WERAM Information

Tag Content
WERAM ID WERAM-Mum-0072
Ensembl Protein ID ENSMUSP00000026663.7
Uniprot Accession Q9QXV1; CBX8_MOUSE
Genbank Protein ID NP_038954.1
Protein Name Chromobox protein homolog 8
Genbank Nucleotide ID NM_013926.1
Gene Name CBX8;Pc3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000025578.9 ENSMUST00000026663.7 ENSMUSP00000026663.7
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader Chromodomain Chromo H3K27me3 K 25500566
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader Chromodomain 3.40e-22 79.7 11 68
Organism Mus musculus
NCBI Taxa ID 10090
Functional Description
(View)		 Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity).
Domain Profile
  Me_Reader Chromodomain
      Chromodomain.txt  1 FeverivdkkelrkgeveYlVrWkGynksddtWepeenLlckelleefekkkekkkkqg 59
                          F++e ++ k+++rkg++eYlV+WkG++++++tWepeen+l+ +ll++fe+++++ +++g
  ENSMUSP00000026663.7 11 FAAEALL-KRRIRKGRMEYLVKWKGWSQKYSTWEPEENILDARLLAAFEEREREMELYG 68
                          899****.**********************************************99876 PP
Protein Sequence
(Fasta)		MELSAVGERV FAAEALLKRR IRKGRMEYLV KWKGWSQKYS TWEPEENILD ARLLAAFEER 60
EREMELYGPK KRGPKPKTFL LKAQAKAKAK TYEFRSDSTR GIRIPYPGRS PQDLASTSRA 120
REGLRNTGLP PPGSSTSTCR ADPPRDRDRE RDRGTSRVDD KPSSPGDSSK KRGPKPRKEP 180
LDPSQRPLGE PSAGLGEYLK GRKLDETSSG TGKFPAGHSV IQLARRQDSD LVQYGVTSPS 240
SAEASSKLAV DTFPARVIKH RAAFLEAKGQ GALDPGGARV RHSSGTPASV GSLYRDMGAQ 300
GGRPSLIARI PVARILGDPE EESWSPSLTN LEKVVVTDVT SNFLTVTIKE SNTDQGFFKE 360
KR 362
Nucleotide Sequence
(Fasta)		GAGAGTGCGC GGGGGAGGGA GGAGAACTGA CGTCAGCGGG AGAGTATTAT GGGCTGTCGA 60
GGGCTGGCTG CTGCTTTTCT GCTCCTGGAA GCGGCTGAGG GGGGAAGCGG CGAGTCAACA 120
TGGAGCTCTC GGCGGTGGGG GAGCGGGTGT TCGCGGCCGA AGCCCTCCTG AAGCGGCGCA 180
TTCGCAAAGG ACGCATGGAA TATCTCGTGA AATGGAAGGG CTGGTCGCAG AAGTACAGCA 240
CGTGGGAGCC CGAAGAAAAT ATTCTGGATG CTCGCCTCCT TGCAGCCTTT GAGGAAAGGG 300
AACGGGAGAT GGAGCTCTAT GGCCCCAAAA AGCGAGGACC CAAGCCTAAA ACCTTCCTTC 360
TCAAGGCCCA GGCCAAGGCA AAGGCCAAAA CCTATGAATT CAGAAGTGAC TCTACCAGAG 420
GCATCCGGAT CCCTTACCCA GGCCGCTCAC CCCAGGATTT GGCGTCTACT TCCAGGGCCC 480
GAGAGGGCCT GCGGAACACG GGGCTACCCC CACCAGGGAG CAGCACCAGT ACCTGCAGGG 540
CAGACCCACC TCGGGACCGG GACCGAGAGA GGGACAGGGG TACCAGCCGT GTAGACGACA 600
AGCCCAGCTC ACCGGGGGAC AGCTCCAAGA AACGAGGACC GAAACCCAGG AAGGAGCCCC 660
TGGACCCTTC ACAGAGACCT TTGGGAGAGC CCAGTGCCGG CCTTGGAGAG TACCTGAAAG 720
GCAGGAAGCT GGATGAGACC TCTTCTGGGA CAGGAAAGTT CCCAGCTGGC CACAGTGTGA 780
TCCAGCTTGC TCGAAGGCAG GACTCAGACC TGGTGCAATA TGGTGTGACC AGTCCTAGCT 840
CAGCAGAGGC CTCGAGCAAG TTGGCTGTGG ACACCTTTCC AGCCAGGGTA ATAAAGCACA 900
GGGCTGCTTT CCTGGAGGCC AAAGGCCAAG GTGCCCTGGA CCCTGGTGGT GCCAGGGTTC 960
GACATAGTTC AGGCACCCCA GCCTCAGTGG GAAGCCTGTA TCGGGACATG GGGGCGCAAG 1020
GGGGAAGGCC CTCCCTCATC GCCAGGATCC CAGTGGCCAG GATCCTGGGG GACCCAGAGG 1080
AAGAGTCCTG GAGCCCCTCT CTGACTAACC TGGAGAAAGT GGTCGTTACA GATGTGACCT 1140
CAAACTTTTT GACCGTCACC ATTAAGGAGA GCAACACGGA CCAAGGATTC TTTAAGGAAA 1200
AAAGATGAAT TGCCGGGGTG GGAGCCCAGG ACCAGTGCAG GGGAGAGTGA GCTCAAATGG 1260
CTTAGTGCTT TTTATTTCTG GGTGACTGTG GCCTCTGGCT GGTCCTGTCC TTCTTCACAC 1320
CCCTCTTCCC TTTCATTCCT CCGTCCTCAG TTCTGGCTGG AAAATTATCT CTAGAGTTCT 1380
ATTTTCTATT AGATGTAAAT ATGTTATTTA AGAGAAAAAT ATCTAAATAT ATATATTTCA 1440
ACTCTTGAAG TTCTTTTATT TAAACGAGGA GAGAGAGAGA GAGAAAGAGA GAGAGACTGT 1500
GGTTTGGTAG GGGAGATAGA CTGAGCTGGC ACAGGAGGGG CCCCTGTCCC TGCAGGGCAC 1560
CAGCAAAGTT GGGGGCCTGG GCCCTGGGAT TTTGGAGGGT GTGTGGAGGG ACTCAGCTGG 1620
CCCACCTCCT CCCTCCACCG CCGGATTCCC AACCCTCCTG GCACCGCAGA AGATTTTTGC 1680
TCTCCTCCCC ATTGGCCAGC TAGGCCAACA AAAGGTTGGC TTCCCAATCA GAAAAAGGGG 1740
GGTGGGGTCA GACCAGTTTT CTTTTTTCTA TTTTCTTTCT GTCTTTTTTT TTTTTTCTTA 1800
AGATGAGGAG GGTTACTAGG GGGGGAAAGT AACAACTCGA ATAACTTTCT CACGTGTGTT 1860
GTTAAAGGTA GAAAAAGGTC GCGAGTGAGT GGGCCGCAGT TCTCCCCGAC CACAGCAGGA 1920
GGGTGCACTT TATGGAGGTG TGAGTGCCGT ACACGCGGAC TGTGTGTGCG TGTCCTGTGG 1980
ACAAAAATCT CCCCGTTACC TCGATTCCTT CCCTTACTTT TGCAAAGAGA AAAGAAATCC 2040
AGCGAATTTG TTTACATTCC CGAAATGCCA GGATAAATTG GGAGGATTGC GTGTCAGTGC 2100
CCAGAGCGCC AGACAGTTGT TTTACAAGAA AAATATTCGG GTGGACTTTT TCTTTTTGCG 2160
TCCTCTAGAT TCGCCAGAAG ACAGGGCGGC CCCACCTCCC AGGAAGACTC GGACAAGCCT 2220
GGCTCGACGG GGGGAGGGTG GGTCCTGCTT TTAGAGGAGC GAGCGGCCGC CAAGCCACCC 2280
TGCGGGGCGG GCAGCGGGCT GCGCACCAGG CCGGTCGGGC TGGGCACGGG GGTCGCAGCC 2340
CGAGTTGGAA CTTGGTCAGG TGGAGCTCAT GGCCGAAGGG GCTCGGCAGG GTTTCCATCC 2400
AAGAATGCGC AGTAGAACTT TAGTGTTTTC CTTCTTCCCC CTTTCTTAAA AGCAAAAGCT 2460
GTAATTTATA GTCCTTTTCG ATTCTGGGAG TGCTCTCCAC GTGAACTCGA CGTTCAGACT 2520
CCGCCGCAGG GGGCGGGGGA GCGCGAGGTG GAGCGGGAGC GGCCGGGGAC CAGTGTGCCC 2580
CGAGACCATC TGCGTCCCTG GTCCCGGCCC ACTCCGGACC GCGCCGCGCG CAGCTCGGAC 2640
TCAAAAGCAC AAATCTGTCC CCGAGCCTAC AGTCGCCGCT TCCAGCAGGG ATCCTGCGGC 2700
CTCTCCACCC TCCCCGCCCT TAAAGGGCCA GCAGACGCTC TAACTTCCAG GGCTTTTGGA 2760
GGGAGGGGCT CTAAGCTCTG CTCGCGGGAC AAAGCACAGA CTTCAGGGGC TCTGGGCTGG 2820
GCTGAAGGAG CTTGGTGATG GGGAGGGACT GAGAGGGACG TCAGCCTCGT CATCTGCACT 2880
CCCGGCTTCC CATCTCCAGA CTCTCGGTCT CTCTTTCCTC CAGACAATTT TTTTTTTTTT 2940
TTTGCCTTTA AAGAGAGGGA GAAAGGGAAA ACGGTGTATT CTACGTGTTT TTATTATTTT 3000
TTTATTTTTT GGAGAATCAA ACTGCGCCTA AAGAGAAGCC CCTAGAATGG GGATTTTTAT 3060
CTGCTCATAT TTGTAAAACT AGTATTTTCG ACTTTGTATA AAGAAGCTCT GTTGCCTGTG 3120
TCTGTCTAGA TGTCGACCCT ATTTTCAGAT GAACCTGTTT TGAAGGGTGC ATCTGTGACC 3180
GAGTGGATGT AACTCCGGAA CAGGAGCTCC CTATCTGGCT ACCGACTCCC TTTCTCTTCT 3240
CTCCTTCCTC GTTTGTATCT TCCTTCCCTC CAACCTTCCT GATTCTGCCC TCACTGCCCT 3300
CGTCGTCCTG CCGTCTGTCC ATGGCCGTCG TGTGTGTCTC CTTAGCTCGC TCTTGAGAGG 3360
CTGACTTGGG GGTGGGGGTG GGGGTGGGCA GGGGTCGGGG GCCACGCGGC TCAGAGTCTG 3420
TGGAGCCTGG GTGTTGGGTT TATGAGTTCT CAGCTATGTA TAAATCTCCA ACTGATCTCT 3480
GCCTCGGCTC AAGAGTGAAC CCTTGGTACC TATCTTGGGT TGTGAATGTG TCTGTATCCA 3540
GTATCACTTT TTACGTGTTT AAATATATGC TTTGTAAATA 3581
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
--
Interpro

IPR000953--Chromo/shadow_dom
IPR023780--Chromo_domain
IPR016197--Chromodomain-like
IPR023779--Chromodomain_CS
PROSITE

PS00598--CHROMO_1
PS50013--CHROMO_2
Pfam

PF00385--Chromo
Gene Ontology

GO:0000792--C:heterochromatin
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0031519--C:PcG protein complex
GO:0035102--C:PRC1 complex
GO:0000151--C:ubiquitin ligase complex
GO:0035064--F:methylated histone binding
GO:0003727--F:single-stranded RNA binding
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0070301--P:cellular response to hydrogen peroxide
GO:0006342--P:chromatin silencing
GO:0016574--P:histone ubiquitination
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0008284--P:positive regulation of cell proliferation
GO:0032967--P:positive regulation of collagen biosynthetic process
GO:0045739--P:positive regulation of DNA repair
GO:0050790--P:regulation of catalytic activity
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Ran-0205 ENSRNOP00000064273.1 Rattus norvegicus 96 3e-161 565
WERAM-Tut-0172 ENSTTRP00000014657.1 Tursiops truncatus 90 3e-152 535
WERAM-Caj-0191 ENSCJAP00000032804.1 Callithrix jacchus 91 2e-151 532
WERAM-Ict-0129 ENSSTOP00000013259.2 Ictidomys tridecemlineatus 92 5e-151 531
WERAM-Paa-0139 ENSPANP00000016271.1 Papio anubis 88 1e-150 529
WERAM-Chs-0028 ENSCSAP00000015690.1 Chlorocebus sabaeus 88 1e-150 529
WERAM-Pat-0081 ENSPTRP00000016554.4 Pan troglodytes 87 4e-150 528
WERAM-Nol-0003 ENSNLEP00000000196.1 Nomascus leucogenys 87 5e-150 527
WERAM-Gog-0114 ENSGGOP00000004562.2 Gorilla gorilla 87 3e-149 525
WERAM-Ova-0016 ENSOARP00000002822.1 Ovis aries 88 4e-147 518
WERAM-Otg-0185 ENSOGAP00000015604.1 Otolemur garnettii 89 5e-147 518
WERAM-Loa-0080 ENSLAFP00000006257.4 Loxodonta africana 91 3e-146 515
WERAM-Hos-0136 ENSP00000269385.4 Homo sapiens 87 7e-146 514
WERAM-Fec-0214 ENSFCAP00000019252.1 Felis catus 87 1e-145 513
WERAM-Aim-0169 ENSAMEP00000015919.1 Ailuropoda melanoleuca 87 6e-144 507
WERAM-Caf-0226 ENSCAFP00000041401.1 Canis familiaris 86 1e-143 506
WERAM-Eqc-0159 ENSECAP00000016784.1 Equus caballus 83 3e-143 505
WERAM-Sus-0128 ENSSSCP00000018184.2 Sus scrofa 85 9e-142 500
WERAM-Sah-0110 ENSSHAP00000011795.1 Sarcophilus harrisii 84 3e-136 482
WERAM-Ere-0051 ENSEEUP00000004327.1 Erinaceus europaeus 80 1e-132 469
WERAM-Ect-0084 ENSETEP00000009565.1 Echinops telfairi 74 2e-127 452
WERAM-Tub-0039 ENSTBEP00000004995.1 Tupaia belangeri 77 2e-126 449
WERAM-Anc-0167 ENSACAP00000015766.2 Anolis carolinensis 67 5e-99 358
WERAM-Poa-0210 ENSPPYP00000024136.1 Pongo abelii 84 1e-97 353
WERAM-Dan-0132 ENSDNOP00000034654.1 Dasypus novemcinctus 85 3e-96 349
WERAM-Cap-0201 ENSCPOP00000016560.1 Cavia porcellus 90 4e-93 338
WERAM-Ptv-0124 ENSPVAP00000010933.1 Pteropus vampyrus 90 1e-92 337
WERAM-Lac-0175 ENSLACP00000020479.1 Latimeria chalumnae 57 2e-88 322
WERAM-Xet-0084 ENSXETP00000028021.2 Xenopus tropicalis 54 2e-79 293
WERAM-Myl-0216 ENSMLUP00000018435.1 Myotis lucifugus 92 4e-74 275
WERAM-Mam-0152 ENSMMUP00000021562.2 Macaca mulatta 97 3e-53 206
WERAM-Orn-0038 ENSONIP00000004211.1 Oreochromis niloticus 75 6e-39 158
WERAM-Tar-0023 ENSTRUP00000004618.1 Takifugu rubripes 76 1e-38 157
WERAM-Xim-0220 ENSXMAP00000017956.1 Xiphophorus maculatus 75 1e-38 157
WERAM-Ten-0054 ENSTNIP00000007258.1 Tetraodon nigroviridis 78 2e-38 157
WERAM-Pof-0201 ENSPFOP00000016501.2 Poecilia formosa 75 3e-38 156
WERAM-Gaa-0194 ENSGACP00000024085.1 Gasterosteus aculeatus 78 7e-37 151
WERAM-Dar-0200 ENSDARP00000129929.1 Danio rerio 74 2e-36 150
WERAM-Orla-0018 ENSORLP00000002308.1 Oryzias latipes 72 2e-36 150
WERAM-Gam-0116 ENSGMOP00000012098.1 Gadus morhua 74 4e-33 139
WERAM-Leo-0139 ENSLOCP00000017078.1 Lepisosteus oculatus 78 1e-32 138
WERAM-Asm-0046 ENSAMXP00000006355.1 Astyanax mexicanus 78 1e-31 134
WERAM-Bot-0218 ENSBTAP00000055457.1 Bos taurus 86 4e-29 126
WERAM-Pes-0118 ENSPSIP00000014005.1 Pelodiscus sinensis 86 4e-29 126
WERAM-Mod-0074 ENSMODP00000011965.2 Monodelphis domestica 86 4e-29 126
WERAM-Mup-0150 ENSMPUP00000013100.1 Mustela putorius furo 86 6e-29 125
WERAM-Dio-0159 ENSDORP00000014864.2 Dipodomys ordii 86 3e-28 123
WERAM-Gaga-0164 ENSGALP00000037077.2 Gallus gallus 63 3e-19 93.6
WERAM-Prc-0153 ENSPCAP00000014543.1 Procavia capensis 64 7e-19 92.0
WERAM-Tag-0129 ENSTGUP00000010594.1 Taeniopygia guttata 62 4e-14 76.6
WERAM-Ora-0048 ENSOANP00000007669.2 Ornithorhynchus anatinus 69 5e-14 76.3
WERAM-Zem-0068 GRMZM2G117100_P01 Zea mays 48 8e-09 58.5
WERAM-Sei-0132 Si036395m Setaria italica 51 9e-09 58.5
WERAM-Orc-0135 ENSOCUP00000011485.2 Oryctolagus cuniculus 53 2e-07 54.3
WERAM-Mim-0051 ENSMICP00000004948.1 Microcebus murinus 53 2e-07 54.3
WERAM-Tas-0030 ENSTSYP00000003062.1 Tarsius syrichta 53 2e-07 54.3
Created Date 25-Jun-2016