WERAM Information

Tag Content
WERAM ID WERAM-Mum-0074
Ensembl Protein ID ENSMUSP00000026888.4
Uniprot Accession Q5HZG4; TAF3_MOUSE; Q3U490; Q3UWX2; Q8BIU8; Q99JH4
Genbank Protein ID NP_082024.2
Protein Name Transcription initiation factor TFIID subunit 3
Genbank Nucleotide ID NM_027748.3
Gene Name TAF3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000025782.12 ENSMUST00000026888.10 ENSMUSP00000026888.4
ENSMUSG00000025782.12 ENSMUST00000114906.1 ENSMUSP00000110556.1
ENSMUSG00000025782.12 ENSMUST00000114907.1 ENSMUSP00000110557.1
ENSMUSG00000025782.12 ENSMUST00000114909.1 ENSMUSP00000110559.1
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader PHD PHD-type H3K4me3 K 18682226
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader PHD 2.10e-12 48.5 869 916
Organism Mus musculus
NCBI Taxa ID 10090
Functional Description
(View)		 Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process.
Domain Profile
  Me_Reader PHD
               PHD.txt   3 iClvCgkddegekemvqCdeCddwfHlkCvklplsslp.egkswyCpsCke 52 
                           iC+ C+k+d+g++ m+ Cd Cddw+H+ Cv++    +p e+ +w+Cp+C +
  ENSMUSP00000026888.4 869 ICPGCNKPDDGSP-MIGCDDCDDWYHWPCVGIM--AAPpEEMQWFCPKCAN 916
                           8**********99.*******************..55547779******86 PP
Protein Sequence
(Fasta)		MCESYSRSLL RVSVAQICQA LGWDSVQLSA CHLLTDVLQR YLQQLGRGCH RYSELYGRTD 60
PILDDVGEAF QLMGVNLHEL EDYIHNIEPV TFPHQIPSFP VSKNNVLQFP QPGSKDAEER 120
KDYIPDYLPP IVSSQEEEEE EQVPTDGGTS AEAMQVPLEE DDEMEEEEVI NDENFLGKRP 180
LDSPEVEEMP SMKRPRLLST KGDSLDVVLL EAREPLSSIN PQKTPPVLSP VRVQDRADLA 240
PPSPQPPMLA PFAKSQLPIA KPLETKSFTP KTKTKASSPG QKTKSPKAAL SPARLGSPIR 300
SPKTIPKEKK SPGRSKSPKS PKSPKIVAHV PQTPVRPETP NRTPSAMVVE KTVKETIPVM 360
KPTQTPPEVV KLNIEMQPKK PVVTDKTIDD SIDAVIARAC AEREPDPFEF SSGSESEGDT 420
FTSPKRISGS ECATPKASTS SNNFTKSLAT PLPLSSGTSS SDNSWTMDAS IDEVVRKAKL 480
GAPSNMPPTF PYISSPSISP PTPEPLHKGY EEKAKLPSSV DVKKKLKKEL KTKLKKKEKQ 540
RDRERERERN KERSKEKDKM REREKEKEAG KELKYPWREL MKDEDSDPYK FKIKEFEDID 600
AAKVRLKDGI VRREREKHKD KKKDRERSKR EKDKRERERL KEKNREDKIK APPTQLVLPP 660
KEMALPLFSP SAVRVPAMLP AFSPMLPEKL FEEKEKPKEK ERKKDKKEKK KKKEKEKEKE 720
KKEREREKER REREKREKEK EKHKHEKIKV EPVIPAPSPV IPRLTLRVGA GQDKIVISKV 780
VPAPEAKPAP SLNRPKTPPP APVPIPVRVS PTPLQPPLLT QAAVCPALMP SPAPALSGIG 840
SAKAPVRSVV TETVSTYVIR DEWGNQIWIC PGCNKPDDGS PMIGCDDCDD WYHWPCVGIM 900
AAPPEEMQWF CPKCANKIKK DKKHKKRKHR AH 932
Nucleotide Sequence
(Fasta)		GCGAGTCCAA AATGGCGGCT CTCAGGCTGG CGCGCTCCGT GCTGCTGAGG CTTTGAGGTG 60
GTCGCTCCGG GTCGGAGGGG GGACGATTTC CCCGCCGCGG GGCCCCCAGA GAATGAATCG 120
GGGGCTCTGC TGAGGCGAGG CGGCAGGGCT GGAGAGCAGT GGCAGCGAAG GGCTGCGGTG 180
GCGTCCACGC AGCGGGATGT GCGAGAGTTA CTCTAGGTCG TTGTTGAGGG TCTCGGTGGC 240
GCAGATCTGC CAGGCGCTGG GCTGGGACTC GGTGCAGCTC AGCGCCTGCC ACCTCCTCAC 300
CGACGTCCTG CAGCGCTATC TGCAGCAGCT GGGCCGGGGC TGCCATCGGT ACTCTGAACT 360
CTATGGCCGA ACAGACCCCA TTTTGGATGA TGTTGGTGAA GCCTTCCAAC TTATGGGAGT 420
TAATCTGCAT GAACTAGAAG ACTATATTCA TAATATTGAA CCTGTCACTT TCCCACATCA 480
AATTCCTTCA TTTCCTGTTA GCAAGAACAA TGTCCTTCAG TTTCCTCAGC CCGGAAGTAA 540
AGATGCAGAG GAAAGAAAAG ACTACATTCC GGATTACCTT CCCCCCATCG TGTCTTCTCA 600
AGAAGAGGAG GAAGAGGAAC AGGTGCCCAC TGATGGGGGC ACCTCAGCAG AAGCCATGCA 660
GGTGCCCTTG GAAGAAGATG ATGAGATGGA GGAGGAGGAA GTCATCAATG ATGAGAACTT 720
CTTGGGTAAG AGGCCACTGG ACAGTCCTGA AGTGGAAGAA ATGCCCTCCA TGAAGCGCCC 780
ACGACTCCTG AGCACTAAAG GGGACTCCCT AGATGTTGTG TTGTTAGAAG CACGAGAACC 840
CCTCAGCTCT ATAAACCCAC AGAAGACCCC ACCAGTGCTC TCTCCTGTGC GTGTCCAGGA 900
CAGGGCTGAT CTGGCCCCTC CATCACCACA GCCTCCCATG CTGGCTCCAT TTGCAAAGTC 960
ACAACTACCA ATTGCAAAGC CGTTAGAAAC AAAGTCGTTT ACACCAAAAA CAAAGACTAA 1020
AGCTAGCTCT CCAGGTCAGA AAACTAAGTC ACCCAAGGCT GCCCTATCAC CAGCAAGGCT 1080
TGGAAGTCCT ATTCGGTCAC CAAAAACCAT CCCAAAAGAA AAGAAGTCAC CTGGACGCTC 1140
CAAGAGCCCC AAGAGTCCTA AGAGCCCCAA GATTGTAGCT CATGTTCCCC AAACCCCTGT 1200
CAGACCTGAA ACACCAAATA GGACCCCTTC AGCCATGGTG GTTGAAAAAA CTGTTAAAGA 1260
GACCATCCCA GTGATGAAAC CAACACAGAC TCCCCCAGAA GTTGTGAAAC TGAACATTGA 1320
AATGCAGCCG AAAAAGCCTG TGGTGACAGA CAAAACCATC GATGACTCCA TCGATGCTGT 1380
GATCGCACGT GCCTGTGCAG AGCGGGAGCC AGACCCTTTC GAGTTTTCTT CCGGATCGGA 1440
ATCGGAAGGA GACACTTTTA CAAGTCCTAA GAGGATTTCA GGCTCAGAGT GCGCCACTCC 1500
AAAAGCCTCC ACTTCCTCCA ATAACTTCAC CAAGTCCCTG GCCACTCCTC TGCCTCTCTC 1560
CAGCGGAACC TCAAGTTCAG ATAACTCGTG GACAATGGAT GCCTCTATTG ATGAGGTGGT 1620
ACGGAAGGCA AAGCTGGGAG CCCCTTCCAA CATGCCTCCC ACCTTCCCAT ATATCTCTTC 1680
TCCCTCAATT TCTCCTCCCA CTCCTGAGCC TCTACACAAG GGGTATGAGG AGAAAGCCAA 1740
GCTGCCTTCG TCTGTGGATG TAAAGAAAAA GTTGAAAAAA GAACTGAAGA CTAAGTTGAA 1800
AAAGAAAGAA AAGCAGCGAG ACAGAGAGAG GGAGAGAGAG AGAAACAAAG AAAGAAGCAA 1860
AGAGAAAGAT AAAATGAGAG AGAGGGAGAA GGAGAAGGAG GCTGGAAAGG AACTTAAGTA 1920
CCCGTGGAGG GAGCTGATGA AAGACGAAGA TTCTGATCCC TATAAGTTTA AAATCAAAGA 1980
ATTTGAAGAC ATTGATGCTG CGAAAGTGCG ATTGAAAGAT GGGATCGTGA GGAGAGAGCG 2040
AGAGAAACAT AAGGACAAGA AGAAAGATCG AGAAAGAAGC AAGCGGGAGA AAGATAAGCG 2100
AGAAAGGGAA AGGCTTAAAG AAAAAAACAG AGAAGACAAG ATAAAGGCCC CTCCAACACA 2160
GCTGGTGTTG CCCCCAAAAG AAATGGCACT GCCTTTGTTC AGCCCTTCAG CAGTGAGGGT 2220
CCCGGCCATG CTGCCGGCCT TCTCACCAAT GCTCCCAGAA AAACTGTTTG AGGAAAAAGA 2280
GAAGCCCAAG GAGAAAGAAA GGAAAAAGGA CAAAAAGGAG AAGAAGAAGA AGAAAGAGAA 2340
GGAGAAAGAA AAGGAGAAGA AAGAGAGGGA GAGGGAGAAG GAGAGAAGGG AGAGAGAGAA 2400
GAGAGAGAAG GAGAAGGAGA AGCACAAACA TGAGAAGATA AAAGTGGAGC CTGTCATCCC 2460
TGCCCCAAGT CCAGTTATCC CCAGGTTGAC TCTGCGAGTT GGCGCTGGCC AGGACAAGAT 2520
TGTTATCAGC AAGGTGGTAC CAGCCCCGGA GGCTAAGCCC GCTCCTTCTC TGAACAGACC 2580
CAAAACCCCA CCTCCAGCCC CAGTCCCTAT TCCTGTGCGA GTGAGCCCTA CTCCCCTGCA 2640
GCCACCACTC CTCACCCAGG CTGCAGTGTG CCCAGCCCTG ATGCCATCCC CAGCTCCCGC 2700
CCTCTCTGGA ATAGGGAGTG CCAAAGCCCC CGTGAGGAGC GTCGTGACTG AGACGGTCAG 2760
CACTTATGTG ATCCGTGATG AGTGGGGCAA TCAGATCTGG ATCTGTCCAG GGTGCAACAA 2820
GCCTGATGAC GGGAGCCCGA TGATTGGCTG TGACGACTGT GACGATTGGT ACCACTGGCC 2880
CTGTGTGGGA ATCATGGCTG CTCCTCCAGA AGAGATGCAG TGGTTCTGCC CGAAGTGTGC 2940
CAACAAGATA AAGAAAGACA AGAAGCACAA GAAGAGGAAG CACCGTGCGC ACTGACATCA 3000
GCGTGGGCAG GACTGCTGCC CTGCGCCGGG TCGGGGCTGG GCTGGTTCTG CCATCCTGTC 3060
TCCCCCGGGC CCTGTGGACT TGCAGCGCAT CCCAGAGGAG CAAGGACAAG AACATGGCAC 3120
CCCTCTGGAT GCTCCCTCTG AAACACATGG GCCTGAGCTC CCGCAGCATG TTGCTGAAGA 3180
AAACTCCAGT GGAGGGCTGG CCCGAGGGCT GGCACCTCCA TCTGCCTATT ACCAGTGACA 3240
AGTATTAATA AAGACGCCAC ACATCTGCCC TCTCGATTTC CTTTCTTCTC TCCAGAACCT 3300
TTCGTCATGG TATTAGATAA GAAGGTAATG TCCAAATGCC TTGACTGATG GAAGGGCGCA 3360
TCGGTAGCTA CAGTTGGCAA GCCCACTCCC TCCACGGGGA GGTAATCAGA AGGAAAGAAC 3420
GCTCCAGTCA CAGCACTGGG AATATTTTTG TGATGAGAGT ATATGAAGCT CCCCACCTCA 3480
CCCGACTTTT ATTACTAACG TGTAAAATGT TCAGGCTTTT GTGAGATACC TTATATTTTT 3540
TAAGAAAAGG GTTTCTATCA TGTCCTGTCC ACCCCTGTGC AGATTGTCTT CATTGGCCTA 3600
TTTTATACCT TGGTTGCATT CCCATCCCAC TGTGTGAACT GCTGGAGTCC CCCTGCTGCG 3660
TGTGCATCCC ATCGACTTGT ATAAAACTCT TGATACTAAG GAGAATCCCC TCACTGTAAA 3720
TAATAAATAT TTATGAAGTA GTTATTTTTA AAATTTTTTA TCGTGTTTAA TTCTGGCTTT 3780
CTCTGGAATC CACTGCGATT TCAGCCATGT CTGTAATTGC TGCTGTGCAT AGGCAAAGAA 3840
GAGAGACGAG GACCCAGAGC CATGACCCTG CCCAAGCGCA CCGCCCACGC AATGGGCGGG 3900
GAGGACCCCG CAACCGGAAG GAAACAGGCA ATTGACATCT CAAGTTGATG GTTTGAAACT 3960
GTTTTGTTTG TTATATATTT TCTGTAAATT TCTCTCACTT TTACTAAAAA GGACATGTAG 4020
TTTCCACAAA AGTAAAAAAA GAGAAAATAC TGTAGCATTT GTGTTTATAT TGTTTTATTT 4080
CACAGATTTG TTCATGGATA TTGTGCTTTA AGGTTGAAAT GAAGTATATT ATGGATTTTT 4140
TTAAGAAAAC TCATCAAATT TCAGGGTATC ACAAAACTTT ATTATATTAC TATACTGCCC 4200
ACTATTTATT TATAGATATC TGAAACGTAA ACCAAATGTT TTATTTTTAA TGTAAAAAAA 4260
AAACATCAAA TTTAACTTTA TTAGCATATT TTAGTGACTT TGGAATAACT ATGGACTTTT 4320
ACTTGATTTT GAAATAATCC CAATTTGGGC ATGCGTGAAG GCTGTCTTGA ATGTTAGAAT 4380
GCAGGATTTG AACCTAATAC AAATATATGA ATAGAAATGT GATTTTTTTT TTACTCCCAA 4440
CTCAATTGAT ATTAGCATTA TAATTACCCC TATTTTAAAA CATATAATGT GGTTTCAGAA 4500
ATGCGGTTCT CGGCCTTGAT GTTAAATTGC AGAAAAGTGG GAATGGAGTC AACCTGTGAA 4560
GAGTGTGGAA GTCACTACCC CCCTTGTTCT AGAAGCCAGA TTGTCCGCCA TCCCCACCCC 4620
ACACCCCAAA AAGTATCTAT GTTGAGATGT GTCTCTTTTC TTTTTGATTT ATTAGAGATC 4680
ATCCTGAATA CTTTATACAA TATTTTCACA TGCACAAGTA TACCCATTAG TGCTTTTTGG 4740
AGGAGACAAA GGGTGGGGGA AGTGCAAAAT AAAGATTATT GGCTGTTTCG TA 4793
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR006565--BTP
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF07524--Bromo_TP
PF00628--PHD
Gene Ontology

GO:0005634--C:nucleus
GO:0005669--C:transcription factor TFIID complex
GO:0002039--F:p53 binding
GO:0008270--F:zinc ion binding
GO:0051457--P:maintenance of protein location in nucleus
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006366--P:transcription from RNA polymerase II promoter
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Ran-0125 ENSRNOP00000025993.4 Rattus norvegicus 96 0.0 1049
WERAM-Orc-0207 ENSOCUP00000021444.2 Oryctolagus cuniculus 87 0.0 971
WERAM-Ict-0014 ENSSTOP00000000954.2 Ictidomys tridecemlineatus 88 0.0 946
WERAM-Otg-0227 ENSOGAP00000016433.1 Otolemur garnettii 81 0.0 944
WERAM-Caf-0060 ENSCAFP00000007470.4 Canis familiaris 84 0.0 935
WERAM-Chs-0164 ENSCSAP00000009590.1 Chlorocebus sabaeus 84 0.0 920
WERAM-Dio-0070 ENSDORP00000007144.1 Dipodomys ordii 84 0.0 919
WERAM-Pat-0017 ENSPTRP00000003857.5 Pan troglodytes 84 0.0 919
WERAM-Paa-0184 ENSPANP00000019866.1 Papio anubis 84 0.0 916
WERAM-Loa-0026 ENSLAFP00000001600.3 Loxodonta africana 83 0.0 915
WERAM-Mup-0189 ENSMPUP00000016286.1 Mustela putorius furo 82 0.0 914
WERAM-Cap-0020 ENSCPOP00000001758.2 Cavia porcellus 84 0.0 914
WERAM-Hos-0180 ENSP00000340271.5 Homo sapiens 82 0.0 902
WERAM-Poa-0020 ENSPPYP00000002407.1 Pongo abelii 83 0.0 889
WERAM-Bot-0035 ENSBTAP00000003674.5 Bos taurus 83 0.0 885
WERAM-Tub-0088 ENSTBEP00000010071.1 Tupaia belangeri 77 0.0 865
WERAM-Nol-0128 ENSNLEP00000014517.2 Nomascus leucogenys 79 0.0 858
WERAM-Ora-0127 ENSOANP00000024297.3 Ornithorhynchus anatinus 76 0.0 695
WERAM-Ptv-0058 ENSPVAP00000006150.1 Pteropus vampyrus 80 0.0 681
WERAM-Mim-0080 ENSMICP00000007535.1 Microcebus murinus 80 0.0 658
WERAM-Myl-0027 ENSMLUP00000002083.2 Myotis lucifugus 81 0.0 637
WERAM-Mod-0146 ENSMODP00000035095.3 Monodelphis domestica 82 2e-172 604
WERAM-Gaga-0074 ENSGALP00000010875.4 Gallus gallus 72 4e-170 596
WERAM-Chh-0038 ENSCHOP00000004739.1 Choloepus hoffmanni 79 3e-167 586
WERAM-Fia-0032 ENSFALP00000001942.1 Ficedula albicollis 70 1e-165 581
WERAM-Tag-0031 ENSTGUP00000002198.1 Taeniopygia guttata 70 3e-158 556
WERAM-Xet-0012 ENSXETP00000003954.3 Xenopus tropicalis 68 1e-139 495
WERAM-Fec-0003 ENSFCAP00000000182.3 Felis catus 81 4e-134 476
WERAM-Dan-0164 ENSDNOP00000031637.1 Dasypus novemcinctus 77 1e-129 462
WERAM-Pes-0125 ENSPSIP00000014849.1 Pelodiscus sinensis 75 5e-126 449
WERAM-Ova-0149 ENSOARP00000014943.1 Ovis aries 77 5e-124 442
WERAM-Ere-0035 ENSEEUP00000002731.1 Erinaceus europaeus 78 3e-118 424
WERAM-Sah-0198 ENSSHAP00000021598.1 Sarcophilus harrisii 71 4e-110 397
WERAM-Sus-0077 ENSSSCP00000011866.2 Sus scrofa 74 4e-110 396
WERAM-Caj-0220 ENSCJAP00000038389.2 Callithrix jacchus 83 2e-104 378
WERAM-Tut-0061 ENSTTRP00000004760.1 Tursiops truncatus 79 2e-94 344
WERAM-Ten-0194 ENSTNIP00000019097.1 Tetraodon nigroviridis 54 3e-92 337
WERAM-Orla-0038 ENSORLP00000004840.1 Oryzias latipes 55 7e-92 336
WERAM-Anp-0084 ENSAPLP00000009751.1 Anas platyrhynchos 67 3e-91 334
WERAM-Xim-0209 ENSXMAP00000016918.1 Xiphophorus maculatus 52 9e-90 329
WERAM-Orn-0098 ENSONIP00000010847.1 Oreochromis niloticus 53 3e-89 327
WERAM-Tar-0207 ENSTRUP00000043296.1 Takifugu rubripes 50 3e-89 327
WERAM-Pof-0161 ENSPFOP00000013193.2 Poecilia formosa 53 6e-88 323
WERAM-Gaa-0039 ENSGACP00000005831.1 Gasterosteus aculeatus 52 3e-86 317
WERAM-Ocp-0016 ENSOPRP00000001649.1 Ochotona princeps 85 8e-86 316
WERAM-Asm-0045 ENSAMXP00000006064.1 Astyanax mexicanus 63 5e-66 250
WERAM-Lac-0038 ENSLACP00000005947.1 Latimeria chalumnae 63 9e-62 236
WERAM-Gam-0105 ENSGMOP00000010866.1 Gadus morhua 78 1e-61 235
WERAM-Dar-0101 ENSDARP00000066928.6 Danio rerio 59 1e-59 229
WERAM-Leo-0162 ENSLOCP00000019305.1 Lepisosteus oculatus 93 3e-39 161
WERAM-Pem-0061 ENSPMAP00000006968.1 Petromyzon marinus 69 8e-25 113
WERAM-Cii-0084 ENSCINP00000031851.1 Ciona intestinalis 66 1e-24 113
WERAM-Drm-0027 FBpp0088179 Drosophila melanogaster 38 6e-23 107
WERAM-Cis-0063 ENSCSAVP00000014613.1 Ciona savignyi 61 7e-23 107
WERAM-Cae-0028 C11G6.1a Caenorhabditis elegans 51 2e-11 68.9
WERAM-Zem-0144 GRMZM2G466270_P01 Zea mays 53 4e-08 58.2
WERAM-Scp-0047 SPCC594.05c.1:pep Schizosaccharomyces pombe 54 9e-08 57.0
WERAM-Scj-0009 EEB06282 Schizosaccharomyces japonicus 51 2e-07 55.5
WERAM-Sob-0139 Sb10g031265.1 Sorghum bicolor 50 3e-07 55.5
WERAM-Sei-0018 Si005667m Setaria italica 50 4e-07 55.1
WERAM-Yal-0012 CAG81489 Yarrowia lipolytica 54 1e-06 53.5
WERAM-Brd-0017 BRADI1G29247.1 Brachypodium distachyon 48 2e-06 52.4
WERAM-Org-0068 ORGLA06G0289400.1 Oryza glaberrima 45 3e-06 52.0
WERAM-Orbr-0078 OB06G36110.1 Oryza brachyantha 45 6e-06 50.8
WERAM-Hov-0095 MLOC_70462.1 Hordeum vulgare 45 6e-06 50.8
WERAM-Tra-0308 Traes_7BL_84671B6A8.1 Triticum aestivum 45 1e-05 50.1
Created Date 25-Jun-2016