| Tag |
Content |
| WERAM ID |
WERAM-Sac-0001 |
| Ensembl Protein ID |
YBL052C |
| Uniprot Accession |
P34218; SAS3_YEAST; D6VPU7
|
| Genbank Protein ID |
NP_009501.1
|
| Protein Name |
Histone acetyltransferase SAS3 |
| Genbank Nucleotide ID |
NM_001178292.1
|
| Gene Name |
SAS3;YBL052C;YBL0507;YBL0515 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HAT |
MYST |
MYST-type HAT |
H3K14 |
K |
17694074
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HAT |
MYST |
5.30e-113 |
375.3 |
269 |
573 |
|
| Organism |
Saccharomyces cerevisiae |
| NCBI Taxa ID |
559292 |
Functional Description
(View)Functional Description
Catalytic component of the histone acetyltransferase NuA3 complex, that acetylates Lys-14 of histone H3. Recruitment of NuA3 to nucleosomes requires methylated histone H3. In conjunction with the FACT complex, NuA3 may be involved in transcriptional regulation. In vitro, SAS3 acetylates free histones H3 and H4. It is involved in silencing the HMR locus. |
Catalytic component of the histone acetyltransferase NuA3 complex, that acetylates Lys-14 of histone H3. Recruitment of NuA3 to nucleosomes requires methylated histone H3. In conjunction with the FACT complex, NuA3 may be involved in transcriptional regulation. In vitro, SAS3 acetylates free histones H3 and H4. It is involved in silencing the HMR locus.
|
| Domain Profile |
HAT MYST
MYST.txt 3 vkniekielgkyeiktwysspfpeelkklkklyicefclkytkskeslkrhlkkCklrkpPgneiyrkdklsvfevdGkkqklycqnlCllaklfldhktl 103
+++ie+i l++yeik+wy+spfpe+++++k+++icefclky++s+ +++rh+ kC ++kpPgneiyr++klsv+e+dG+++ lycqnlCllak+f+++ktl
YBL052C 269 FSQIEYIVLRNYEIKPWYTSPFPEHINQNKMVFICEFCLKYMTSRYTFYRHQLKCLTFKPPGNEIYRDGKLSVWEIDGRENVLYCQNLCLLAKCFINSKTL 369
689************************************************************************************************** PP
MYST.txt 104 yydvepflFYvltetdekg.........ahlvGyFskekesaekynlaCilvlPpyqrkGyGklLiefsYelsrkegkigsPekPLsdlgllsYrsyWkev 195
yydvepf+FY+lte+++++ +h+vGyFskek ++++ynl+Cil+lP+yqrkGyG++L+efsY+lsrke+k+g+PekPLsdlgll+Yr++Wk +
YBL052C 370 YYDVEPFIFYILTEREDTEnhpyqnaakFHFVGYFSKEKFNSNDYNLSCILTLPIYQRKGYGQFLMEFSYLLSRKESKFGTPEKPLSDLGLLTYRTFWKIK 470
***************99999********************************************************************************* PP
MYST.txt 196 llell.............kekeekk.....kitikelskatgiaveDivstleslnlikekkg.........qyil.lksekiveellklakskkkklkvd 268
++e+l k + ++++++++k tg+ ++D+v le+l+++ ++k+ +yi+ ++s++ +e++ +++s+k++ +v+
YBL052C 471 CAEVLlklrdsarrrsnnK-----NedtfqQVSLNDIAKLTGMIPTDVVFGLEQLQVLYRHKTrslsslddfNYIIkIDSWNRIENI-YKTWSSKNYPRVK 565
*****99999987654333.....144566*******************************97777788888888878888666666.477889******* PP
MYST.txt 269 eeklkwkp 276
++kl w+p
YBL052C 566 YDKLLWEP 573
******97 PP
|
Protein Sequence
(Fasta) | MSLTANDESP KPKKNALLKN LEIDDLIHSQ FVRSDTNGHR TTRRLFNSDA SISHRIRGSV 60
RSDKGLNKIK KGLISQQSKL ASENSSQNIV NRDNKMGAVS FPIIEPNIEV SEELKVRIKY 120
DSIKFFNFER LISKSSVIAP LVNKNITSSG PLIGFQRRVN RLKQTWDLAT ENMEYPYSSD 180
NTPFRDNDSW QWYVPYGGTI KKMKDFSTKR TLPTWEDKIK FLTFLENSKS ATYINGNVSL 240
CNHNETDQEN EDRKKRKGKV PRIKNKVWFS QIEYIVLRNY EIKPWYTSPF PEHINQNKMV 300
FICEFCLKYM TSRYTFYRHQ LKCLTFKPPG NEIYRDGKLS VWEIDGRENV LYCQNLCLLA 360
KCFINSKTLY YDVEPFIFYI LTEREDTENH PYQNAAKFHF VGYFSKEKFN SNDYNLSCIL 420
TLPIYQRKGY GQFLMEFSYL LSRKESKFGT PEKPLSDLGL LTYRTFWKIK CAEVLLKLRD 480
SARRRSNNKN EDTFQQVSLN DIAKLTGMIP TDVVFGLEQL QVLYRHKTRS LSSLDDFNYI 540
IKIDSWNRIE NIYKTWSSKN YPRVKYDKLL WEPIILGPSF GINGMMNLEP TALADEALTN 600
ETMAPVISNN THIENYNNSR AHNKRRRRRR RSSEHKTSKL HVNNIIEPEV PATDFFEDTV 660
SSLTEYMCDY KNTNNDRLIY QAEKRVLESI HDRKGIPRSK FSTETHWELC FTIKNSETPL 720
GNHAARRNDT GISSLEQDEV ENDVDTELYV GENAKEDEDE DEDFTLDDDI EDEQISEEND 780
EEEDTYEEDS DDDEDGKRKG QEQDENDIES HIRKERVRKR RKITLIEDDE E 831Protein Fasta Sequence
>YBL052C|SAS3;YBL052C;YBL0507;YBL0515|Saccharomyces cerevisiae
MSLTANDESPKPKKNALLKNLEIDDLIHSQFVRSDTNGHRTTRRLFNSDASISHRIRGSVRSDKGLNKIKKGLISQQSKLASENSSQNIVNRDNKMGAVSFPIIEPNIEVSEELKVRIKYDSIKFFNFERLISKSSVIAPLVNKNITSSGPLIGFQRRVNRLKQTWDLATENMEYPYSSDNTPFRDNDSWQWYVPYGGTIKKMKDFSTKRTLPTWEDKIKFLTFLENSKSATYINGNVSLCNHNETDQENEDRKKRKGKVPRIKNKVWFSQIEYIVLRNYEIKPWYTSPFPEHINQNKMVFICEFCLKYMTSRYTFYRHQLKCLTFKPPGNEIYRDGKLSVWEIDGRENVLYCQNLCLLAKCFINSKTLYYDVEPFIFYILTEREDTENHPYQNAAKFHFVGYFSKEKFNSNDYNLSCILTLPIYQRKGYGQFLMEFSYLLSRKESKFGTPEKPLSDLGLLTYRTFWKIKCAEVLLKLRDSARRRSNNKNEDTFQQVSLNDIAKLTGMIPTDVVFGLEQLQVLYRHKTRSLSSLDDFNYIIKIDSWNRIENIYKTWSSKNYPRVKYDKLLWEPIILGPSFGINGMMNLEPTALADEALTNETMAPVISNNTHIENYNNSRAHNKRRRRRRRSSEHKTSKLHVNNIIEPEVPATDFFEDTVSSLTEYMCDYKNTNNDRLIYQAEKRVLESIHDRKGIPRSKFSTETHWELCFTIKNSETPLGNHAARRNDTGISSLEQDEVENDVDTELYVGENAKEDEDEDEDFTLDDDIEDEQISEENDEEEDTYEEDSDDDEDGKRKGQEQDENDIESHIRKERVRKRRKITLIEDDEE |
Nucleotide Sequence
(Fasta) | ATGTCATTAA CAGCAAACGA CGAATCGCCA AAACCCAAAA AAAATGCATT ATTGAAAAAC 60
TTAGAGATCG ATGATCTGAT ACATTCTCAA TTTGTCAGAA GCGATACAAA TGGACATAGA 120
ACTACAAGAC GACTATTCAA CTCCGATGCC AGTATATCAC ATCGAATAAG AGGAAGTGTT 180
CGGTCTGATA AAGGCCTTAA TAAAATAAAA AAAGGGTTGA TTTCCCAGCA GTCCAAACTT 240
GCGTCAGAAA ATTCTTCTCA AAATATCGTT AATAGGGACA ATAAGATGGG AGCAGTAAGT 300
TTCCCCATTA TTGAACCTAA TATTGAAGTC AGCGAGGAGT TGAAGGTTAG AATTAAGTAT 360
GATTCTATCA AATTTTTCAA TTTTGAAAGA CTAATATCTA AATCTTCAGT CATAGCACCT 420
TTAGTTAACA AAAATATAAC ATCATCCGGT CCTCTAATCG GGTTTCAAAG AAGAGTTAAC 480
AGGTTAAAGC AAACATGGGA TCTAGCAACC GAAAACATGG AGTACCCATA TTCTTCTGAT 540
AATACGCCAT TCAGGGATAA CGATTCTTGG CAATGGTACG TACCATACGG CGGAACAATA 600
AAAAAAATGA AAGATTTCAG TACAAAAAGA ACTTTACCCA CCTGGGAAGA TAAAATAAAG 660
TTTCTTACAT TTTTAGAAAA CTCTAAGTCT GCAACGTACA TTAATGGTAA CGTATCACTT 720
TGCAATCATA ATGAAACCGA TCAAGAAAAC GAAGATAGGA AAAAAAGGAA AGGGAAAGTA 780
CCAAGAATCA AAAATAAAGT GTGGTTTTCC CAGATAGAAT ACATTGTTCT TCGAAATTAT 840
GAAATTAAAC CTTGGTATAC ATCTCCTTTT CCGGAACACA TCAACCAAAA TAAAATGGTT 900
TTTATATGTG AGTTCTGCCT AAAATATATG ACTTCTCGAT ATACTTTTTA TAGACACCAA 960
CTAAAGTGTC TAACTTTTAA GCCCCCCGGA AATGAAATTT ATCGCGACGG TAAGCTGTCT 1020
GTTTGGGAAA TTGATGGGCG GGAGAATGTC TTGTATTGTC AAAATCTTTG CCTGTTGGCA 1080
AAATGTTTTA TCAATTCTAA GACTTTGTAT TACGATGTTG AACCGTTTAT ATTCTATATT 1140
CTAACGGAGA GAGAGGATAC AGAGAACCAT CCCTATCAAA ACGCAGCCAA ATTCCATTTC 1200
GTAGGCTATT TCTCCAAGGA AAAATTCAAC TCCAATGACT ATAACCTAAG TTGTATTTTA 1260
ACTCTACCCA TATACCAGAG GAAAGGATAT GGTCAGTTTT TGATGGAATT TTCATATTTA 1320
TTATCCAGAA AGGAGTCAAA ATTTGGAACT CCTGAAAAAC CATTGTCGGA TTTAGGATTA 1380
TTGACTTACA GAACGTTTTG GAAGATAAAA TGTGCTGAAG TGCTATTAAA ATTAAGAGAC 1440
AGTGCTAGAC GTCGATCAAA TAATAAAAAT GAAGATACTT TTCAGCAGGT TAGCCTAAAC 1500
GATATCGCTA AACTAACAGG AATGATACCA ACAGACGTTG TGTTTGGATT GGAACAACTT 1560
CAAGTTTTGT ATCGCCATAA AACACGCTCA TTATCCAGTT TGGATGATTT CAACTATATT 1620
ATTAAAATCG ATTCTTGGAA CAGGATTGAA AATATTTACA AAACTTGGAG CTCAAAAAAC 1680
TATCCTCGCG TCAAATATGA CAAACTATTG TGGGAACCTA TTATATTAGG GCCGTCATTT 1740
GGTATAAATG GGATGATGAA CTTAGAACCC ACCGCATTAG CGGACGAAGC TCTTACAAAT 1800
GAAACTATGG CTCCGGTAAT TTCGAATAAC ACACATATAG AAAACTATAA CAACAGTAGA 1860
GCACATAATA AACGCAGAAG AAGAAGAAGA AGAAGTAGTG AGCACAAAAC ATCCAAGCTT 1920
CATGTAAACA ATATCATAGA ACCGGAAGTA CCTGCTACTG ATTTTTTTGA AGACACTGTT 1980
TCCTCCTTAA CAGAGTATAT GTGTGATTAT AAGAACACAA ATAATGATAG ATTAATCTAT 2040
CAAGCGGAAA AAAGAGTGCT GGAAAGCATC CATGATCGCA AAGGGATACC AAGATCAAAA 2100
TTTAGTACAG AAACTCATTG GGAGCTCTGC TTCACTATTA AAAACTCCGA AACACCACTT 2160
GGAAATCATG CAGCTAGGAG AAACGATACT GGAATATCAA GTTTAGAGCA GGATGAAGTA 2220
GAAAACGATG TAGATACTGA ATTATATGTA GGTGAAAACG CCAAAGAAGA TGAAGACGAA 2280
GACGAAGACT TTACCCTTGA TGATGACATT GAGGATGAGC AAATATCAGA AGAAAATGAT 2340
GAGGAGGAAG ACACATATGA AGAAGACAGT GATGATGATG AGGATGGGAA GAGAAAAGGA 2400
CAAGAGCAGG ATGAAAACGA TATAGAAAGC CACATAAGGA AGGAGAGAGT CAGAAAAAGA 2460
AGAAAAATAA CTCTAATAGA GGATGACGAA GAATAA
2497Nucleotide Fasta Sequence
>YBL052C|MYST|Saccharomyces cerevisiae
ATGTCATTAACAGCAAACGACGAATCGCCAAAACCCAAAAAAAATGCATTATTGAAAAACTTAGAGATCGATGATCTGATACATTCTCAATTTGTCAGAAGCGATACAAATGGACATAGAACTACAAGACGACTATTCAACTCCGATGCCAGTATATCACATCGAATAAGAGGAAGTGTTCGGTCTGATAAAGGCCTTAATAAAATAAAAAAAGGGTTGATTTCCCAGCAGTCCAAACTTGCGTCAGAAAATTCTTCTCAAAATATCGTTAATAGGGACAATAAGATGGGAGCAGTAAGTTTCCCCATTATTGAACCTAATATTGAAGTCAGCGAGGAGTTGAAGGTTAGAATTAAGTATGATTCTATCAAATTTTTCAATTTTGAAAGACTAATATCTAAATCTTCAGTCATAGCACCTTTAGTTAACAAAAATATAACATCATCCGGTCCTCTAATCGGGTTTCAAAGAAGAGTTAACAGGTTAAAGCAAACATGGGATCTAGCAACCGAAAACATGGAGTACCCATATTCTTCTGATAATACGCCATTCAGGGATAACGATTCTTGGCAATGGTACGTACCATACGGCGGAACAATAAAAAAAATGAAAGATTTCAGTACAAAAAGAACTTTACCCACCTGGGAAGATAAAATAAAGTTTCTTACATTTTTAGAAAACTCTAAGTCTGCAACGTACATTAATGGTAACGTATCACTTTGCAATCATAATGAAACCGATCAAGAAAACGAAGATAGGAAAAAAAGGAAAGGGAAAGTACCAAGAATCAAAAATAAAGTGTGGTTTTCCCAGATAGAATACATTGTTCTTCGAAATTATGAAATTAAACCTTGGTATACATCTCCTTTTCCGGAACACATCAACCAAAATAAAATGGTTTTTATATGTGAGTTCTGCCTAAAATATATGACTTCTCGATATACTTTTTATAGACACCAACTAAAGTGTCTAACTTTTAAGCCCCCCGGAAATGAAATTTATCGCGACGGTAAGCTGTCTGTTTGGGAAATTGATGGGCGGGAGAATGTCTTGTATTGTCAAAATCTTTGCCTGTTGGCAAAATGTTTTATCAATTCTAAGACTTTGTATTACGATGTTGAACCGTTTATATTCTATATTCTAACGGAGAGAGAGGATACAGAGAACCATCCCTATCAAAACGCAGCCAAATTCCATTTCGTAGGCTATTTCTCCAAGGAAAAATTCAACTCCAATGACTATAACCTAAGTTGTATTTTAACTCTACCCATATACCAGAGGAAAGGATATGGTCAGTTTTTGATGGAATTTTCATATTTATTATCCAGAAAGGAGTCAAAATTTGGAACTCCTGAAAAACCATTGTCGGATTTAGGATTATTGACTTACAGAACGTTTTGGAAGATAAAATGTGCTGAAGTGCTATTAAAATTAAGAGACAGTGCTAGACGTCGATCAAATAATAAAAATGAAGATACTTTTCAGCAGGTTAGCCTAAACGATATCGCTAAACTAACAGGAATGATACCAACAGACGTTGTGTTTGGATTGGAACAACTTCAAGTTTTGTATCGCCATAAAACACGCTCATTATCCAGTTTGGATGATTTCAACTATATTATTAAAATCGATTCTTGGAACAGGATTGAAAATATTTACAAAACTTGGAGCTCAAAAAACTATCCTCGCGTCAAATATGACAAACTATTGTGGGAACCTATTATATTAGGGCCGTCATTTGGTATAAATGGGATGATGAACTTAGAACCCACCGCATTAGCGGACGAAGCTCTTACAAATGAAACTATGGCTCCGGTAATTTCGAATAACACACATATAGAAAACTATAACAACAGTAGAGCACATAATAAACGCAGAAGAAGAAGAAGAAGAAGTAGTGAGCACAAAACATCCAAGCTTCATGTAAACAATATCATAGAACCGGAAGTACCTGCTACTGATTTTTTTGAAGACACTGTTTCCTCCTTAACAGAGTATATGTGTGATTATAAGAACACAAATAATGATAGATTAATCTATCAAGCGGAAAAAAGAGTGCTGGAAAGCATCCATGATCGCAAAGGGATACCAAGATCAAAATTTAGTACAGAAACTCATTGGGAGCTCTGCTTCACTATTAAAAACTCCGAAACACCACTTGGAAATCATGCAGCTAGGAGAAACGATACTGGAATATCAAGTTTAGAGCAGGATGAAGTAGAAAACGATGTAGATACTGAATTATATGTAGGTGAAAACGCCAAAGAAGATGAAGACGAAGACGAAGACTTTACCCTTGATGATGACATTGAGGATGAGCAAATATCAGAAGAAAATGATGAGGAGGAAGACACATATGAAGAAGACAGTGATGATGATGAGGATGGGAAGAGAAAAGGACAAGAGCAGGATGAAAACGATATAGAAAGCCACATAAGGAAGGAGAGAGTCAGAAAAAGAAGAAAAATAACTCTAATAGAGGATGACGAAGAATAA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0007--Acetylation
KW-0012--Acyltransferase
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
--
|
| Interpro |
IPR016181--Acyl_CoA_acyltransferase
IPR002717--HAT_MYST-type
|
| PROSITE |
PS51726--MYST_HAT
|
| Pfam |
PF01853--MOZ_SAS
|
| Gene Ontology |
GO:0000781--C:chromosome, telomeric region
GO:0033100--C:NuA3 histone acetyltransferase complex
GO:1990467--C:NuA3a histone acetyltransferase complex
GO:1990468--C:NuA3b histone acetyltransferase complex
GO:0004402--F:histone acetyltransferase activity
GO:0046872--F:metal ion binding
GO:0016568--P:chromatin modification
GO:0030466--P:chromatin silencing at silent mating-type cassette
GO:0006348--P:chromatin silencing at telomere
GO:0016573--P:histone acetylation
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
