WERAM Information

Tag Content
WERAM ID WERAM-Hos-0065
Ensembl Protein ID ENSP00000219315.4
Uniprot Accession Q8TBK2; SETD6_HUMAN; A8K380; B5ME38; Q9H787
Genbank Protein ID NP_001153777.1; NP_079136.2
Protein Name N-lysine methyltransferase SETD6
Genbank Nucleotide ID NM_001160305.2; NM_024860.3
Gene Name SETD6
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000103037.11 ENST00000219315.8 ENSP00000219315.4
Details
Type Family Domain Substrates AA References (PMIDs)
HMT HMT_other SET H2A.ZK4me1; H2A.ZK7me1 K 24316985; 23324626
Status Reviewed
Classification
Type Family E-value Score Start End
HMT HMT_other 0 830
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity (PubMed:21131967). Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (PubMed:23324626). Required for the maintenance of embryonic stem cell self-renewal (By similarity).
Domain Profile
  HMT HMT_other
Query: 1   MATQAKRPRVAGPVDGGDLDPVACFLSWCRRVGLELSPKVSEXXXXXXXXXXXXXXLTSP 60
           MATQAKRPRVAGPVDGGDLDPVACFLSWCRRVGLELSPKVSE              LTSP
Sbjct: 1   MATQAKRPRVAGPVDGGDLDPVACFLSWCRRVGLELSPKVSERAGGRRTRGGARAALTSP 60
Query: 61  PAQVAVSRQGTVAGYGMVARESVQAGELLFVVPRAALLSQHTCSIGGLLERERVALQSQS 120
           PAQVAVSRQGTVAGYGMVARESVQAGELLFVVPRAALLSQHTCSIGGLLERERVALQSQS
Sbjct: 61  PAQVAVSRQGTVAGYGMVARESVQAGELLFVVPRAALLSQHTCSIGGLLERERVALQSQS 120
Query: 121 GWVPXXXXXXXXXQAPASRWRPYFALWPELGRLEHPMFWPEEERRCLLQGTGVPEAVEKD 180
           GWVP         QAPASRWRPYFALWPELGRLEHPMFWPEEERRCLLQGTGVPEAVEKD
Sbjct: 121 GWVPLLLALLHELQAPASRWRPYFALWPELGRLEHPMFWPEEERRCLLQGTGVPEAVEKD 180
Query: 181 LANIRSEYQSIVLPFMEAHPDLFSLRVRSLELYHQLVALVMAYSFQXXXXXXXXXXXPNS 240
           LANIRSEYQSIVLPFMEAHPDLFSLRVRSLELYHQLVALVMAYSFQ           PNS
Sbjct: 181 LANIRSEYQSIVLPFMEAHPDLFSLRVRSLELYHQLVALVMAYSFQEPLEEEEDEKEPNS 240
Query: 241 PVMVPAADIXXXXXXXXXXXEYSANCLRMVATQPIPKGHEIFNTYGQMANWQLIHMYGFV 300
           PVMVPAADI           EYSANCLRMVATQPIPKGHEIFNTYGQMANWQLIHMYGFV
Sbjct: 241 PVMVPAADILNHLANHNANLEYSANCLRMVATQPIPKGHEIFNTYGQMANWQLIHMYGFV 300
Query: 301 EPYPDNTDDTADIQMVTVREAALQGTKTEAERHLVYERWDFLCKLEMVGEEGAFVIGRXX 360
           EPYPDNTDDTADIQMVTVREAALQGTKTEAERHLVYERWDFLCKLEMVGEEGAFVIGR  
Sbjct: 301 EPYPDNTDDTADIQMVTVREAALQGTKTEAERHLVYERWDFLCKLEMVGEEGAFVIGREE 360
Query: 361 XXXXXXXXXXXXXXCMPAEEFRELKDQDGGGDDKREEGSLTITNIPKLKASWRQLLQNSV 420
                         CMPAEEFRELKDQDGGGDDKREEGSLTITNIPKLKASWRQLLQNSV
Sbjct: 361 VLTEEELTTTLKVLCMPAEEFRELKDQDGGGDDKREEGSLTITNIPKLKASWRQLLQNSV 420
Query: 421 LLTLQTYATDLKTDQGLLSNKEVYAKLSWREQQALQVRYGQKMILHQLLELTS 473
           LLTLQTYATDLKTDQGLLSNKEVYAKLSWREQQALQVRYGQKMILHQLLELTS
Sbjct: 421 LLTLQTYATDLKTDQGLLSNKEVYAKLSWREQQALQVRYGQKMILHQLLELTS 473
Protein Sequence
(Fasta)		MATQAKRPRV AGPVDGGDLD PVACFLSWCR RVGLELSPKV SERAGGRRTR GGARAALTSP 60
PAQVAVSRQG TVAGYGMVAR ESVQAGELLF VVPRAALLSQ HTCSIGGLLE RERVALQSQS 120
GWVPLLLALL HELQAPASRW RPYFALWPEL GRLEHPMFWP EEERRCLLQG TGVPEAVEKD 180
LANIRSEYQS IVLPFMEAHP DLFSLRVRSL ELYHQLVALV MAYSFQEPLE EEEDEKEPNS 240
PVMVPAADIL NHLANHNANL EYSANCLRMV ATQPIPKGHE IFNTYGQMAN WQLIHMYGFV 300
EPYPDNTDDT ADIQMVTVRE AALQGTKTEA ERHLVYERWD FLCKLEMVGE EGAFVIGREE 360
VLTEEELTTT LKVLCMPAEE FRELKDQDGG GDDKREEGSL TITNIPKLKA SWRQLLQNSV 420
LLTLQTYATD LKTDQGLLSN KEVYAKLSWR EQQALQVRYG QKMILHQLLE LTS 473
Nucleotide Sequence
(Fasta)		GGAAGTGACC GCGCGGTGCG CCGGCCCGCG AGGAAACGCG CTCTTAGACC ATGGCGACCC 60
AGGCGAAGCG TCCACGGGTG GCGGGGCCCG TGGACGGCGG CGACCTGGAT CCTGTGGCCT 120
GCTTCCTGAG CTGGTGCCGG CGGGTGGGGC TGGAGCTGAG TCCCAAGGTG AGCGAGCGAG 180
CCGGCGGGCG GAGGACCCGC GGCGGGGCGC GGGCTGCCCT GACCAGCCCT CCTGCTCAGG 240
TGGCGGTCAG CCGGCAGGGC ACGGTGGCCG GCTACGGCAT GGTGGCCCGG GAGAGCGTGC 300
AGGCCGGAGA GCTGTTGTTC GTGGTGCCGC GGGCCGCGCT CCTGTCGCAG CACACCTGCT 360
CCATCGGCGG CCTGCTGGAG CGAGAGCGAG TTGCGCTGCA GAGCCAGTCG GGCTGGGTGC 420
CACTGCTGCT GGCGCTGCTC CACGAGCTGC AGGCCCCGGC CTCACGCTGG AGGCCCTACT 480
TTGCGCTCTG GCCCGAGCTG GGCCGCTTGG AGCACCCGAT GTTCTGGCCA GAGGAGGAGC 540
GCCGGTGCCT GCTCCAGGGC ACAGGCGTAC CTGAGGCCGT GGAGAAGGAT TTGGCCAACA 600
TCCGCAGCGA GTACCAGTCC ATCGTGCTGC CCTTCATGGA AGCCCACCCC GATCTCTTCA 660
GCCTCAGGGT TCGCTCCCTA GAACTCTACC ACCAGCTGGT GGCCCTTGTG ATGGCCTATA 720
GCTTTCAGGA ACCACTGGAG GAAGAAGAGG ATGAAAAGGA GCCCAACTCC CCCGTGATGG 780
TGCCTGCTGC AGACATACTA AACCACTTAG CCAATCACAA CGCCAATCTA GAATACTCTG 840
CGAATTGTCT TCGGATGGTA GCCACTCAGC CCATTCCTAA AGGCCATGAG ATTTTCAACA 900
CTTATGGGCA AATGGCTAAC TGGCAACTGA TTCATATGTA CGGTTTTGTT GAACCATATC 960
CTGACAACAC AGATGACACA GCTGACATTC AGATGGTGAC AGTTCGTGAG GCAGCATTAC 1020
AGGGAACAAA AACTGAAGCT GAAAGGCACC TAGTGTACGA GCGCTGGGAT TTCCTATGCA 1080
AACTGGAGAT GGTAGGGGAA GAGGGAGCCT TTGTGATAGG GAGGGAGGAG GTGCTGACTG 1140
AAGAGGAGCT GACCACCACA CTAAAGGTAC TGTGCATGCC TGCTGAGGAG TTCAGAGAGC 1200
TTAAAGACCA GGATGGAGGG GGAGATGATA AAAGGGAAGA GGGCAGCCTG ACGATCACAA 1260
ATATTCCCAA GCTCAAAGCA TCGTGGAGAC AGCTGCTTCA AAACAGTGTT CTACTGACTT 1320
TGCAGACCTA TGCCACAGAC TTAAAAACTG ACCAAGGTTT ACTCAGTAAT AAGGAAGTCT 1380
ATGCGAAACT CAGCTGGAGG GAACAGCAAG CCTTACAGGT TCGCTATGGT CAGAAGATGA 1440
TCTTACATCA GTTGTTGGAG CTGACAAGTT AGCAGTTTCC CTGTTCCCTG AAGGAACAGC 1500
AATAAGAACT TTATTCTAAG CTAATACTCA TTGATGTTTG AAAAAGAGGA AAA 1554
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
--
Interpro

IPR011383--N-lys_methylase_SETD6
IPR015353--Rubisco_LSMT_subst-bd
IPR001214--SET_dom
PROSITE

PS50280--SET
Pfam

PF09273--Rubis-subs-bind
PF00856--SET
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0051059--F:NF-kappaB binding
GO:0016279--F:protein-lysine N-methyltransferase activity
GO:0034968--P:histone lysine methylation
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0018026--P:peptidyl-lysine monomethylation
GO:0050727--P:regulation of inflammatory response
GO:0048863--P:stem cell differentiation
GO:0019827--P:stem cell population maintenance
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Mam-0133 ENSMMUP00000019187.2 Macaca mulatta 97 0.0 793
WERAM-Pat-0065 ENSPTRP00000013971.4 Pan troglodytes 94 0.0 790
WERAM-Poa-0068 ENSPPYP00000008373.1 Pongo abelii 93 0.0 779
WERAM-Nol-0036 ENSNLEP00000004294.2 Nomascus leucogenys 93 0.0 776
WERAM-Paa-0121 ENSPANP00000012969.1 Papio anubis 92 0.0 774
WERAM-Caj-0118 ENSCJAP00000021216.2 Callithrix jacchus 88 0.0 736
WERAM-Sus-0182 ENSSSCP00000021130.1 Sus scrofa 86 0.0 707
WERAM-Otg-0011 ENSOGAP00000000486.2 Otolemur garnettii 86 0.0 706
WERAM-Mup-0055 ENSMPUP00000004781.1 Mustela putorius furo 85 0.0 703
WERAM-Bot-0178 ENSBTAP00000027690.4 Bos taurus 85 0.0 694
WERAM-Aim-0197 ENSAMEP00000018265.1 Ailuropoda melanoleuca 87 0.0 692
WERAM-Ova-0010 ENSOARP00000001568.1 Ovis aries 85 0.0 691
WERAM-Prc-0033 ENSPCAP00000002984.1 Procavia capensis 86 0.0 690
WERAM-Caf-0096 ENSCAFP00000012423.3 Canis familiaris 85 0.0 689
WERAM-Chs-0050 ENSCSAP00000001036.1 Chlorocebus sabaeus 97 0.0 689
WERAM-Fec-0072 ENSFCAP00000006134.2 Felis catus 91 0.0 688
WERAM-Dan-0097 ENSDNOP00000010261.3 Dasypus novemcinctus 83 0.0 686
WERAM-Ptv-0036 ENSPVAP00000004014.1 Pteropus vampyrus 81 0.0 683
WERAM-Ere-0063 ENSEEUP00000005298.1 Erinaceus europaeus 84 0.0 671
WERAM-Orc-0062 ENSOCUP00000005973.2 Oryctolagus cuniculus 87 0.0 667
WERAM-Tut-0095 ENSTTRP00000008019.1 Tursiops truncatus 82 0.0 659
WERAM-Loa-0001 ENSLAFP00000000082.3 Loxodonta africana 79 0.0 658
WERAM-Dio-0015 ENSDORP00000001964.1 Dipodomys ordii 82 0.0 657
WERAM-Ict-0056 ENSSTOP00000004894.2 Ictidomys tridecemlineatus 82 0.0 656
WERAM-Eqc-0050 ENSECAP00000006711.1 Equus caballus 93 0.0 653
WERAM-Gog-0111 ENSGGOP00000009322.2 Gorilla gorilla 99 0.0 632
WERAM-Ran-0081 ENSRNOP00000016626.4 Rattus norvegicus 79 6e-180 627
WERAM-Mum-0123 ENSMUSP00000034096.4 Mus musculus 78 3e-179 625
WERAM-Ect-0088 ENSETEP00000010382.1 Echinops telfairi 73 2e-173 606
WERAM-Mae-0057 ENSMEUP00000005599.1 Macropus eugenii 75 1e-168 590
WERAM-Cap-0198 ENSCPOP00000016246.1 Cavia porcellus 74 2e-159 559
WERAM-Chh-0078 ENSCHOP00000008571.1 Choloepus hoffmanni 87 1e-156 550
WERAM-Mod-0126 ENSMODP00000017721.2 Monodelphis domestica 72 2e-155 546
WERAM-Pes-0036 ENSPSIP00000005783.1 Pelodiscus sinensis 65 3e-142 502
WERAM-Ora-0102 ENSOANP00000019177.1 Ornithorhynchus anatinus 67 7e-141 498
WERAM-Fia-0092 ENSFALP00000007602.1 Ficedula albicollis 63 1e-140 497
WERAM-Gaga-0022 ENSGALP00000003512.4 Gallus gallus 65 2e-140 496
WERAM-Tag-0087 ENSTGUP00000006068.1 Taeniopygia guttata 63 7e-135 478
WERAM-Sah-0137 ENSSHAP00000014783.1 Sarcophilus harrisii 76 2e-132 470
WERAM-Ocp-0058 ENSOPRP00000005124.1 Ochotona princeps 86 6e-132 468
WERAM-Meg-0018 ENSMGAP00000001519.2 Meleagris gallopavo 68 3e-130 462
WERAM-Lac-0116 ENSLACP00000014023.2 Latimeria chalumnae 56 2e-124 443
WERAM-Leo-0056 ENSLOCP00000007614.1 Lepisosteus oculatus 56 4e-123 439
WERAM-Xet-0092 ENSXETP00000030207.3 Xenopus tropicalis 53 2e-119 426
WERAM-Anp-0062 ENSAPLP00000007039.1 Anas platyrhynchos 71 2e-117 419
WERAM-Gaa-0022 ENSGACP00000003410.1 Gasterosteus aculeatus 51 4e-110 395
WERAM-Vip-0091 ENSVPAP00000008229.1 Vicugna pacos 93 7e-109 391
WERAM-Myl-0198 ENSMLUP00000017493.1 Myotis lucifugus 85 1e-104 377
WERAM-Orn-0125 ENSONIP00000012804.1 Oreochromis niloticus 50 4e-104 375
WERAM-Pem-0099 ENSPMAP00000010301.1 Petromyzon marinus 52 7e-104 375
WERAM-Orla-0160 ENSORLP00000018697.1 Oryzias latipes 49 2e-102 370
WERAM-Xim-0068 ENSXMAP00000006043.1 Xiphophorus maculatus 47 2e-99 360
WERAM-Dar-0097 ENSDARP00000064572.4 Danio rerio 46 1e-98 357
WERAM-Pof-0052 ENSPFOP00000003945.1 Poecilia formosa 48 2e-98 357
WERAM-Mim-0068 ENSMICP00000006429.1 Microcebus murinus 89 6e-94 342
WERAM-Gam-0133 ENSGMOP00000013758.1 Gadus morhua 47 2e-91 333
WERAM-Tub-0058 ENSTBEP00000007273.1 Tupaia belangeri 83 4e-90 329
WERAM-Anc-0022 ENSACAP00000002392.2 Anolis carolinensis 58 3e-89 326
WERAM-Soa-0105 ENSSARP00000009987.1 Sorex araneus 64 4e-61 233
WERAM-Asm-0143 ENSAMXP00000013589.1 Astyanax mexicanus 46 2e-48 190
WERAM-Cii-0052 ENSCINP00000020186.3 Ciona intestinalis 39 9e-46 182
WERAM-Yal-0035 CAG78787 Yarrowia lipolytica 29 2e-19 94.7
WERAM-Phn-0033 SNOT_16462 Phaeosphaeria nodorum 27 4e-19 93.6
WERAM-Asfu-0002 CADAFUAP00000443 Aspergillus fumigatus 28 1e-18 92.4
WERAM-Pytr-0003 EDU40046 Pyrenophora triticirepentis 31 1e-18 91.7
WERAM-Pyt-0033 EFQ87682 Pyrenophora teres 30 3e-18 90.5
WERAM-Sem-0005 EFJ21283 Selaginella moellendorffii 27 2e-17 87.8
WERAM-Trr-0028 EGR49364 Trichoderma reesei 33 2e-17 87.8
WERAM-Scs-0001 EDN90812 Sclerotinia sclerotiorum 28 3e-16 84.0
WERAM-Asni-0033 CADANGAP00011546 Aspergillus niger 28 6e-16 82.8
WERAM-Asn-0028 CADANIAP00007342 Aspergillus nidulans 31 2e-15 81.6
WERAM-Ast-0005 CADATEAP00003204 Aspergillus terreus 28 2e-15 80.9
WERAM-Crn-0042 AAW46458 Cryptococcus neoformans 29 9e-15 79.0
WERAM-Lem-0012 CBY00997 Leptosphaeria maculans 26 1e-14 79.0
WERAM-Scj-0032 EEB08704 Schizosaccharomyces japonicus 23 2e-14 78.2
WERAM-Fuo-0027 FOXG_09043P0 Fusarium oxysporum 28 2e-14 78.2
WERAM-Asf-0015 CADAFLAP00006159 Aspergillus flavus 27 2e-14 77.8
WERAM-Coi-0016 EAS37352 Coccidioides immitis 27 3e-14 77.0
WERAM-Chg-0045 EAQ83002 Chaetomium globosum 29 4e-14 77.0
WERAM-Sac-0009 YDR257C Saccharomyces cerevisiae 26 1e-13 75.5
WERAM-Chr-0018 EDP06053 Chlamydomonas reinhardtii 29 1e-13 75.1
WERAM-Cag-0034 CAG62706 Candida glabrata 29 3e-13 74.3
WERAM-Mao-0015 MGG_04887T0 Magnaporthe oryzae 26 3e-13 73.9
WERAM-Asc-0038 CADACLAP00009113 Aspergillus clavatus 25 6e-13 73.2
WERAM-Asg-0017 AAS52460 Ashbya gossypii 25 2e-12 71.2
WERAM-Ved-0017 EGY23548 Verticillium dahliae 28 4e-12 70.5
WERAM-Viv-0048 VIT_07s0130g00260.t01 Vitis vinifera 23 1e-11 68.6
WERAM-Nec-0036 EFNCRP00000009614 Neurospora crassa 27 2e-11 67.8
WERAM-Trv-0040 EHK25932 Trichoderma virens 27 7e-11 66.2
WERAM-Zem-0059 GRMZM2G092759_P03 Zea mays 24 9e-11 65.9
WERAM-Miv-0004 MVLG_00247T0 Microbotryum violaceum 27 9e-11 65.9
WERAM-Scp-0021 SPAC688.14.1:pep Schizosaccharomyces pombe 31 1e-10 65.5
WERAM-Lab-0015 EDR11920 Laccaria bicolor 31 1e-10 65.5
WERAM-Put-0021 PTTG_08638P0 Puccinia triticina 28 5e-09 60.1
WERAM-Mel-0038 EGG03367 Melampsora laricipopulina 25 2e-08 58.2
WERAM-Pug-0003 EFP74686 Puccinia graminis 27 3e-08 57.4
Created Date 25-Jun-2016