WERAM Information

Tag Content
WERAM ID WERAM-Scp-0048
Ensembl Protein ID SPCC622.16c.1:pep
Uniprot Accession O94603; JHD1_SCHPO
Genbank Protein ID NP_588188.1
Protein Name Putative JmjC domain-containing histone demethylation protein 1
Genbank Nucleotide ID NM_001023178.2
Gene Name JHD1;Epe1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
SPCC622.16c SPCC622.16c.1 SPCC622.16c.1:pep
Details
Type Family Domain Substrates AA References (PMIDs)
HDM JHDM1 Jmjc H3K9; H3K36 K 16983801; 17449867
Status Reviewed
Classification
Type Family E-value Score Start End
HDM JHDM1 1.80e-72 240.5 243 520
Organism Schizosaccharomyces pombe
NCBI Taxa ID 284812
Functional Description
(View)		 May be a histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code (By similarity). Represses transcriptional silencing by negatively affecting heterochromatin stability.
Domain Profile
  HDM JHDM1
          JHDM1.txt   1 fsktkleelvkkpevvrqidlvdnvWpkalkekqtegtnaleemkyPkvqkyclmsvkncytdfhidfgGtsvyyhvlkGskvfwliPptek 92 
                        +s+tkl+++v+kp++vr++dlv++vWp        +g++al+e  yP+v++yclms++n+yt+fhi+fgG+s+yy++l+G+k+f+liP+t+k
  SPCC622.16c.1:pep 243 VSTTKLAYYVRKPNIVRDLDLVNTVWP--------PGSFALGE--YPHVDTYCLMSAENSYTEFHIEFGGSSAYYNILDGCKIFYLIPGTSK 324
                        699************************........9******9..*********************************************** PP
          JHDM1.txt  93 nlelyeewvlsgkqsd.iflgdrvekcqrvelkagdtlliPsGwihavytPvdslvfgGnflhslniktqlkiyeie 168
                        n+e+y++w++s+++sd +fl+++v+ c++ve+++++t+l+PsGwi+av+tP+d+++++Gnfl++l+i+ ql+iy++e
  SPCC622.16c.1:pep 325 NWEAYTAWLTSSNDSDkKFLPNMVDVCYCVEVHSQQTILVPSGWIYAVVTPCDTISIAGNFLTFLHIYPQLSIYNLE 401
                        ***************989*********************************************************98 PP
          JHDM1.txt   6 leelvkkpevvrqidlvdnvWpkalkekqtegtnaleemkyPkvqkyclmsv 57 
                        l++l  + +++r+ d++  ++ + +k ++++g n    m  P +++ c+  v
  SPCC622.16c.1:pep 469 LNYLYIRAQILRDCDIIIDIYNEPVKISKNNGYNSAYTMVPPDLDEICVDFV 520
                        5667778899******************************9*9999997655 PP
Protein Sequence
(Fasta)		MDSWLEYDDI INQDIDIPSN DLSGSGTLCV GVHSSLLENS LNSIDSFISS KEEISWCGNQ 60
STPIATKSHL SCINPQYVNP FDTSPVSVDT EFQDTYLLDA PSFAQPHFSE RQSVDKTRSR 120
CLSRNRRRKR HPNLHKNHQR LLGMSFPQDG FRRMPAESVN FSYFRDTGFN EPTIFPSSDT 180
QNTRQLNLSK IATLIGYDCP LALVDVVTQK QIPNKMDMES WVKYMSLEPS KRGRIYDVLS 240
LEVSTTKLAY YVRKPNIVRD LDLVNTVWPP GSFALGEYPH VDTYCLMSAE NSYTEFHIEF 300
GGSSAYYNIL DGCKIFYLIP GTSKNWEAYT AWLTSSNDSD KKFLPNMVDV CYCVEVHSQQ 360
TILVPSGWIY AVVTPCDTIS IAGNFLTFLH IYPQLSIYNL ELQLGIEKEY QYPYFESIMW 420
YTAIHFYLAF PDNSSRDGID DIIAEYETGR LFDINAFTEQ ELDGFEELLN YLYIRAQILR 480
DCDIIIDIYN EPVKISKNNG YNSAYTMVPP DLDEICVDFV QKFGAWITYH HRRSAKHPSC 540
NCFSHLQTKL IDSGPKPANN SYQHQSNFIG VVISTNHNII KKCQESQIQT GKNNCSFQLV 600
KKRIKSTKKA PSWRSIIKAF KKRENTRCNF LSSLHATTFR EDIVVRPKIK SFVLEQLIFQ 660
ALFSFAINWT PSFFLNHSNF ENIALSKETF NFGGEANCEN TDTTLFTTWG DQGFRPSDSI 720
CYNDFNLLET ANSDAEASIH ELELQPLNAV NEREVDISQT DMTPSTALDT RVDTRVDSLP 780
EFSNLILSPS SNDDSFQLDD LLSPSSSNLK QQIQKVVPQN SLEFSVGEKE KKAAEYSLLH 840
TFSYKRLSME NEKPDTTKVP LKYNIQHEEM KAYRRKNDLE YIDQHFASSK SGISNGRNNN 900
KEVNLTKAEN VGIKKRRIMK NENNIYDFED HSPVREKWGH RLRSRGAS 948
Nucleotide Sequence
(Fasta)		ACCAACATTT AATTACTATT CAAAAATTCT GGGTAGTTTG TAACTCAACT CTACGGAAGC 60
TTTAGAATTG GCTCATCTTT CCAAAGCTGC ACAATAGAAG TGCGCTTGTG CTAAATCGTA 120
TAAAAGAGAC ACGCAAGCTT ATGGAGTGGA CGTTTTGAAG TCTATGGATT ACTGCTTATT 180
TATAATTGAT ATTATTTCGT TTCTTGAACA AAGCTTCAGG TTGAATTAGA GGATCATCAT 240
TATTGTTGAC TGAGAGTTCG GTTTTATTGG CATTTTGAAG AAAAAGTTAG ACTCAAATCT 300
AACGAGTTTG CCTGCTTTTT TTTGGATACT TATCATTTCT GTTATTATAT GTAATGCTAT 360
ATTACTAGTC ACTAGCAGTT TTAAACTCAT TTTTTTTTTC AAAGAACACA GCCATAGAAT 420
CTCCTTAGTT TGCATCGCAA TTTTATAGTT ACCTTTTTGC TAGTAAGCAA TTAATTTTTG 480
GGACTTTTAA GATGGATTCC TGGCTTGAAT ACGATGACAT TATAAATCAA GACATTGATA 540
TTCCTAGCAA TGACCTGAGT GGTTCAGGCA CTCTCTGCGT TGGTGTACAC TCTTCCCTTT 600
TAGAAAACTC TTTAAACTCA ATAGACTCGT TTATTTCTTC GAAAGAGGAA ATTTCATGGT 660
GCGGAAACCA GTCAACTCCT ATTGCGACAA AATCACATTT ATCCTGCATA AACCCTCAAT 720
ACGTCAATCC TTTTGATACT TCACCTGTCT CGGTAGATAC AGAATTTCAG GATACATATT 780
TGCTTGATGC ACCTTCCTTT GCACAGCCTC ACTTCAGTGA GAGACAATCT GTAGACAAAA 840
CAAGATCACG ATGCCTTAGT CGTAATCGTC GTCGAAAAAG ACATCCCAAT CTTCATAAAA 900
ACCATCAAAG ATTACTTGGC ATGTCTTTTC CACAAGACGG CTTTCGTCGT ATGCCTGCCG 960
AAAGTGTAAA TTTTAGTTAT TTTAGGGATA CTGGATTTAA TGAACCCACA ATATTTCCTT 1020
CGTCTGATAC ACAAAATACG CGGCAACTAA ATCTGAGTAA AATCGCTACT TTAATTGGTT 1080
ATGATTGTCC GCTCGCCCTT GTGGATGTTG TGACACAAAA ACAAATTCCA AATAAAATGG 1140
ACATGGAAAG TTGGGTAAAG TACATGAGCC TCGAGCCCAG CAAACGTGGT CGAATATACG 1200
ACGTCTTGAG CTTAGAGGTT TCTACAACAA AACTTGCCTA TTACGTCCGG AAGCCTAACA 1260
TCGTTCGTGA TCTCGATTTG GTTAATACTG TCTGGCCTCC TGGTTCCTTT GCGTTGGGTG 1320
AGTATCCCCA TGTTGATACT TACTGCTTAA TGTCAGCGGA AAACTCGTAT ACTGAATTCC 1380
ATATTGAATT TGGTGGATCC TCAGCTTACT ACAATATTCT AGACGGATGT AAGATATTTT 1440
ACCTTATTCC AGGAACATCT AAGAATTGGG AAGCTTATAC AGCCTGGCTA ACATCTTCAA 1500
ATGACAGCGA CAAAAAGTTT CTACCCAATA TGGTTGATGT ATGCTACTGC GTCGAAGTTC 1560
ATTCGCAGCA AACAATTTTG GTTCCTTCAG GATGGATTTA TGCCGTTGTG ACACCTTGTG 1620
ATACAATTTC TATTGCTGGT AATTTCTTAA CGTTCCTTCA TATCTATCCC CAGTTGTCAA 1680
TCTACAATCT TGAGCTACAA TTGGGAATTG AAAAAGAGTA TCAGTATCCA TATTTCGAGA 1740
GCATAATGTG GTACACAGCT ATACATTTTT ACCTTGCGTT CCCAGATAAT TCGAGTCGTG 1800
ATGGAATTGA TGATATAATT GCTGAATATG AAACTGGTAG ATTGTTTGAT ATCAATGCGT 1860
TTACAGAACA AGAATTGGAT GGATTTGAAG AATTGCTTAA TTATCTTTAT ATTCGTGCGC 1920
AGATTTTACG AGATTGCGAT ATAATTATAG ACATTTATAA TGAACCCGTA AAAATATCAA 1980
AAAATAATGG CTATAACTCA GCATATACGA TGGTACCTCC GGATTTGGAT GAGATTTGTG 2040
TTGACTTTGT ACAAAAGTTT GGCGCCTGGA TTACTTACCA TCATAGACGT AGCGCTAAAC 2100
ACCCATCTTG CAATTGTTTT TCACACCTAC AAACGAAGCT TATAGATTCG GGGCCTAAAC 2160
CTGCAAATAA CTCTTATCAG CATCAGTCTA ATTTCATTGG CGTTGTGATT TCAACTAATC 2220
ATAATATCAT TAAGAAATGT CAAGAATCTC AAATACAAAC AGGAAAGAAT AATTGCTCTT 2280
TTCAGTTAGT AAAAAAGAGG ATTAAGAGTA CTAAAAAGGC ACCCAGCTGG CGCTCGATAA 2340
TTAAGGCTTT CAAGAAGCGA GAAAATACTA GGTGTAATTT TCTGTCAAGT TTACATGCAA 2400
CTACGTTTCG TGAGGACATT GTCGTTCGTC CTAAAATCAA GTCATTCGTT CTCGAACAGT 2460
TGATCTTTCA GGCGTTGTTT TCATTTGCTA TCAATTGGAC ACCAAGCTTC TTTTTGAATC 2520
ACTCCAATTT TGAGAATATT GCGTTGAGTA AAGAAACGTT TAACTTTGGA GGTGAAGCCA 2580
ATTGCGAAAA TACGGACACC ACATTATTTA CTACTTGGGG CGATCAAGGT TTTAGACCAA 2640
GTGATTCTAT TTGCTATAAC GACTTTAATT TATTGGAAAC GGCGAATTCT GATGCTGAAG 2700
CTTCAATACA TGAACTCGAA CTTCAACCGC TGAATGCAGT GAATGAAAGA GAGGTTGATA 2760
TATCGCAAAC CGACATGACT CCATCCACGG CGTTAGACAC TAGGGTAGAC ACTAGGGTAG 2820
ACTCTTTACC AGAATTTTCA AACTTGATAC TTTCGCCCTC AAGCAATGAC GACAGTTTTC 2880
AACTTGACGA CTTGTTGTCC CCCTCTTCAT CAAATCTCAA ACAACAGATT CAAAAAGTCG 2940
TTCCTCAAAA TTCCCTAGAA TTTTCTGTTG GTGAGAAAGA AAAAAAGGCA GCCGAATATA 3000
GCCTGCTTCA TACGTTTTCT TACAAACGAC TCTCTATGGA AAATGAGAAA CCAGATACTA 3060
CAAAGGTACC TTTAAAATAT AACATACAAC ATGAAGAAAT GAAAGCGTAT CGAAGAAAAA 3120
ATGATTTAGA ATATATAGAT CAGCACTTTG CAAGCTCTAA GAGTGGAATT TCGAATGGGA 3180
GGAATAATAA TAAAGAGGTC AACTTAACAA AAGCTGAAAA TGTCGGCATC AAAAAACGTC 3240
GAATCATGAA AAATGAAAAT AACATTTATG ATTTTGAAGA TCACTCTCCT GTTAGGGAAA 3300
AATGGGGGCA CAGGCTTCGG TCCAGAGGTG CTAGTTAAAG TACCTCGGCA CTTTTTATTT 3360
CCTTCGGCTA CCATTGAATA TTTATCCCCA CGTGCTTATG ATTCTTGAGT AGTTCACATT 3420
TTATGAGTAT ATCATGAAGG TTTCATCAAA TAATTAAGAC TCTTTTTTTT TCTATTAATT 3480
GGGTTTTTAT TTATAAAACG ATTAAGAGCA TCAATCCACT TTGACTCGTT GTTTGCTTTT 3540
AAACTACGAT CGTCCTAAAA TGATTTATGG ACTACATAAC ACACAATGGA GTCATTGAAA 3600
GCGTGGACAT CCCCATGAAG CGGCGCAGGG ACACTCAACC TGAACGGATT GTATCAAAGC 3660
CGGATACTAC AACACACTTT TTAATATGAA TGTCTCCTAT TGGCGTCGTC TCGTCTACTT 3720
TATCCATCTC AGCTGATGCA ACGACGCTTC AGGGTTTTCC ATCCAAATCC CAATTTACCA 3780
GCCTTACTTT TTTATAATGT GCTAATATTG TTGAATTGTG CTCAAATATG TACATATACT 3840
ACCCGATATA ATGATTCTAT AAATACTCTT TTTCTGTTTT TTTTTTTGGA ACTCATATAA 3900
ATAAATAATC CGGCGATCTA ACTACAAGCC ACGTTTCTAT TAATCTAATC GGTCGTTTCA 3960
TCTTTGAATA TTATTTAATT AATTTATTT
Sequence Source Ensembl
Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0408--Iron
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
--
Interpro

IPR003347--JmjC_dom
PROSITE

PS51184--JMJC
Pfam

PF02373--JmjC
Gene Ontology

GO:0034507--C:chromosome, centromeric outer repeat region
GO:0044732--C:mitotic spindle pole body
GO:0005720--C:nuclear heterochromatin
GO:0005634--C:nucleus
GO:0051864--F:histone demethylase activity (H3-K36 specific)
GO:0046872--F:metal ion binding
GO:0006338--P:chromatin remodeling
GO:1990141--P:chromatin silencing at centromere outer repeat region
GO:0070544--P:histone H3-K36 demethylation
GO:0033696--P:negative regulation of extent of heterochromatin assembly
GO:0001672--P:regulation of chromatin assembly or disassembly
GO:0090052--P:regulation of chromatin silencing at centromere
GO:0090054--P:regulation of chromatin silencing at silent mating-type cassette
GO:0031454--P:regulation of extent of heterochromatin assembly
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Asfu-0014 CADAFUAP00003457 Aspergillus fumigatus 32 1e-55 215
WERAM-Asni-0008 CADANGAP00002884 Aspergillus niger 33 6e-54 210
WERAM-Phn-0032 SNOT_15868 Phaeosphaeria nodorum 30 1e-51 202
WERAM-Asm-0097 ENSAMXP00000010134.1 Astyanax mexicanus 34 1e-51 202
WERAM-Asn-0004 CADANIAP00000548 Aspergillus nidulans 32 1e-51 202
WERAM-Miv-0040 MVLG_06132T0 Microbotryum violaceum 32 2e-51 202
WERAM-Orn-0055 ENSONIP00000006472.1 Oreochromis niloticus 35 7e-51 200
WERAM-Anc-0010 ENSACAP00000001822.2 Anolis carolinensis 32 7e-51 200
WERAM-Lem-0005 CBY01870 Leptosphaeria maculans 34 3e-50 197
WERAM-Drm-0062 FBpp0289915 Drosophila melanogaster 32 4e-50 197
WERAM-Dar-0126 ENSDARP00000121246.1 Danio rerio 34 1e-49 196
WERAM-Orla-0116 ENSORLP00000013894.1 Oryzias latipes 35 1e-49 196
WERAM-Tar-0061 ENSTRUP00000012810.1 Takifugu rubripes 35 2e-49 195
WERAM-Ict-0172 ENSSTOP00000017598.1 Ictidomys tridecemlineatus 36 3e-49 194
WERAM-Fec-0097 ENSFCAP00000008359.3 Felis catus 36 3e-49 194
WERAM-Caf-0027 ENSCAFP00000003277.3 Canis familiaris 32 4e-49 194
WERAM-Eqc-0141 ENSECAP00000016047.1 Equus caballus 35 5e-49 194
WERAM-Myl-0001 ENSMLUP00000000097.2 Myotis lucifugus 36 5e-49 193
WERAM-Sah-0164 ENSSHAP00000017245.1 Sarcophilus harrisii 32 6e-49 193
WERAM-Mum-0151 ENSMUSP00000047308.7 Mus musculus 36 6e-49 193
WERAM-Aim-0078 ENSAMEP00000007124.1 Ailuropoda melanoleuca 36 8e-49 193
WERAM-Tag-0055 ENSTGUP00000003831.1 Taeniopygia guttata 32 8e-49 193
WERAM-Ptv-0154 ENSPVAP00000012790.1 Pteropus vampyrus 36 1e-48 192
WERAM-Pof-0114 ENSPFOP00000009916.2 Poecilia formosa 33 1e-48 192
WERAM-Caj-0183 ENSCJAP00000032032.2 Callithrix jacchus 36 1e-48 192
WERAM-Mup-0050 ENSMPUP00000004383.1 Mustela putorius furo 32 1e-48 192
WERAM-Sus-0058 ENSSSCP00000008629.2 Sus scrofa 35 2e-48 192
WERAM-Gam-0153 ENSGMOP00000015244.1 Gadus morhua 35 2e-48 192
WERAM-Mam-0065 ENSMMUP00000010859.2 Macaca mulatta 36 2e-48 192
WERAM-Xim-0117 ENSXMAP00000009995.1 Xiphophorus maculatus 33 2e-48 192
WERAM-Poa-0184 ENSPPYP00000021733.2 Pongo abelii 36 2e-48 192
WERAM-Xet-0105 ENSXETP00000034422.2 Xenopus tropicalis 35 2e-48 191
WERAM-Gog-0045 ENSGGOP00000004337.2 Gorilla gorilla 36 2e-48 191
WERAM-Hos-0232 ENSP00000352185.4 Homo sapiens 36 2e-48 191
WERAM-Orc-0117 ENSOCUP00000009920.2 Oryctolagus cuniculus 35 3e-48 191
WERAM-Pes-0029 ENSPSIP00000005255.1 Pelodiscus sinensis 34 3e-48 191
WERAM-Gaa-0187 ENSGACP00000023440.1 Gasterosteus aculeatus 33 3e-48 191
WERAM-Prc-0075 ENSPCAP00000006754.1 Procavia capensis 35 4e-48 191
WERAM-Yal-0025 CAG80193 Yarrowia lipolytica 34 4e-48 191
WERAM-Anp-0115 ENSAPLP00000013232.1 Anas platyrhynchos 35 4e-48 191
WERAM-Pat-0177 ENSPTRP00000036115.5 Pan troglodytes 36 4e-48 191
WERAM-Fia-0091 ENSFALP00000007322.1 Ficedula albicollis 32 5e-48 190
WERAM-Mod-0060 ENSMODP00000009649.3 Monodelphis domestica 34 6e-48 190
WERAM-Mae-0004 ENSMEUP00000000188.1 Macropus eugenii 37 7e-48 190
WERAM-Loa-0083 ENSLAFP00000006561.3 Loxodonta africana 36 8e-48 189
WERAM-Pyt-0030 EFQ88214 Pyrenophora teres 36 8e-48 189
WERAM-Otg-0187 ENSOGAP00000018216.1 Otolemur garnettii 35 9e-48 189
WERAM-Gaga-0056 ENSGALP00000008273.4 Gallus gallus 32 1e-47 189
WERAM-Paa-0079 ENSPANP00000000080.1 Papio anubis 34 1e-47 189
WERAM-Lac-0161 ENSLACP00000019069.1 Latimeria chalumnae 37 1e-47 189
WERAM-Chs-0099 ENSCSAP00000004730.1 Chlorocebus sabaeus 34 1e-47 189
WERAM-Ova-0096 ENSOARP00000010105.1 Ovis aries 35 1e-47 189
WERAM-Nol-0063 ENSNLEP00000007667.1 Nomascus leucogenys 34 1e-47 189
WERAM-Dan-0017 ENSDNOP00000001589.3 Dasypus novemcinctus 34 1e-47 189
WERAM-Ocp-0120 ENSOPRP00000012395.2 Ochotona princeps 34 1e-47 189
WERAM-Tut-0051 ENSTTRP00000004269.1 Tursiops truncatus 35 2e-47 189
WERAM-Meg-0060 ENSMGAP00000005425.2 Meleagris gallopavo 35 2e-47 188
WERAM-Ect-0067 ENSETEP00000007585.1 Echinops telfairi 34 3e-47 187
WERAM-Cap-0086 ENSCPOP00000006433.2 Cavia porcellus 35 4e-47 187
WERAM-Dio-0118 ENSDORP00000011537.1 Dipodomys ordii 36 4e-47 187
WERAM-Ran-0123 ENSRNOP00000051732.2 Rattus norvegicus 34 4e-47 187
WERAM-Pytr-0008 EDU41456 Pyrenophora triticirepentis 35 4e-47 187
WERAM-Soa-0095 ENSSARP00000008902.1 Sorex araneus 42 7e-47 186
WERAM-Bot-0124 ENSBTAP00000017673.4 Bos taurus 41 9e-47 186
WERAM-Tas-0113 ENSTSYP00000011554.1 Tarsius syrichta 41 1e-46 186
WERAM-Leo-0042 ENSLOCP00000006157.1 Lepisosteus oculatus 35 2e-46 185
WERAM-Ten-0161 ENSTNIP00000016121.1 Tetraodon nigroviridis 34 3e-46 184
WERAM-Pem-0097 ENSPMAP00000010124.1 Petromyzon marinus 35 5e-46 184
WERAM-Ora-0007 ENSOANP00000001114.1 Ornithorhynchus anatinus 36 6e-46 183
WERAM-Tub-0093 ENSTBEP00000010730.1 Tupaia belangeri 41 2e-45 181
WERAM-Ere-0005 ENSEEUP00000000200.1 Erinaceus europaeus 36 2e-44 178
WERAM-Vip-0043 ENSVPAP00000003846.1 Vicugna pacos 36 7e-44 176
WERAM-Mim-0139 ENSMICP00000014201.1 Microcebus murinus 33 8e-44 176
Created Date 25-Jun-2016