.3 Canis familiaris 93 0.0 1742
WERAM-Ran-0135 ENSRNOP00000027622.5 Rattus norvegicus 94 0.0 1736
WERAM-Mum-0077 ENSMUSP00000008995.8 Mus musculus 94 0.0 1734
WERAM-Gog-0157 ENSGGOP00000013985.2 Gorilla gorilla 93 0.0 1729
WERAM-Myl-0159 ENSMLUP00000013297.2 Myotis lucifugus 94 0.0 1726
WERAM-Ict-0095 ENSSTOP00000009983.2 Ictidomys tridecemlineatus 94 0.0 1709
WERAM-Tag-0050 ENSTGUP00000003338.1 Taeniopygia guttata 90 0.0 1697
WERAM-Sus-0169 ENSSSCP00000025173.1 Sus scrofa 92 0.0 1694
WERAM-Fec-0140 ENSFCAP00000013207.3 Felis catus 94 0.0 1688
WERAM-Gaga-0049 ENSGALP00000033098.3 Gallus gallus 90 0.0 1667
WERAM-Ora-0108 ENSOANP00000020481.2 Ornithorhynchus anatinus 89 0.0 1666
WERAM-Pes-0174 ENSPSIP00000020522.1 Pelodiscus sinensis 89 0.0 1654
WERAM-Dan-0037 ENSDNOP00000003826.3 Dasypus novemcinctus 90 0.0 1644
WERAM-Anc-0099 ENSACAP00000009498.3 Anolis carolinensis 81 0.0 1610
WERAM-Lac-0062 ENSLACP00000008432.1 Latimeria chalumnae 84 0.0 1605
WERAM-Anp-0035 ENSAPLP00000004005.1 Anas platyrhynchos 88 0.0 1602
WERAM-Loa-0107 ENSLAFP00000009167.2 Loxodonta africana 86 0.0 1597
WERAM-Otg-0061 ENSOGAP00000004404.2 Otolemur garnettii 89 0.0 1582
WERAM-Fia-0056 ENSFALP00000004005.1 Ficedula albicollis 89 0.0 1547
WERAM-Dio-0038 ENSDORP00000004330.1 Dipodomys ordii 83 0.0 1506
WERAM-Xet-0035 ENSXETP00000010592.2 Xenopus tropicalis 80 0.0 1487
WERAM-Meg-0023 ENSMGAP00000001752.2 Meleagris gallopavo 90 0.0 1483
WERAM-Leo-0082 ENSLOCP00000011105.1 Lepisosteus oculatus 80 0.0 1474
WERAM-Dar-0198 ENSDARP00000131327.1 Danio rerio 78 0.0 1436
WERAM-Ova-0200 ENSOARP00000020106.1 Ovis aries 85 0.0 1430
WERAM-Orn-0049 ENSONIP00000005635.1 Oreochromis niloticus 72 0.0 1278
WERAM-Tar-0063 ENSTRUP00000012899.1 Takifugu rubripes 70 0.0 1258
WERAM-Ten-0103 ENSTNIP00000011743.1 Tetraodon nigroviridis 70 0.0 1249
WERAM-Xim-0022 ENSXMAP00000002092.1 Xiphophorus maculatus 69 0.0 1236
WERAM-Pof-0029 ENSPFOP00000001978.1 Poecilia formosa 70 0.0 1227
WERAM-Asm-0146 ENSAMXP00000013789.1 Astyanax mexicanus 69 0.0 1190
WERAM-Paa-0012 ENSPANP00000003104.1 Papio anubis 99 0.0 1188
WERAM-Caj-0101 ENSCJAP00000017313.2 Callithrix jacchus 98 0.0 1176
WERAM-Tas-0071 ENSTSYP00000007103.1 Tarsius syrichta 77 0.0 1090
WERAM-Tut-0038 ENSTTRP00000002947.1 Tursiops truncatus 84 0.0 982
WERAM-Ptv-0078 ENSPVAP00000007254.1 Pteropus vampyrus 75 0.0 974
WERAM-Sah-0044 ENSSHAP00000005074.1 Sarcophilus harrisii 67 0.0 972
WERAM-Nol-0183 ENSNLEP00000020216.1 Nomascus leucogenys 55 0.0 937
WERAM-Eqc-0153 ENSECAP00000016533.1 Equus caballus 55 0.0 930
WERAM-Orc-0142 ENSOCUP00000012429.3 Oryctolagus cuniculus 55 0.0 930
WERAM-Mod-0016 ENSMODP00000001749.3 Monodelphis domestica 54 0.0 923
WERAM-Gaa-0020 ENSGACP00000002894.1 Gasterosteus aculeatus 84 0.0 843
WERAM-Vip-0084 ENSVPAP00000007862.1 Vicugna pacos 50 0.0 815
WERAM-Orla-0199 ENSORLP00000022663.1 Oryzias latipes 79 0.0 793
WERAM-Soa-0055 ENSSARP00000005400.1 Sorex araneus 54 0.0 771
WERAM-Gam-0063 ENSGMOP00000006368.1 Gadus morhua 77 0.0 759
WERAM-Pem-0041 ENSPMAP00000005402.1 Petromyzon marinus 70 0.0 736
WERAM-Mae-0089 ENSMEUP00000008883.1 Macropus eugenii 86 0.0 732
WERAM-Ocp-0087 ENSOPRP00000007869.2 Ochotona princeps 71 0.0 699
WERAM-Prc-0092 ENSPCAP00000008303.1 Procavia capensis 72 0.0 692
WERAM-Mim-0022 ENSMICP00000002393.1 Microcebus murinus 70 0.0 664
WERAM-Ere-0042 ENSEEUP00000003697.1 Erinaceus europaeus 68 0.0 634
WERAM-Ect-0068 ENSETEP00000007698.1 Echinops telfairi 43 1e-162 571
WERAM-Drm-0080 FBpp0290513 Drosophila melanogaster 58 5e-158 556
WERAM-Tub-0137 ENSTBEP00000014805.1 Tupaia belangeri 70 3e-132 470
WERAM-Cii-0046 ENSCINP00000016829.3 Ciona intestinalis 53 3e-131 467
WERAM-Chh-0086 ENSCHOP00000009630.1 Choloepus hoffmanni 50 1e-130 465
WERAM-Cae-0008 C10E2.3a Caenorhabditis elegans 48 7e-120 429
WERAM-Cis-0060 ENSCSAVP00000013851.1 Ciona savignyi 55 3e-92 337
WERAM-Sem-0010 EFJ19764 Selaginella moellendorffii 43 1e-78 292
WERAM-Bro-0168 Bo9g014470.1 Brassica oleracea 43 4e-78 290
WERAM-Brr-0181 Bra035942.1-P Brassica rapa 44 5e-78 290
Created Date 25-Jun-2016