WERAM Information

Tag Content
WERAM ID WERAM-Hos-0138
Ensembl Protein ID ENSP00000263377.1
Uniprot Accession O60885; BRD4_HUMAN; O60433; Q4G0X8; Q86YS8; Q96PD3
Genbank Protein ID NP_055114.1; NP_490597.1; XP_011526156.1; XP_011526157.1; XP_011526158.1
Protein Name Bromodomain-containing protein 4
Genbank Nucleotide ID NM_014299.2; NM_058243.2; XM_011527854.1; XM_011527855.1; XM_011527856.1
Gene Name BRD4;CAP;MCAP;HUNK1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000141867.17 ENST00000263377.6 ENSP00000263377.1
ENSG00000141867.17 ENST00000360016.9 ENSP00000353112.4
ENSG00000141867.17 ENST00000371835.8 ENSP00000360901.3
ENSG00000141867.17 ENST00000597315.5 ENSP00000470108.1
ENSG00000141867.17 ENST00000594841.5 ENSP00000470481.1
ENSG00000141867.17 ENST00000601941.1 ENSP00000471240.1
ENSG00000141867.17 ENST00000630599.2 ENSP00000486621.1
Details
Type Family Domain Substrates AA References (PMIDs)
Ac_Reader Bromodomain Bromodomain H3K9; H3K14; H4K5; H4K8; H4K12; H4K16; H4K20; H4K31 K 22464331
Status Reviewed
Classification
Type Family E-value Score Start End
Ac_Reader Bromodomain 1.40e-55 187.5 76 439
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure. During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters: BRD4 is required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II. Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II. According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II; these data however need additional evidences in vivo (PubMed:22509028). In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B. Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters.
Domain Profile
  Ac_Reader Bromodomain
          BROMO.txt   2 ehevsepFrepvdpq.leipdYydiikePmdLstikerleegnYsspeefvkDvrlifnNakaynenkssv 71 
                        +h++++pF++pvd+  l++pdYy+iik+Pmd+ tik+rle+++Y++++e+++D++ +f+N++ yn++++++
  ENSP00000263377.1  76 KHQFAWPFQQPVDAVkLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDI 146
                        79*****************************************************************9997 PP
          BROMO.txt   4 evsepFrepvdpq.leipdYydiikePmdLstikerleegnYsspeefvkDvrlifnNakaynenkssv 71 
                         +++pF +pvd + l ++dY+diik+Pmd+stik++le+++Y++++ef +Dvrl+f+N+++yn+++++v
  ENSP00000263377.1 371 AYAWPFYKPVDVEaLGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEV 439
                        679***************************************************************998 PP
Protein Sequence
(Fasta)		MSAESGPGTR LRNLPVMGDG LETSQMSTTQ AQAQPQPANA ASTNPPPPET SNPNKPKRQT 60
NQLQYLLRVV LKTLWKHQFA WPFQQPVDAV KLNLPDYYKI IKTPMDMGTI KKRLENNYYW 120
NAQECIQDFN TMFTNCYIYN KPGDDIVLMA EALEKLFLQK INELPTEETE IMIVQAKGRG 180
RGRKETGTAK PGVSTVPNTT QASTPPQTQT PQPNPPPVQA TPHPFPAVTP DLIVQTPVMT 240
VVPPQPLQTP PPVPPQPQPP PAPAPQPVQS HPPIIAATPQ PVKTKKGVKR KADTTTPTTI 300
DPIHEPPSLP PEPKTTKLGQ RRESSRPVKP PKKDVPDSQQ HPAPEKSSKV SEQLKCCSGI 360
LKEMFAKKHA AYAWPFYKPV DVEALGLHDY CDIIKHPMDM STIKSKLEAR EYRDAQEFGA 420
DVRLMFSNCY KYNPPDHEVV AMARKLQDVF EMRFAKMPDE PEEPVVAVSS PAVPPPTKVV 480
APPSSSDSSS DSSSDSDSST DDSEEERAQR LAELQEQLKA VHEQLAALSQ PQQNKPKKKE 540
KDKKEKKKEK HKRKEEVEEN KKSKAKEPPP KKTKKNNSSN SNVSKKEPAP MKSKPPPTYE 600
SEEEDKCKPM SYEEKRQLSL DINKLPGEKL GRVVHIIQSR EPSLKNSNPD EIEIDFETLK 660
PSTLRELERY VTSCLRKKRK PQAEKVDVIA GSSKMKGFSS SESESSSESS SSDSEDSETE 720
MAPKSKKKGH PGREQKKHHH HHHQQMQQAP APVPQQPPPP PQQPPPPPPP QQQQQPPPPP 780
PPPSMPQQAA PAMKSSPPPF IATQVPVLEP QLPGSVFDPI GHFTQPILHL PQPELPPHLP 840
QPPEHSTPPH LNQHAVVSPP ALHNALPQQP SRPSNRAAAL PPKPARPPAV SPALTQTPLL 900
PQPPMAQPPQ VLLEDEEPPA PPLTSMQMQL YLQQLQKVQP PTPLLPSVKV QSQPPPPLPP 960
PPHPSVQQQL QQQPPPPPPP QPQPPPQQQH QPPPRPVHLQ PMQFSTHIQQ PPPPQGQQPP 1020
HPPPGQQPPP PQPAKPQQVI QHHHSPRHHK SDPYSTGHLR EAPSPLMIHS PQMSQFQSLT 1080
HQSPPQQNVQ PKKQELRAAS VVQPQPLVVV KEEKIHSPII RSEPFSPSLR PEPPKHPESI 1140
KAPVHLPQRP EMKPVDVGRP VIRPPEQNAP PPGAPDKDKQ KQEPKTPVAP KKDLKIKNMG 1200
SWASLVQKHP TTPSSTAKSS SDSFEQFRRA AREKEEREKA LKAQAEHAEK EKERLRQERM 1260
RSREDEDALE QARRAHEEAR RRQEQQQQQR QEQQQQQQQQ AAAVAAAATP QAQSSQPQSM 1320
LDQQRELARK REQERRRREA MAATIDMNFQ SDLLSIFEEN LF 1362
Nucleotide Sequence
(Fasta)		ATTCTTTGGA ATACTACTGC TAGAAGTCTG ACTTAAGACC CAGCTTATGG GCCACATGGC 60
ACCCAGCTGC TTCTGCAGAG AAGGCAGGCC ACTGATGGGT ACAGCAAAGT GTGGTGCTGC 120
TGGCCAAGCC AAAGACCCGT GTAGGATGAC TGGGCCTCTG CCCCTTGTGG GTGTTGCCAC 180
TGTGCTTGAG TGCCTGGTGA AGAATGTGAT GGGATCACTA GCATGTCTGC GGAGAGCGGC 240
CCTGGGACGA GATTGAGAAA TCTGCCAGTA ATGGGGGATG GACTAGAAAC TTCCCAAATG 300
TCTACAACAC AGGCCCAGGC CCAACCCCAG CCAGCCAACG CAGCCAGCAC CAACCCCCCG 360
CCCCCAGAGA CCTCCAACCC TAACAAGCCC AAGAGGCAGA CCAACCAACT GCAATACCTG 420
CTCAGAGTGG TGCTCAAGAC ACTATGGAAA CACCAGTTTG CATGGCCTTT CCAGCAGCCT 480
GTGGATGCCG TCAAGCTGAA CCTCCCTGAT TACTATAAGA TCATTAAAAC GCCTATGGAT 540
ATGGGAACAA TAAAGAAGCG CTTGGAAAAC AACTATTACT GGAATGCTCA GGAATGTATC 600
CAGGACTTCA ACACTATGTT TACAAATTGT TACATCTACA ACAAGCCTGG AGATGACATA 660
GTCTTAATGG CAGAAGCTCT GGAAAAGCTC TTCTTGCAAA AAATAAATGA GCTACCCACA 720
GAAGAAACCG AGATCATGAT AGTCCAGGCA AAAGGAAGAG GACGTGGGAG GAAAGAAACA 780
GGGACAGCAA AACCTGGCGT TTCCACGGTA CCAAACACAA CTCAAGCATC GACTCCTCCG 840
CAGACCCAGA CCCCTCAGCC GAATCCTCCT CCTGTGCAGG CCACGCCTCA CCCCTTCCCT 900
GCCGTCACCC CGGACCTCAT CGTCCAGACC CCTGTCATGA CAGTGGTGCC TCCCCAGCCA 960
CTGCAGACGC CCCCGCCAGT GCCCCCCCAG CCACAACCCC CACCCGCTCC AGCTCCCCAG 1020
CCCGTACAGA GCCACCCACC CATCATCGCG GCCACCCCAC AGCCTGTGAA GACAAAGAAG 1080
GGAGTGAAGA GGAAAGCAGA CACCACCACC CCCACCACCA TTGACCCCAT TCACGAGCCA 1140
CCCTCGCTGC CCCCGGAGCC CAAGACCACC AAGCTGGGCC AGCGGCGGGA GAGCAGCCGG 1200
CCTGTGAAAC CTCCAAAGAA GGACGTGCCC GACTCTCAGC AGCACCCAGC ACCAGAGAAG 1260
AGCAGCAAGG TCTCGGAGCA GCTCAAGTGC TGCAGCGGCA TCCTCAAGGA GATGTTTGCC 1320
AAGAAGCACG CCGCCTACGC CTGGCCCTTC TACAAGCCTG TGGACGTGGA GGCACTGGGC 1380
CTACACGACT ACTGTGACAT CATCAAGCAC CCCATGGACA TGAGCACAAT CAAGTCTAAA 1440
CTGGAGGCCC GTGAGTACCG TGATGCTCAG GAGTTTGGTG CTGACGTCCG ATTGATGTTC 1500
TCCAACTGCT ATAAGTACAA CCCTCCTGAC CATGAGGTGG TGGCCATGGC CCGCAAGCTC 1560
CAGGATGTGT TCGAAATGCG CTTTGCCAAG ATGCCGGACG AGCCTGAGGA GCCAGTGGTG 1620
GCCGTGTCCT CCCCGGCAGT GCCCCCTCCC ACCAAGGTTG TGGCCCCGCC CTCATCCAGC 1680
GACAGCAGCA GCGATAGCTC CTCGGACAGT GACAGTTCGA CTGATGACTC TGAGGAGGAG 1740
CGAGCCCAGC GGCTGGCTGA GCTCCAGGAG CAGCTCAAAG CCGTGCACGA GCAGCTTGCA 1800
GCCCTCTCTC AGCCCCAGCA GAACAAACCA AAGAAAAAGG AGAAAGACAA GAAGGAAAAG 1860
AAAAAAGAAA AGCACAAAAG GAAAGAGGAA GTGGAAGAGA ATAAAAAAAG CAAAGCCAAG 1920
GAACCTCCTC CTAAAAAGAC GAAGAAAAAT AATAGCAGCA ACAGCAATGT GAGCAAGAAG 1980
GAGCCAGCGC CCATGAAGAG CAAGCCCCCT CCCACGTATG AGTCGGAGGA AGAGGACAAG 2040
TGCAAGCCTA TGTCCTATGA GGAGAAGCGG CAGCTCAGCT TGGACATCAA CAAGCTCCCC 2100
GGCGAGAAGC TGGGCCGCGT GGTGCACATC ATCCAGTCAC GGGAGCCCTC CCTGAAGAAT 2160
TCCAACCCCG ACGAGATTGA AATCGACTTT GAGACCCTGA AGCCGTCCAC ACTGCGTGAG 2220
CTGGAGCGCT ATGTCACCTC CTGTTTGCGG AAGAAAAGGA AACCTCAAGC TGAGAAAGTT 2280
GATGTGATTG CCGGCTCCTC CAAGATGAAG GGCTTCTCGT CCTCAGAGTC GGAGAGCTCC 2340
AGTGAGTCCA GCTCCTCTGA CAGCGAAGAC TCCGAAACAG AGATGGCTCC GAAGTCAAAA 2400
AAGAAGGGGC ACCCCGGGAG GGAGCAGAAG AAGCACCATC ATCACCACCA TCAGCAGATG 2460
CAGCAGGCCC CGGCTCCTGT GCCCCAGCAG CCGCCCCCGC CTCCCCAGCA GCCCCCACCG 2520
CCTCCACCTC CGCAGCAGCA ACAGCAGCCG CCACCCCCGC CTCCCCCACC CTCCATGCCG 2580
CAGCAGGCAG CCCCGGCGAT GAAGTCCTCG CCCCCACCCT TCATTGCCAC CCAGGTGCCC 2640
GTCCTGGAGC CCCAGCTCCC AGGCAGCGTC TTTGACCCCA TCGGCCACTT CACCCAGCCC 2700
ATCCTGCACC TGCCGCAGCC TGAGCTGCCC CCTCACCTGC CCCAGCCGCC TGAGCACAGC 2760
ACTCCACCCC ATCTCAACCA GCACGCAGTG GTCTCTCCTC CAGCTTTGCA CAACGCACTA 2820
CCCCAGCAGC CATCACGGCC CAGCAACCGA GCCGCTGCCC TGCCTCCCAA GCCCGCCCGG 2880
CCCCCAGCCG TGTCACCAGC CTTGACCCAA ACACCCCTGC TCCCACAGCC CCCCATGGCC 2940
CAACCCCCCC AAGTGCTGCT GGAGGATGAA GAGCCACCTG CCCCACCCCT CACCTCCATG 3000
CAGATGCAGC TGTACCTGCA GCAGCTGCAG AAGGTGCAGC CCCCTACGCC GCTACTCCCT 3060
TCCGTGAAGG TGCAGTCCCA GCCCCCACCC CCCCTGCCGC CCCCACCCCA CCCCTCTGTG 3120
CAGCAGCAGC TGCAGCAGCA GCCGCCACCA CCCCCACCAC CCCAGCCCCA GCCTCCACCC 3180
CAGCAGCAGC ATCAGCCCCC TCCACGGCCC GTGCACTTGC AGCCCATGCA GTTTTCCACC 3240
CACATCCAAC AGCCCCCGCC ACCCCAGGGC CAGCAGCCCC CCCATCCGCC CCCAGGCCAG 3300
CAGCCACCCC CGCCGCAGCC TGCCAAGCCT CAGCAAGTCA TCCAGCACCA CCATTCACCC 3360
CGGCACCACA AGTCGGACCC CTACTCAACC GGTCACCTCC GCGAAGCCCC CTCCCCGCTT 3420
ATGATACATT CCCCCCAGAT GTCACAGTTC CAGAGCCTGA CCCACCAGTC TCCACCCCAG 3480
CAAAACGTCC AGCCTAAGAA ACAGGAGCTG CGTGCTGCCT CCGTGGTCCA GCCCCAGCCC 3540
CTCGTGGTGG TGAAGGAGGA GAAGATCCAC TCACCCATCA TCCGCAGCGA GCCCTTCAGC 3600
CCCTCGCTGC GGCCGGAGCC CCCCAAGCAC CCGGAGAGCA TCAAGGCCCC CGTCCACCTG 3660
CCCCAGCGGC CGGAAATGAA GCCTGTGGAT GTCGGGAGGC CTGTGATCCG GCCCCCAGAG 3720
CAGAACGCAC CGCCACCAGG GGCCCCTGAC AAGGACAAAC AGAAACAGGA GCCGAAGACT 3780
CCAGTTGCGC CCAAAAAGGA CCTGAAAATC AAGAACATGG GCTCCTGGGC CAGCCTAGTG 3840
CAGAAGCATC CGACCACCCC CTCCTCCACA GCCAAGTCAT CCAGCGACAG CTTCGAGCAG 3900
TTCCGCCGCG CCGCTCGGGA GAAAGAGGAG CGTGAGAAGG CCCTGAAGGC TCAGGCCGAG 3960
CACGCTGAGA AGGAGAAGGA GCGGCTGCGG CAGGAGCGCA TGAGGAGCCG AGAGGACGAG 4020
GATGCGCTGG AGCAGGCCCG GCGGGCCCAT GAGGAGGCAC GTCGGCGCCA GGAGCAGCAG 4080
CAGCAGCAGC GCCAGGAGCA ACAGCAGCAG CAGCAACAGC AAGCAGCTGC GGTGGCTGCC 4140
GCCGCCACCC CACAGGCCCA GAGCTCCCAG CCCCAGTCCA TGCTGGACCA GCAGAGGGAG 4200
TTGGCCCGGA AGCGGGAGCA GGAGCGAAGA CGCCGGGAAG CCATGGCAGC TACCATTGAC 4260
ATGAATTTCC AGAGTGATCT ATTGTCAATA TTTGAAGAAA ATCTTTTCTG AGCGCACCTA 4320
GGTGGCTTCT GACTTTGATT TTCTGGCAAA ACATTGACTT TCCATAGTGT TAGGGGCGGT 4380
GGTGGAGGTG GGATCAGCGG CCAGGGGATG CCTCAGGGCC TGGCCCTCCT GCATGCTATG 4440
CCCGGGGCAG GCCTGACGGG CAGCTGAGGA TTGCAGAGCC TGTCTGCCTT ACGGCCAGTC 4500
GGACAGACGT CCCGCCACCC ACCACCCCTC ACAGGACGTC CGCTCAGCAC ACGCCTTGTT 4560
ACGAGCAAGT GCCGGCTGGA CCCAAGCCCT GCATCCCCAC ATGCGGGGCA GAGGCCCTTC 4620
TCTCCGCCAA ATGTCTACAC AGTATACACA GGACATCGTT GCTGCCGCCG TGACTGGTTT 4680
TCTGTCCCCA AGAACGTGAC GTTCGTGATG TCCTGCCCGC CGGGAGTCTT TCCCCACACC 4740
CCAGCCATCG CCGCCCGCTC CCAGGAGGCC AGGGCAGGCC TGCGTGGGCT GGAGGCGGGC 4800
GAGGCCGGCC CACCCCCTCG CTGGCACTGA CTTTGCCTTG AACAGACCCC CCGACCCTCC 4860
CCCACAAGCC TTTAATTGAG AGCCGCTCTC TGTAAGTGTT TGCTTGTGCA AAAGGGAATA 4920
GTGCCGTGGA GGTGTGTGTG TCCATGGCAT CCGGAGCGAG GCGACTGTCC TGCGTGGGTA 4980
GCCCTCGGCC GGGGAGTGAG GCCACCAACC AAAGTCAGTT CCTTCCCACC TGTGTTTCTG 5040
TTTCGTTTTT TTTTTTCTTT TTTTTCTATA TATATTTTTT GTTGAATTCT ATTTTATTTT 5100
TAATTCTCTC TTCTCCTCCA GACACAATGG CACTGCTTAT CTCCGAAATG GTGTGATCGT 5160
CTCCTCATTG AGCAGCGGCT GCCACCGCGC TGTGGGTAGT GTGTGACCGT GGCTGTACTG 5220
TATAGTGAAC ATAGTTGGCA TATCTTTGTT TGAAGTTTGT TGGTGACTCC ACCAAACTGG 5280
TGTGAAAAAA GAAAAAAGCT CAAAAAAATC CACAAAAAGA CAAAACACAC AAAAAAAATC 5340
CTGCCTATAT TTTACTCAGT TTCAAACTTT ATTAGTCTAT TTTTAATTAT AAAACCAGAA 5400
AGCTACAATT TCTTTTCTTT CCCCTCCACC CCCCCCCCCC CCACCCATTT GTTGGCTTTT 5460
TTGTTTTTTA ATGTCAGATC TGTTGAGTTG GTTTTTTTGG TTTTGGTTTT TGTTTTTGTT 5520
TTTGTTTTTT ACTGAGAAAG GAAGGGCCAA GGGATGAGGT GGGAACCGGG CCCTGGGGGC 5580
GCCACAGACT AAGGCAGAGA CTCCCCTACC TGGCGCCCAG CCCCAACCAG CTGGCCGCTC 5640
CTGCCCATGC TTTTTTTTTT TTTTTTTTTT AATTTTTATA ATTGGAGCCC CTGGTGAGGT 5700
TACGCGTGCC ATGAGAACCC ACTCTACACC ACGACGCTGG TGCCTCAGTG TTGGCCAAAC 5760
TCTGGAGTCA CTGACTGGTT TGACTTTCAT ACGGTGAATA TGCATTTGGT CTGTACTGAT 5820
CATGGAATAA ACACATCTCT CTTTTTTTAA TGCTGGCGTC TCCCTGACAT TTCTTTGTGA 5880
ACCAACTGTT GCCTAGGCTA GGCCCAGGGG ACCCCCTGGA CCCCAGACCA CCTCTGTACA 5940
GGAACTACTG CCAGGGATTA CCTAGCCCCT CTCCTGTGAC CTGTCCCTGT CTGCCCTGGG 6000
CGGGAGCCAC GCAGACTCAT AGCAACCACC CCAAGCTGAA GCTGTGACGC AGAGCCCGGT 6060
ACCCATCCTT GTGGACCCTG GCTGAGGTGG AGGGTGTGCT CTAGCAGAAC CCTGGCCAGA 6120
CTCCAGACAG TATTCTTCCC CTCCACCCTA CTCCATCCTG TCCCCCCTAC TCCATCCTGT 6180
CCCCCCACTC ACCAAAGGAC TTGGGCCACT TCTCCCACCT TGCCTGCCTC AACCTAACTC 6240
CTCCTTTCAT TTAAGCTCAG GGTTAACCAG ATACTCTTAG ATATAAGTCT ACATCCCCCA 6300
AAATAGGATC CTCACCCCCC ATGCACATAC ACACACATTC CTGTCCAAGA AAGCCCACAG 6360
GTGGCTGCTC TGCCTGTGTG TCCACTTGTG TATGTACATG CCCCAGCCAC AAGGCACGGG 6420
TGACGCCCAA GAAGAGCCCC TAAGATGTAA GATACAAGTA TATAATTTAT ATGTATGCAG 6480
AGACAAACTG ATTGAAACAT TTCTAGCACT GTTTATTCTC CTACATCCCC TCTTTTTGAC 6540
CTGAAAGGTC CTTTATTGTC TTTGGATCTG CCAAACCTCC CTGTGAGGGT GTGGTTCAGG 6600
CATCCAGCCA GAGGTCCCCC CACTTCTTCG ATGTCCATGC CCACTCAGGC ACTTTCTCAT 6660
ATACCACTGT GCCACTTCAA GTGTGACGTA TTTAGGTTCT TTGGGGTTTC TTCCATCTCA 6720
TCCCACCCAC TCATTTTTGT TCCTTGTTTT GTTCAGACAC TTCCCCAGCC TGGGTCCAAC 6780
TGCTGAGCTG GATAGTTTTC TCTGCAGCTT CCTGCTGAAG ATTTAACTCA GCCATGGCCT 6840
TCTCCACACC TCCCTGATGG GTGTCTCTCT ACCTGGGTTG TAATTAGAAC TGGGATCTAT 6900
TTAATTTCTC CAGCCATTTC CCAACCCTTC CCACAGTACT AGAAATCTTA GTCCTATACC 6960
AGAGTAAGAG GTGTGTACAA GCCCCCACTG TACTGTATGC ACGGATCGCT TGGCCAATAA 7020
TTATGTCAGT GAATCTGAGA CTTGTATTAA ACACTTTAGA CATTTGTAGA AGGGAATTCG 7080
TAGACTTTTC ACTTACATAC GAAAGGTTTT TTTTTTTTTT TGTGCAGTTC TCATTGCAAA 7140
AATAAACATT TGTACTGAGT ATAAAGTTA
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0103--Bromodomain
KW-0156--Chromatin regulator
KW-0160--Chromosomal rearrangement
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0945--Host-virus interaction
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
--
Interpro

IPR031354--BRD4_CDT
IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR027353--NET_dom
PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS51525--NET
Pfam

PF17035--BET
PF17105--BRD4_CDT
PF00439--Bromodomain
Gene Ontology

GO:0005694--C:chromosome
GO:0000794--C:condensed nuclear chromosome
GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0070577--F:lysine-acetylated histone binding
GO:0002039--F:p53 binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0016568--P:chromatin modification
GO:0006338--P:chromatin remodeling
GO:2000002--P:negative regulation of DNA damage checkpoint
GO:0010971--P:positive regulation of G2/M transition of mitotic cell cycle
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0032968--P:positive regulation of transcription elongation from RNA polymerase II promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0050727--P:regulation of inflammatory response
GO:1901407--P:regulation of phosphorylation of RNA polymerase II C-terminal domain
GO:0000083--P:regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0006351--P:transcription, DNA-templated
GO:0016032--P:viral process
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Poa-0084 ENSPPYP00000010837.2 Pongo abelii 99 0.0 1291
WERAM-Gog-0122 ENSGGOP00000010164.2 Gorilla gorilla 100 0.0 1290
WERAM-Nol-0052 ENSNLEP00000006353.1 Nomascus leucogenys 99 0.0 1289
WERAM-Chs-0069 ENSCSAP00000002413.1 Chlorocebus sabaeus 98 0.0 1287
WERAM-Mam-0196 ENSMMUP00000028168.2 Macaca mulatta 96 0.0 1279
WERAM-Eqc-0187 ENSECAP00000019958.1 Equus caballus 96 0.0 934
WERAM-Caf-0165 ENSCAFP00000023676.4 Canis familiaris 97 0.0 931
WERAM-Mup-0183 ENSMPUP00000015981.1 Mustela putorius furo 96 0.0 926
WERAM-Fec-0010 ENSFCAP00000000851.2 Felis catus 96 0.0 925
WERAM-Ptv-0180 ENSPVAP00000015952.1 Pteropus vampyrus 88 0.0 869
WERAM-Bot-0030 ENSBTAP00000003242.5 Bos taurus 97 0.0 862
WERAM-Sus-0153 ENSSSCP00000019596.1 Sus scrofa 97 0.0 858
WERAM-Tut-0179 ENSTTRP00000015157.1 Tursiops truncatus 97 0.0 857
WERAM-Dio-0017 ENSDORP00000002078.1 Dipodomys ordii 96 0.0 854
WERAM-Myl-0052 ENSMLUP00000004424.2 Myotis lucifugus 93 0.0 842
WERAM-Otg-0016 ENSOGAP00000000748.2 Otolemur garnettii 98 0.0 838
WERAM-Cap-0011 ENSCPOP00000001274.2 Cavia porcellus 94 0.0 830
WERAM-Ova-0027 ENSOARP00000003891.1 Ovis aries 94 0.0 827
WERAM-Loa-0211 ENSLAFP00000026806.1 Loxodonta africana 89 0.0 827
WERAM-Pat-0089 ENSPTRP00000018122.4 Pan troglodytes 95 0.0 805
WERAM-Mod-0130 ENSMODP00000018187.4 Monodelphis domestica 84 0.0 800
WERAM-Gaga-0127 ENSGALP00000035122.2 Gallus gallus 85 0.0 786
WERAM-Tub-0133 ENSTBEP00000014554.1 Tupaia belangeri 86 0.0 677
WERAM-Mim-0129 ENSMICP00000013010.1 Microcebus murinus 98 0.0 655
WERAM-Paa-0190 ENSPANP00000010376.1 Papio anubis 94 0.0 654
WERAM-Orc-0130 ENSOCUP00000011195.2 Oryctolagus cuniculus 97 0.0 650
WERAM-Ran-0040 ENSRNOP00000008963.6 Rattus norvegicus 95 0.0 647
WERAM-Mum-0055 ENSMUSP00000113070.1 Mus musculus 95 0.0 645
WERAM-Aim-0034 ENSAMEP00000002443.1 Ailuropoda melanoleuca 89 0.0 632
WERAM-Ect-0055 ENSETEP00000005894.1 Echinops telfairi 91 5e-179 626
WERAM-Ora-0083 ENSOANP00000013848.2 Ornithorhynchus anatinus 85 3e-169 593
WERAM-Anp-0078 ENSAPLP00000009547.1 Anas platyrhynchos 82 4e-167 587
WERAM-Sah-0090 ENSSHAP00000010568.1 Sarcophilus harrisii 88 2e-164 578
WERAM-Caj-0016 ENSCJAP00000003945.2 Callithrix jacchus 93 5e-161 566
WERAM-Anc-0179 ENSACAP00000017011.3 Anolis carolinensis 80 2e-159 561
WERAM-Vip-0066 ENSVPAP00000005996.1 Vicugna pacos 99 1e-149 528
WERAM-Lac-0047 ENSLACP00000006835.1 Latimeria chalumnae 72 1e-146 519
WERAM-Ocp-0044 ENSOPRP00000003823.1 Ochotona princeps 80 7e-130 463
WERAM-Gam-0073 ENSGMOP00000007682.1 Gadus morhua 56 5e-91 333
WERAM-Prc-0023 ENSPCAP00000001851.1 Procavia capensis 89 1e-90 333
WERAM-Mae-0088 ENSMEUP00000008845.1 Macropus eugenii 89 2e-81 302
WERAM-Pes-0043 ENSPSIP00000006386.1 Pelodiscus sinensis 86 2e-79 295
WERAM-Meg-0092 ENSMGAP00000008728.2 Meleagris gallopavo 89 1e-78 292
WERAM-Leo-0065 ENSLOCP00000008328.1 Lepisosteus oculatus 72 8e-70 263
WERAM-Xet-0088 ENSXETP00000028569.3 Xenopus tropicalis 76 3e-68 258
WERAM-Ten-0049 ENSTNIP00000004900.1 Tetraodon nigroviridis 71 3e-66 251
WERAM-Pof-0102 ENSPFOP00000009161.2 Poecilia formosa 90 6e-66 250
WERAM-Xim-0169 ENSXMAP00000013871.1 Xiphophorus maculatus 90 1e-65 249
WERAM-Orn-0042 ENSONIP00000004818.1 Oreochromis niloticus 90 4e-65 248
WERAM-Tar-0198 ENSTRUP00000040915.1 Takifugu rubripes 89 4e-64 244
WERAM-Gaa-0105 ENSGACP00000013356.1 Gasterosteus aculeatus 70 4e-64 244
WERAM-Dan-0151 ENSDNOP00000024058.1 Dasypus novemcinctus 91 8e-64 243
WERAM-Orla-0106 ENSORLP00000012941.1 Oryzias latipes 91 1e-63 243
WERAM-Asm-0188 ENSAMXP00000018107.1 Astyanax mexicanus 86 5e-63 241
WERAM-Dar-0182 ENSDARP00000101616.2 Danio rerio 85 1e-58 226
WERAM-Ict-0138 ENSSTOP00000014229.2 Ictidomys tridecemlineatus 80 1e-57 223
WERAM-Tag-0083 ENSTGUP00000005921.1 Taeniopygia guttata 71 2e-57 223
WERAM-Fia-0022 ENSFALP00000001679.1 Ficedula albicollis 71 2e-57 222
WERAM-Soa-0062 ENSSARP00000006154.1 Sorex araneus 66 2e-55 215
WERAM-Drm-0012 FBpp0071074 Drosophila melanogaster 72 6e-55 214
WERAM-Tas-0039 ENSTSYP00000004094.1 Tarsius syrichta 78 1e-54 213
WERAM-Ere-0096 ENSEEUP00000009790.1 Erinaceus europaeus 77 9e-54 210
WERAM-Pem-0020 ENSPMAP00000002717.1 Petromyzon marinus 70 4e-53 208
WERAM-Chh-0047 ENSCHOP00000005329.1 Choloepus hoffmanni 64 7e-51 200
Created Date 25-Jun-2016