| Tag |
Content |
| WERAM ID |
WERAM-Sac-0021 |
| Ensembl Protein ID |
YHR119W |
| Uniprot Accession |
P38827; SET1_YEAST; D3DL69
|
| Genbank Protein ID |
NP_011987.1
|
| Protein Name |
Histone-lysine N-methyltransferase, H3 lysine-4 specific |
| Genbank Nucleotide ID |
NM_001179249.1
|
| Gene Name |
SET1 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HMT |
SET1 |
SET |
H3K4 |
K |
20236312
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HMT |
SET1 |
1.00e-45 |
153.1 |
339 |
1055 |
|
| Organism |
Saccharomyces cerevisiae |
| NCBI Taxa ID |
559292 |
Functional Description
(View)Functional Description
Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation. |
Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.
|
| Domain Profile |
HMT SET1
SET1.txt 80 nhscepNceakvvavdge 97
+hs N+ +k v+++ +
YHR119W 339 KHSILNNIISKFVEINVK 356
79999******9999865 PP
SET1.txt 1 kelevakskikglglvakkeiekeelviEYvGevirsevadkrekeyekkeig.vylfrldedaevvvdatkkgniarfinhscepNceakvvavdgek 98
k++++a+s+i+++gl+a ++i+++e++iEYvGe ir+ va++rek+y k++ig +ylfr+de+ +v+datkkg+iarfinh+c+pNc+ak+++v g++
YHR119W 938 KPVMFARSAIHNWGLYALDSIAAKEMIIEYVGERIRQPVAEMREKRYLKNGIGsSYLFRVDEN--TVIDATKKGGIARFINHCCDPNCTAKIIKVGGRR 1034
689**************************************************9*********..********************************** PP
SET1.txt 99 kiviyakraIekgeeltydYk 119
+iviya r+I++ eeltydYk
YHR119W 1035 RIVIYALRDIAASEELTYDYK 1055
********************7 PP
|
Protein Sequence
(Fasta) | MSNYYRRAHA SSGSYRQPQE QPQYSRSGHY QYSNGHSHQQ YSSQYNQRRR YNHNDGTRRR 60
YNDDRPHSSN NASTRQYYAT NNSQSGPYVN KKSDISSRRG MSQSRYSNSN VHNTLASSSG 120
SLPTESALLL QQRPPSVLRY NTDNLKSKFH YFDPIKGEFF NKDKMLSWKA TDKEFSETGY 180
YVVKELQDGQ FKFKIKHRHP EIKASDPRNE NGIMTSGKVA THRKCRNSLI LLPRISYDRY 240
SLGPPPSCEI VVYPAQDSTT TNIQDISIKN YFKKYGEISH FEAFNDPNSA LPLHVYLIKY 300
ASSDGKINDA AKAAFSAVRK HESSGCFIMG FKFEVILNKH SILNNIISKF VEINVKKLQK 360
LQENLKKAKE KEAENEKAKE LQGKDITLPK EPKVDTLSHS SGSEKRIPYD LLGVVNNRPV 420
LHVSKIFVAK HRFCVEDFKY KLRGYRCAKF IDHPTGIYII FNDIAHAQTC SNAESGNLTI 480
MSRSRRIPIL IKFHLILPRF QNRTRFNKSS SSSNSTNVPI KYESKEEFIE ATAKQILKDL 540
EKTLHVDIKK RLIGPTVFDA LDHANFPELL AKRELKEKEK RQQIASKIAE DELKRKEEAK 600
RDFDLFGLYG GYAKSNKRNL KRHNSLALDH TSLKRKKLSN GIKPMAHLLN EETDSKETTP 660
LNDEGITRVS KEHDEEDENM TSSSSEEEEE EAPDKKFKSE SEPTTPESDH LHGIKPLVPD 720
QNGSSDVLDA SSMYKPTATE IPEPVYPPEE YDLKYSQTLS SMDLQNAIKD EEDMLILKQL 780
LSTYTPTVTP ETSAALEYKI WQSRRKVLEE EKASDWQIEL NGTLFDSELQ PGSSFKAEGF 840
RKIADKLKIN YLPHRRRVHQ PLNTVNIHNE RNEYTPELCQ REESSNKEPS DSVPQEVSSS 900
RDNRASNRRF QQDIEAQKAA IGTESELLSL NQLNKRKKPV MFARSAIHNW GLYALDSIAA 960
KEMIIEYVGE RIRQPVAEMR EKRYLKNGIG SSYLFRVDEN TVIDATKKGG IARFINHCCD 1020
PNCTAKIIKV GGRRRIVIYA LRDIAASEEL TYDYKFEREK DDEERLPCLC GAPNCKGFLN 1080
Protein Fasta Sequence
>YHR119W|SET1|Saccharomyces cerevisiae
MSNYYRRAHASSGSYRQPQEQPQYSRSGHYQYSNGHSHQQYSSQYNQRRRYNHNDGTRRRYNDDRPHSSNNASTRQYYATNNSQSGPYVNKKSDISSRRGMSQSRYSNSNVHNTLASSSGSLPTESALLLQQRPPSVLRYNTDNLKSKFHYFDPIKGEFFNKDKMLSWKATDKEFSETGYYVVKELQDGQFKFKIKHRHPEIKASDPRNENGIMTSGKVATHRKCRNSLILLPRISYDRYSLGPPPSCEIVVYPAQDSTTTNIQDISIKNYFKKYGEISHFEAFNDPNSALPLHVYLIKYASSDGKINDAAKAAFSAVRKHESSGCFIMGFKFEVILNKHSILNNIISKFVEINVKKLQKLQENLKKAKEKEAENEKAKELQGKDITLPKEPKVDTLSHSSGSEKRIPYDLLGVVNNRPVLHVSKIFVAKHRFCVEDFKYKLRGYRCAKFIDHPTGIYIIFNDIAHAQTCSNAESGNLTIMSRSRRIPILIKFHLILPRFQNRTRFNKSSSSSNSTNVPIKYESKEEFIEATAKQILKDLEKTLHVDIKKRLIGPTVFDALDHANFPELLAKRELKEKEKRQQIASKIAEDELKRKEEAKRDFDLFGLYGGYAKSNKRNLKRHNSLALDHTSLKRKKLSNGIKPMAHLLNEETDSKETTPLNDEGITRVSKEHDEEDENMTSSSSEEEEEEAPDKKFKSESEPTTPESDHLHGIKPLVPDQNGSSDVLDASSMYKPTATEIPEPVYPPEEYDLKYSQTLSSMDLQNAIKDEEDMLILKQLLSTYTPTVTPETSAALEYKIWQSRRKVLEEEKASDWQIELNGTLFDSELQPGSSFKAEGFRKIADKLKINYLPHRRRVHQPLNTVNIHNERNEYTPELCQREESSNKEPSDSVPQEVSSSRDNRASNRRFQQDIEAQKAAIGTESELLSLNQLNKRKKPVMFARSAIHNWGLYALDSIAAKEMIIEYVGERIRQPVAEMREKRYLKNGIGSSYLFRVDENTVIDATKKGGIARFINHCCDPNCTAKIIKVGGRRRIVIYALRDIAASEELTYDYKFEREKDDEERLPCLCGAPNCKGFLN |
Nucleotide Sequence
(Fasta) | ATGTCAAATT ACTATAGAAG AGCACACGCG TCTTCTGGTT CATACAGACA ACCCCAGGAA 60
CAGCCTCAAT ATTCGCGTTC TGGTCACTAT CAGTATTCAA ACGGCCATTC TCACCAACAA 120
TATTCTAGTC AATATAATCA ACGTCGACGT TATAACCATA ATGATGGTAC AAGGCGACGC 180
TATAATGACG ATCGCCCACA TAGTTCAAAC AATGCAAGTA CGCGACAGTA CTATGCTACT 240
AACAACAGCC AAAGCGGCCC ATATGTAAAT AAGAAATCTG ACATCAGTAG TCGGAGGGGC 300
ATGTCTCAAT CACGGTATTC AAATAGCAAT GTTCACAATA CATTAGCGTC TTCGAGTGGA 360
TCTCTTCCCA CAGAATCTGC TCTGCTTTTG CAACAAAGAC CACCTTCAGT TTTGAGATAC 420
AACACAGATA ATTTGAAGTC TAAGTTTCAT TATTTTGATC CCATAAAAGG CGAGTTCTTC 480
AATAAGGATA AGATGCTTTC GTGGAAGGCT ACAGATAAAG AATTTTCTGA AACAGGTTAT 540
TACGTAGTCA AAGAGTTACA AGATGGACAG TTTAAGTTCA AAATAAAACA CAGACATCCG 600
GAGATAAAAG CATCCGACCC ACGTAATGAA AACGGTATCA TGACTAGCGG AAAAGTGGCA 660
ACCCACAGAA AATGCAGGAA CTCACTAATT CTATTGCCTC GCATATCTTA TGACAGGTAC 720
TCCTTAGGGC CTCCCCCTTC ATGTGAAATA GTTGTCTATC CAGCGCAAGA TTCAACAACA 780
ACCAATATCC AAGACATATC AATAAAAAAC TATTTTAAAA AGTATGGAGA AATTTCTCAT 840
TTTGAAGCAT TTAATGATCC TAATAGCGCT TTACCTTTGC ATGTTTATCT TATAAAGTAT 900
GCCAGTTCTG ATGGAAAAAT TAATGATGCA GCAAAAGCAG CCTTTAGTGC CGTTAGAAAG 960
CACGAATCTT CGGGTTGCTT TATCATGGGC TTCAAGTTCG AAGTGATTTT AAACAAGCAT 1020
TCCATTTTGA ATAATATCAT TTCTAAATTT GTTGAAATAA ATGTCAAAAA GCTACAGAAG 1080
TTACAAGAGA ACCTGAAGAA GGCTAAAGAG AAAGAAGCAG AAAACGAAAA AGCAAAGGAA 1140
TTACAGGGCA AAGATATTAC CTTGCCCAAG GAACCTAAGG TAGACACATT ATCTCATTCG 1200
TCCGGAAGTG AAAAAAGAAT TCCATATGAT CTCTTGGGGG TAGTTAATAA CAGACCTGTT 1260
TTACATGTCT CCAAAATATT TGTTGCCAAA CATAGGTTCT GCGTTGAGGA CTTTAAATAC 1320
AAGTTAAGGG GATACAGATG TGCGAAATTT ATTGATCATC CAACTGGTAT CTATATTATT 1380
TTTAATGACA TTGCCCATGC GCAAACATGT TCGAATGCAG AGTCAGGAAA TTTAACAATA 1440
ATGTCTCGGA GCAGAAGAAT TCCTATTCTA ATAAAGTTTC ATCTCATTCT CCCTAGGTTC 1500
CAAAACAGAA CTAGATTCAA TAAATCTAGC TCATCTTCAA ATTCTACAAA TGTACCTATA 1560
AAATACGAGT CCAAAGAGGA GTTCATTGAA GCTACAGCAA AACAAATATT AAAAGATTTG 1620
GAAAAGACTT TACATGTTGA TATTAAGAAG AGATTGATTG GTCCTACGGT ATTTGATGCT 1680
TTGGACCATG CAAATTTTCC TGAATTGTTA GCTAAAAGAG AACTAAAGGA GAAAGAGAAG 1740
AGACAACAGA TTGCATCTAA AATTGCTGAA GATGAATTGA AACGTAAAGA AGAAGCCAAA 1800
AGAGATTTTG ATTTGTTTGG TTTATATGGT GGCTATGCAA AATCTAATAA AAGAAATTTA 1860
AAAAGGCATA ATTCACTCGC GTTGGATCAT ACTTCTTTAA AGAGGAAAAA GCTATCCAAT 1920
GGTATCAAAC CAATGGCACA TTTACTGAAC GAAGAAACCG ATTCCAAAGA AACTACCCCA 1980
TTGAACGATG AAGGGATCAC TCGCGTATCA AAAGAACATG ATGAAGAAGA CGAAAATATG 2040
ACATCTTCAT CTTCTGAAGA AGAGGAAGAA GAAGCTCCAG ATAAGAAATT CAAGAGTGAG 2100
TCTGAGCCAA CCACCCCCGA ATCTGATCAC CTTCATGGTA TTAAGCCGTT AGTACCCGAT 2160
CAAAATGGGT CGTCTGACGT ACTGGATGCT TCTTCGATGT ATAAACCTAC TGCTACCGAA 2220
ATTCCCGAAC CTGTATATCC ACCTGAGGAA TATGACTTGA AATATAGTCA GACTTTATCT 2280
TCTATGGATT TGCAGAATGC TATCAAAGAT GAGGAAGATA TGCTAATTTT AAAGCAGTTA 2340
TTGAGCACAT ATACTCCTAC CGTCACACCA GAAACAAGCG CAGCTCTGGA ATATAAAATT 2400
TGGCAATCTC GCCGAAAAGT TCTTGAAGAA GAGAAGGCTT CCGATTGGCA AATAGAGCTT 2460
AATGGAACTT TATTTGATAG TGAACTACAA CCAGGTAGCT CTTTTAAAGC TGAAGGGTTC 2520
AGGAAAATTG CGGATAAATT AAAAATTAAT TACCTACCCC ATCGTCGCAG AGTTCACCAA 2580
CCTTTAAATA CGGTGAATAT TCACAATGAA AGGAATGAGT ACACACCTGA ACTTTGTCAA 2640
AGAGAAGAAT CCTCGAATAA AGAACCTTCA GACTCAGTTC CTCAAGAAGT TTCATCCTCT 2700
AGAGATAATA GGGCATCAAA TAGAAGATTT CAGCAGGACA TAGAGGCACA GAAAGCCGCA 2760
ATTGGTACGG AATCTGAGCT GCTATCACTA AATCAATTAA ATAAAAGAAA AAAGCCAGTT 2820
ATGTTCGCTC GTTCAGCAAT TCACAACTGG GGTTTATATG CTCTAGACTC TATCGCAGCA 2880
AAGGAAATGA TTATCGAGTA CGTTGGTGAA AGGATCAGGC AACCTGTAGC AGAAATGAGA 2940
GAGAAAAGAT ATCTGAAAAA TGGGATTGGA TCCAGTTACC TTTTTAGGGT TGATGAAAAC 3000
ACGGTTATTG ATGCCACCAA GAAAGGTGGT ATAGCCCGTT TCATTAATCA TTGTTGTGAT 3060
CCAAATTGTA CGGCAAAGAT TATAAAGGTT GGCGGGAGAA GGAGAATTGT TATCTATGCA 3120
CTGCGTGATA TCGCGGCAAG CGAAGAGTTG ACATATGATT ACAAATTTGA GAGAGAAAAG 3180
GATGACGAGG AAAGACTTCC TTGTTTATGT GGAGCACCTA ATTGTAAAGG TTTCTTGAAC 3240
TGA
3244Nucleotide Fasta Sequence
>YHR119W|SET1|Saccharomyces cerevisiae
ATGTCAAATTACTATAGAAGAGCACACGCGTCTTCTGGTTCATACAGACAACCCCAGGAACAGCCTCAATATTCGCGTTCTGGTCACTATCAGTATTCAAACGGCCATTCTCACCAACAATATTCTAGTCAATATAATCAACGTCGACGTTATAACCATAATGATGGTACAAGGCGACGCTATAATGACGATCGCCCACATAGTTCAAACAATGCAAGTACGCGACAGTACTATGCTACTAACAACAGCCAAAGCGGCCCATATGTAAATAAGAAATCTGACATCAGTAGTCGGAGGGGCATGTCTCAATCACGGTATTCAAATAGCAATGTTCACAATACATTAGCGTCTTCGAGTGGATCTCTTCCCACAGAATCTGCTCTGCTTTTGCAACAAAGACCACCTTCAGTTTTGAGATACAACACAGATAATTTGAAGTCTAAGTTTCATTATTTTGATCCCATAAAAGGCGAGTTCTTCAATAAGGATAAGATGCTTTCGTGGAAGGCTACAGATAAAGAATTTTCTGAAACAGGTTATTACGTAGTCAAAGAGTTACAAGATGGACAGTTTAAGTTCAAAATAAAACACAGACATCCGGAGATAAAAGCATCCGACCCACGTAATGAAAACGGTATCATGACTAGCGGAAAAGTGGCAACCCACAGAAAATGCAGGAACTCACTAATTCTATTGCCTCGCATATCTTATGACAGGTACTCCTTAGGGCCTCCCCCTTCATGTGAAATAGTTGTCTATCCAGCGCAAGATTCAACAACAACCAATATCCAAGACATATCAATAAAAAACTATTTTAAAAAGTATGGAGAAATTTCTCATTTTGAAGCATTTAATGATCCTAATAGCGCTTTACCTTTGCATGTTTATCTTATAAAGTATGCCAGTTCTGATGGAAAAATTAATGATGCAGCAAAAGCAGCCTTTAGTGCCGTTAGAAAGCACGAATCTTCGGGTTGCTTTATCATGGGCTTCAAGTTCGAAGTGATTTTAAACAAGCATTCCATTTTGAATAATATCATTTCTAAATTTGTTGAAATAAATGTCAAAAAGCTACAGAAGTTACAAGAGAACCTGAAGAAGGCTAAAGAGAAAGAAGCAGAAAACGAAAAAGCAAAGGAATTACAGGGCAAAGATATTACCTTGCCCAAGGAACCTAAGGTAGACACATTATCTCATTCGTCCGGAAGTGAAAAAAGAATTCCATATGATCTCTTGGGGGTAGTTAATAACAGACCTGTTTTACATGTCTCCAAAATATTTGTTGCCAAACATAGGTTCTGCGTTGAGGACTTTAAATACAAGTTAAGGGGATACAGATGTGCGAAATTTATTGATCATCCAACTGGTATCTATATTATTTTTAATGACATTGCCCATGCGCAAACATGTTCGAATGCAGAGTCAGGAAATTTAACAATAATGTCTCGGAGCAGAAGAATTCCTATTCTAATAAAGTTTCATCTCATTCTCCCTAGGTTCCAAAACAGAACTAGATTCAATAAATCTAGCTCATCTTCAAATTCTACAAATGTACCTATAAAATACGAGTCCAAAGAGGAGTTCATTGAAGCTACAGCAAAACAAATATTAAAAGATTTGGAAAAGACTTTACATGTTGATATTAAGAAGAGATTGATTGGTCCTACGGTATTTGATGCTTTGGACCATGCAAATTTTCCTGAATTGTTAGCTAAAAGAGAACTAAAGGAGAAAGAGAAGAGACAACAGATTGCATCTAAAATTGCTGAAGATGAATTGAAACGTAAAGAAGAAGCCAAAAGAGATTTTGATTTGTTTGGTTTATATGGTGGCTATGCAAAATCTAATAAAAGAAATTTAAAAAGGCATAATTCACTCGCGTTGGATCATACTTCTTTAAAGAGGAAAAAGCTATCCAATGGTATCAAACCAATGGCACATTTACTGAACGAAGAAACCGATTCCAAAGAAACTACCCCATTGAACGATGAAGGGATCACTCGCGTATCAAAAGAACATGATGAAGAAGACGAAAATATGACATCTTCATCTTCTGAAGAAGAGGAAGAAGAAGCTCCAGATAAGAAATTCAAGAGTGAGTCTGAGCCAACCACCCCCGAATCTGATCACCTTCATGGTATTAAGCCGTTAGTACCCGATCAAAATGGGTCGTCTGACGTACTGGATGCTTCTTCGATGTATAAACCTACTGCTACCGAAATTCCCGAACCTGTATATCCACCTGAGGAATATGACTTGAAATATAGTCAGACTTTATCTTCTATGGATTTGCAGAATGCTATCAAAGATGAGGAAGATATGCTAATTTTAAAGCAGTTATTGAGCACATATACTCCTACCGTCACACCAGAAACAAGCGCAGCTCTGGAATATAAAATTTGGCAATCTCGCCGAAAAGTTCTTGAAGAAGAGAAGGCTTCCGATTGGCAAATAGAGCTTAATGGAACTTTATTTGATAGTGAACTACAACCAGGTAGCTCTTTTAAAGCTGAAGGGTTCAGGAAAATTGCGGATAAATTAAAAATTAATTACCTACCCCATCGTCGCAGAGTTCACCAACCTTTAAATACGGTGAATATTCACAATGAAAGGAATGAGTACACACCTGAACTTTGTCAAAGAGAAGAATCCTCGAATAAAGAACCTTCAGACTCAGTTCCTCAAGAAGTTTCATCCTCTAGAGATAATAGGGCATCAAATAGAAGATTTCAGCAGGACATAGAGGCACAGAAAGCCGCAATTGGTACGGAATCTGAGCTGCTATCACTAAATCAATTAAATAAAAGAAAAAAGCCAGTTATGTTCGCTCGTTCAGCAATTCACAACTGGGGTTTATATGCTCTAGACTCTATCGCAGCAAAGGAAATGATTATCGAGTACGTTGGTGAAAGGATCAGGCAACCTGTAGCAGAAATGAGAGAGAAAAGATATCTGAAAAATGGGATTGGATCCAGTTACCTTTTTAGGGTTGATGAAAACACGGTTATTGATGCCACCAAGAAAGGTGGTATAGCCCGTTTCATTAATCATTGTTGTGATCCAAATTGTACGGCAAAGATTATAAAGGTTGGCGGGAGAAGGAGAATTGTTATCTATGCACTGCGTGATATCGCGGCAAGCGAAGAGTTGACATATGATTACAAATTTGAGAGAGAAAAGGATGACGAGGAAAGACTTCCTTGTTTATGTGGAGCACCTAATTGTAAAGGTTTCTTGAACTGA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0002--3D-structure
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
--
|
| Interpro |
IPR024657--COMPASS_Set1_N-SET
IPR017111--Hist_H3-K4_MeTrfase_1_fun
IPR003616--Post-SET_dom
IPR024636--SET_assoc
IPR001214--SET_dom
|
| PROSITE |
PS50868--POST_SET
PS51572--SAM_MT43_1
PS50280--SET
|
| Pfam |
PF11764--N-SET
PF00856--SET
PF11767--SET_assoc
|
| Gene Ontology |
GO:0000781--C:chromosome, telomeric region
GO:0048188--C:Set1C/COMPASS complex
GO:0042054--F:histone methyltransferase activity
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0016279--F:protein-lysine N-methyltransferase activity
GO:0003723--F:RNA binding
GO:0030437--P:ascospore formation
GO:0030466--P:chromatin silencing at silent mating-type cassette
GO:0006348--P:chromatin silencing at telomere
GO:0044648--P:histone H3-K4 dimethylation
GO:0051568--P:histone H3-K4 methylation
GO:0080182--P:histone H3-K4 trimethylation
GO:0018027--P:peptidyl-lysine dimethylation
GO:0035066--P:positive regulation of histone acetylation
GO:1903341--P:regulation of meiotic DNA double-strand break formation
GO:0043618--P:regulation of transcription from RNA polymerase II promoter in response to stress
GO:0000723--P:telomere maintenance
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
