WERAM Information

Tag Content
WERAM ID WERAM-Sac-0049
Ensembl Protein ID YPL138C
Uniprot Accession Q03012; SPP1_YEAST; D6W3N0
Genbank Protein ID NP_015187.1
Protein Name COMPASS component SPP1
Genbank Nucleotide ID NM_001183952.1
Gene Name Spp1;CPS40;SAF41;YPL138C
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YPL138C YPL138C YPL138C
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader PHD PHD-type H3K4me3 K 17142463
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader PHD 6.40e-13 47.2 23 70
Organism Saccharomyces cerevisiae
NCBI Taxa ID 559292
Functional Description
(View)		 The COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.
Domain Profile
  Me_Reader PHD
  PHD.txt  2 tiClvCgkddegekemvqCdeCddwfHlkCvklplsslpeg..kswyCpsCk 51
              +C+ C+++d+ge  mv Cd+CddwfH +C+++p  +  ++   s+yCp C+
  YPL138C 23 VYCI-CKRPDYGEL-MVGCDGCDDWFHFTCLHIP--EQFKDlvFSFYCPYCQ 70
             69*9.*******98.*******************..666665679******8 PP
Protein Sequence
(Fasta)		MSLPQWCPPH STLKRNPTTG EDVYCICKRP DYGELMVGCD GCDDWFHFTC LHIPEQFKDL 60
VFSFYCPYCQ AGITGKNKDA IINGEGSLPK TLWKRKCRIS DCYKPCLQDS KYCSEEHGRE 120
FVNDIWSRLK TDEDRAVVKK MVEQTGHIDK FKKFGQLDFI DNNIVVKTDD EKEIFDQIVV 180
RDMTLKTLED DLQEVQEISL PLFKKKLELL EVYLGWLDNV YTEMRKLDDD AASHVECGKE 240
DSKGTKRKKK KNSSRSRARK NICGYCSTYE RIPCSVEEFV RDFGSNEEAT KIHEVCTKWK 300
CNRHLDWVST NQEQYLQQID SLESMQERLQ HLIQARKKQL NIQYYEEILR RGL 353
Nucleotide Sequence
(Fasta)		ATGTCATTAC CACAATGGTG TCCACCGCAT TCCACCTTAA AAAGAAATCC AACTACAGGA 60
GAGGACGTAT ACTGCATATG TAAAAGGCCA GACTATGGGG AGCTGATGGT GGGATGTGAT 120
GGTTGTGATG ACTGGTTTCA TTTCACCTGC CTTCATATTC CTGAGCAGTT TAAGGACCTG 180
GTGTTCTCTT TTTATTGTCC TTACTGTCAA GCGGGGATTA CTGGTAAGAA TAAGGACGCC 240
ATAATCAATG GTGAAGGGAG CTTGCCAAAA ACCTTATGGA AAAGAAAATG TAGGATAAGT 300
GATTGCTACA AACCATGTTT ACAGGATAGT AAATACTGTT CTGAGGAACA TGGTAGAGAA 360
TTTGTGAATG ATATTTGGTC GCGATTGAAA ACAGATGAGG ATAGAGCAGT CGTCAAGAAA 420
ATGGTCGAAC AAACAGGACA CATAGATAAA TTCAAGAAAT TTGGACAACT GGATTTCATT 480
GATAACAATA TAGTTGTAAA AACAGATGAC GAAAAGGAAA TATTCGATCA AATTGTTGTA 540
CGAGACATGA CGTTAAAAAC TCTTGAAGAT GATCTGCAAG AGGTTCAAGA GATATCGCTA 600
CCATTATTCA AAAAAAAGCT AGAACTTTTG GAAGTATATT TGGGATGGTT AGACAACGTA 660
TATACCGAAA TGCGCAAGCT GGACGATGAT GCTGCAAGCC ATGTGGAATG TGGTAAAGAA 720
GATTCCAAGG GGACAAAAAG GAAGAAGAAG AAAAATAGCA GCAGGAGTAG GGCTAGGAAA 780
AATATATGTG GCTATTGTTC TACATACGAG CGAATACCCT GCTCTGTGGA AGAATTTGTC 840
AGAGATTTTG GAAGTAATGA GGAAGCCACC AAAATACATG AGGTATGCAC GAAGTGGAAG 900
TGTAACAGAC ATTTGGATTG GGTGTCTACT AATCAGGAAC AATACCTCCA GCAGATTGAC 960
TCTTTAGAAT CTATGCAAGA AAGGTTGCAA CATCTGATAC AGGCCAGGAA AAAGCAACTA 1020
AATATACAAT ACTATGAGGA AATTTTAAGA AGAGGTTTGT AA 1063
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF00628--PHD
Gene Ontology

GO:0000781--C:chromosome, telomeric region
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0048188--C:Set1C/COMPASS complex
GO:0003682--F:chromatin binding
GO:0035064--F:methylated histone binding
GO:0008270--F:zinc ion binding
GO:0006348--P:chromatin silencing at telomere
GO:0051568--P:histone H3-K4 methylation
GO:1903341--P:regulation of meiotic DNA double-strand break formation
GO:0006355--P:regulation of transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Cag-0032 CAG62435 Candida glabrata 44 1e-73 274
WERAM-Asg-0005 AAS51341 Ashbya gossypii 39 1e-66 250
WERAM-Kll-0016 CAH00481 Kluyveromyces lactis 39 7e-65 244
WERAM-Caa-0003 KGT72513 Candida albicans 37 3e-25 113
WERAM-Scp-0047 SPCC594.05c.1:pep Schizosaccharomyces pombe 39 1e-23 107
WERAM-Yal-0012 CAG81489 Yarrowia lipolytica 29 2e-22 103
WERAM-Scj-0009 EEB06282 Schizosaccharomyces japonicus 38 6e-22 102
WERAM-Kop-0011 CAY68814 Komagataella pastoris 46 3e-21 100
WERAM-Zyt-0034 Mycgr3P92586 Zymoseptoria tritici 36 1e-18 91.3
WERAM-Asc-0015 CADACLAP00003680 Aspergillus clavatus 37 3e-18 89.7
WERAM-Asf-0010 CADAFLAP00002425 Aspergillus flavus 41 3e-17 86.7
WERAM-Asni-0006 CADANGAP00002236 Aspergillus niger 41 3e-17 86.7
WERAM-Asn-0038 CADANIAP00010240 Aspergillus nidulans 42 1e-16 84.7
WERAM-Asfu-0024 CADAFUAP00005847 Aspergillus fumigatus 42 3e-16 83.2
WERAM-Pyt-0009 EFQ93938 Pyrenophora teres 37 4e-16 82.8
WERAM-Lem-0010 CBY00576 Leptosphaeria maculans 40 7e-16 82.4
WERAM-Coi-0019 EAS32695 Coccidioides immitis 33 8e-16 82.0
WERAM-Phn-0028 SNOT_14703 Phaeosphaeria nodorum 38 2e-15 80.5
WERAM-Pytr-0001 EDU39597 Pyrenophora triticirepentis 36 2e-15 80.5
WERAM-Ast-0021 CADATEAP00006682 Aspergillus terreus 33 2e-15 80.5
WERAM-Mel-0006 EGF99467 Melampsora laricipopulina 37 9e-13 72.0
WERAM-Miv-0020 MVLG_02819T0 Microbotryum violaceum 31 2e-12 70.5
WERAM-Pug-0002 EFP74236 Puccinia graminis 35 3e-11 67.0
WERAM-Usm-0001 UM00443P0 Ustilago maydis 33 4e-11 66.2
WERAM-Ten-0014 ENSTNIP00000003243.1 Tetraodon nigroviridis 45 1e-10 65.1
WERAM-Scs-0018 EDO02949 Sclerotinia sclerotiorum 33 3e-10 63.2
WERAM-Tar-0056 ENSTRUP00000012538.1 Takifugu rubripes 43 3e-10 63.2
WERAM-Crn-0026 AAW44599 Cryptococcus neoformans 23 4e-10 62.8
WERAM-Asm-0177 ENSAMXP00000017441.1 Astyanax mexicanus 33 1e-09 61.2
WERAM-Trv-0034 EHK18941 Trichoderma virens 29 2e-09 60.8
WERAM-Chg-0026 EAQ89690 Chaetomium globosum 27 2e-09 60.5
WERAM-Gaa-0011 ENSGACP00000001497.1 Gasterosteus aculeatus 32 3e-09 60.5
WERAM-Lab-0024 EDR15609 Laccaria bicolor 33 3e-09 60.1
WERAM-Leo-0152 ENSLOCP00000018078.1 Lepisosteus oculatus 40 4e-09 59.7
WERAM-Loa-0215 ENSLAFP00000022842.1 Loxodonta africana 37 4e-09 59.7
WERAM-Orn-0010 ENSONIP00000001053.1 Oreochromis niloticus 35 4e-09 59.7
WERAM-Trr-0002 EGR45377 Trichoderma reesei 27 5e-09 59.7
WERAM-Ran-0096 ENSRNOP00000020472.4 Rattus norvegicus 37 5e-09 59.3
WERAM-Ptv-0169 ENSPVAP00000014716.1 Pteropus vampyrus 44 5e-09 59.3
WERAM-Xim-0161 ENSXMAP00000013079.1 Xiphophorus maculatus 38 5e-09 59.3
WERAM-Prc-0020 ENSPCAP00000001625.1 Procavia capensis 37 6e-09 59.3
WERAM-Bot-0188 ENSBTAP00000029172.3 Bos taurus 37 6e-09 59.3
WERAM-Lac-0009 ENSLACP00000001551.1 Latimeria chalumnae 44 6e-09 59.3
WERAM-Tut-0175 ENSTTRP00000014718.1 Tursiops truncatus 37 6e-09 59.3
WERAM-Nol-0124 ENSNLEP00000014342.1 Nomascus leucogenys 37 6e-09 58.9
WERAM-Ict-0206 ENSSTOP00000021043.1 Ictidomys tridecemlineatus 37 6e-09 58.9
WERAM-Paa-0069 ENSPANP00000000581.1 Papio anubis 37 7e-09 58.9
WERAM-Gam-0026 ENSGMOP00000002893.1 Gadus morhua 38 7e-09 58.9
WERAM-Pat-0083 ENSPTRP00000017038.5 Pan troglodytes 37 7e-09 58.9
WERAM-Dar-0215 ENSDARP00000132286.1 Danio rerio 40 7e-09 58.9
WERAM-Mum-0060 ENSMUSP00000025444.6 Mus musculus 37 7e-09 58.9
WERAM-Aim-0004 ENSAMEP00000000290.1 Ailuropoda melanoleuca 37 7e-09 58.9
WERAM-Gog-0192 ENSGGOP00000016570.2 Gorilla gorilla 37 7e-09 58.9
WERAM-Mup-0092 ENSMPUP00000008761.1 Mustela putorius furo 37 7e-09 58.9
WERAM-Caf-0194 ENSCAFP00000027880.3 Canis familiaris 37 7e-09 58.9
WERAM-Sus-0030 ENSSSCP00000004872.2 Sus scrofa 37 8e-09 58.9
WERAM-Otg-0225 ENSOGAP00000021460.1 Otolemur garnettii 37 8e-09 58.9
WERAM-Mam-0075 ENSMMUP00000011869.2 Macaca mulatta 37 8e-09 58.9
WERAM-Chs-0213 ENSCSAP00000014093.1 Chlorocebus sabaeus 37 8e-09 58.9
WERAM-Eqc-0138 ENSECAP00000015570.1 Equus caballus 37 8e-09 58.9
WERAM-Caj-0058 ENSCJAP00000052060.1 Callithrix jacchus 37 8e-09 58.9
WERAM-Hos-0165 ENSP00000285106.6 Homo sapiens 37 8e-09 58.9
WERAM-Myl-0201 ENSMLUP00000021844.1 Myotis lucifugus 37 8e-09 58.9
WERAM-Xet-0139 ENSXETP00000047467.2 Xenopus tropicalis 44 9e-09 58.5
WERAM-Put-0028 PTTG_09916P0 Puccinia triticina 37 9e-09 58.5
WERAM-Tub-0096 ENSTBEP00000011303.1 Tupaia belangeri 37 9e-09 58.5
WERAM-Orc-0197 ENSOCUP00000023194.2 Oryctolagus cuniculus 37 1e-08 58.5
WERAM-Orla-0152 ENSORLP00000017766.1 Oryzias latipes 31 1e-08 58.5
WERAM-Dio-0004 ENSDORP00000000837.1 Dipodomys ordii 37 1e-08 58.5
WERAM-Fec-0065 ENSFCAP00000005703.2 Felis catus 37 1e-08 58.5
WERAM-Pof-0018 ENSPFOP00000001589.2 Poecilia formosa 38 2e-08 57.8
WERAM-Ora-0117 ENSOANP00000022988.1 Ornithorhynchus anatinus 42 2e-08 57.8
WERAM-Anc-0059 ENSACAP00000005932.2 Anolis carolinensis 44 2e-08 57.8
WERAM-Nec-0017 EFNCRP00000002975 Neurospora crassa 31 3e-08 57.0
WERAM-Mod-0029 ENSMODP00000004239.3 Monodelphis domestica 39 3e-08 56.6
WERAM-Spr-0002 CBQ67853 Sporisorium reilianum 34 4e-08 56.2
WERAM-Mae-0018 ENSMEUP00000001345.1 Macropus eugenii 40 5e-08 56.2
WERAM-Dan-0075 ENSDNOP00000007530.3 Dasypus novemcinctus 28 7e-08 55.8
WERAM-Sah-0038 ENSSHAP00000004511.1 Sarcophilus harrisii 40 8e-08 55.5
WERAM-Ect-0089 ENSETEP00000010402.1 Echinops telfairi 35 8e-08 55.5
WERAM-Hov-0095 MLOC_70462.1 Hordeum vulgare 36 8e-08 55.5
WERAM-Drm-0035 FBpp0071263 Drosophila melanogaster 40 9e-08 55.5
WERAM-Tra-0308 Traes_7BL_84671B6A8.1 Triticum aestivum 34 9e-08 55.1
WERAM-Fuo-0023 FOXG_06241P0 Fusarium oxysporum 25 1e-07 55.1
WERAM-Mao-0009 MGG_03005T0 Magnaporthe oryzae 28 1e-07 55.1
WERAM-Cap-0047 ENSCPOP00000003843.2 Cavia porcellus 35 1e-07 55.1
WERAM-Gaga-0038 ENSGALP00000005731.3 Gallus gallus 37 1e-07 54.7
WERAM-Vip-0018 ENSVPAP00000001709.1 Vicugna pacos 35 1e-07 54.7
WERAM-Meg-0081 ENSMGAP00000007705.2 Meleagris gallopavo 37 1e-07 54.7
WERAM-Pes-0076 ENSPSIP00000009390.1 Pelodiscus sinensis 37 1e-07 54.7
WERAM-Fia-0038 ENSFALP00000002451.1 Ficedula albicollis 37 1e-07 54.7
WERAM-Anp-0050 ENSAPLP00000005439.1 Anas platyrhynchos 42 1e-07 54.7
WERAM-Aet-0037 EMT30548 Aegilops tauschii 36 2e-07 54.3
WERAM-Mua-0143 GSMUA_Achr9P20540_001 Musa acuminata 43 2e-07 54.3
WERAM-Sol-0104 Solyc08g081000.2.1 Solanum lycopersicum 29 2e-07 54.3
WERAM-Tru-0011 TRIUR3_05779-P1 Triticum urartu 36 2e-07 54.3
WERAM-Aso-0009 CADAORAP00001340 Aspergillus oryzae 40 2e-07 53.9
WERAM-Sot-0037 PGSC0003DMT400031830 Solanum tuberosum 29 3e-07 53.9
WERAM-Zem-0144 GRMZM2G466270_P01 Zea mays 42 3e-07 53.5
WERAM-Tag-0061 ENSTGUP00000004652.1 Taeniopygia guttata 42 3e-07 53.5
WERAM-Pem-0098 ENSPMAP00000010155.1 Petromyzon marinus 35 3e-07 53.5
WERAM-Gag-0032 GGTG_10343T0 Gaeumannomyces graminis 26 3e-07 53.5
WERAM-Ova-0034 ENSOARP00000004613.1 Ovis aries 35 3e-07 53.5
WERAM-Orbr-0078 OB06G36110.1 Oryza brachyantha 37 4e-07 53.1
WERAM-Poa-0073 ENSPPYP00000009623.2 Pongo abelii 40 4e-07 53.1
WERAM-Chh-0090 ENSCHOP00000010104.1 Choloepus hoffmanni 35 4e-07 53.1
WERAM-Map-0007 MAPG_02504T0 Magnaporthe poae 30 5e-07 52.8
WERAM-Orm-0066 OMERI06G28260.1 Oryza meridionalis 41 6e-07 52.8
WERAM-Orr-0072 ORUFI06G30290.1 Oryza rufipogon 41 6e-07 52.8
WERAM-Orgl-0068 OGLUM06G29760.1 Oryza glumaepatula 41 6e-07 52.8
WERAM-Orb-0070 OBART06G28370.1 Oryza barthii 41 6e-07 52.8
WERAM-Orni-0069 ONIVA06G31490.1 Oryza nivara 41 6e-07 52.4
WERAM-Orp-0067 OPUNC06G25880.1 Oryza punctata 41 6e-07 52.4
WERAM-Lep-0069 LPERR06G23820.1 Leersia perrieri 41 6e-07 52.4
WERAM-Org-0068 ORGLA06G0289400.1 Oryza glaberrima 41 7e-07 52.4
WERAM-Cii-0050 ENSCINP00000019842.3 Ciona intestinalis 37 8e-07 52.0
WERAM-Brd-0017 BRADI1G29247.1 Brachypodium distachyon 41 1e-06 52.0
WERAM-Sob-0139 Sb10g031265.1 Sorghum bicolor 38 1e-06 51.6
WERAM-Cis-0022 ENSCSAVP00000004511.1 Ciona savignyi 41 1e-06 51.6
WERAM-Amt-0017 ERM95079 Amborella trichopoda 38 1e-06 51.2
WERAM-Sei-0018 Si005667m Setaria italica 38 2e-06 50.8
WERAM-Chr-0037 EDP04619 Chlamydomonas reinhardtii 39 2e-06 50.8
WERAM-Sem-0081 EFJ17782 Selaginella moellendorffii 45 2e-06 50.4
WERAM-Glm-0121 GLYMA11G02580.4 Glycine max 34 2e-06 50.4
WERAM-Ved-0008 EGY19707 Verticillium dahliae 31 3e-06 50.4
WERAM-Arl-0103 fgenesh2_kg.7__ 111__ AT4G39100.1 Arabidopsis lyrata 35 3e-06 50.1
WERAM-Ere-0035 ENSEEUP00000002731.1 Erinaceus europaeus 43 3e-06 50.1
WERAM-Mim-0080 ENSMICP00000007535.1 Microcebus murinus 43 4e-06 50.1
Created Date 25-Jun-2016