WERAM Information

Tag Content
WERAM ID WERAM-Mum-0071
Ensembl Protein ID ENSMUSP00000026662.7
Uniprot Accession P30658; CBX2_MOUSE; A2ABG2; O35731; Q8CIA0
Genbank Protein ID NP_031649.2
Protein Name Chromobox protein homolog 2
Genbank Nucleotide ID NM_007623.3
Gene Name CBX2;M33
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000025577.7 ENSMUST00000026662.7 ENSMUSP00000026662.7
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader Chromodomain Chromo H3K27me3 K 24525102
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader Chromodomain 7.40e-22 78.7 12 69
Organism Mus musculus
NCBI Taxa ID 10090
Functional Description
(View)		 Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Domain Profile
  Me_Reader Chromodomain
      Chromodomain.txt  1 FeverivdkkelrkgeveYlVrWkGynksddtWepeenLlckelleefekkkekkkkqg 59
                          F++e+i+  k+lrkg+ eYlV+W+G+++++++Wepeen+l+++ll +f+kk+++k+ q+
  ENSMUSP00000026662.7 12 FAAECIL-SKRLRKGKLEYLVKWRGWSSKHNSWEPEENILDPRLLLAFQKKEHEKEVQN 69
                          99*****.***********************************************9987 PP
Protein Sequence
(Fasta)		MEELSSVGEQ VFAAECILSK RLRKGKLEYL VKWRGWSSKH NSWEPEENIL DPRLLLAFQK 60
KEHEKEVQNR KRGKRPRGRP RKHTVTSSCS RRSKLKEPDA PSKSKSSSSS SSSTSSSSSS 120
DEEEDDSDLD SKRGPRGRET HPVPQKKAQI LVAKPELKDP IRKKRGRKPL PPEQKAARRP 180
VSLAKVLKTT RKDLGTSAAK LPPPLSAPVA GLAALKAHTK EACGGPSTMA TPENLASLMK 240
GMAGSPSRGG IWQSSIVHYM NRMSQSQVQA ASRLALKAQA TNKCGLGLDL KVRTQKGGEL 300
GGSPAGGKVP KAPGGGAAEQ QRGNHSGSPG AQLAPTQELS LQVLDLQSVK NGVPGVGLLA 360
RHAPAKAIPA TNPATGKGPG SGPTGANMTN APTDNNKGEK LTCKATALPA PSVKRDTVKS 420
VAASGGQEGH TAPGEGRKPP ALSELSTGEE NSSSDSDPDS TSLPSAAQNL SVAIQTSQDW 480
KPTRSLIEHV FVTDVTANLI TVTVKESPTS VGFFNLRHY 519
Nucleotide Sequence
(Fasta)		CCGGCGCGCC TATTGGCCCG GCGGCTGCGG GTAGAGCAGC GCGGGCGACT CCGGCGCGCG 60
TGCGCGGGGC GGGGCGCGGC GGGGGCGGCG CTTTGTGTGC AGCAGTGAGC CGGGGTCTGC 120
GGGGCGCGGG CCGCGGCGGG CGGCGGCATG GAGGAGCTGA GCAGCGTGGG CGAGCAGGTC 180
TTCGCCGCCG AGTGCATCCT GAGCAAGCGG CTCCGCAAGG GCAAGCTGGA GTACCTGGTC 240
AAGTGGCGCG GCTGGTCCTC CAAACACAAC AGCTGGGAGC CAGAAGAGAA CATTTTGGAC 300
CCGAGGCTGC TCCTAGCCTT CCAGAAGAAG GAACATGAGA AGGAGGTTCA GAACCGGAAG 360
AGAGGCAAGA GACCCAGGGG CAGGCCGAGG AAACACACAG TCACATCCTC CTGCAGCCGG 420
CGCTCCAAGC TCAAGGAACC AGATGCGCCA TCCAAATCCA AATCCAGCAG TTCGTCCTCT 480
TCCTCCACAT CTTCCTCCTC TTCCTCGGAC GAAGAGGAAG ACGACAGCGA CCTAGACTCC 540
AAGAGAGGCC CCCGGGGCCG TGAAACCCAT CCAGTGCCTC AGAAAAAAGC CCAGATCCTG 600
GTAGCCAAGC CAGAGCTGAA GGATCCCATT AGAAAGAAAC GGGGACGCAA GCCTCTACCC 660
CCAGAACAGA AGGCAGCTCG GAGACCCGTC AGCCTGGCCA AGGTGCTAAA GACCACCAGG 720
AAGGATCTGG GGACCTCAGC CGCCAAGCTG CCCCCTCCAC TCAGCGCTCC GGTGGCAGGC 780
CTGGCTGCCC TGAAGGCCCA CACCAAAGAG GCCTGTGGTG GCCCCAGCAC TATGGCGACC 840
CCAGAGAACC TGGCCAGTCT GATGAAAGGC ATGGCCGGGA GCCCCAGCAG AGGCGGCATC 900
TGGCAGAGCT CCATCGTACA CTACATGAAC CGCATGAGCC AGAGTCAGGT TCAGGCTGCC 960
AGCCGACTGG CACTCAAGGC CCAGGCCACC AACAAGTGCG GTCTCGGGCT AGACCTGAAA 1020
GTGAGGACGC AGAAGGGGGG TGAGCTAGGG GGGAGCCCCG CAGGAGGCAA GGTCCCGAAG 1080
GCCCCCGGTG GCGGAGCTGC AGAGCAGCAG AGAGGGAACC ATTCGGGGAG CCCAGGTGCT 1140
CAGCTGGCAC CCACTCAGGA GTTGAGCCTT CAGGTCCTTG ACTTGCAAAG CGTCAAGAAC 1200
GGTGTGCCTG GTGTGGGCCT GCTTGCTCGC CATGCCCCAG CCAAGGCTAT TCCTGCTACC 1260
AACCCAGCCA CAGGGAAAGG TCCTGGGAGC GGCCCCACAG GAGCAAACAT GACCAACGCT 1320
CCCACAGACA ACAACAAAGG GGAAAAGCTG ACTTGCAAGG CAACGGCTCT GCCTGCCCCT 1380
TCCGTCAAGC GGGACACCGT TAAAAGCGTC GCTGCCTCCG GCGGGCAGGA GGGCCACACA 1440
GCCCCGGGAG AAGGCCGAAA GCCACCTGCG CTGTCTGAGC TGAGCACGGG AGAGGAGAAT 1500
AGTAGCTCTG ACTCGGACCC TGACTCGACC TCGCTTCCCA GTGCTGCGCA GAACCTATCT 1560
GTAGCTATCC AGACCAGCCA GGACTGGAAA CCTACCCGCA GTCTCATCGA ACACGTCTTT 1620
GTCACGGATG TCACAGCCAA CCTCATCACT GTCACCGTGA AGGAGTCGCC CACCAGCGTG 1680
GGCTTCTTCA ACTTGAGGCA TTATTGAGAC CATTGCCCGA GCCAGACCTG CCTTCCAGTC 1740
TCTGGTTTTG CTTTGATGCC TGACCTGGGG GCCAACTCTG CCCTGTCCTG AGACTCAGGG 1800
CTGGGAAATG GCTTCCTGCT GATTCTACCT CTCTGGGCCT CCACTTCAGT CTGTCCTGTC 1860
ATCTCAGGAA AGCCGGGTGG CCACTGACTT AAAAGCTACC TGCTTGGACA TAGCATCCTT 1920
TCTACACATC CCTCCTTAAC CTAGTGAGAC CCTCCCCTCC CTGGCCAACT ACTGTGAGGT 1980
GGATTGGGGA GGGGGGGGCA CTGATACAGC TCCCTCCCCA GGCCGTTGAG GAGAGGGGTG 2040
GGGCTGGTAG GGCCTTCTCC CACATCCAGC CACGGCAGGG TCTTTCTGGT GAGGGAGACA 2100
CTCTATGCTT TGCAAGTAAG GCTATAACTT CAGTTTTAAA AGGCTAATTA GTTGTGTGGT 2160
TGGGCTCAGG GACCCTGCGG AAATCTTCAG TCTCTATCCG TGGTGTGGTG TCCCCTCTAG 2220
TTGCAATTGT AGTCCCAAAG CCCAGTCAGG GTTTGGAGTC CTGGCACTAA GGTGTACCTG 2280
GGTGCTTCTG GACTTGGGAA TAGAGAGAGC CATGTCCTTA TTGCCTCCTT CAAGCAGGCT 2340
CAAGCCCCAG TGAGAAGTGA CCCTGTTCCT CTCTGGGTCT GGACCCATAC CCCTGCTTTG 2400
GCCCACTAAA TTGCACCCTA GTTCTGAGGT CTGACACTCC TGGGCTTGGG GAAGGAGCAG 2460
GCTAGACACC CAGAGCAAGC TGATGTAGGC ACTTGGAGTC CTGGGCAAGC AATCTTCCTT 2520
CATGTTGGAC TTTTATTACT AGGACCCCAT AAGTCACCAT GGTGGCACCA GTGTGGGAAT 2580
GCAGGTGTTT TGTGGGGGCC TGTCACCCTG CTGCCTGTCT AGACATCTCT AAACTACTGT 2640
GGAAGCATTT TCTATAGTCA GTCTTGGTGC AGAGCTCCGC CTGGTGAGTG GGCCACTCTT 2700
GGGTCCCATA TTCCCTGACA ATCCTCTCCC ACATTTGGGA GCTTGTGTTT CCTCCCTCGC 2760
TGAGAAGCAA TAGCCCTATG CCATTTGTGT GGTGGGGTCG TTTAGGAGCC CACCTGGCAG 2820
GGGGCCCCTA ATTTCTTTCC CATCCTAGGA GATAAGTCTA GTGCTGAGCC CCTTTCTAAA 2880
TGCCTTCTCC CCTGTCCCCC ATCCCGGGTA ACTGTCTTGA AACTACCTTG TCAGATTGCT 2940
GGCCGATGAC AGGATTTTCT GTCCTGGGAT ATCACGGTGG GCCGTGACAA TCTGGTCAGT 3000
GAGTCTGTGA TGCCAAAAAG TAGGGGTGCT ATGAAACCCT GGTTCTGCTT CTGCCATTGA 3060
CTGATCAGCC AGCAGGTGTG GGCTCTTCAC TCCAGTTGCC TTGAAGGGAA ATGTTTCCCC 3120
TTCTAAAACC AGTCAGACAG TGGGCTGAGG TGTCTGGGAC CTGCCACACT TTCAAAGTGC 3180
ACCCCACCCC CACCCCAGTA GCTCACCCTG CACACCAAAT AAGATGGTCT TTGTGTAACC 3240
AAACCAACCT CAATGCTGTG CCTTTTGGGG CAGACCCATA TCCACAGCTC CTGAGAGATG 3300
CCTGTGATGT GCCAGGGGAC CATGTTACTG GCAGCAGGAG CTACGTACTG GGAAGAATTC 3360
AGGGCCAGGA AGTGGGTAAC AAAGGGGAAA GGGTTGCCTA CTGCATTATC AATGTCCCTC 3420
CCTGCCCTCA GCCAGGGTCT GCAACCTTTG TACCAGACAC TGCCTTTACA AACACCTCCC 3480
CGTCTCTTTG GGGTCCCATG AGCTGTTGGA GAAGTGACCC TGTTTGGGGA TCTGGGTTGA 3540
CTGGCCTTTG TCCCCTGCTG CCAGTCTCCA AATCCCAATT TGGTGCCTTT TATTTTACTG 3600
GTTACGTCAG TCCCAAAGTT GAAATCTACA AATCCTTTCC TCTCAGCCAC TTTGCCTTCT 3660
TGTGTGTTTT TCCTGGTGCT GTGACCCCAG TGGTCTATGT CACAAAGCAC ATGTGTGTAG 3720
TGCGCCAGCG CGAGCCCCAC TGGAGCAGCG CCATTCGCTC TGAGTCAAGT TCTCGTGTTT 3780
ACCGATAAAT AAAGTAGTTG GTTTTTA 3808
Sequence Source Ensembl
Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
--
Interpro

IPR000953--Chromo/shadow_dom
IPR023780--Chromo_domain
IPR016197--Chromodomain-like
IPR023779--Chromodomain_CS
PROSITE

PS00598--CHROMO_1
PS50013--CHROMO_2
Pfam

PF00385--Chromo
Gene Ontology

GO:0000791--C:euchromatin
GO:0000792--C:heterochromatin
GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0031519--C:PcG protein complex
GO:0035102--C:PRC1 complex
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0035064--F:methylated histone binding
GO:0016568--P:chromatin modification
GO:0045137--P:development of primary sexual characteristics
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Ran-0212 ENSRNOP00000067878.1 Rattus norvegicus 90 0.0 758
WERAM-Gog-0113 ENSGGOP00000009573.2 Gorilla gorilla 81 0.0 666
WERAM-Pat-0080 ENSPTRP00000016553.4 Pan troglodytes 81 0.0 664
WERAM-Bot-0206 ENSBTAP00000053512.2 Bos taurus 80 0.0 657
WERAM-Chs-0029 ENSCSAP00000015688.1 Chlorocebus sabaeus 80 0.0 647
WERAM-Tut-0171 ENSTTRP00000014651.1 Tursiops truncatus 79 0.0 645
WERAM-Otg-0173 ENSOGAP00000014742.2 Otolemur garnettii 80 1e-179 626
WERAM-Cap-0064 ENSCPOP00000005046.2 Cavia porcellus 81 1e-179 626
WERAM-Mod-0023 ENSMODP00000002597.3 Monodelphis domestica 68 3e-163 572
WERAM-Ere-0050 ENSEEUP00000004312.1 Erinaceus europaeus 71 3e-155 545
WERAM-Anc-0169 ENSACAP00000015786.2 Anolis carolinensis 60 5e-125 445
WERAM-Xet-0024 ENSXETP00000006551.3 Xenopus tropicalis 43 6e-78 289
WERAM-Hos-0207 ENSP00000269399.5 Homo sapiens 97 1e-39 161
WERAM-Orla-0010 ENSORLP00000001129.1 Oryzias latipes 63 4e-33 140
WERAM-Leo-0120 ENSLOCP00000015077.1 Lepisosteus oculatus 88 4e-32 136
WERAM-Tar-0024 ENSTRUP00000004919.1 Takifugu rubripes 87 2e-31 134
WERAM-Pof-0224 ENSPFOP00000018363.1 Poecilia formosa 87 7e-31 132
WERAM-Orn-0116 ENSONIP00000012010.1 Oreochromis niloticus 85 8e-31 132
WERAM-Xim-0158 ENSXMAP00000012949.1 Xiphophorus maculatus 87 9e-31 132
WERAM-Ten-0133 ENSTNIP00000014215.1 Tetraodon nigroviridis 85 2e-30 130
WERAM-Gam-0135 ENSGMOP00000013915.1 Gadus morhua 50 3e-30 130
WERAM-Dar-0099 ENSDARP00000066052.6 Danio rerio 84 3e-30 130
WERAM-Gaa-0146 ENSGACP00000019004.1 Gasterosteus aculeatus 84 1e-29 129
WERAM-Ora-0048 ENSOANP00000007669.2 Ornithorhynchus anatinus 90 6e-26 116
WERAM-Ict-0199 ENSSTOP00000021274.1 Ictidomys tridecemlineatus 68 5e-23 106
WERAM-Paa-0138 ENSPANP00000016273.1 Papio anubis 68 6e-23 106
WERAM-Sus-0127 ENSSSCP00000018183.2 Sus scrofa 68 7e-23 106
WERAM-Caj-0191 ENSCJAP00000032804.1 Callithrix jacchus 66 2e-22 104
WERAM-Aim-0169 ENSAMEP00000015919.1 Ailuropoda melanoleuca 66 2e-22 104
WERAM-Caf-0226 ENSCAFP00000041401.1 Canis familiaris 66 2e-22 104
WERAM-Fec-0214 ENSFCAP00000019252.1 Felis catus 66 2e-22 104
WERAM-Eqc-0159 ENSECAP00000016784.1 Equus caballus 66 2e-22 104
WERAM-Ptv-0124 ENSPVAP00000010933.1 Pteropus vampyrus 66 2e-22 104
WERAM-Loa-0080 ENSLAFP00000006257.4 Loxodonta africana 66 2e-22 104
WERAM-Ect-0084 ENSETEP00000009565.1 Echinops telfairi 66 2e-22 104
WERAM-Tub-0039 ENSTBEP00000004995.1 Tupaia belangeri 66 3e-22 104
WERAM-Poa-0210 ENSPPYP00000024136.1 Pongo abelii 66 3e-22 104
WERAM-Dan-0132 ENSDNOP00000034654.1 Dasypus novemcinctus 66 4e-22 103
WERAM-Nol-0003 ENSNLEP00000000196.1 Nomascus leucogenys 65 5e-22 103
WERAM-Mam-0152 ENSMMUP00000021562.2 Macaca mulatta 66 5e-22 103
WERAM-Lac-0174 ENSLACP00000020449.1 Latimeria chalumnae 66 5e-22 103
WERAM-Pes-0118 ENSPSIP00000014005.1 Pelodiscus sinensis 65 5e-22 103
WERAM-Myl-0216 ENSMLUP00000018435.1 Myotis lucifugus 66 5e-22 103
WERAM-Sah-0110 ENSSHAP00000011795.1 Sarcophilus harrisii 65 7e-22 102
WERAM-Asm-0047 ENSAMXP00000006389.1 Astyanax mexicanus 65 8e-22 102
WERAM-Mup-0150 ENSMPUP00000013100.1 Mustela putorius furo 65 8e-22 102
WERAM-Dio-0159 ENSDORP00000014864.2 Dipodomys ordii 65 1e-21 102
WERAM-Ova-0016 ENSOARP00000002822.1 Ovis aries 65 3e-20 97.4
WERAM-Gaga-0164 ENSGALP00000037077.2 Gallus gallus 64 7e-19 92.8
WERAM-Prc-0153 ENSPCAP00000014543.1 Procavia capensis 67 3e-18 90.9
WERAM-Tag-0129 ENSTGUP00000010594.1 Taeniopygia guttata 63 2e-13 75.1
WERAM-Orc-0135 ENSOCUP00000011485.2 Oryctolagus cuniculus 48 2e-09 61.2
WERAM-Vip-0116 ENSVPAP00000010686.1 Vicugna pacos 48 2e-09 61.2
WERAM-Mim-0051 ENSMICP00000004948.1 Microcebus murinus 48 2e-09 61.2
WERAM-Tas-0030 ENSTSYP00000003062.1 Tarsius syrichta 48 2e-09 61.2
WERAM-Mae-0074 ENSMEUP00000007510.1 Macropus eugenii 48 2e-09 61.2
WERAM-Sei-0132 Si036395m Setaria italica 56 5e-09 60.1
Created Date 25-Jun-2016