| Tag |
Content |
| WERAM ID |
WERAM-Art-0096 |
| Ensembl Protein ID |
AT4G02020.1 |
| Uniprot Accession |
Q9ZSM8; EZA1_ARATH; O04246
|
| Genbank Protein ID |
NP_567221.1
|
| Protein Name |
Histone-lysine N-methyltransferase EZA1 |
| Genbank Nucleotide ID |
NM_116433.2
|
| Gene Name |
EZA1;SWN |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HMT |
EZ |
SET |
H3K27 |
K |
20703330
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HMT |
EZ |
2.30e-64 |
215.4 |
269 |
822 |
| HMT |
SET1 |
2.60e-30 |
105.7 |
708 |
822 |
|
| Organism |
Arabidopsis thaliana |
| NCBI Taxa ID |
3702 |
Functional Description
(View)Functional Description
Polycomb group (PcG) protein. Catalytic subunit of some PcG multiprotein complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development (By similarity). |
Polycomb group (PcG) protein. Catalytic subunit of some PcG multiprotein complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development (By similarity).
|
| Domain Profile |
HMT EZ
EZ.txt 3 illgksdvaGwGlflkesvekneylgeytGel 34
l+ ++G l + ek+ y ++y G++
AT4G02020.1 269 CLVFDCRLHGCSQPLISASEKQPYWSDYEGDR 300
5666777889999999999*********9975 PP
EZ.txt 1 krillgksdvaGwGlflkesvekneylgeytGelisddeadkrGkiydrakssflfnlndqlvidakrkGnklkfanhsakpncyakvllvaGdhriG 98
+rillgksdvaGwG+flk+sv+kneylgeytGelis++eadkrGkiydra+ssflf+lndq+v+da+rkG+klkfanhsakpncyakv++vaGdhr+G
AT4G02020.1 707 QRILLGKSDVAGWGAFLKNSVSKNEYLGEYTGELISHHEADKRGKIYDRANSSFLFDLNDQYVLDAQRKGDKLKFANHSAKPNCYAKVMFVAGDHRVG 804
79************************************************************************************************ PP
EZ.txt 99 lfakrrieaseelffdyr 116
+fa++rieaseelf+dyr
AT4G02020.1 805 IFANERIEASEELFYDYR 822
*****************7 PP
HMT SET1
SET1.txt 2 elevakskikglglvakkeiekeelviEYvGevirsevadkrekeyekkeigvylfrldedaevvvdatkkgniarfinhscepNceakvvavdgekk 99
++ + ks+++g+g + k++++k+e + EY+Ge+i++++adkr k y++ + +++lf l+++ +v+da++kg++ +f nhs +pNc+akv+ v g+++
AT4G02020.1 708 RILLGKSDVAGWGAFLKNSVSKNEYLGEYTGELISHHEADKRGKIYDRAN-SSFLFDLNDQ--YVLDAQRKGDKLKFANHSAKPNCYAKVMFVAGDHR 802
577889*****************************************995.56********..*********************************** PP
SET1.txt 100 iviyakraIekgeeltydYk 119
++i+a+ +Ie+ eel+ydY+
AT4G02020.1 803 VGIFANERIEASEELFYDYR 822
*******************6 PP
|
Protein Sequence
(Fasta) | MVTDDSNSSG RIKSHVDDDD DGEEEEDRLE GLENRLSELK RKIQGERVRS IKEKFEANRK 60
KVDAHVSPFS SAASSRATAE DNGNSNMLSS RMRMPLCKLN GFSHGVGDRD YVPTKDVISA 120
SVKLPIAERI PPYTTWIFLD RNQRMAEDQS VVGRRQIYYE QHGGETLICS DSEEEPEPEE 180
EKREFSEGED SIIWLIGQEY GMGEEVQDAL CQLLSVDASD ILERYNELKL KDKQNTEEFS 240
NSGFKLGISL EKGLGAALDS FDNLFCRRCL VFDCRLHGCS QPLISASEKQ PYWSDYEGDR 300
KPCSKHCYLQ LKAVREVPET CSNFASKAEE KASEEECSKA VSSDVPHAAA SGVSLQVEKT 360
DIGIKNVDSS SGVEQEHGIR GKREVPILKD SNDLPNLSNK KQKTAASDTK MSFVNSVPSL 420
DQALDSTKGD QGGTTDNKVN RDSEADAKEV GEPIPDNSVH DGGSSICQPH HGSGNGAIII 480
AEMSETSRPS TEWNPIEKDL YLKGVEIFGR NSCLIARNLL SGLKTCLDVS NYMRENEVSV 540
FRRSSTPNLL LDDGRTDPGN DNDEVPPRTR LFRRKGKTRK LKYSTKSAGH PSVWKRIAGG 600
KNQSCKQYTP CGCLSMCGKD CPCLTNETCC EKYCGCSKSC KNRFRGCHCA KSQCRSRQCP 660
CFAAGRECDP DVCRNCWVSC GDGSLGEAPR RGEGQCGNMR LLLRQQQRIL LGKSDVAGWG 720
AFLKNSVSKN EYLGEYTGEL ISHHEADKRG KIYDRANSSF LFDLNDQYVL DAQRKGDKLK 780
FANHSAKPNC YAKVMFVAGD HRVGIFANER IEASEELFYD YRYGPDQAPV WARKPEGSKK 840
DDSAITHRRA RKHQSH 856Protein Fasta Sequence
>AT4G02020.1|EZA1;SWN|Arabidopsis thaliana
MVTDDSNSSGRIKSHVDDDDDGEEEEDRLEGLENRLSELKRKIQGERVRSIKEKFEANRKKVDAHVSPFSSAASSRATAEDNGNSNMLSSRMRMPLCKLNGFSHGVGDRDYVPTKDVISASVKLPIAERIPPYTTWIFLDRNQRMAEDQSVVGRRQIYYEQHGGETLICSDSEEEPEPEEEKREFSEGEDSIIWLIGQEYGMGEEVQDALCQLLSVDASDILERYNELKLKDKQNTEEFSNSGFKLGISLEKGLGAALDSFDNLFCRRCLVFDCRLHGCSQPLISASEKQPYWSDYEGDRKPCSKHCYLQLKAVREVPETCSNFASKAEEKASEEECSKAVSSDVPHAAASGVSLQVEKTDIGIKNVDSSSGVEQEHGIRGKREVPILKDSNDLPNLSNKKQKTAASDTKMSFVNSVPSLDQALDSTKGDQGGTTDNKVNRDSEADAKEVGEPIPDNSVHDGGSSICQPHHGSGNGAIIIAEMSETSRPSTEWNPIEKDLYLKGVEIFGRNSCLIARNLLSGLKTCLDVSNYMRENEVSVFRRSSTPNLLLDDGRTDPGNDNDEVPPRTRLFRRKGKTRKLKYSTKSAGHPSVWKRIAGGKNQSCKQYTPCGCLSMCGKDCPCLTNETCCEKYCGCSKSCKNRFRGCHCAKSQCRSRQCPCFAAGRECDPDVCRNCWVSCGDGSLGEAPRRGEGQCGNMRLLLRQQQRILLGKSDVAGWGAFLKNSVSKNEYLGEYTGELISHHEADKRGKIYDRANSSFLFDLNDQYVLDAQRKGDKLKFANHSAKPNCYAKVMFVAGDHRVGIFANERIEASEELFYDYRYGPDQAPVWARKPEGSKKDDSAITHRRARKHQSH |
Nucleotide Sequence
(Fasta) | CCGTTCGTCC TTCTCACAAG TCTGATTGCG GAAAAAGCAG AGAGAGAGAG AAAGTTCGAG 60
CGGAAGAGAA GCGGAAAGCT CGAGGAGTCA TCAATGGTGA CGGACGATAG CAACTCCTCT 120
GGACGAATCA AGTCTCATGT AGATGATGAT GATGATGGTG AAGAAGAAGA AGATAGACTC 180
GAGGGTTTGG AAAACAGATT AAGTGAGCTT AAAAGGAAAA TTCAAGGAGA AAGAGTTAGG 240
TCTATTAAAG AGAAATTTGA GGCTAATAGA AAGAAAGTGG ATGCTCATGT TTCTCCCTTT 300
TCATCTGCTG CATCGAGCCG AGCTACCGCA GAGGATAATG GAAATAGCAA TATGCTTTCT 360
TCGAGAATGA GAATGCCACT CTGCAAGTTA AATGGTTTTT CTCATGGTGT GGGAGATAGA 420
GACTATGTTC CTACTAAGGA TGTTATATCA GCAAGTGTCA AGCTTCCTAT TGCTGAGAGA 480
ATACCGCCAT ACACTACCTG GATATTTTTG GACAGAAATC AAAGAATGGC TGAAGATCAG 540
TCTGTGGTTG GTCGAAGACA AATCTACTAT GAACAACATG GTGGTGAGAC GCTAATATGC 600
AGCGATAGTG AGGAAGAACC AGAACCTGAG GAGGAAAAAC GTGAATTTTC CGAGGGTGAA 660
GATTCCATTA TATGGTTAAT TGGGCAGGAG TATGGCATGG GTGAGGAAGT GCAGGATGCC 720
CTTTGCCAGT TGCTAAGCGT AGATGCTTCT GATATCCTGG AAAGATACAA TGAGCTCAAG 780
TTGAAGGATA AGCAGAATAC CGAGGAATTT TCTAATTCCG GATTCAAGCT GGGAATATCT 840
CTGGAAAAGG GCCTTGGTGC AGCTCTAGAT TCTTTTGATA ATCTTTTCTG CCGCCGTTGC 900
TTGGTATTTG ACTGTCGTCT GCATGGATGT TCTCAGCCTT TGATTAGTGC TAGTGAAAAA 960
CAGCCTTATT GGTCTGATTA TGAAGGTGAT AGGAAACCCT GCAGCAAACA TTGTTACCTC 1020
CAGCTCAAGG CGGTCAGAGA AGTACCAGAA ACATGCAGTA ATTTTGCATC TAAAGCAGAA 1080
GAGAAAGCTT CAGAAGAGGA ATGCAGCAAG GCTGTCTCCT CTGATGTTCC CCATGCTGCT 1140
GCTAGTGGTG TCAGTCTGCA AGTTGAGAAG ACTGATATTG GTATCAAGAA TGTAGATTCA 1200
TCCTCTGGTG TAGAACAAGA GCATGGAATT AGAGGAAAGC GTGAGGTCCC AATTCTAAAA 1260
GACTCCAATG ATCTGCCTAA TTTATCGAAC AAGAAACAGA AGACCGCAGC CTCAGATACA 1320
AAAATGTCAT TTGTTAATTC TGTCCCTAGC TTAGATCAGG CATTGGATAG CACAAAGGGT 1380
GATCAAGGTG GAACAACTGA CAATAAAGTA AACAGAGACT CAGAAGCTGA TGCAAAAGAA 1440
GTAGGTGAGC CTATTCCAGA CAATTCGGTC CATGATGGTG GTTCCTCAAT TTGTCAGCCA 1500
CACCATGGTA GTGGAAACGG AGCAATAATC ATTGCAGAAA TGTCTGAGAC AAGTCGACCA 1560
TCTACAGAGT GGAATCCTAT CGAGAAGGAT CTTTACTTGA AGGGAGTCGA AATCTTTGGA 1620
AGAAACAGCT GTCTTATTGC AAGAAACCTG CTTTCTGGCT TGAAGACATG CCTAGATGTG 1680
TCCAATTACA TGCGTGAAAA CGAAGTTTCA GTTTTTCGAA GATCTAGTAC CCCAAATTTG 1740
CTGTTGGATG ATGGCAGGAC TGACCCAGGG AATGATAATG ATGAGGTGCC TCCAAGGACA 1800
AGATTGTTCC GTAGAAAAGG CAAAACCCGG AAGCTAAAAT ACTCTACAAA GTCTGCTGGT 1860
CATCCGTCTG TCTGGAAAAG AATAGCTGGT GGCAAAAACC AGTCCTGTAA ACAATACACG 1920
CCGTGTGGAT GCCTGTCAAT GTGCGGAAAG GATTGCCCTT GTCTAACTAA TGAAACTTGC 1980
TGCGAGAAAT ATTGCGGGTG CTCAAAAAGC TGTAAAAATC GTTTCCGAGG ATGTCATTGT 2040
GCAAAGAGTC AATGCAGAAG TAGGCAGTGT CCCTGCTTTG CTGCTGGCAG AGAATGTGAT 2100
CCAGATGTTT GCAGAAATTG CTGGGTTAGT TGTGGAGATG GTTCTCTCGG TGAAGCACCA 2160
AGACGCGGAG AAGGGCAATG CGGAAACATG AGACTTCTCC TGAGGCAACA ACAGAGGATC 2220
CTATTGGGAA AGTCTGATGT TGCTGGATGG GGTGCTTTTC TAAAGAACTC GGTCAGCAAA 2280
AATGAATACC TTGGAGAATA CACCGGTGAA TTGATCTCAC ACCATGAGGC GGATAAGCGT 2340
GGGAAAATAT ATGACCGGGC AAATTCGTCC TTCCTCTTTG ACTTGAATGA TCAGTACGTC 2400
CTCGATGCTC AACGCAAAGG TGACAAGCTG AAATTTGCCA ATCACTCAGC TAAACCCAAT 2460
TGCTACGCTA AGGTGATGTT TGTAGCAGGA GATCACAGGG TCGGGATTTT TGCAAACGAA 2520
CGAATAGAAG CTAGCGAAGA GCTTTTCTAT GACTATAGAT ATGGACCAGA CCAAGCACCA 2580
GTGTGGGCTC GCAAACCTGA AGGCTCCAAG AAAGATGATT CAGCCATTAC TCATCGTAGA 2640
GCCAGAAAGC ACCAATCTCA TTGATGATTA CTGGCTAAGA GAAGTAACTT TTATAAAAAT 2700
AACTTATAGA GTTGTGAGAG ATGATATTTG AAGTTTGATA ACTTAAGCTT GTCTTTATTA 2760
ATTAATTATT ATAGAGTTGA GATTTTATTT TATTTTGACA TCGAGTTTGG ACTTTGTATA 2820
GGTGATAAAA CAATTTATGA ATTATTGGGG TCAATAAGTA AAAATGTATC ATTTCG
2877Nucleotide Fasta Sequence
>AT4G02020.1|SET1|Arabidopsis thaliana
CCGTTCGTCCTTCTCACAAGTCTGATTGCGGAAAAAGCAGAGAGAGAGAGAAAGTTCGAGCGGAAGAGAAGCGGAAAGCTCGAGGAGTCATCAATGGTGACGGACGATAGCAACTCCTCTGGACGAATCAAGTCTCATGTAGATGATGATGATGATGGTGAAGAAGAAGAAGATAGACTCGAGGGTTTGGAAAACAGATTAAGTGAGCTTAAAAGGAAAATTCAAGGAGAAAGAGTTAGGTCTATTAAAGAGAAATTTGAGGCTAATAGAAAGAAAGTGGATGCTCATGTTTCTCCCTTTTCATCTGCTGCATCGAGCCGAGCTACCGCAGAGGATAATGGAAATAGCAATATGCTTTCTTCGAGAATGAGAATGCCACTCTGCAAGTTAAATGGTTTTTCTCATGGTGTGGGAGATAGAGACTATGTTCCTACTAAGGATGTTATATCAGCAAGTGTCAAGCTTCCTATTGCTGAGAGAATACCGCCATACACTACCTGGATATTTTTGGACAGAAATCAAAGAATGGCTGAAGATCAGTCTGTGGTTGGTCGAAGACAAATCTACTATGAACAACATGGTGGTGAGACGCTAATATGCAGCGATAGTGAGGAAGAACCAGAACCTGAGGAGGAAAAACGTGAATTTTCCGAGGGTGAAGATTCCATTATATGGTTAATTGGGCAGGAGTATGGCATGGGTGAGGAAGTGCAGGATGCCCTTTGCCAGTTGCTAAGCGTAGATGCTTCTGATATCCTGGAAAGATACAATGAGCTCAAGTTGAAGGATAAGCAGAATACCGAGGAATTTTCTAATTCCGGATTCAAGCTGGGAATATCTCTGGAAAAGGGCCTTGGTGCAGCTCTAGATTCTTTTGATAATCTTTTCTGCCGCCGTTGCTTGGTATTTGACTGTCGTCTGCATGGATGTTCTCAGCCTTTGATTAGTGCTAGTGAAAAACAGCCTTATTGGTCTGATTATGAAGGTGATAGGAAACCCTGCAGCAAACATTGTTACCTCCAGCTCAAGGCGGTCAGAGAAGTACCAGAAACATGCAGTAATTTTGCATCTAAAGCAGAAGAGAAAGCTTCAGAAGAGGAATGCAGCAAGGCTGTCTCCTCTGATGTTCCCCATGCTGCTGCTAGTGGTGTCAGTCTGCAAGTTGAGAAGACTGATATTGGTATCAAGAATGTAGATTCATCCTCTGGTGTAGAACAAGAGCATGGAATTAGAGGAAAGCGTGAGGTCCCAATTCTAAAAGACTCCAATGATCTGCCTAATTTATCGAACAAGAAACAGAAGACCGCAGCCTCAGATACAAAAATGTCATTTGTTAATTCTGTCCCTAGCTTAGATCAGGCATTGGATAGCACAAAGGGTGATCAAGGTGGAACAACTGACAATAAAGTAAACAGAGACTCAGAAGCTGATGCAAAAGAAGTAGGTGAGCCTATTCCAGACAATTCGGTCCATGATGGTGGTTCCTCAATTTGTCAGCCACACCATGGTAGTGGAAACGGAGCAATAATCATTGCAGAAATGTCTGAGACAAGTCGACCATCTACAGAGTGGAATCCTATCGAGAAGGATCTTTACTTGAAGGGAGTCGAAATCTTTGGAAGAAACAGCTGTCTTATTGCAAGAAACCTGCTTTCTGGCTTGAAGACATGCCTAGATGTGTCCAATTACATGCGTGAAAACGAAGTTTCAGTTTTTCGAAGATCTAGTACCCCAAATTTGCTGTTGGATGATGGCAGGACTGACCCAGGGAATGATAATGATGAGGTGCCTCCAAGGACAAGATTGTTCCGTAGAAAAGGCAAAACCCGGAAGCTAAAATACTCTACAAAGTCTGCTGGTCATCCGTCTGTCTGGAAAAGAATAGCTGGTGGCAAAAACCAGTCCTGTAAACAATACACGCCGTGTGGATGCCTGTCAATGTGCGGAAAGGATTGCCCTTGTCTAACTAATGAAACTTGCTGCGAGAAATATTGCGGGTGCTCAAAAAGCTGTAAAAATCGTTTCCGAGGATGTCATTGTGCAAAGAGTCAATGCAGAAGTAGGCAGTGTCCCTGCTTTGCTGCTGGCAGAGAATGTGATCCAGATGTTTGCAGAAATTGCTGGGTTAGTTGTGGAGATGGTTCTCTCGGTGAAGCACCAAGACGCGGAGAAGGGCAATGCGGAAACATGAGACTTCTCCTGAGGCAACAACAGAGGATCCTATTGGGAAAGTCTGATGTTGCTGGATGGGGTGCTTTTCTAAAGAACTCGGTCAGCAAAAATGAATACCTTGGAGAATACACCGGTGAATTGATCTCACACCATGAGGCGGATAAGCGTGGGAAAATATATGACCGGGCAAATTCGTCCTTCCTCTTTGACTTGAATGATCAGTACGTCCTCGATGCTCAACGCAAAGGTGACAAGCTGAAATTTGCCAATCACTCAGCTAAACCCAATTGCTACGCTAAGGTGATGTTTGTAGCAGGAGATCACAGGGTCGGGATTTTTGCAAACGAACGAATAGAAGCTAGCGAAGAGCTTTTCTATGACTATAGATATGGACCAGACCAAGCACCAGTGTGGGCTCGCAAACCTGAAGGCTCCAAGAAAGATGATTCAGCCATTACTCATCGTAGAGCCAGAAAGCACCAATCTCATTGATGATTACTGGCTAAGAGAAGTAACTTTTATAAAAATAACTTATAGAGTTGTGAGAGATGATATTTGAAGTTTGATAACTTAAGCTTGTCTTTATTAATTAATTATTATAGAGTTGAGATTTTATTTTATTTTGACATCGAGTTTGGACTTTGTATAGGTGATAAAACAATTTATGAATTATTGGGGTCAATAAGTAAAAATGTATCATTTCG
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0181--Complete proteome
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
--
|
| Interpro |
IPR026489--CXC_dom
IPR025778--Hist-Lys_N-MeTrfase_EZ
IPR001005--SANT/Myb
IPR001214--SET_dom
IPR033467--Tesmin/TSO1-like_CXC
|
| PROSITE |
PS51633--CXC
PS51576--SAM_MT43_EZ
PS50280--SET
|
| Pfam |
PF00856--SET
|
| Gene Ontology |
GO:0005677--C:chromatin silencing complex
GO:0005634--C:nucleus
GO:0031519--C:PcG protein complex
GO:0009506--C:plasmodesma
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0003727--F:single-stranded RNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0006349--P:regulation of gene expression by genetic imprinting
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
