WERAM Information

Tag Content
WERAM ID WERAM-Art-0066
Ensembl Protein ID AT3G07610.1
Uniprot Accession Q9SSE9; JMJ25_ARATH
Genbank Protein ID NP_187418.1
Protein Name Lysine-specific demethylase JMJ25
Genbank Nucleotide ID NM_111640.1
Gene Name JMJ25;IBM1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
AT3G07610 AT3G07610.1 AT3G07610.1
AT3G07610 AT3G07610.3 AT3G07610.3
Details
Type Family Domain Substrates AA References (PMIDs)
HDM JHDM2 Jmjc H3K4me1/2; H3K9me1/2 K 18218897
Status Reviewed
Classification
Type Family E-value Score Start End
HDM JHDM2 4.30e-92 308.3 635 860
Organism Arabidopsis thaliana
NCBI Taxa ID 3702
Functional Description
(View)		 Histone demethylase that demethylates 'Lys-9' (H3K9me) of histone H3 with a specific activity for H3K9me2 and H3K9me1. No activity on H3K9me3, H3K4me3/2/1, H3K27me3/2/1 and H3K36me3/2/1. Involved in the control of several developmental processes by protecting genes from silencing. Demethylates H3K9me2 in the promoter regions of RDR2 and DCL3 and mediates the repression of ectopic non-CpG methylation at RDR2, DCL3 and APC13 loci. Protects also a large number of transcribed genes from non-CpG methylation. May regulate gene expression via a pathway involving indirect silencing of gene expression through small RNA-directed DNA methylation (RdDM)-directed repression.
Domain Profile
  HDM JHDM2
    JHDM2.txt   4 krdgklNLasklpknfvrpdlgPklynAyGlateedrklgttnlhldvsdavnilvy..........vgilkkkwaeedlkellksieee....elde 87 
                  +++g+lNLa+klp+n+++pd+gPk+y+A+G+a+e +r++++t+lh+d+sdavnil++          +g+lkkk+ae+dlkel++s++++    e++e
  AT3G07610.1 635 PVNGPLNLAVKLPQNCLKPDMGPKTYVASGFAQELGRGDSVTKLHCDMSDAVNILTHisevpnmqpgIGNLKKKHAEQDLKELYSSVANKeemmEILE 732
                  479*************************************************************************************99899999** PP
    JHDM2.txt  88 vtrkrvqdpkekpgalWhifaakdaekirellekvskeqga....evppdhdpihdqswyldrklrkrLfeeyGvegwtlvQklgdavlipagapHqv 181
                  ++r++vq++++++galW+if+++d++k+++++ek++ke+++    +v+++++pihdq++yl+r+++++L+eeyG+e+wt++Qklgdavlip+g+pHqv
  AT3G07610.1 733 NSRQQVQNVETDDGALWDIFRREDIPKLESYIEKHHKEFRHlyccPVSQVVHPIHDQNFYLTRYHIMKLKEEYGIEPWTFNQKLGDAVLIPVGCPHQV 830
                  *****************************************99999**************************************************** PP
    JHDM2.txt 182 qnlkscvkvaedFvsPEnvkecfrltkeyr 211
                  +nlksc+kva dFvsPEnv+ec+rltk+yr
  AT3G07610.1 831 RNLKSCNKVALDFVSPENVSECLRLTKQYR 860
                  *****************************8 PP
Protein Sequence
(Fasta)		MDSVEEEGVV RVEEENGRGG LRRHRRVSTK LANYVDPPTD DEEDGGPKRK GKRGGNRAPK 60
KTPKKDEEMQ KNEIDEANRV TGLVKEKRAA TKILNRKDSI IEVGEASGSM PKEVKGIRIG 120
KRKGEIDGEI PTKPGKKPKT TVDPRIIGYR PDNMCHQCQK SDRIVERCQT CNSKRYCHPC 180
LDTWYPLIAK EDVAKKCMFC SSTCNCRACL RLDTKLKGIN SNLIVSEEEK VQASKFILQS 240
LLPHLKGIND EQVAEKEVEA KIYGLKFEEV RPQDAKAFPD ERLYCDICKT SIYDLHRNCK 300
SCSFDICLSC CLEIRNGKAL ACKEDVSWNY INRGLEYEHG QEGKVIEKPA NKLDDKLKDK 360
LDGKPDDKPK GKPKGRPKGK PDDKPKGKLK GKQDDKPDDK PDEKPVNTDH MKYPSLWKAN 420
EAGIITCCCG AGELVLKRLL PDGWISELVN RVEKTAEAGE LLNLPETVLE RCPCSNSDRH 480
IDIDSCNLLK AACREGSEDN YLYSPSVWDV QQDDLKHFQH HWVKGEPVIV RNVLEATSGL 540
SWEPMVMHRA CRQISHVQHG SLKDVVAVDC LDFCEVKVNL HEFFTGYTDG RYDRMGWPLV 600
LKLKDWPPAK VFKDNLPRHA EEFLCSLPLK HYTHPVNGPL NLAVKLPQNC LKPDMGPKTY 660
VASGFAQELG RGDSVTKLHC DMSDAVNILT HISEVPNMQP GIGNLKKKHA EQDLKELYSS 720
VANKEEMMEI LENSRQQVQN VETDDGALWD IFRREDIPKL ESYIEKHHKE FRHLYCCPVS 780
QVVHPIHDQN FYLTRYHIMK LKEEYGIEPW TFNQKLGDAV LIPVGCPHQV RNLKSCNKVA 840
LDFVSPENVS ECLRLTKQYR LLPPNHFAKE DKLGVKKMIV HAVDKALRDL SGEKSPEPEE 900
KKQNMRGPKK GAAKAVAKAL KDLSPSEKKS SEAAEEEISN GIVNAIDKGL KDLPPSEEKS 960
SEAKVEISNG IVSAMDKDLE HISSSEKKST EEEGVKRPNI VRTYERRKKL GSEVTNAYID 1020
RLEMEKM 1027
Nucleotide Sequence
(Fasta)		ATGGATTCTG TGGAGGAAGA AGGTGTTGTT AGGGTTGAAG AAGAGAACGG ACGCGGTGGT 60
CTCCGTAGGC ATCGGAGGGT TTCTACGAAG CTGGCGAATT ACGTAGATCC TCCGACTGAC 120
GACGAAGAAG ATGGAGGACC CAAGCGAAAG GGCAAAAGGG GTGGAAATAG GGCTCCGAAA 180
AAGACACCGA AGAAAGACGA GGAGATGCAA AAGAACGAAA TTGATGAAGC AAACCGAGTC 240
ACTGGTCTGG TGAAGGAAAA AAGAGCCGCG ACTAAGATTC TGAATCGCAA AGACTCCATT 300
ATTGAAGTAG GAGAAGCTTC TGGAAGCATG CCCAAGGAAG TAAAGGGAAT TAGGATTGGG 360
AAAAGGAAGG GAGAAATCGA TGGTGAGATT CCAACTAAGC CGGGCAAGAA GCCAAAGACT 420
ACAGTAGACC CGAGAATCAT TGGTTACAGA CCGGACAATA TGTGCCATCA ATGTCAAAAG 480
AGCGATAGGA TTGTTGAACG GTGTCAGACC TGCAATAGTA AGCGTTATTG TCATCCATGC 540
TTGGACACTT GGTACCCCCT TATAGCAAAA GAAGATGTTG CCAAGAAATG CATGTTCTGC 600
TCTAGTACTT GCAATTGCAG AGCATGCTTG CGTCTAGATA CTAAATTGAA AGGGATAAAT 660
TCGAACCTCA TAGTCAGCGA GGAAGAAAAG GTCCAAGCCT CTAAGTTTAT TCTGCAGAGC 720
CTTCTCCCAC ATCTGAAAGG AATAAATGAT GAACAAGTTG CTGAGAAGGA AGTTGAGGCC 780
AAAATATACG GACTGAAGTT TGAAGAGGTG AGGCCCCAAG ACGCTAAAGC TTTCCCTGAT 840
GAAAGACTAT ACTGTGATAT CTGCAAGACT TCTATCTATG ATCTCCATAG GAATTGCAAG 900
TCCTGTAGTT TTGATATCTG CCTTAGCTGT TGCCTTGAGA TCCGCAATGG AAAGGCTCTG 960
GCATGTAAGG AGGATGTGTC TTGGAATTAT ATTAACCGAG GTTTAGAGTA TGAACATGGA 1020
CAAGAAGGAA AAGTGATTGA AAAGCCGGCG AATAAGCTAG ATGATAAGTT GAAAGATAAG 1080
CTGGATGGTA AGCCGGATGA TAAGCCGAAG GGTAAGCCAA AGGGTAGGCC AAAGGGTAAG 1140
CCGGATGATA AGCCGAAGGG TAAACTGAAG GGTAAGCAGG ATGATAAACC GGATGATAAG 1200
CCAGATGAGA AGCCGGTTAA TACAGACCAT ATGAAGTACC CTTCTCTGTG GAAAGCAAAT 1260
GAAGCTGGGA TCATTACTTG TTGTTGTGGT GCTGGGGAGT TAGTGCTGAA ACGACTACTT 1320
CCGGATGGTT GGATATCTGA GTTGGTCAAC AGAGTTGAAA AAACTGCTGA AGCTGGCGAG 1380
CTTTTGAATT TACCTGAAAC GGTTTTGGAG CGATGCCCTT GTTCTAACTC TGACAGACAT 1440
ATTGACATAG ACAGCTGTAA TTTGTTAAAA GCTGCTTGTC GAGAAGGTTC AGAAGACAAT 1500
TATCTTTACT CTCCAAGTGT ATGGGATGTT CAACAAGATG ATTTGAAGCA TTTTCAGCAC 1560
CATTGGGTAA AAGGCGAGCC TGTGATTGTG AGAAATGTGC TTGAAGCTAC ATCTGGTTTA 1620
AGCTGGGAAC CAATGGTAAT GCATCGTGCC TGCCGCCAGA TAAGCCATGT CCAGCATGGA 1680
TCACTTAAGG ATGTTGTTGC TGTTGATTGT TTGGACTTCT GTGAGGTAAA AGTTAATCTT 1740
CATGAATTTT TTACTGGATA CACGGATGGC CGATATGATC GAATGGGTTG GCCACTAGTT 1800
CTGAAACTGA AAGATTGGCC TCCAGCTAAA GTCTTCAAAG ATAACTTGCC ACGTCATGCT 1860
GAGGAGTTCT TATGTAGTTT GCCTTTGAAG CATTACACTC ATCCGGTTAA TGGACCTTTG 1920
AATCTCGCTG TCAAGCTTCC CCAAAATTGC TTGAAGCCAG ACATGGGACC AAAGACGTAC 1980
GTTGCTTCTG GATTTGCTCA AGAATTAGGC CGTGGAGATT CTGTTACTAA GCTCCACTGC 2040
GACATGTCTG ATGCGGTGAA TATTTTGACG CACATATCTG AAGTGCCCAA TATGCAACCT 2100
GGAATTGGAA ATCTGAAAAA GAAGCATGCC GAACAAGATC TCAAGGAGCT GTATAGCTCA 2160
GTAGCTAACA AGGAGGAAAT GATGGAGATT CTTGAAAATT CCAGACAACA AGTCCAAAAT 2220
GTTGAAACTG ATGATGGAGC TCTTTGGGAC ATTTTCCGTA GAGAAGATAT TCCTAAATTA 2280
GAAAGTTACA TTGAGAAACA TCACAAGGAG TTCAGACATC TCTACTGCTG TCCTGTGTCT 2340
CAGGTTGTTC ATCCTATACA TGACCAGAAC TTCTATCTGA CGCGGTATCA TATAATGAAG 2400
CTGAAAGAAG AATATGGCAT TGAACCTTGG ACCTTCAATC AGAAGCTTGG TGATGCTGTT 2460
TTGATACCTG TAGGTTGCCC TCATCAAGTT AGAAATTTGA AGTCCTGCAA TAAGGTAGCG 2520
CTTGACTTCG TCTCACCTGA AAATGTCAGC GAGTGTTTAC GCTTGACAAA ACAGTATCGT 2580
CTACTTCCAC CAAATCATTT TGCAAAAGAA GACAAGTTAG GGGTTAAGAA GATGATAGTC 2640
CATGCAGTTG ATAAAGCTCT CAGAGACTTA AGTGGAGAGA AGTCTCCAGA ACCTGAAGAG 2700
AAGAAACAAA ATATGAGAGG GCCGAAGAAG GGGGCAGCCA AGGCAGTTGC CAAGGCTCTC 2760
AAAGACTTAT CTCCAAGTGA AAAGAAGTCT TCGGAAGCAG CTGAAGAGGA GATATCAAAT 2820
GGGATAGTCA ATGCAATCGA TAAGGGTCTC AAAGACTTAC CTCCAAGTGA AGAGAAGTCT 2880
TCCGAAGCCA AAGTGGAGAT ATCAAATGGG ATAGTCAGTG CAATGGATAA GGATCTCGAA 2940
CACATATCTT CAAGCGAAAA GAAGTCTACG GAAGAGGAAG GGGTGAAAAG ACCAAATATT 3000
GTGAGGACAT ATGAGCGGAG AAAAAAGCTG GGAAGTGAAG TAACCAACGC ATACATTGAC 3060
AGATTAGAAA TGGAGAAGAT GTAG 3085
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0408--Iron
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR003347--JmjC_dom
PROSITE

PS51184--JMJC
Pfam

PF02373--JmjC
Gene Ontology

GO:0005634--C:nucleus
GO:0051213--F:dioxygenase activity
GO:0032454--F:histone demethylase activity (H3-K9 specific)
GO:0046872--F:metal ion binding
GO:0033169--P:histone H3-K9 demethylation
GO:0060969--P:negative regulation of gene silencing
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Arl-0071 fgenesh2_kg.3__ 790__ AT3G07610.1 Arabidopsis lyrata 90 0.0 1051
WERAM-Brr-0149 Bra029664.1-P Brassica rapa 73 0.0 754
WERAM-Bro-0103 Bo5g141320.1 Brassica oleracea 73 0.0 753
WERAM-Pot-0063 POPTR_0005s09360.1 Populus trichocarpa 60 2e-169 593
WERAM-Met-0036 AES62955 Medicago truncatula 58 1e-161 568
WERAM-Glm-0245 GLYMA19G12090.1 Glycine max 51 3e-159 560
WERAM-Thc-0088 EOY14163 Theobroma cacao 56 2e-156 551
WERAM-Sot-0046 PGSC0003DMT400042379 Solanum tuberosum 53 5e-144 509
WERAM-Sol-0031 Solyc02g082400.2.1 Solanum lycopersicum 52 4e-142 503
WERAM-Prp-0037 EMJ15852 Prunus persica 51 5e-142 503
WERAM-Sob-0006 Sb01g015210.1 Sorghum bicolor 50 4e-141 500
WERAM-Sei-0128 Si034182m Setaria italica 50 5e-141 499
WERAM-Zem-0137 GRMZM2G417089_P01 Zea mays 49 3e-140 497
WERAM-Viv-0067 VIT_10s0116g00960.t01 Vitis vinifera 52 2e-139 494
WERAM-Lep-0100 LPERR09G06290.1 Leersia perrieri 51 5e-128 456
WERAM-Orm-0094 OMERI09G07170.1 Oryza meridionalis 50 7e-126 449
WERAM-Tra-0233 Traes_5DL_9DCF29857.2 Triticum aestivum 48 4e-123 440
WERAM-Aet-0048 EMT13865 Aegilops tauschii 48 6e-123 439
WERAM-Php-0101 PP1S444_19V6.1 Physcomitrella patens 44 9e-123 439
WERAM-Orbr-0045 OB03G31290.1 Oryza brachyantha 43 3e-122 437
WERAM-Orp-0097 OPUNC09G07740.1 Oryza punctata 50 3e-122 437
WERAM-Tru-0042 TRIUR3_19853-P1 Triticum urartu 48 6e-121 433
WERAM-Brd-0109 BRADI4G29617.1 Brachypodium distachyon 53 7e-121 432
WERAM-Orb-0104 OBART09G09130.1 Oryza barthii 50 9e-121 432
WERAM-Orgl-0100 OGLUM09G09380.1 Oryza glumaepatula 50 1e-120 431
WERAM-Orr-0107 ORUFI09G09860.1 Oryza rufipogon 50 2e-120 431
WERAM-Orl-0059 KN539156.1_FGP008 Oryza longistaminata 50 3e-120 431
WERAM-Ori-0112 BGIOSGA030706-PA Oryza indica 50 3e-120 430
WERAM-Orni-0101 ONIVA09G08110.1 Oryza nivara 50 4e-120 430
WERAM-Ors-0092 OS09T0393200-01 Oryza sativa 54 9e-113 405
WERAM-Org-0036 ORGLA03G0163900.1 Oryza glaberrima 31 2e-100 364
WERAM-Hov-0014 MLOC_13090.1 Hordeum vulgare 54 6e-99 360
WERAM-Mua-0058 GSMUA_Achr3P14190_001 Musa acuminata 47 2e-91 334
WERAM-Amt-0026 ERN14091 Amborella trichopoda 50 5e-83 307
WERAM-Tar-0009 ENSTRUP00000002076.1 Takifugu rubripes 37 2e-59 229
WERAM-Gaa-0189 ENSGACP00000023958.1 Gasterosteus aculeatus 36 2e-57 221
WERAM-Ten-0123 ENSTNIP00000013426.1 Tetraodon nigroviridis 37 3e-57 221
WERAM-Fec-0021 ENSFCAP00000001589.3 Felis catus 37 3e-57 221
WERAM-Nol-0092 ENSNLEP00000010895.1 Nomascus leucogenys 37 3e-57 221
WERAM-Asm-0165 ENSAMXP00000016507.1 Astyanax mexicanus 37 3e-57 221
WERAM-Caf-0016 ENSCAFP00000001774.3 Canis familiaris 37 4e-57 221
WERAM-Aim-0189 ENSAMEP00000017468.1 Ailuropoda melanoleuca 37 4e-57 221
WERAM-Mam-0003 ENSMMUP00000000618.2 Macaca mulatta 37 4e-57 221
WERAM-Hos-0102 ENSP00000326563.5 Homo sapiens 37 4e-57 221
WERAM-Poa-0141 ENSPPYP00000017696.1 Pongo abelii 37 4e-57 221
WERAM-Loa-0020 ENSLAFP00000001269.3 Loxodonta africana 37 4e-57 221
WERAM-Mup-0101 ENSMPUP00000009333.1 Mustela putorius furo 37 4e-57 221
WERAM-Pat-0141 ENSPTRP00000029560.2 Pan troglodytes 37 4e-57 221
WERAM-Dan-0091 ENSDNOP00000009144.3 Dasypus novemcinctus 37 4e-57 221
WERAM-Ova-0174 ENSOARP00000017606.1 Ovis aries 37 4e-57 221
WERAM-Ptv-0087 ENSPVAP00000007885.1 Pteropus vampyrus 37 4e-57 221
WERAM-Orc-0080 ENSOCUP00000007280.2 Oryctolagus cuniculus 37 4e-57 221
WERAM-Gog-0012 ENSGGOP00000000822.2 Gorilla gorilla 37 4e-57 221
WERAM-Eqc-0143 ENSECAP00000015928.1 Equus caballus 37 4e-57 221
WERAM-Cap-0028 ENSCPOP00000002138.2 Cavia porcellus 37 5e-57 220
WERAM-Bot-0099 ENSBTAP00000013278.4 Bos taurus 37 5e-57 220
WERAM-Mim-0018 ENSMICP00000001555.1 Microcebus murinus 37 5e-57 220
WERAM-Myl-0184 ENSMLUP00000015336.2 Myotis lucifugus 37 5e-57 220
WERAM-Chs-0157 ENSCSAP00000009298.1 Chlorocebus sabaeus 37 5e-57 220
WERAM-Mum-0157 ENSMUSP00000037628.7 Mus musculus 37 5e-57 220
WERAM-Otg-0093 ENSOGAP00000008081.2 Otolemur garnettii 37 5e-57 220
WERAM-Mod-0100 ENSMODP00000015209.4 Monodelphis domestica 37 7e-57 220
WERAM-Sus-0108 ENSSSCP00000015245.2 Sus scrofa 37 7e-57 220
WERAM-Paa-0043 ENSPANP00000002578.1 Papio anubis 37 8e-57 219
WERAM-Caj-0074 ENSCJAP00000012191.1 Callithrix jacchus 37 9e-57 219
WERAM-Sah-0129 ENSSHAP00000013821.1 Sarcophilus harrisii 37 9e-57 219
WERAM-Ran-0218 ENSRNOP00000067649.2 Rattus norvegicus 37 1e-56 219
WERAM-Leo-0085 ENSLOCP00000011676.1 Lepisosteus oculatus 37 1e-56 219
WERAM-Orn-0157 ENSONIP00000016309.1 Oreochromis niloticus 37 1e-56 219
WERAM-Anc-0075 ENSACAP00000007027.2 Anolis carolinensis 37 2e-56 219
WERAM-Orla-0053 ENSORLP00000006841.1 Oryzias latipes 35 2e-56 218
WERAM-Xim-0102 ENSXMAP00000009010.1 Xiphophorus maculatus 36 2e-56 218
WERAM-Pof-0098 ENSPFOP00000008824.2 Poecilia formosa 36 2e-56 218
WERAM-Gam-0008 ENSGMOP00000000972.1 Gadus morhua 36 3e-56 218
WERAM-Pem-0063 ENSPMAP00000006992.1 Petromyzon marinus 37 5e-56 217
WERAM-Meg-0102 ENSMGAP00000010078.1 Meleagris gallopavo 36 7e-56 216
WERAM-Gaga-0080 ENSGALP00000012399.4 Gallus gallus 36 7e-56 216
WERAM-Fia-0049 ENSFALP00000003539.1 Ficedula albicollis 36 1e-55 216
WERAM-Anp-0111 ENSAPLP00000012780.1 Anas platyrhynchos 36 1e-55 216
WERAM-Dar-0145 ENSDARP00000084278.5 Danio rerio 36 1e-55 216
WERAM-Ora-0023 ENSOANP00000003317.1 Ornithorhynchus anatinus 36 1e-55 216
WERAM-Lac-0170 ENSLACP00000020024.1 Latimeria chalumnae 35 2e-55 215
WERAM-Xet-0043 ENSXETP00000014664.3 Xenopus tropicalis 36 2e-55 215
WERAM-Tag-0001 ENSTGUP00000000018.1 Taeniopygia guttata 36 5e-55 214
WERAM-Mae-0023 ENSMEUP00000001666.1 Macropus eugenii 36 1e-54 212
WERAM-Pes-0047 ENSPSIP00000007045.1 Pelodiscus sinensis 36 2e-54 211
Created Date 25-Jun-2016