WERAM Information


Tag Content
WERAM ID WERAM-Art-0007
Ensembl Protein ID AT1G08460.1
Uniprot Accession Q94EJ2; HDA8_ARATH; Q944J5; Q9SJE6
Genbank Protein ID NP_563817.1
Protein Name Histone deacetylase 8
Genbank Nucleotide ID NM_100719.3
Gene Name HDA8;At1g08460;T27G7.14;T27G7_7
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
AT1G08460 AT1G08460.1 AT1G08460.1
Details
Type Family Domain Substrates AA References (PMIDs)
HDAC Class-II Histone deacetylase H2A; H2B; H3; H4 K 26689639
Status Reviewed
Classification
Type Family E-value Score Start End
HDAC Class-II 5.10e-91 306 6 335
HDAC Class-I 4.10e-37 129.2 37 326
Organism Arabidopsis thaliana
NCBI Taxa ID 3702
Functional Description
(View)
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).
Domain Profile
  HDAC Class-II

  class-2.txt   2 aglvydekmlkhqaleenkek............hpEkpeRiqailsrlqeagllekleelkarkatkeelqlvHseehvelletae.klekeeleslt 86 
++++++e ml+h+a+e+ ++ hpE+++R++++ls l++ ++++++++++ a +el+++H++e++e+l +a+ + e++e++
AT1G08460.1 6 VDVFWHEGMLRHDAVEGVFDTgydpgfldvlekHPENADRVRNMLSILRRGPIAPHVNWFTGLPAIVSELLMFHTSEYIEKLVEADkSGERCEIA--- 100
5799**************9999*************************************************************997566666666... PP
class-2.txt 87 vdsdsiylesksikaarlavGavlelvdkvlkgelkngfavvRPPGHHaeestamGFClfnnvavaakllqqklkvkkilivDwDvHhGnGtqeifyk 184
+++++ s++aa la+G++l++++++l+++ k+++a+vRPPGHH+++++a+G+C++nn+a+a+kl++++ +++++ ++D+DvH+GnGt e fy+
AT1G08460.1 101 ---AGTFMSPGSWEAALLAAGTTLSAMQHILDCHGKIAYALVRPPGHHSQPTQADGYCFLNNAALAVKLALNSGSCSRVAVIDIDVHYGNGTAEGFYT 195
...489******************************************************************************************** PP
class-2.txt 185 dpkvlylSlHRydkgsffpesgs..gavdevgegkgegfnvNvawngglmgdaeylaafrevvlpiakeFkPdlvlvsaGfDaaegdplgglsvtakc 280
++kvl++SlH +++gs+ +s+ g++de+ge+ g+g+n+Nv++++g+ gd+ y++a++e+v+p++++F Pd+v++ +G+D++++dp+g++s+t+++
AT1G08460.1 196 SDKVLTVSLH-MNHGSW-GSSHPqkGSIDELGEDVGLGYNLNVPLPNGT-GDRGYEYAMNELVVPAVRRFGPDMVVLVVGQDSSAFDPNGRQSLTMNG 290
**********.*****5.4443335*********************998.************************************************ PP
class-2.txt 281 yatltkqllkl....aggrvvlvlEGGynlkaiaeaveavvkaLl 321
y+++ + ++++ ++gr+++v EGGy++++ a++ +a+++++l
AT1G08460.1 291 YRRIGQIMRGVaeehSHGRLLMVQEGGYHVTYAAYCLHAMLEGVL 335
**********988889*************************9987 PP

  HDAC Class-I

  class-1.txt  18 qkhpmkpkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyieflkkvepenaeelskelkkfnvgedcPvfdglfeycqlitGasleaakk 115
+khp r++ + +++ + +++ ++ a ++ell fh+ eyie l + ++ + ++ ++ + + g +e + l +G++l+a+++
AT1G08460.1 37 EKHPENADRVRNMLSILRRGPIAPHVNWFTGLPAIVSELLMFHTSEYIEKLVEADK--------SGERCEIAAGTFMSPGSWEAALLAAGTTLSAMQH 126
6899999999999999999999999999********************99866543........345667788888999******************* PP
class-1.txt 116 Lnkkeadiainw.aGGlhhakkseasGfcyvnDivlailellk..khkrvlyididlhhGDgveeafyttdrvmtvsfhkygeef...fPgtGdlsdv 207
+ + + +ia hh++ ++a G+c++n+ la+ l + +rv idid+h+G+g e fyt+d+v+tvs+h + ++ P G++++
AT1G08460.1 127 ILDCHGKIAYALvRPPGHHSQPTQADGYCFLNNAALAVKLALNsgSCSRVAVIDIDVHYGNGTAEGFYTSDKVLTVSLHMNHGSWgssHPQKGSIDEL 224
********987624567********************9766554789********************************8766553448********* PP
class-1.txt 208 gaekgkyyavnvPlkdgidDesyekifksviskvieafePeavvlqcGaDslagDrlgefnlsikghaecvkfvksf.....nlpllvlGGGGYtlrn 300
g++ g y +nvPl +g D+ ye +++++ + +++f P++vvl +G Ds a D+ g +l+++g+ ++ ++++ + ll++ GGY ++
AT1G08460.1 225 GEDVGLGYNLNVPLPNGTGDRGYEYAMNELVVPAVRRFGPDMVVLVVGQDSSAFDPNGRQSLTMNGYRRIGQIMRGVaeehsHGRLLMVQEGGYHVTY 322
******************************************************************99998888865321134579*********999 PP
class-1.txt 301 vaRc 304
a c
AT1G08460.1 323 AAYC 326
8877 PP

Protein Sequence
(Fasta)
MVTNRVDVFW HEGMLRHDAV EGVFDTGYDP GFLDVLEKHP ENADRVRNML SILRRGPIAP 60
HVNWFTGLPA IVSELLMFHT SEYIEKLVEA DKSGERCEIA AGTFMSPGSW EAALLAAGTT 120
LSAMQHILDC HGKIAYALVR PPGHHSQPTQ ADGYCFLNNA ALAVKLALNS GSCSRVAVID 180
IDVHYGNGTA EGFYTSDKVL TVSLHMNHGS WGSSHPQKGS IDELGEDVGL GYNLNVPLPN 240
GTGDRGYEYA MNELVVPAVR RFGPDMVVLV VGQDSSAFDP NGRQSLTMNG YRRIGQIMRG 300
VAEEHSHGRL LMVQEGGYHV TYAAYCLHAM LEGVLKIPEP HLSDPIAYYP EEEANAVAAV 360
ESIKTYHTEF VPFLRGT 377
Nucleotide Sequence
(Fasta)
GTGAGCATCC TCCATTATTA CACCACCGTT GGCCTCCGAC GACGGCTCAA GCCTATCTTC 60
GTCGCCGGCT TCTCCGATGG TTACCAATCG CGTAGACGTC TTCTGGCACG AAGGAATGCT 120
CCGACACGAC GCCGTAGAAG GCGTCTTCGA CACTGGATAC GACCCTGGAT TCCTCGACGT 180
ATTGGAGAAG CACCCGGAGA ACGCCGATCG CGTCAGGAAC ATGCTTTCGA TTCTCCGACG 240
CGGTCCCATC GCTCCTCATG TCAATTGGTT TACCGGTCTT CCAGCAATCG TTTCGGAGCT 300
TCTAATGTTT CACACTTCAG AGTACATTGA GAAGCTAGTG GAGGCAGATA AATCAGGAGA 360
AAGGTGTGAA ATTGCCGCAG GTACTTTCAT GAGCCCAGGC TCGTGGGAAG CTGCTCTTCT 420
TGCAGCTGGA ACAACTCTTT CAGCAATGCA ACATATTCTT GATTGCCATG GGAAAATTGC 480
ATATGCTCTG GTACGCCCAC CAGGTCACCA CTCACAGCCT ACTCAGGCTG ATGGGTATTG 540
CTTCCTCAAC AACGCTGCTC TTGCTGTCAA GCTGGCATTG AATTCGGGTT CTTGTTCCCG 600
AGTTGCGGTT ATTGACATCG ATGTACATTA TGGAAATGGC ACAGCTGAAG GGTTTTATAC 660
ATCTGATAAG GTTCTTACGG TGTCACTCCA TATGAACCAT GGATCATGGG GATCGTCCCA 720
CCCGCAGAAA GGGTCGATTG ATGAACTTGG TGAAGACGTG GGATTGGGTT ACAATCTGAA 780
TGTCCCTTTA CCGAATGGCA CGGGTGACCG GGGATATGAA TATGCCATGA ATGAGCTGGT 840
GGTTCCTGCA GTTAGAAGGT TTGGACCCGA TATGGTTGTT CTCGTTGTTG GTCAAGACTC 900
TAGCGCTTTT GATCCAAACG GGAGACAAAG CCTGACAATG AATGGATACA GAAGGATTGG 960
GCAGATAATG AGGGGAGTTG CAGAGGAGCA CAGCCATGGA AGGTTGCTTA TGGTGCAAGA 1020
AGGCGGGTAT CATGTAACAT ATGCAGCTTA CTGCCTCCAC GCCATGCTCG AAGGGGTGCT 1080
GAAGATTCCA GAACCGCATC TATCTGATCC GATCGCTTAT TATCCCGAAG AAGAAGCTAA 1140
TGCTGTTGCT GCTGTGGAGT CAATCAAAAC ATATCACACC GAATTTGTTC CATTTCTCAG 1200
AGGAACTTGA AAATGGGACG TATGAATGAG TTTATGTTAT TCCTCGTTGT CTTGTGACCT 1260
TTTGGAACAC AGATCCAAAT CAATCAGGTC AAACCGTATA TATCAAAATA CTTGTTGATC 1320
AAACTATCTT TTGTATGAAA ACTTATTCAC ACGATCCGAC TTTGTTTTT
Sequence Source Ensembl
Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
--

Interpro

IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom

PROSITE
Pfam

PF00850--Hist_deacetyl

Gene Ontology

GO:0005634--C:nucleus
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Arl-0048 fgenesh2_kg.1__ 860__ AT1G08460.1 Arabidopsis lyrata 94 0.0 663
WERAM-Bro-0161 Bo8g112460.1 Brassica oleracea 90 0.0 638
WERAM-Brr-0156 Bra031628.1-P Brassica rapa 88 4e-180 627
WERAM-Prp-0067 EMJ06546 Prunus persica 73 8e-148 520
WERAM-Met-0052 AES67133 Medicago truncatula 71 1e-145 513
WERAM-Lep-0054 LPERR05G14310.1 Leersia perrieri 70 7e-143 504
WERAM-Mua-0091 GSMUA_Achr6P19520_001 Musa acuminata 72 7e-143 504
WERAM-Pot-0100 POPTR_0009s02560.1 Populus trichocarpa 73 1e-139 493
WERAM-Orgl-0054 OGLUM05G19120.1 Oryza glumaepatula 69 2e-139 492
WERAM-Orr-0055 ORUFI05G19220.1 Oryza rufipogon 70 2e-139 492
WERAM-Ors-0049 OS05T0440250-01 Oryza sativa 70 3e-139 491
WERAM-Ori-0058 BGIOSGA017971-PA Oryza indica 70 3e-139 491
WERAM-Glm-0150 GLYMA12G31380.1 Glycine max 69 6e-139 491
WERAM-Org-0053 ORGLA05G0156700.1 Oryza glaberrima 70 6e-139 491
WERAM-Sob-0125 Sb09g021720.1 Sorghum bicolor 69 7e-139 491
WERAM-Brd-0045 BRADI2G24020.1 Brachypodium distachyon 70 7e-139 491
WERAM-Orni-0050 ONIVA05G18980.1 Oryza nivara 72 7e-138 487
WERAM-Tra-0017 Traes_1BL_B77909838.1 Triticum aestivum 70 1e-137 487
WERAM-Sol-0084 Solyc06g074080.2.1 Solanum lycopersicum 71 2e-137 485
WERAM-Aet-0025 EMT04688 Aegilops tauschii 69 4e-137 484
WERAM-Amt-0035 ERN16099 Amborella trichopoda 69 1e-136 483
WERAM-Sei-0083 Si022311m Setaria italica 70 1e-136 483
WERAM-Viv-0042 VIT_06s0080g00210.t01 Vitis vinifera 72 1e-135 480
WERAM-Sot-0016 PGSC0003DMT400015085 Solanum tuberosum 70 6e-135 478
WERAM-Orl-0065 KN539375.1_FGP010 Oryza longistaminata 70 5e-134 474
WERAM-Orbr-0062 OB05G25730.1 Oryza brachyantha 70 1e-132 469
WERAM-Thc-0113 EOY33305 Theobroma cacao 62 1e-130 463
WERAM-Tru-0024 TRIUR3_12332-P1 Triticum urartu 69 8e-130 460
WERAM-Orm-0052 OMERI05G15690.1 Oryza meridionalis 70 3e-127 452
WERAM-Php-0020 PP1S142_41V6.1 Physcomitrella patens 66 6e-124 441
WERAM-Orp-0051 OPUNC05G15950.1 Oryza punctata 66 2e-111 399
WERAM-Sem-0041 EFJ29828 Selaginella moellendorffii 59 2e-110 396
WERAM-Orb-0053 OBART05G18100.1 Oryza barthii 61 4e-107 385
WERAM-Zem-0043 GRMZM2G056539_P01 Zea mays 70 9e-101 364
WERAM-Hov-0039 MLOC_38610.1 Hordeum vulgare 73 8e-59 224
WERAM-Mum-0115 ENSMUSP00000033501.8 Mus musculus 30 1e-33 141
WERAM-Ran-0209 ENSRNOP00000009295.5 Rattus norvegicus 30 1e-32 137
WERAM-Osl-0036 ABP01312 Ostreococcus lucimarinus 32 4e-32 136
WERAM-Scj-0031 EEB08679 Schizosaccharomyces japonicus 31 7e-32 135
WERAM-Cag-0018 CAG60803 Candida glabrata 30 8e-31 132
WERAM-Sac-0037 YNL021W Saccharomyces cerevisiae 30 2e-30 130
WERAM-Orc-0102 ENSOCUP00000008741.3 Oryctolagus cuniculus 31 3e-30 130
WERAM-Aim-0139 ENSAMEP00000013236.1 Ailuropoda melanoleuca 32 5e-30 129
WERAM-Cae-0060 F41H10.6b Caenorhabditis elegans 30 1e-29 127
WERAM-Myl-0104 ENSMLUP00000008295.2 Myotis lucifugus 32 2e-29 127
WERAM-Ict-0125 ENSSTOP00000012693.2 Ictidomys tridecemlineatus 31 2e-29 127
WERAM-Fec-0031 ENSFCAP00000002366.3 Felis catus 31 3e-29 126
WERAM-Chr-0012 EDP07560 Chlamydomonas reinhardtii 32 5e-29 126
WERAM-Eqc-0001 ENSECAP00000001121.1 Equus caballus 31 6e-29 125
WERAM-Caf-0161 ENSCAFP00000022990.3 Canis familiaris 31 6e-29 125
WERAM-Mup-0158 ENSMPUP00000013557.1 Mustela putorius furo 32 7e-29 125
WERAM-Cap-0109 ENSCPOP00000008049.2 Cavia porcellus 32 1e-28 124
WERAM-Scp-0036 SPBC800.03.1:pep Schizosaccharomyces pombe 30 1e-28 124
WERAM-Ova-0124 ENSOARP00000012678.1 Ovis aries 31 3e-28 123
WERAM-Kop-0012 CAY68916 Komagataella pastoris 29 4e-28 123
WERAM-Asm-0181 ENSAMXP00000017644.1 Astyanax mexicanus 32 7e-28 122
WERAM-Lem-0023 CBX90551 Leptosphaeria maculans 29 8e-28 122
WERAM-Drm-0028 FBpp0290988 Drosophila melanogaster 30 1e-27 121
WERAM-Chs-0158 ENSCSAP00000009365.1 Chlorocebus sabaeus 32 1e-27 121
WERAM-Mam-0153 ENSMMUP00000021637.2 Macaca mulatta 32 2e-27 120
WERAM-Hos-0047 ENSP00000365804.2 Homo sapiens 32 2e-27 120
WERAM-Paa-0049 ENSPANP00000006915.1 Papio anubis 31 2e-27 120
WERAM-Ocp-0057 ENSOPRP00000005096.1 Ochotona princeps 31 2e-27 120
WERAM-Gog-0047 ENSGGOP00000004443.2 Gorilla gorilla 32 2e-27 120
WERAM-Otg-0144 ENSOGAP00000012420.2 Otolemur garnettii 31 2e-27 120
WERAM-Mel-0037 EGG03660 Melampsora laricipopulina 28 2e-27 120
WERAM-Dar-0023 ENSDARP00000124246.1 Danio rerio 33 3e-27 120
WERAM-Pem-0058 ENSPMAP00000006830.1 Petromyzon marinus 34 4e-27 119
WERAM-Caj-0022 ENSCJAP00000004409.2 Callithrix jacchus 31 5e-27 119
WERAM-Mod-0081 ENSMODP00000012731.2 Monodelphis domestica 30 5e-27 119
WERAM-Prc-0036 ENSPCAP00000003334.1 Procavia capensis 30 6e-27 119
WERAM-Tut-0056 ENSTTRP00000004443.1 Tursiops truncatus 31 7e-27 119
WERAM-Sus-0177 ENSSSCP00000022636.1 Sus scrofa 30 9e-27 118
WERAM-Xet-0155 ENSXETP00000050501.3 Xenopus tropicalis 32 1e-26 118
WERAM-Asg-0010 AAS51704 Ashbya gossypii 28 1e-26 118
WERAM-Bot-0122 ENSBTAP00000017618.5 Bos taurus 31 2e-26 117
WERAM-Pug-0031 EFP89333 Puccinia graminis 26 2e-26 117
WERAM-Loa-0047 ENSLAFP00000003196.3 Loxodonta africana 31 2e-26 117
WERAM-Dio-0075 ENSDORP00000007462.1 Dipodomys ordii 31 2e-26 117
WERAM-Crn-0010 AAW42071 Cryptococcus neoformans 35 3e-26 116
WERAM-Dan-0022 ENSDNOP00000002136.3 Dasypus novemcinctus 32 4e-26 116
WERAM-Usm-0012 UM02102P0 Ustilago maydis 36 4e-26 116
WERAM-Tas-0021 ENSTSYP00000002661.1 Tarsius syrichta 31 1e-25 115
WERAM-Caa-0034 KGT64501 Candida albicans 29 1e-25 115
WERAM-Ere-0025 ENSEEUP00000001892.1 Erinaceus europaeus 35 1e-25 114
WERAM-Coi-0028 EAS30926 Coccidioides immitis 36 2e-25 114
WERAM-Kll-0020 CAG99415 Kluyveromyces lactis 28 2e-25 113
WERAM-Pytr-0015 EDU46537 Pyrenophora triticirepentis 29 3e-25 113
WERAM-Zyt-0016 Mycgr3P37223 Zymoseptoria tritici 32 4e-25 113
WERAM-Mae-0111 ENSMEUP00000010640.1 Macropus eugenii 31 5e-25 112
WERAM-Lab-0047 EDQ99497 Laccaria bicolor 29 5e-25 112
WERAM-Ptv-0077 ENSPVAP00000007213.1 Pteropus vampyrus 31 6e-25 112
WERAM-Pyt-0023 EFQ89752 Pyrenophora teres 29 8e-25 112
WERAM-Pat-0122 ENSPTRP00000025053.4 Pan troglodytes 31 1e-24 111
WERAM-Nol-0005 ENSNLEP00000000692.2 Nomascus leucogenys 31 1e-24 111
WERAM-Yal-0023 CAG79971 Yarrowia lipolytica 30 2e-24 110
WERAM-Phn-0010 SNOT_01279 Phaeosphaeria nodorum 34 3e-24 110
WERAM-Pof-0022 ENSPFOP00000001799.2 Poecilia formosa 29 3e-24 110
WERAM-Asn-0017 CADANIAP00004063 Aspergillus nidulans 33 4e-24 109
WERAM-Ten-0019 ENSTNIP00000004593.1 Tetraodon nigroviridis 31 4e-24 109
WERAM-Miv-0034 MVLG_04888T0 Microbotryum violaceum 31 4e-24 109
WERAM-Asc-0002 CADACLAP00000048 Aspergillus clavatus 33 5e-24 109
WERAM-Anc-0037 ENSACAP00000004435.3 Anolis carolinensis 35 5e-24 109
WERAM-Gaa-0053 ENSGACP00000006953.1 Gasterosteus aculeatus 33 6e-24 109
WERAM-Fia-0129 ENSFALP00000010805.1 Ficedula albicollis 34 6e-24 108
WERAM-Pes-0141 ENSPSIP00000016742.1 Pelodiscus sinensis 29 7e-24 108
WERAM-Orn-0011 ENSONIP00000001061.1 Oreochromis niloticus 29 7e-24 108
Created Date 25-Jun-2016