| Tag |
Content |
| WERAM ID |
WERAM-Mum-0161 |
| Ensembl Protein ID |
ENSMUSP00000111301.3 |
| Uniprot Accession |
O54864; SUV91_MOUSE; Q3TEW2; Q3UT51; Q8C2L3; Q9JLC7; Q9JLP8
|
| Genbank Protein ID |
NP_001277645.1; NP_035644.1
|
| Protein Name |
Histone-lysine N-methyltransferase SUV39H1 |
| Genbank Nucleotide ID |
NM_001290716.1; NM_011514.2
|
| Gene Name |
Suv39h1 |
| Ensembl Information |
|
| Details |
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HMT |
SUV39 |
4.70e-42 |
145 |
244 |
366 |
| HMT |
SET1 |
9.00e-27 |
95 |
249 |
366 |
| Me_Reader |
Chromodomain |
5.40e-19 |
69.5 |
43 |
97 |
|
| Organism |
Mus musculus |
| NCBI Taxa ID |
10090 |
Functional Description
(View)Functional Description
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. Recruited by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation. |
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. Recruited by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.
|
| Domain Profile |
HMT SUV39
SUV39.txt 2 rLqvfktenk.GwGvrclddiakgsFvciyaGeiltddeaekegl...eegdeyladldskes 60
L +f+t++ GwGvr+l++i+k sFv++y+Gei+t++eae++g+ ++g +yl+dld++e+
ENSMUSP00000111301.3 244 DLCIFRTNDGrGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQiydRQGATYLFDLDYVED 306
699*****988********************************8889999*********9876 PP
SUV39.txt 89 eseyiidakkegnvgrflnHscspNlfvqnvfvdthdlrfprvafFaskrikagtELtwdYg 150
e++y++da+++gn+++f+nHsc+pNl v nvf+d+ d+r+pr+afFa+++i ag+ELt+dY+
ENSMUSP00000111301.3 305 EDVYTVDAAYYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIWAGEELTFDYN 366
789**********************************************************7 PP
HMT SET1
SET1.txt 6 akskikglglvakkeiekeelviEYvGevirsevadkrekeyekkeigvylfrldedae.vvvdatkkgniarfinhscepNceakvva 93
++++ +g+g+++ ++i+k+ +v+EYvGe+i se+a++r + y+++++ +ylf ld ++ + vda gni++f+nhsc+pN+++ v
ENSMUSP00000111301.3 249 RTNDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGA-TYLFDLDYVEDvYTVDAAYYGNISHFVNHSCDPNLQVYNVF 336
567788**************************************955.6******9888799**********************99998 PP
SET1.txt 94 vdge....kkiviyakraIekgeeltydYk 119
+d+ +i +a+r+I +geelt+dY+
ENSMUSP00000111301.3 337 IDNLderlPRIAFFATRTIWAGEELTFDYN 366
8764222369*******************7 PP
Me_Reader Chromodomain
Chromodomain.txt 1 FeverivdkkelrkgeveYlVrWkGynksddtWepeenLlckelleefekkkekkk 56
Feve+++d+k++r++e+ YlV+W+Gy++s++tWep++nL+c ++l++f+k+ e++
ENSMUSP00000111301.3 43 FEVEYLCDYKKIREQEY-YLVKWRGYPDSENTWEPRQNLKCIRVLKQFHKDLEREL 97
9****************.********************************999875 PP
|
Protein Sequence
(Fasta) | MAENLKGCSV CCKSSWNQLQ DLCRLAKLSC PALGVSKKNL YDFEVEYLCD YKKIREQEYY 60
LVKWRGYPDS ENTWEPRQNL KCIRVLKQFH KDLERELVRR HRRSKPPRHL DPNLANYLVQ 120
KAKQRRALQR WEQELNAKRS HLGRITVENE VDLDGPPRSF VYINEYRVGE GITLNQVAVG 180
CECQDCLLAP TGGCCPGASL HKFAYNDQGQ VRLKAGQPIY ECNSRCCCGY DCPNRVVQKG 240
IRYDLCIFRT NDGRGWGVRT LEKIRKNSFV MEYVGEIITS EEAERRGQIY DRQGATYLFD 300
LDYVEDVYTV DAAYYGNISH FVNHSCDPNL QVYNVFIDNL DERLPRIAFF ATRTIWAGEE 360
LTFDYNMQVD PVDMESTRMD SNFGLAGLPG SPKKRVRIEC KCGTTACRKY LF 412Protein Fasta Sequence
>ENSMUSP00000111301.3|Suv39h1|Mus musculus
MAENLKGCSVCCKSSWNQLQDLCRLAKLSCPALGVSKKNLYDFEVEYLCDYKKIREQEYYLVKWRGYPDSENTWEPRQNLKCIRVLKQFHKDLERELVRRHRRSKPPRHLDPNLANYLVQKAKQRRALQRWEQELNAKRSHLGRITVENEVDLDGPPRSFVYINEYRVGEGITLNQVAVGCECQDCLLAPTGGCCPGASLHKFAYNDQGQVRLKAGQPIYECNSRCCCGYDCPNRVVQKGIRYDLCIFRTNDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVEDVYTVDAAYYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIWAGEELTFDYNMQVDPVDMESTRMDSNFGLAGLPGSPKKRVRIECKCGTTACRKYLF |
Nucleotide Sequence
(Fasta) | TGAATAAAGG CAGCGAGCAC GGGCTCTCGA GACCACTCCT GGTGACGGGA GGAGTCCAGG 60
CACAGCTCCG CGGTTGGTCC GAGCCGGAGC TGCGAGCGGC GAGGAGCGGC CAATCGACTG 120
CGCGTCCCCG GCCACGCCCG CGCGCGCTCT CTTCTCGCGA GGCCGGTTAG GCCCGAATGT 180
TGTTAGCTGT GGAGAAAGAT GGCGGAAAAT TTAAAAGGTT GCAGTGTGTG CTGTAAATCT 240
TCTTGGAATC AACTGCAGGA CCTGTGCCGA CTAGCCAAGC TTTCTTGTCC TGCCCTTGGT 300
GTTTCTAAGA AGAATCTGTA TGACTTTGAA GTTGAATACC TGTGTGATTA TAAGAAGATC 360
CGTGAGCAGG AGTATTACCT GGTTAAGTGG CGTGGGTATC CCGACTCAGA AAACACCTGG 420
GAGCCACGGC AGAATCTAAA ATGTATACGA GTTCTTAAGC AGTTCCACAA GGACTTAGAA 480
AGAGAGCTTG TCCGACGACA CCGCCGGTCA AAGCCACCCA GGCATCTGGA CCCAAACCTA 540
GCCAATTACC TGGTGCAGAA GGCCAAGCAG AGGCGGGCAC TTCAGCGTTG GGAACAAGAG 600
CTCAATGCCA AGCGCAGCCA CCTGGGGCGG ATCACCGTGG AGAATGAGGT AGACCTGGAT 660
GGCCCTCCAA GGTCCTTTGT CTATATCAAT GAGTATCGAG TTGGTGAGGG CATCACCCTC 720
AACCAGGTAG CTGTTGGCTG TGAGTGCCAG GACTGTCTGT TGGCACCCAC TGGAGGCTGT 780
TGCCCTGGAG CATCCCTGCA CAAGTTTGCC TACAATGACC AAGGCCAGGT GCGACTGAAA 840
GCTGGGCAGC CCATCTACGA GTGCAACTCC CGCTGTTGCT GTGGCTATGA CTGCCCAAAC 900
CGTGTAGTCC AGAAAGGCAT CCGCTACGAT CTCTGCATCT TCCGCACTAA TGATGGCCGA 960
GGCTGGGGTG TCCGCACGCT GGAAAAGATC CGAAAAAATA GCTTTGTTAT GGAGTATGTG 1020
GGAGAGATTA TTACCTCAGA GGAGGCAGAG CGGAGGGGCC AGATCTACGA CCGCCAGGGC 1080
GCCACCTACC TCTTTGACCT GGACTACGTG GAAGACGTAT ATACCGTGGA TGCCGCTTAT 1140
TATGGCAACA TCTCTCATTT TGTCAACCAT AGTTGTGATC CCAACCTGCA GGTGTACAAC 1200
GTATTCATAG ACAACCTTGA TGAGCGACTA CCCCGCATCG CATTCTTTGC CACAAGAACC 1260
ATCTGGGCGG GCGAGGAGCT CACCTTTGAT TACAACATGC AAGTGGACCC CGTGGACATG 1320
GAGAGTACCC GAATGGACTC CAACTTTGGC CTGGCTGGGC TCCCCGGCTC CCCCAAGAAA 1380
CGAGTCCGTA TTGAATGCAA ATGTGGGACA ACGGCTTGCC GAAAATACCT CTTCTAGCCC 1440
TGAGAAGTCT GAGGCCAGAC TAACTGAAGG GGCCTGAAGC CACCTTCCTC TCCTACAGCT 1500
ACCCTCTTGT CAAGGATGAC CATCAATCAG AGCCTTGTCT GCCTCCACTT GTCCTCACCT 1560
ACCCTAACCT GCTCTAGGGT CAGGGCTGTT GTGAGGACTA ACTCCGGGTA CCCTTTTCCT 1620
GTTCCTTTCC CCCTGTTCCA GGCCCATCAG GCATTGCACT TAAAACTCCC AGCCCCATTT 1680
TCAGAAACAT ATTTTTCACA TCATGATTCC CTAGAGTTGG AATTCATGTC ATATAATGGA 1740
GGTCCAGATT GAGGAACTCG GCTGTAAAAC AGATTCTTTG TTTTGGACAG CATCTCTGCA 1800
GCTCTATGTA GTAAGTCTGG TGTTTGGACC GTTAATCTTC CTGTCTCAGC CTTCCTCATG 1860
ATGAGATTGT AGGTGTAAAC CCAGCTAAGA TTTTTGTTCT AATTGCATCT GCTTCTGCTT 1920
GGAGCTTGTG TGTGACCTGT TGCAGGCCTC TTCATTACTC TAATGGTATG AGGAAGCAAC 1980
CCCCTGGCAG ACAGACATCA GAGCTGAGAT ACCAGCCTAA CATCAAGCTG GATCAGCAAC 2040
CCCAGAGCCT TTGTACTCAG GAAAGAAAAG GCAATCTTCA GAGCTGGGAG ATAAGGCTGG 2100
TTCCGCTCTT TGTGCTTTTG ATGCTGGCTG GTATTAACCT TAAGACCTAT AGGGTCTCAA 2160
CAGTTGCAAG TCTGAAAAGT AGTTGCCCAA ATGCCATCAG AATGGGGATG GAGTAAATAC 2220
CTCTTTGAAA GCCCCACAGA AAGGTTAGAA CTAAGTTTTA CCATCAGGAA GTACAGTGCT 2280
GGACTTGCTG GAAACCCAGC CTTGGCATTT GATGGCCACT AGAACTACTA GAAGCTGGAA 2340
CCAAGATCTA GGTATTCTTT AGATAGCACT TAAGACAGTA ATGTGCATCG ACTAGAAGGC 2400
GATGTGATGC CAGGCACTTG GTAGAGCACC TGGTCCATAC AGATTGTCTC AGGGAAGCCT 2460
TGAAAACCAC AAAGGTGGAG CCCAGAAAAA AGCCCATGTG ACAGAAGGCA ATGTCTAGGC 2520
CAAAAATACT TGTCAGCTCC AAGTATTCAC CTGGGTCCAC TTGTCTCAGT TAACTGCCTA 2580
GAAATGTACA AAAGGCAAAG ATTCTGATGG CTGCCTTGCC CCCTGCTTCC CCACCTCCAG 2640
GAAGCCTTTC CTGACTTCCT GTGCCCAGAG TGCCCTATGT GAAACTCTGT ACCCTGCTAC 2700
CAGATGCCAG GTCTGTGTGT GTATTTTGTA TATATGTTTC CTGCCCATAC TTCCCAGGCT 2760
GACCTTCAGG CATGGACTGA ATCTGGTTCT CTCTGTACCC CTCAGCCCTC CCTAGCCTGG 2820
AGTGCACACC AATAAACTGT GTTGTTGAGT TAATAAGCTT GAGATTTGGG AGATTGAGGT 2880
CTTGATGATA ACTGGGAAAT GAGAGGTTAG AAGCTGGGGT TGAGTTGCTC TAGAATGCGG 2940
TCAGAAAGGC TTGAGTCATC TCACCGTGAT CTTCCTATTT GGGGCCCCTT ATAAAGTGGT 3000
CTAAAGCCAT TTTAAAAACA CACTTGAACA AATAGTCCAG CTTTTTCTAA ATTGATTTGT 3060
TGCTACAAAC AAAAATAACT ACCTGAAGAA ATAAATACAA TGGAAGTCAA TGTGCT
3117Nucleotide Fasta Sequence
>ENSMUSP00000111301.3|Chromodomain|Mus musculus
TGAATAAAGGCAGCGAGCACGGGCTCTCGAGACCACTCCTGGTGACGGGAGGAGTCCAGGCACAGCTCCGCGGTTGGTCCGAGCCGGAGCTGCGAGCGGCGAGGAGCGGCCAATCGACTGCGCGTCCCCGGCCACGCCCGCGCGCGCTCTCTTCTCGCGAGGCCGGTTAGGCCCGAATGTTGTTAGCTGTGGAGAAAGATGGCGGAAAATTTAAAAGGTTGCAGTGTGTGCTGTAAATCTTCTTGGAATCAACTGCAGGACCTGTGCCGACTAGCCAAGCTTTCTTGTCCTGCCCTTGGTGTTTCTAAGAAGAATCTGTATGACTTTGAAGTTGAATACCTGTGTGATTATAAGAAGATCCGTGAGCAGGAGTATTACCTGGTTAAGTGGCGTGGGTATCCCGACTCAGAAAACACCTGGGAGCCACGGCAGAATCTAAAATGTATACGAGTTCTTAAGCAGTTCCACAAGGACTTAGAAAGAGAGCTTGTCCGACGACACCGCCGGTCAAAGCCACCCAGGCATCTGGACCCAAACCTAGCCAATTACCTGGTGCAGAAGGCCAAGCAGAGGCGGGCACTTCAGCGTTGGGAACAAGAGCTCAATGCCAAGCGCAGCCACCTGGGGCGGATCACCGTGGAGAATGAGGTAGACCTGGATGGCCCTCCAAGGTCCTTTGTCTATATCAATGAGTATCGAGTTGGTGAGGGCATCACCCTCAACCAGGTAGCTGTTGGCTGTGAGTGCCAGGACTGTCTGTTGGCACCCACTGGAGGCTGTTGCCCTGGAGCATCCCTGCACAAGTTTGCCTACAATGACCAAGGCCAGGTGCGACTGAAAGCTGGGCAGCCCATCTACGAGTGCAACTCCCGCTGTTGCTGTGGCTATGACTGCCCAAACCGTGTAGTCCAGAAAGGCATCCGCTACGATCTCTGCATCTTCCGCACTAATGATGGCCGAGGCTGGGGTGTCCGCACGCTGGAAAAGATCCGAAAAAATAGCTTTGTTATGGAGTATGTGGGAGAGATTATTACCTCAGAGGAGGCAGAGCGGAGGGGCCAGATCTACGACCGCCAGGGCGCCACCTACCTCTTTGACCTGGACTACGTGGAAGACGTATATACCGTGGATGCCGCTTATTATGGCAACATCTCTCATTTTGTCAACCATAGTTGTGATCCCAACCTGCAGGTGTACAACGTATTCATAGACAACCTTGATGAGCGACTACCCCGCATCGCATTCTTTGCCACAAGAACCATCTGGGCGGGCGAGGAGCTCACCTTTGATTACAACATGCAAGTGGACCCCGTGGACATGGAGAGTACCCGAATGGACTCCAACTTTGGCCTGGCTGGGCTCCCCGGCTCCCCCAAGAAACGAGTCCGTATTGAATGCAAATGTGGGACAACGGCTTGCCGAAAATACCTCTTCTAGCCCTGAGAAGTCTGAGGCCAGACTAACTGAAGGGGCCTGAAGCCACCTTCCTCTCCTACAGCTACCCTCTTGTCAAGGATGACCATCAATCAGAGCCTTGTCTGCCTCCACTTGTCCTCACCTACCCTAACCTGCTCTAGGGTCAGGGCTGTTGTGAGGACTAACTCCGGGTACCCTTTTCCTGTTCCTTTCCCCCTGTTCCAGGCCCATCAGGCATTGCACTTAAAACTCCCAGCCCCATTTTCAGAAACATATTTTTCACATCATGATTCCCTAGAGTTGGAATTCATGTCATATAATGGAGGTCCAGATTGAGGAACTCGGCTGTAAAACAGATTCTTTGTTTTGGACAGCATCTCTGCAGCTCTATGTAGTAAGTCTGGTGTTTGGACCGTTAATCTTCCTGTCTCAGCCTTCCTCATGATGAGATTGTAGGTGTAAACCCAGCTAAGATTTTTGTTCTAATTGCATCTGCTTCTGCTTGGAGCTTGTGTGTGACCTGTTGCAGGCCTCTTCATTACTCTAATGGTATGAGGAAGCAACCCCCTGGCAGACAGACATCAGAGCTGAGATACCAGCCTAACATCAAGCTGGATCAGCAACCCCAGAGCCTTTGTACTCAGGAAAGAAAAGGCAATCTTCAGAGCTGGGAGATAAGGCTGGTTCCGCTCTTTGTGCTTTTGATGCTGGCTGGTATTAACCTTAAGACCTATAGGGTCTCAACAGTTGCAAGTCTGAAAAGTAGTTGCCCAAATGCCATCAGAATGGGGATGGAGTAAATACCTCTTTGAAAGCCCCACAGAAAGGTTAGAACTAAGTTTTACCATCAGGAAGTACAGTGCTGGACTTGCTGGAAACCCAGCCTTGGCATTTGATGGCCACTAGAACTACTAGAAGCTGGAACCAAGATCTAGGTATTCTTTAGATAGCACTTAAGACAGTAATGTGCATCGACTAGAAGGCGATGTGATGCCAGGCACTTGGTAGAGCACCTGGTCCATACAGATTGTCTCAGGGAAGCCTTGAAAACCACAAAGGTGGAGCCCAGAAAAAAGCCCATGTGACAGAAGGCAATGTCTAGGCCAAAAATACTTGTCAGCTCCAAGTATTCACCTGGGTCCACTTGTCTCAGTTAACTGCCTAGAAATGTACAAAAGGCAAAGATTCTGATGGCTGCCTTGCCCCCTGCTTCCCCACCTCCAGGAAGCCTTTCCTGACTTCCTGTGCCCAGAGTGCCCTATGTGAAACTCTGTACCCTGCTACCAGATGCCAGGTCTGTGTGTGTATTTTGTATATATGTTTCCTGCCCATACTTCCCAGGCTGACCTTCAGGCATGGACTGAATCTGGTTCTCTCTGTACCCCTCAGCCCTCCCTAGCCTGGAGTGCACACCAATAAACTGTGTTGTTGAGTTAATAAGCTTGAGATTTGGGAGATTGAGGTCTTGATGATAACTGGGAAATGAGAGGTTAGAAGCTGGGGTTGAGTTGCTCTAGAATGCGGTCAGAAAGGCTTGAGTCATCTCACCGTGATCTTCCTATTTGGGGCCCCTTATAAAGTGGTCTAAAGCCATTTTAAAAACACACTTGAACAAATAGTCCAGCTTTTTCTAAATTGATTTGTTGCTACAAACAAAAATAACTACCTGAAGAAATAAATACAATGGAAGTCAATGTGCT
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0090--Biological rhythms
KW-0131--Cell cycle
KW-0137--Centromere
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0221--Differentiation
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0698--rRNA processing
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0862--Zinc
--
|
| Interpro |
IPR000953--Chromo/shadow_dom
IPR023780--Chromo_domain
IPR016197--Chromodomain-like
IPR023779--Chromodomain_CS
IPR011381--Histone_H3-K9_MeTrfase
IPR003616--Post-SET_dom
IPR007728--Pre-SET_dom
IPR001214--SET_dom
|
| PROSITE |
PS00598--CHROMO_1
PS50013--CHROMO_2
PS50868--POST_SET
PS50867--PRE_SET
PS51579--SAM_MT43_SUVAR39_3
PS50280--SET
|
| Pfam |
PF00385--Chromo
PF05033--Pre-SET
PF00856--SET
|
| Gene Ontology |
GO:0005677--C:chromatin silencing complex
GO:0000775--C:chromosome, centromeric region
GO:0000792--C:heterochromatin
GO:0005720--C:nuclear heterochromatin
GO:0005652--C:nuclear lamina
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0033553--C:rDNA heterochromatin
GO:0042054--F:histone methyltransferase activity
GO:0046974--F:histone methyltransferase activity (H3-K9 specific)
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0008168--F:methyltransferase activity
GO:0008276--F:protein methyltransferase activity
GO:0047485--F:protein N-terminus binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0008757--F:S-adenosylmethionine-dependent methyltransferase activity
GO:0000976--F:transcription regulatory region sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0007049--P:cell cycle
GO:0030154--P:cell differentiation
GO:0006974--P:cellular response to DNA damage stimulus
GO:0071456--P:cellular response to hypoxia
GO:0006342--P:chromatin silencing
GO:0000183--P:chromatin silencing at rDNA
GO:0006323--P:DNA packaging
GO:0036123--P:histone H3-K9 dimethylation
GO:0051567--P:histone H3-K9 methylation
GO:0036124--P:histone H3-K9 trimethylation
GO:0034968--P:histone lysine methylation
GO:0042754--P:negative regulation of circadian rhythm
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0048511--P:rhythmic process
GO:0006364--P:rRNA processing
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
