| Tag |
Content |
| WERAM ID |
WERAM-Sac-0045 |
| Ensembl Protein ID |
YPL001W |
| Uniprot Accession |
Q12341; HAT1_YEAST; D6W411; Q6Q5I5
|
| Genbank Protein ID |
NP_015324.1
|
| Protein Name |
Histone acetyltransferase type B catalytic subunit |
| Genbank Nucleotide ID |
NM_001183815.1
|
| Gene Name |
HAT1;YPL001W;LPA16W;YP8132.12 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HAT |
HAT1 |
N-acetyltransferase |
H4K5; H4K12 |
K |
12671650
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HAT |
HAT1 |
4.40e-70 |
233.5 |
27 |
303 |
|
| Organism |
Saccharomyces cerevisiae |
| NCBI Taxa ID |
559292 |
Functional Description
(View)Functional Description
Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of free histone H4 in the cytoplasm. The complex is also found in the nucleus, however it is not certain that it modifies histone H4 when packaged in chromatin. Histone H4 'Lys-12' acetylation is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair. |
Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of free histone H4 in the cytoplasm. The complex is also found in the nucleus, however it is not certain that it modifies histone H4 when packaged in chromatin. Histone H4 'Lys-12' acetylation is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.
|
| Domain Profile |
HAT HAT1
HAT1.txt 23 distfkpeilyqlfgddetifGYkdlkvtvhylaksldeyidvkYsskinkekgscleaddveskleqk.iteetivdnkeeFlqlldkqddF...kpfge 119
++ +f p +y ++gd e+i+GYkdl + + + + ++++y++vkYs+k+ +++ dve kl ++ +iv ++ ++ + + +++ e
YPL001W 27 NAVQFSPLFTYPIYGDSEKIYGYKDLIIHLAFDSVTFKPYVNVKYSAKLGDDNI-----VDVEKKLLSFlPKDDVIVRDEAKWVDCFAEERKThnlSDVFE 122
4567*********************************************88888.....777777777744567777777777777766655433377889 PP
HAT1.txt 120 lihkyrklgkdfeiykaedlsdeflellerlqtlelfFie 159
++++y+ +g++f++yk + d ++++++r+q+++l+Fie
YPL001W 123 KVSEYSLNGEEFVVYKSSLVDDFARRMHRRVQIFSLLFIE 162
9*******************99999**************8 PP
HAT1.txt 1 rvveanevielllveakeeid.tdistfkpeilyqlfgddetifGYkdlkvtvhyl.aksldeyidvkYsski..........nkekgscleaddveskle 89
r+++++++++ll++ea+++id td+s ++i+++l++++++++G++++++++hyl aks+de+id+k+++ki nk++gscl++++++s+le
YPL001W 148 RMHRRVQIFSLLFIEAANYIDeTDPS---WQIYWLLNKKTKELIGFVTTYKYWHYLgAKSFDEDIDKKFRAKIsqflifppyqNKGHGSCLYEAIIQSWLE 245
69************************...************************************************************************ PP
HAT1.txt 90 qk.iteetivdnkeeFlqlldkqddFkpfgelihkyrklgkdfeiykaedlsdeflellerlqtle 154
+k ite+t++d++e+F++l+d++d i+++rklg+d++++k++dlsdefle+++++++le
YPL001W 246 DKsITEITVEDPNEAFDDLRDRND--------IQRLRKLGYDAVFQKHSDLSDEFLESSRKSLKLE 303
************************........*******************************996 PP
|
Protein Sequence
(Fasta) | MSANDFKPET WTSSANEALR VSIVGENAVQ FSPLFTYPIY GDSEKIYGYK DLIIHLAFDS 60
VTFKPYVNVK YSAKLGDDNI VDVEKKLLSF LPKDDVIVRD EAKWVDCFAE ERKTHNLSDV 120
FEKVSEYSLN GEEFVVYKSS LVDDFARRMH RRVQIFSLLF IEAANYIDET DPSWQIYWLL 180
NKKTKELIGF VTTYKYWHYL GAKSFDEDID KKFRAKISQF LIFPPYQNKG HGSCLYEAII 240
QSWLEDKSIT EITVEDPNEA FDDLRDRNDI QRLRKLGYDA VFQKHSDLSD EFLESSRKSL 300
KLEERQFNRL VEMLLLLNNS PSFELKVKNR LYIKNYDALD QTDPEKAREA LQNSFILVKD 360
DYRRIIESIN KSQG 374Protein Fasta Sequence
>YPL001W|HAT1;YPL001W;LPA16W;YP8132.12|Saccharomyces cerevisiae
MSANDFKPETWTSSANEALRVSIVGENAVQFSPLFTYPIYGDSEKIYGYKDLIIHLAFDSVTFKPYVNVKYSAKLGDDNIVDVEKKLLSFLPKDDVIVRDEAKWVDCFAEERKTHNLSDVFEKVSEYSLNGEEFVVYKSSLVDDFARRMHRRVQIFSLLFIEAANYIDETDPSWQIYWLLNKKTKELIGFVTTYKYWHYLGAKSFDEDIDKKFRAKISQFLIFPPYQNKGHGSCLYEAIIQSWLEDKSITEITVEDPNEAFDDLRDRNDIQRLRKLGYDAVFQKHSDLSDEFLESSRKSLKLEERQFNRLVEMLLLLNNSPSFELKVKNRLYIKNYDALDQTDPEKAREALQNSFILVKDDYRRIIESINKSQG |
Nucleotide Sequence
(Fasta) | ATGTCTGCCA ATGATTTCAA GCCTGAAACG TGGACTTCAA GCGCCAACGA AGCCTTAAGA 60
GTTTCTATAG TTGGAGAAAA CGCTGTTCAG TTTTCACCAT TATTCACGTA TCCAATTTAC 120
GGTGACTCCG AAAAGATCTA CGGCTATAAG GATCTCATCA TCCACCTAGC ATTTGATTCA 180
GTAACATTCA AGCCGTATGT TAACGTCAAG TATTCAGCAA AATTAGGAGA CGACAATATT 240
GTAGACGTGG AAAAAAAATT ACTCTCATTT CTACCAAAGG ATGATGTAAT TGTTAGGGAT 300
GAAGCTAAAT GGGTAGATTG CTTTGCAGAA GAACGAAAAA CACATAATTT ATCTGATGTT 360
TTTGAAAAAG TATCAGAGTA TTCGTTGAAT GGGGAAGAAT TTGTTGTATA TAAATCGAGT 420
TTGGTTGACG ATTTTGCCAG GAGAATGCAT CGTCGTGTTC AAATCTTTTC ATTACTTTTT 480
ATCGAAGCCG CTAACTATAT AGATGAGACT GACCCGAGTT GGCAAATCTA TTGGTTGTTG 540
AACAAGAAAA CAAAAGAATT GATTGGTTTC GTCACTACTT ACAAGTATTG GCACTACCTT 600
GGAGCAAAAT CTTTCGATGA GGATATAGAT AAAAAATTCA GAGCCAAAAT ATCTCAATTT 660
CTGATCTTTC CACCTTATCA AAATAAAGGC CACGGATCCT GTCTTTATGA GGCTATAATC 720
CAATCTTGGC TAGAAGACAA AAGTATTACT GAAATTACTG TAGAGGATCC AAACGAAGCA 780
TTTGACGATC TTCGCGACAG GAATGATATT CAAAGACTGC GAAAACTTGG TTATGATGCT 840
GTCTTTCAGA AGCACTCCGA CCTTTCTGAT GAGTTTTTGG AGTCAAGCCG AAAATCTTTA 900
AAACTGGAAG AAAGACAGTT TAATCGTCTT GTGGAAATGC TTCTTCTTTT AAACAATTCT 960
CCATCATTTG AATTAAAGGT AAAGAATAGG TTGTACATTA AAAATTATGA TGCCCTAGAT 1020
CAAACTGATC CAGAAAAGGC AAGAGAAGCT TTACAAAATT CATTTATTTT AGTCAAAGAT 1080
GATTATAGGC GTATTATAGA GTCGATAAAT AAATCTCAAG GTTAA
1126Nucleotide Fasta Sequence
>YPL001W|HAT1|Saccharomyces cerevisiae
ATGTCTGCCAATGATTTCAAGCCTGAAACGTGGACTTCAAGCGCCAACGAAGCCTTAAGAGTTTCTATAGTTGGAGAAAACGCTGTTCAGTTTTCACCATTATTCACGTATCCAATTTACGGTGACTCCGAAAAGATCTACGGCTATAAGGATCTCATCATCCACCTAGCATTTGATTCAGTAACATTCAAGCCGTATGTTAACGTCAAGTATTCAGCAAAATTAGGAGACGACAATATTGTAGACGTGGAAAAAAAATTACTCTCATTTCTACCAAAGGATGATGTAATTGTTAGGGATGAAGCTAAATGGGTAGATTGCTTTGCAGAAGAACGAAAAACACATAATTTATCTGATGTTTTTGAAAAAGTATCAGAGTATTCGTTGAATGGGGAAGAATTTGTTGTATATAAATCGAGTTTGGTTGACGATTTTGCCAGGAGAATGCATCGTCGTGTTCAAATCTTTTCATTACTTTTTATCGAAGCCGCTAACTATATAGATGAGACTGACCCGAGTTGGCAAATCTATTGGTTGTTGAACAAGAAAACAAAAGAATTGATTGGTTTCGTCACTACTTACAAGTATTGGCACTACCTTGGAGCAAAATCTTTCGATGAGGATATAGATAAAAAATTCAGAGCCAAAATATCTCAATTTCTGATCTTTCCACCTTATCAAAATAAAGGCCACGGATCCTGTCTTTATGAGGCTATAATCCAATCTTGGCTAGAAGACAAAAGTATTACTGAAATTACTGTAGAGGATCCAAACGAAGCATTTGACGATCTTCGCGACAGGAATGATATTCAAAGACTGCGAAAACTTGGTTATGATGCTGTCTTTCAGAAGCACTCCGACCTTTCTGATGAGTTTTTGGAGTCAAGCCGAAAATCTTTAAAACTGGAAGAAAGACAGTTTAATCGTCTTGTGGAAATGCTTCTTCTTTTAAACAATTCTCCATCATTTGAATTAAAGGTAAAGAATAGGTTGTACATTAAAAATTATGATGCCCTAGATCAAACTGATCCAGAAAAGGCAAGAGAAGCTTTACAAAATTCATTTATTTTAGTCAAAGATGATTATAGGCGTATTATAGAGTCGATAAATAAATCTCAAGGTTAA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0002--3D-structure
KW-0012--Acyltransferase
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0227--DNA damage
KW-0234--DNA repair
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
--
|
| Interpro |
IPR016181--Acyl_CoA_acyltransferase
IPR000182--GNAT_dom
IPR019467--Hat1_N
IPR017380--Hist_AcTrfase_B-typ_cat-su
IPR013523--Hist_AcTrfase_HAT1_C
|
| PROSITE |
PS51186--GNAT
|
| Pfam |
PF00583--Acetyltransf_1
PF10394--Hat1_N
|
| Gene Ontology |
GO:0000781--C:chromosome, telomeric region
GO:0005737--C:cytoplasm
GO:0000123--C:histone acetyltransferase complex
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0010485--F:H4 histone acetyltransferase activity
GO:0004402--F:histone acetyltransferase activity
GO:0006348--P:chromatin silencing at telomere
GO:0006281--P:DNA repair
GO:0016573--P:histone acetylation
GO:0043967--P:histone H4 acetylation
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
