| Tag |
Content |
| WERAM ID |
WERAM-Sac-0050 |
| Ensembl Protein ID |
YPL181W |
| Uniprot Accession |
Q08923; CTI6_YEAST; D6W3I7; Q6B1X3
|
| Genbank Protein ID |
NP_015144.1
|
| Protein Name |
Histone deacetylase complex subunit CTI6 |
| Genbank Nucleotide ID |
NM_001183995.1
|
| Gene Name |
Cti6;RXT1;YPL181W |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| Me_Reader |
PHD |
PHD-type |
H3K4me |
K |
17142463
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| Me_Reader |
PHD |
1.50e-10 |
39.5 |
73 |
122 |
|
| Organism |
Saccharomyces cerevisiae |
| NCBI Taxa ID |
559292 |
Functional Description
(View)Functional Description
Component of the RPD3C(L) histone deacetylase complex (HDAC). Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. CTI6 links the SAGA coactivator to the CYC8-TUP1 corepressor. Involved in transcription regulation of heme-regulated genes and required for GCN5 recruitment, histone H3 acetylation and SPT15/TBP binding to promoters. |
Component of the RPD3C(L) histone deacetylase complex (HDAC). Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. CTI6 links the SAGA coactivator to the CYC8-TUP1 corepressor. Involved in transcription regulation of heme-regulated genes and required for GCN5 recruitment, histone H3 acetylation and SPT15/TBP binding to promoters.
|
| Domain Profile |
Me_Reader PHD
PHD.txt 2 tiClvCg..kddegekemvqCdeCddwfHlkCvklplsslpegkswyCpsCke 52
t C+ Cg ++ +++ +++qC++C+ w H++Cv++++ ++p++ ++C++C+
YPL181W 73 TRCI-CGelDTPDDSGFFIQCEQCSSWQHGYCVSITQDNAPDK--YWCEQCRP 122
6798.*64566666777*******************8888876..******95 PP
|
Protein Sequence
(Fasta) | MESTAIVPKG PVVGSEDMEK AEVIASGSTD IISTTSTATT TAAIGSVQEE SVKQEDVPME 60
GGEGEVEEEE GETRCICGEL DTPDDSGFFI QCEQCSSWQH GYCVSITQDN APDKYWCEQC 120
RPELHQLFTT DTGEARSIYK PVQEKRRQSR RKARSAAASK SHAANEAEKS PRNTSNTDDN 180
VDDIGDEEDE VEDEASAVAL AKDGNTRSSR RRRRNSMDDA STDQYSLDPG DSDKKLLDRK 240
RATFMAREEK QYQRMLEKAL KESRRTSHQE DPESYENDAD IYQGDTDNHN GTTRLQTDVM 300
LTEGKPDSVT NDDMKESLRP SKEQSMEKTN DVEKEASQEK ESSTGSAQDT EKTDEPILPL 360
TSISSSEDDS RKASSRGSKR VSKPARKGNR TRRSNTSSDT NQNRRSADIG TDKPVKPRLP 420
PQRTSLNEMR RRVSAILEFI SRTQWELSED QSDREEFVRF VENQHFVEKV DTIYNGYNES 480
LSMMDDLTRE LLLWEKKYSN NTNAIQ 506Protein Fasta Sequence
>YPL181W|Cti6;RXT1;YPL181W|Saccharomyces cerevisiae
MESTAIVPKGPVVGSEDMEKAEVIASGSTDIISTTSTATTTAAIGSVQEESVKQEDVPMEGGEGEVEEEEGETRCICGELDTPDDSGFFIQCEQCSSWQHGYCVSITQDNAPDKYWCEQCRPELHQLFTTDTGEARSIYKPVQEKRRQSRRKARSAAASKSHAANEAEKSPRNTSNTDDNVDDIGDEEDEVEDEASAVALAKDGNTRSSRRRRRNSMDDASTDQYSLDPGDSDKKLLDRKRATFMAREEKQYQRMLEKALKESRRTSHQEDPESYENDADIYQGDTDNHNGTTRLQTDVMLTEGKPDSVTNDDMKESLRPSKEQSMEKTNDVEKEASQEKESSTGSAQDTEKTDEPILPLTSISSSEDDSRKASSRGSKRVSKPARKGNRTRRSNTSSDTNQNRRSADIGTDKPVKPRLPPQRTSLNEMRRRVSAILEFISRTQWELSEDQSDREEFVRFVENQHFVEKVDTIYNGYNESLSMMDDLTRELLLWEKKYSNNTNAIQ |
Nucleotide Sequence
(Fasta) | ATGGAATCGA CAGCAATAGT GCCTAAAGGC CCTGTTGTGG GTAGTGAAGA TATGGAGAAA 60
GCGGAAGTCA TTGCTAGTGG GTCCACAGAC ATTATATCAA CAACATCAAC AGCGACAACA 120
ACGGCGGCGA TTGGAAGTGT ACAGGAAGAA AGTGTAAAAC AAGAAGATGT TCCTATGGAA 180
GGTGGAGAGG GGGAAGTCGA GGAAGAGGAA GGCGAAACTC GCTGTATCTG TGGAGAGCTC 240
GATACTCCAG ATGACTCCGG ATTTTTCATT CAATGTGAGC AGTGCAGTTC CTGGCAGCAC 300
GGTTATTGTG TGAGTATTAC TCAAGACAAC GCACCTGATA AATATTGGTG CGAGCAATGC 360
AGACCGGAGT TACATCAGCT CTTTACCACA GATACTGGCG AAGCAAGGTC AATCTATAAA 420
CCTGTGCAAG AGAAAAGGAG GCAATCAAGA AGGAAGGCAC GAAGTGCAGC TGCAAGTAAA 480
TCTCATGCCG CCAATGAAGC AGAGAAAAGT CCCAGAAATA CCAGCAATAC CGATGATAAC 540
GTCGACGATA TCGGCGACGA AGAAGATGAA GTAGAAGATG AAGCTTCGGC TGTAGCATTA 600
GCCAAGGACG GCAACACGAG GTCAAGTAGA AGGAGGAGGA GGAATTCAAT GGATGATGCT 660
TCTACCGATC AGTATTCACT GGATCCTGGA GATAGTGATA AGAAGCTACT GGATAGAAAA 720
AGGGCAACTT TCATGGCAAG AGAAGAAAAG CAATATCAAA GAATGCTTGA AAAAGCCTTG 780
AAAGAAAGCA GGAGGACATC ACATCAAGAA GATCCTGAAA GTTATGAAAA TGATGCTGAT 840
ATATACCAAG GTGATACCGA CAATCACAAC GGCACCACTC GATTACAAAC GGATGTTATG 900
CTAACGGAAG GCAAACCGGA CTCGGTAACA AATGATGATA TGAAAGAAAG CCTACGACCA 960
TCGAAAGAGC AATCAATGGA AAAAACAAAT GATGTGGAAA AAGAAGCTAG TCAAGAAAAG 1020
GAATCTTCTA CGGGTTCGGC GCAAGACACT GAGAAAACTG ATGAACCCAT CCTACCCCTA 1080
ACCTCAATAT CTTCTTCTGA GGATGATTCA AGGAAAGCTA GTTCGAGGGG TTCTAAAAGA 1140
GTTTCCAAAC CAGCAAGAAA GGGCAACAGA ACTCGTCGAA GCAATACAAG TTCAGACACC 1200
AACCAAAATA GAAGGAGTGC TGATATAGGT ACCGACAAAC CAGTAAAGCC CAGATTACCC 1260
CCTCAAAGGA CCTCATTAAA CGAAATGAGA AGAAGGGTAT CCGCTATTTT GGAGTTCATT 1320
TCTAGAACTC AATGGGAATT GAGTGAAGAT CAGTCTGATC GAGAGGAATT TGTACGATTC 1380
GTGGAAAACC AGCATTTCGT AGAAAAAGTT GATACGATTT ACAACGGTTA TAATGAAAGT 1440
CTATCAATGA TGGACGACCT GACTAGAGAG TTACTACTAT GGGAGAAAAA ATATTCAAAT 1500
AACACTAATG CCATTCAATA A
1522Nucleotide Fasta Sequence
>YPL181W|PHD|Saccharomyces cerevisiae
ATGGAATCGACAGCAATAGTGCCTAAAGGCCCTGTTGTGGGTAGTGAAGATATGGAGAAAGCGGAAGTCATTGCTAGTGGGTCCACAGACATTATATCAACAACATCAACAGCGACAACAACGGCGGCGATTGGAAGTGTACAGGAAGAAAGTGTAAAACAAGAAGATGTTCCTATGGAAGGTGGAGAGGGGGAAGTCGAGGAAGAGGAAGGCGAAACTCGCTGTATCTGTGGAGAGCTCGATACTCCAGATGACTCCGGATTTTTCATTCAATGTGAGCAGTGCAGTTCCTGGCAGCACGGTTATTGTGTGAGTATTACTCAAGACAACGCACCTGATAAATATTGGTGCGAGCAATGCAGACCGGAGTTACATCAGCTCTTTACCACAGATACTGGCGAAGCAAGGTCAATCTATAAACCTGTGCAAGAGAAAAGGAGGCAATCAAGAAGGAAGGCACGAAGTGCAGCTGCAAGTAAATCTCATGCCGCCAATGAAGCAGAGAAAAGTCCCAGAAATACCAGCAATACCGATGATAACGTCGACGATATCGGCGACGAAGAAGATGAAGTAGAAGATGAAGCTTCGGCTGTAGCATTAGCCAAGGACGGCAACACGAGGTCAAGTAGAAGGAGGAGGAGGAATTCAATGGATGATGCTTCTACCGATCAGTATTCACTGGATCCTGGAGATAGTGATAAGAAGCTACTGGATAGAAAAAGGGCAACTTTCATGGCAAGAGAAGAAAAGCAATATCAAAGAATGCTTGAAAAAGCCTTGAAAGAAAGCAGGAGGACATCACATCAAGAAGATCCTGAAAGTTATGAAAATGATGCTGATATATACCAAGGTGATACCGACAATCACAACGGCACCACTCGATTACAAACGGATGTTATGCTAACGGAAGGCAAACCGGACTCGGTAACAAATGATGATATGAAAGAAAGCCTACGACCATCGAAAGAGCAATCAATGGAAAAAACAAATGATGTGGAAAAAGAAGCTAGTCAAGAAAAGGAATCTTCTACGGGTTCGGCGCAAGACACTGAGAAAACTGATGAACCCATCCTACCCCTAACCTCAATATCTTCTTCTGAGGATGATTCAAGGAAAGCTAGTTCGAGGGGTTCTAAAAGAGTTTCCAAACCAGCAAGAAAGGGCAACAGAACTCGTCGAAGCAATACAAGTTCAGACACCAACCAAAATAGAAGGAGTGCTGATATAGGTACCGACAAACCAGTAAAGCCCAGATTACCCCCTCAAAGGACCTCATTAAACGAAATGAGAAGAAGGGTATCCGCTATTTTGGAGTTCATTTCTAGAACTCAATGGGAATTGAGTGAAGATCAGTCTGATCGAGAGGAATTTGTACGATTCGTGGAAAACCAGCATTTCGTAGAAAAAGTTGATACGATTTACAACGGTTATAATGAAAGTCTATCAATGATGGACGACCTGACTAGAGAGTTACTACTATGGGAGAAAAAATATTCAAATAACACTAATGCCATTCAATAA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
--
|
| Interpro |
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
|
| PROSITE |
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
|
| Pfam |
PF00628--PHD
|
| Gene Ontology |
GO:0005634--C:nucleus
GO:0033698--C:Rpd3L complex
GO:0035064--F:methylated histone binding
GO:0008134--F:transcription factor binding
GO:0008270--F:zinc ion binding
GO:0016568--P:chromatin modification
GO:0061188--P:negative regulation of chromatin silencing at rDNA
GO:0061186--P:negative regulation of chromatin silencing at silent mating-type cassette
GO:0031939--P:negative regulation of chromatin silencing at telomere
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0030174--P:regulation of DNA-dependent DNA replication initiation
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
