WERAM Information

Tag Content
WERAM ID WERAM-Cae-0065
Ensembl Protein ID T26A5.5a
Uniprot Accession Q95Q98; JHD1_CAEEL; Q95Q99
Genbank Protein ID NP_498418.3; NP_498419.3
Protein Name JmjC domain-containing histone demethylation protein 1
Genbank Nucleotide ID NM_066017.6; NM_066018.9
Gene Name JHD1;jhdm-1T26A5.5
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00020821 T26A5.5a T26A5.5a
WBGene00020821 T26A5.5b T26A5.5b
Details
Type Family Domain Substrates AA References (PMIDs)
HDM JHDM1 Jmjc H3K27me2/3 K 22570628; 21834846
Status Reviewed
Classification
Type Family E-value Score Start End
HDM JHDM1 6.30e-84 280.4 93 265
Organism Caenorhabditis elegans
NCBI Taxa ID 6239
Functional Description
(View)		 Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code (By similarity). Has a role in regulating lifespan.
Domain Profile
  HDM JHDM1
  JHDM1.txt   1 fsktkleelvkkpevvrqidlvdnvWpkalkek.....qtegtnaleemkyPkvqkyclmsvkncytdfhidfgGtsvyyhvlkGskvfwliPpteknle 95 
                fs+t+le+lvk+pe+vrqid+v+n+Wp+al+++      +++++++ ++++Pkvq+yclmsv+ncytdfhidf+Gtsv+yhvlkG+kvfwliPpte+n+ 
   T26A5.5a  93 FSQTPLEDLVKSPELVRQIDWVGNQWPDALRQRwisfnGRDKKFYNPHHTFPKVQNYCLMSVANCYTDFHIDFSGTSVWYHVLKGRKVFWLIPPTETNFF 192
                89******************************9999999************************************************************* PP
  JHDM1.txt  96 lyeewvlsgkqsdiflgdrvekcqrvelkagdtlliPsGwihavytPvdslvfgGnflhslniktqlkiyeied 169
                +y+e+++++++++ f+g++vekc++++l++gdt+liPsGwihavytP+dslvfgGnflhs+++ktql++y++e+
   T26A5.5a 193 IYQEFIKTVNDNA-FFGKSVEKCHVAILEPGDTMLIPSGWIHAVYTPDDSLVFGGNFLHSQSCKTQLRVYQVEN 265
                ************9.**********************************************************96 PP
Protein Sequence
(Fasta)		MDPEALNLEF YDKNGLDNPI HFRCDPKRIG MTLPSPDFSV DDVLELVGGN RMIEVVQVQN 60
QGSVKMSLQE FINFYKTPQE KREVLYNVLS LEFSQTPLED LVKSPELVRQ IDWVGNQWPD 120
ALRQRWISFN GRDKKFYNPH HTFPKVQNYC LMSVANCYTD FHIDFSGTSV WYHVLKGRKV 180
FWLIPPTETN FFIYQEFIKT VNDNAFFGKS VEKCHVAILE PGDTMLIPSG WIHAVYTPDD 240
SLVFGGNFLH SQSCKTQLRV YQVENKLNIT RKFRLPYNEE LIFYVIADYV KQWTGREYVR 300
PLRIEDAKYD YVGDKWKTAG GHHKKIEYSD YETGVELTND MIKGDEESTK DEVKVIAMHA 360
ENSLFGYPMV SKATFSADTG LEEEADEDEV KYQETKEEMD ARRDAEIDEL ANSNSLIFYK 420
NRTHDFVRNK CVPDHKLPIG HEPPIYFNDD EISRISPRLL DELETLGTYI RRKARVEVAE 480
GICQPASLIN TFQTVLKKRR SELTGKKFEF NQIMPRRYTR STMETGEYDF QPTQEVPQES 540
ARRSTRFKVD NFPDELLESE VTDKPIILPQ QPSSGPLEYL PAPKDEIKED INGFEEEFEE 600
EYEGIGQRDD QEEEEYDAEE PEDQEEEEED EYQAEEYTPT PVTRRSSSRR SGAKNDESEE 660
VSVKKDKKEK MEKVEKDEKR RNSKSKKDKI SKEKKKKERE RIELESQLDA ELRAAHGGGS 720
SKSKKKKPEK PAFVGGLPTS SIQIDPVVSN PYNYDPRMEM MKLGTGQLKS AYRKTKNNVE 780
LHIEKNLYKI EPKRGSEEGS QSREQSMEPE HSTPVFTTFD DINEANNDHY DGQKPPTKRA 840
KYEAISVDTY ETPSSSRNKE HKEYRPSPNA APTPSPSHHQ KPKLSSPAMV SSTNEYQLRK 900
HMSSERRSSD AGSAMKKGVY MPAMSRQDKM IAEGASAPSS RHSSISSERR PSFIPDFNSS 960
RNSSIDTPYT PTTVTPSRSS WLPNTSSINR HSIEDDSPID VVNDSLSPIN IASSPTYPTA 1020
ITPPPVTLSD LKKDMSNGRK SHSQHHDDGH KHKIPSKEAI AELKLLVGKL KAINDS 1076
Nucleotide Sequence
(Fasta)		ATGCCGCCGA AACGGAAATC AAATGGAAAA ACGCCAGCGA ACGGTAAAAA GGGCGCAAAG 60
AAGGCTAGGA AAGAGTCAAG TTCAGAGCAC GAACATAGTG CTTCAGAAGG TGAAGAAACT 120
ACTGGATTCG ATAAGTCGTC ACTTCAACGA TGTGTGAATT TTGATTTCGA AGCTCTGATG 180
AATGATCCGT CTTTCCAACA TCCCGAATTT GTACATACAA TGGACCCAGA AGCTTTAAAT 240
TTGGAGTTCT ACGACAAAAA TGGACTTGAC AACCCGATAC ATTTCCGATG TGATCCAAAA 300
AGAATAGGAA TGACACTTCC CTCACCAGAT TTCTCAGTGG ATGATGTCCT CGAACTGGTA 360
GGCGGAAATC GAATGATAGA AGTTGTTCAA GTCCAGAATC AAGGAAGTGT GAAAATGTCG 420
TTACAGGAAT TTATAAACTT CTACAAAACG CCACAAGAAA AACGAGAAGT ACTGTACAAT 480
GTTCTATCTC TAGAATTTTC CCAAACTCCC TTAGAAGATC TCGTAAAATC TCCAGAACTT 540
GTTCGTCAAA TCGACTGGGT TGGAAACCAG TGGCCAGATG CTCTGCGCCA GAGGTGGATC 600
TCATTCAACG GAAGAGACAA AAAATTCTAC AATCCGCATC ATACTTTTCC AAAAGTTCAA 660
AACTACTGCC TGATGAGCGT AGCGAACTGT TATACAGATT TTCACATTGA TTTTAGTGGA 720
ACATCTGTGT GGTATCATGT ACTGAAAGGT CGTAAAGTCT TTTGGTTGAT TCCACCAACC 780
GAAACCAACT TTTTTATTTA TCAAGAATTT ATTAAAACTG TCAACGATAA TGCGTTCTTT 840
GGAAAGTCGG TCGAAAAGTG CCACGTGGCT ATCTTGGAGC CAGGAGACAC GATGCTAATT 900
CCAAGTGGAT GGATTCATGC CGTATATACT CCAGATGATA GTCTCGTTTT TGGAGGCAAT 960
TTTCTTCACT CACAATCATG CAAAACACAA TTAAGAGTTT ATCAAGTTGA AAATAAGTTG 1020
AATATCACTA GAAAATTTCG CTTACCGTAC AATGAAGAAC TTATTTTCTA CGTTATAGCT 1080
GATTATGTAA AACAATGGAC AGGAAGAGAA TATGTGAGAC CACTTCGAAT CGAAGATGCA 1140
AAATATGACT ATGTTGGAGA CAAATGGAAA ACCGCTGGTG GCCATCATAA GAAAATCGAA 1200
TACTCAGATT ACGAAACTGG AGTTGAATTG ACAAACGATA TGATTAAAGG AGACGAGGAA 1260
TCCACAAAAG ATGAAGTTAA AGTGATTGCA ATGCACGCGG AGAATTCACT ATTTGGTTAT 1320
CCTATGGTCA GCAAAGCAAC GTTTTCAGCT GACACGGGTC TTGAAGAAGA AGCTGACGAA 1380
GATGAAGTCA AGTATCAAGA AACTAAAGAA GAAATGGATG CTCGACGCGA TGCTGAAATC 1440
GATGAACTAG CTAATTCAAA TTCATTAATT TTCTACAAGA ACCGTACGCA CGATTTTGTT 1500
CGAAATAAAT GCGTGCCGGA CCACAAACTT CCAATTGGAC ACGAGCCGCC AATCTACTTT 1560
AACGATGATG AGATTTCTAG GATATCCCCT CGACTTTTGG ATGAACTTGA AACTCTTGGC 1620
ACTTATATTC GTCGAAAAGC ACGTGTCGAA GTGGCTGAAG GAATATGCCA GCCAGCGTCT 1680
CTCATTAACA CATTCCAAAC TGTTTTGAAA AAAAGACGTT CTGAATTGAC AGGGAAGAAA 1740
TTTGAATTCA ACCAGATAAT GCCTCGAAGA TATACTCGAT CCACCATGGA AACCGGTGAA 1800
TATGACTTCC AGCCGACGCA AGAAGTACCA CAAGAATCTG CGAGAAGAAG CACAAGATTC 1860
AAAGTTGATA ACTTTCCCGA TGAGCTTTTA GAATCGGAAG TGACTGATAA GCCTATTATA 1920
TTGCCTCAAC AACCATCATC AGGACCTCTC GAATATCTTC CTGCACCCAA AGATGAAATT 1980
AAAGAGGATA TTAATGGTTT TGAAGAAGAA TTTGAGGAGG AATATGAAGG AATTGGGCAA 2040
CGTGATGATC AGGAGGAAGA GGAATACGAT GCCGAAGAGC CGGAAGATCA AGAGGAGGAA 2100
GAAGAAGATG AATATCAAGC CGAAGAATAT ACTCCAACTC CAGTTACAAG ACGTTCTAGT 2160
TCAAGACGTT CAGGTGCTAA AAATGATGAA TCAGAAGAAG TGTCAGTAAA GAAGGACAAA 2220
AAGGAAAAGA TGGAGAAAGT TGAAAAAGAC GAGAAGAGAA GGAATTCGAA GAGTAAGAAA 2280
GACAAAATTT CGAAGGAAAA GAAGAAGAAG GAGAGAGAAC GTATTGAATT GGAAAGTCAA 2340
CTCGATGCAG AGCTCAGAGC TGCTCATGGA GGAGGATCGA GCAAATCTAA AAAGAAAAAG 2400
CCAGAGAAGC CGGCATTTGT TGGTGGACTT CCAACTTCAT CTATTCAAAT CGATCCAGTT 2460
GTTTCAAATC CGTATAACTA TGATCCCAGA ATGGAGATGA TGAAGCTTGG AACTGGACAG 2520
CTCAAGTCAG CATACAGAAA AACGAAAAAT AACGTCGAAC TTCATATTGA AAAGAATCTC 2580
TACAAGATTG AGCCGAAACG AGGAAGTGAG GAAGGAAGTC AAAGCCGCGA GCAAAGTATG 2640
GAACCAGAGC ACAGTACTCC AGTTTTCACG ACTTTTGATG ATATAAATGA AGCAAATAAT 2700
GATCATTACG ATGGACAGAA GCCTCCAACT AAAAGAGCTA AATATGAGGC AATTAGTGTT 2760
GACACATATG AAACTCCATC GTCTTCAAGA AATAAAGAAC ACAAAGAATA TCGTCCCAGT 2820
CCGAACGCTG CTCCAACTCC ATCACCATCC CATCATCAAA AACCAAAACT TTCATCTCCA 2880
GCAATGGTCT CATCGACAAA CGAATATCAG TTACGAAAAC ACATGTCGAG CGAACGGCGA 2940
AGCAGTGATG CAGGATCGGC AATGAAAAAG GGCGTATATA TGCCTGCAAT GTCTCGTCAG 3000
GATAAGATGA TTGCTGAGGG AGCATCTGCT CCCTCGTCAC GTCACTCCTC GATCTCATCT 3060
GAACGTCGTC CGAGTTTCAT ACCTGATTTC AACTCTTCTC GTAATTCATC TATTGATACA 3120
CCATACACTC CGACTACTGT AACACCTTCA AGATCTTCTT GGCTCCCGAA CACGTCGTCC 3180
ATTAATCGTC ACTCAATTGA AGATGATTCT CCAATAGATG TTGTCAATGA TTCATTATCA 3240
CCAATAAATA TAGCCAGCTC GCCGACCTAC CCAACTGCAA TCACTCCACC ACCGGTTACT 3300
CTCAGCGATT TGAAGAAGGA TATGTCAAAT GGACGCAAAA GTCATAGTCA GCATCATGAC 3360
GATGGGCACA AGCACAAGAT TCCATCAAAA GAAGCGATTG CAGAGCTGAA GCTTCTCGTC 3420
GGAAAACTTA AAGCTATCAA TGATTCCTAG TTCTGATCTG CTATTCAACT AAGGAATCGA 3480
TCGTCGCCTC TTTACATTTT CATTTACAAT TATTTTCTTG TTTTTAACAA AAATGTTCTT 3540
AATCAACAAG TTCGGGCTCT GTCGCAAAAT ATAAGCTCTC ATTTTCCAAC ATTTGTTTCT 3600
ATCTTAATGT CCATTAATAT ATGGTTTTTG TTGTTATCTC GTGTTATTTT AAGTTCCAGC 3660
ATTTGCGAAA GTTGTCTGAA TTTCTTGAAT TAACACATCC ATTGTTTTTT CAAGCTACCT 3720
CAATTTGCAA TGTTATTCAA ACACCTATTG CTGTTCATTT TTCATTCCAA ATTATCTATC 3780
TTTACCCGTT TTTTACTCCT CCCATTTTTC AAAAATAATT TTATCTGCAA CGTCGTGGTC 3840
TGATGATGAT TCTCGTACAG AAATTCTTTT TTGCATCTCA ATGTTTCCAA CTAATTTCCC 3900
GTCGATATCC GTTGTTTTTT ATCTATCGTA TTTTTTTAAA AACAAATGCC AATACCAATT 3960
CACGAGAGCT TTACTTGCCT TGATGAACCG TATCTCTGTA TTCATTTTTT GTTTACTTGA 4020
TCCTTTTCTA GTTTTTTCAT TTTAATAAAG CAGACG 4057
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0408--Iron
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
--
Interpro

IPR003347--JmjC_dom
PROSITE

PS51184--JMJC
Pfam
Gene Ontology

GO:0005634--C:nucleus
GO:0051864--F:histone demethylase activity (H3-K36 specific)
GO:0046872--F:metal ion binding
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Xim-0199 ENSXMAP00000016026.1 Xiphophorus maculatus 49 4e-81 300
WERAM-Pof-0139 ENSPFOP00000011700.1 Poecilia formosa 49 8e-81 300
WERAM-Gaga-0048 ENSGALP00000006714.4 Gallus gallus 45 9e-81 299
WERAM-Fia-0112 ENSFALP00000009545.1 Ficedula albicollis 45 1e-80 298
WERAM-Anp-0036 ENSAPLP00000004086.1 Anas platyrhynchos 45 1e-79 296
WERAM-Meg-0044 ENSMGAP00000004134.2 Meleagris gallopavo 45 2e-79 295
WERAM-Tar-0061 ENSTRUP00000012810.1 Takifugu rubripes 48 2e-79 295
WERAM-Mum-0097 ENSMUSP00000038229.9 Mus musculus 45 2e-79 295
WERAM-Fec-0126 ENSFCAP00000011553.3 Felis catus 46 2e-79 295
WERAM-Tag-0091 ENSTGUP00000006194.1 Taeniopygia guttata 47 4e-79 293
WERAM-Ova-0147 ENSOARP00000014881.1 Ovis aries 46 5e-79 293
WERAM-Bot-0027 ENSBTAP00000003003.5 Bos taurus 46 6e-79 293
WERAM-Cap-0124 ENSCPOP00000009897.2 Cavia porcellus 46 8e-79 293
WERAM-Myl-0148 ENSMLUP00000012120.2 Myotis lucifugus 46 8e-79 293
WERAM-Mup-0021 ENSMPUP00000002083.1 Mustela putorius furo 46 1e-78 292
WERAM-Caf-0093 ENSCAFP00000012157.5 Canis familiaris 46 1e-78 292
WERAM-Aim-0164 ENSAMEP00000015147.1 Ailuropoda melanoleuca 46 2e-78 291
WERAM-Poa-0047 ENSPPYP00000005754.2 Pongo abelii 46 2e-78 291
WERAM-Orc-0053 ENSOCUP00000005165.3 Oryctolagus cuniculus 46 2e-78 291
WERAM-Orn-0055 ENSONIP00000006472.1 Oreochromis niloticus 42 3e-78 291
WERAM-Paa-0080 ENSPANP00000004785.1 Papio anubis 46 3e-78 291
WERAM-Chs-0025 ENSCSAP00000015833.1 Chlorocebus sabaeus 46 3e-78 291
WERAM-Gaa-0176 ENSGACP00000021682.1 Gasterosteus aculeatus 48 3e-78 291
WERAM-Pat-0045 ENSPTRP00000009437.5 Pan troglodytes 46 3e-78 291
WERAM-Hos-0045 ENSP00000366271.3 Homo sapiens 46 3e-78 291
WERAM-Gam-0007 ENSGMOP00000000834.1 Gadus morhua 47 3e-78 291
WERAM-Eqc-0179 ENSECAP00000019563.1 Equus caballus 46 4e-78 290
WERAM-Xet-0105 ENSXETP00000034422.2 Xenopus tropicalis 47 5e-78 290
WERAM-Asm-0097 ENSAMXP00000010134.1 Astyanax mexicanus 47 8e-78 290
WERAM-Nol-0175 ENSNLEP00000019607.2 Nomascus leucogenys 46 9e-78 289
WERAM-Mam-0200 ENSMMUP00000028400.2 Macaca mulatta 46 1e-77 289
WERAM-Dan-0096 ENSDNOP00000010165.3 Dasypus novemcinctus 45 1e-77 289
WERAM-Loa-0202 ENSLAFP00000021565.1 Loxodonta africana 45 2e-77 288
WERAM-Orla-0116 ENSORLP00000013894.1 Oryzias latipes 47 2e-77 288
WERAM-Dar-0180 ENSDARP00000099910.3 Danio rerio 46 4e-77 287
WERAM-Drm-0062 FBpp0289915 Drosophila melanogaster 47 5e-77 287
WERAM-Anc-0079 ENSACAP00000007492.3 Anolis carolinensis 42 5e-77 287
WERAM-Pes-0029 ENSPSIP00000005255.1 Pelodiscus sinensis 45 7e-77 286
WERAM-Ran-0123 ENSRNOP00000051732.2 Rattus norvegicus 39 9e-77 286
WERAM-Mod-0060 ENSMODP00000009649.3 Monodelphis domestica 45 1e-76 285
WERAM-Caj-0008 ENSCJAP00000001914.2 Callithrix jacchus 45 2e-76 285
WERAM-Ptv-0088 ENSPVAP00000008067.1 Pteropus vampyrus 45 2e-76 285
WERAM-Ocp-0120 ENSOPRP00000012395.2 Ochotona princeps 45 2e-76 285
WERAM-Ect-0067 ENSETEP00000007585.1 Echinops telfairi 45 2e-76 285
WERAM-Sah-0004 ENSSHAP00000000156.1 Sarcophilus harrisii 44 4e-76 284
WERAM-Otg-0110 ENSOGAP00000009515.2 Otolemur garnettii 45 6e-76 283
WERAM-Soa-0015 ENSSARP00000001674.1 Sorex araneus 45 1e-75 282
WERAM-Leo-0042 ENSLOCP00000006157.1 Lepisosteus oculatus 45 5e-75 280
WERAM-Sus-0150 ENSSSCP00000025010.1 Sus scrofa 45 7e-75 280
WERAM-Mim-0139 ENSMICP00000014201.1 Microcebus murinus 48 1e-74 279
WERAM-Dio-0063 ENSDORP00000006291.1 Dipodomys ordii 45 1e-74 279
WERAM-Ict-0192 ENSSTOP00000017380.1 Ictidomys tridecemlineatus 49 1e-74 279
WERAM-Ten-0029 ENSTNIP00000000534.1 Tetraodon nigroviridis 49 6e-74 276
WERAM-Mae-0022 ENSMEUP00000001662.1 Macropus eugenii 44 2e-73 275
WERAM-Cis-0003 ENSCSAVP00000000437.1 Ciona savignyi 44 1e-72 272
WERAM-Tas-0128 ENSTSYP00000013512.1 Tarsius syrichta 43 2e-71 268
WERAM-Ora-0061 ENSOANP00000009538.1 Ornithorhynchus anatinus 44 1e-69 262
WERAM-Cii-0015 ENSCINP00000005646.3 Ciona intestinalis 45 5e-68 257
WERAM-Gog-0162 ENSGGOP00000014352.2 Gorilla gorilla 45 3e-67 254
WERAM-Vip-0108 ENSVPAP00000009910.1 Vicugna pacos 41 2e-66 251
WERAM-Tut-0006 ENSTTRP00000000351.1 Tursiops truncatus 44 3e-66 251
WERAM-Lac-0125 ENSLACP00000014816.1 Latimeria chalumnae 43 1e-65 249
WERAM-Tub-0093 ENSTBEP00000010730.1 Tupaia belangeri 44 2e-64 245
WERAM-Pem-0097 ENSPMAP00000010124.1 Petromyzon marinus 43 3e-64 244
WERAM-Prc-0011 ENSPCAP00000000805.1 Procavia capensis 41 7e-64 243
WERAM-Ere-0005 ENSEEUP00000000200.1 Erinaceus europaeus 40 2e-62 238
WERAM-Miv-0040 MVLG_06132T0 Microbotryum violaceum 38 1e-56 219
Created Date 25-Jun-2016