WERAM Information

Tag Content
WERAM ID WERAM-Sac-0054
Ensembl Protein ID YPR193C
Uniprot Accession Q06592; HPA2_YEAST; D6W4J3
Genbank Protein ID NP_015519.1
Protein Name Histone acetyltransferase HPA2
Genbank Nucleotide ID NM_001184290.1
Gene Name HPA2;YPR193C;P9677.12
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YPR193C YPR193C YPR193C
Details
Type Family Domain Substrates AA References (PMIDs)
HAT HPA2 N-acetyltransferase H4K5; H4K12 K 23775086
Status Reviewed
Classification
Type Family E-value Score Start End
HAT HPA2 3.70e-79 262.8 9 156
Organism Saccharomyces cerevisiae
NCBI Taxa ID 559292
Functional Description
(View)		 N-acetyltransferase that acetylates histone H3 at 'Lys-14' and histone H4 at 'Lys-5' and 'Lys-12'. Also acetylates polyamines like putrescine, spermidine and spermine, and certain other small basic proteins like nuclear HMG proteins.
Domain Profile
  HAT HPA2
  HPA2.txt   1 irvrsvikedkeavqklikeyqefekvedpvevaevafgrfidevvklaaavaiesesdkaiGlaiylnhlttWtvkekiyledlyvrerarvkGvGskll 101
               i+vr+v+++dke++q+l+k+yq+f++v++p+++++++fgrf+d+++k++aava+es+s+k+iG+++++nh+ttW++k+kiy++dlyv+e++rvkG+G+kl+
   YPR193C   9 ITVRFVTENDKEGWQRLWKSYQDFYEVSFPDDLDDFNFGRFLDPNIKMWAAVAVESSSEKIIGMINFFNHMTTWDFKDKIYINDLYVDENSRVKGAGGKLI 109
               79*************************************************************************************************** PP
  HPA2.txt 102 efvyreadklGtravyWvvddynhraqllyekvgykkkkllykrkGy 148
               +fvy+eadklGt++vyW++d++nhraqlly+kvgyk++k+lykrkGy
   YPR193C 110 QFVYDEADKLGTPSVYWCTDESNHRAQLLYVKVGYKAPKILYKRKGY 156
               **********************************************8 PP
Protein Sequence
(Fasta)		MSNTSEDNIT VRFVTENDKE GWQRLWKSYQ DFYEVSFPDD LDDFNFGRFL DPNIKMWAAV 60
AVESSSEKII GMINFFNHMT TWDFKDKIYI NDLYVDENSR VKGAGGKLIQ FVYDEADKLG 120
TPSVYWCTDE SNHRAQLLYV KVGYKAPKIL YKRKGY 156
Nucleotide Sequence
(Fasta)		ATGTCCAACA CTAGCGAAGA TAACATTACC GTAAGGTTTG TAACCGAAAA CGATAAGGAG 60
GGTTGGCAAA GGCTTTGGAA ATCCTATCAA GATTTTTATG AAGTCTCTTT TCCCGATGAC 120
TTGGACGATT TCAATTTCGG CAGATTCCTA GATCCTAACA TTAAAATGTG GGCAGCCGTA 180
GCTGTGGAAA GTTCGAGCGA AAAAATTATT GGAATGATAA ACTTTTTCAA CCATATGACT 240
ACTTGGGATT TCAAGGACAA GATATACATC AACGATCTCT ATGTTGATGA GAATTCTAGG 300
GTCAAAGGCG CGGGCGGCAA ACTAATCCAA TTTGTCTACG ACGAAGCTGA TAAACTGGGC 360
ACACCAAGCG TGTATTGGTG TACGGATGAG TCAAACCATA GAGCTCAGCT GCTATACGTC 420
AAGGTCGGCT ATAAAGCCCC AAAAATATTA TACAAGAGGA AGGGATATTA A 472
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0012--Acyltransferase
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
--
Interpro

IPR016181--Acyl_CoA_acyltransferase
IPR000182--GNAT_dom
IPR032962--HPA2/HPA3
PROSITE

PS51186--GNAT
Pfam

PF00583--Acetyltransf_1
Gene Ontology

GO:0004402--F:histone acetyltransferase activity
GO:0042802--F:identical protein binding
GO:0042803--F:protein homodimerization activity
GO:0016573--P:histone acetylation
GO:0051289--P:protein homotetramerization
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Scp-0002 SPAC1002.07c.1:pep Schizosaccharomyces pombe 30 2e-06 48.9
Created Date 25-Jun-2016