WERAM Information

Tag Content
WERAM ID WERAM-Scp-0020
Ensembl Protein ID SPAC664.01c.1:pep
Uniprot Accession P40381; SWI6_SCHPO
Genbank Protein ID NP_593449.1
Protein Name Chromatin-associated protein swi6
Genbank Nucleotide ID NM_001018882.2
Gene Name Swi6,SPAC664.01c,SPAC824.10c
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
SPAC664.01c SPAC664.01c.1 SPAC664.01c.1:pep
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader DCD Chromo1 H3K9me3 K 22683269
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader DCD 1.50e-28 85.7 82 135
Organism Schizosaccharomyces pombe
NCBI Taxa ID 284812
Functional Description
(View)		 Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Involved in the repression of the silent mating-type loci MAT2 and MAT3. May compact MAT2/3 into a heterochromatin-like conformation which represses the transcription of these silent cassettes.
Domain Profile
  Me_Reader DCD
       Chromo-2.txt   2 mverIinhsv.dkkGelhyLikWkdlpYdeas...wesatvenkkypqlvqsfyeer 54 
                        +ve+++ h    k G  +yL+kW +  Yd  s   w s++ +   + ql++++++e+
  SPAC664.01c.1:pep  82 VVEKVLKHRMaRKGGGYEYLLKWEG--YDDPSdntW-SSEADCSGCKQLIEAYWNEH 135
                        68*******9889999*********..897652315.55667889**********98 PP
       Chromo-2.txt   2 mverIinhsv....dkkGelhyLikWkdlpYdeaswesatvenkkypqlvqsfyeeresmrgee 61 
                        ++e+++++++    +++G+l+++++Wk+   +++s++++t++nkk+pq++ +fye+++++r++e
  SPAC664.01c.1:pep 268 SWEDLVSSIDtierKDDGTLEIYLTWKN---GAISHHPSTITNKKCPQKMLQFYESHLTFRENE 328
                        89**************************...9*****************************987 PP
Protein Sequence
(Fasta)		MKKGGVRSYR RSSTSKRSVI DDDSEPELPS MTKEAIASHK ADSGSSDNEV ESDHESKSSS 60
KKLKENAKEE EGGEEEEEDE YVVEKVLKHR MARKGGGYEY LLKWEGYDDP SDNTWSSEAD 120
CSGCKQLIEA YWNEHGGRPE PSKRKRTARP KKPEAKEPSP KSRKTDEDKH DKDSNEKIED 180
VNEKTIKFAD KSQEEFNENG PPSGQPNGHI ESDNESKSPS QKESNESEDI QIAETPSNVT 240
PKKKPSPEVP KLPDNRELTV KQVENYDSWE DLVSSIDTIE RKDDGTLEIY LTWKNGAISH 300
HPSTITNKKC PQKMLQFYES HLTFRENE 328
Nucleotide Sequence
(Fasta)		GCGAAATTGA TGTTTAGTAC TTTTTAAAAT ATTCTGAAAT CTCGTTTATT TTCATATTAA 60
GACAAGTGAA AAATGAAGAA AGGAGGTGTT CGATCTTATC GGCGCTCCTC TACTTCAAAA 120
CGATCAGTTA TTGACGACGA TTCGGAACCA GAGTTACCAA GCATGACAAA GGAGGCTATT 180
GCTTCTCATA AAGCAGACTC TGGGTCGTCG GACAATGAAG TTGAAAGCGA TCATGAAAGT 240
AAATCTTCGT CGAAGAAATT GAAAGAAAAT GCCAAAGAAG AAGAAGGAGG AGAAGAAGAA 300
GAAGAGGATG AATATGTTGT AGAAAAGGTT TTAAAACACC GTATGGCGAG AAAAGGTGGA 360
GGCTATGAAT ACCTTTTGAA ATGGGAAGGT TATGACGATC CCAGTGATAA TACATGGAGT 420
TCAGAAGCCG ATTGTAGCGG TTGCAAACAG TTGATAGAAG CATATTGGAA TGAACATGGA 480
GGAAGACCAG AACCTTCTAA AAGAAAGAGG ACTGCAAGAC CTAAAAAGCC CGAAGCAAAG 540
GAGCCTTCAC CAAAGTCTCG TAAAACTGAT GAAGATAAAC ACGACAAAGA TTCCAATGAA 600
AAGATTGAAG ATGTGAATGA GAAAACTATT AAATTCGCCG ATAAATCGCA AGAGGAATTT 660
AATGAGAACG GCCCACCTTC TGGTCAGCCG AATGGTCACA TTGAATCTGA CAATGAGTCT 720
AAATCTCCTT CACAAAAAGA ATCGAATGAA AGTGAGGATA TTCAAATAGC AGAGACCCCT 780
AGCAATGTTA CTCCGAAAAA GAAGCCTAGT CCGGAAGTTC CCAAACTTCC GGACAACAGA 840
GAGCTGACGG TTAAACAAGT AGAAAACTAT GATTCTTGGG AAGACTTGGT ATCTAGCATC 900
GATACAATTG AACGAAAAGA TGATGGAACC TTGGAAATTT ATCTGACTTG GAAGAACGGT 960
GCAATATCTC ATCATCCTAG TACTATCACC AATAAAAAAT GTCCTCAGAA GATGCTTCAA 1020
TTTTATGAAA GCCACTTAAC GTTCCGTGAA AATGAATAAT TTTTTTGTGT TCCTTTAAAA 1080
AATTCTTTTT CTTTTGTTTA TAAATTAGAT TTCGCTTTTT TCTGACGTTA TTGCTTTTAT 1140
CAAGTCCCGT GTCGTAGTAT GAGTTCTTGT TCTCTTACTC GAAAAATGCA TCTAACATTA 1200
TACTTATACA AATTTTTGTT AGGCGCTTAA CATCACATTC TAGTTTATGA ACGCCTTTGT 1260
TTTCTTTCAC ATTGAATTGA TTACGAGTGA CTTGAGAAAT GTAAAATACC TTTTGTCGTT 1320
ATGGTTTGAC ATTCTAAATA ACCTAAGGTT TGACATTCTA GATAACCTAA TTTCTTTAAT 1380
TTTACCATTT ATTAATTTAG CATGCACTGC TCTTCATGCA TTCAAAATCG TGTCTAATAA 1440
TAACGTAATT TTACTCGTTA AATAAAGAAT TTATGCATGC AAAATCGTTA CTCATAAACC 1500
TCAGCAGATA AATTTGTTAA CAAAAATGAG GGTGCATGAA TATCTGCCTT CTCCGTTTCT 1560
TCTGTTCCAT ATGCTTCTAA GTTTGGGTTA CCAACTGAAC TCAAAGATAG GGTCAAGATG 1620
TAGTGTATCA AGTTTGAATC TTTATCAAGT ACTATGTTGC CTCTTGAG 1669
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
--
Interpro

IPR000953--Chromo/shadow_dom
IPR023780--Chromo_domain
IPR008251--Chromo_shadow_dom
IPR016197--Chromodomain-like
IPR023779--Chromodomain_CS
PROSITE

PS00598--CHROMO_1
PS50013--CHROMO_2
Pfam

PF00385--Chromo
PF01393--Chromo_shadow
Gene Ontology

GO:0034507--C:chromosome, centromeric outer repeat region
GO:0000781--C:chromosome, telomeric region
GO:0000780--C:condensed nuclear chromosome, centromeric region
GO:0031934--C:mating-type region heterochromatin
GO:0044732--C:mitotic spindle pole body
GO:0000790--C:nuclear chromatin
GO:0005720--C:nuclear heterochromatin
GO:0031618--C:nuclear pericentric heterochromatin
GO:1990707--C:nuclear subtelomeric heterochromatin
GO:0005634--C:nucleus
GO:0005721--C:pericentric heterochromatin
GO:0035064--F:methylated histone binding
GO:0031492--F:nucleosomal DNA binding
GO:0031493--F:nucleosomal histone binding
GO:0003723--F:RNA binding
GO:0034613--P:cellular protein localization
GO:0006325--P:chromatin organization
GO:0006338--P:chromatin remodeling
GO:0030702--P:chromatin silencing at centromere
GO:1990141--P:chromatin silencing at centromere outer repeat region
GO:0030466--P:chromatin silencing at silent mating-type cassette
GO:0006348--P:chromatin silencing at telomere
GO:0072356--P:chromosome passenger complex localization to kinetochore
GO:0007535--P:donor selection
GO:0007534--P:gene conversion at mating-type locus
GO:0007533--P:mating type switching
GO:0007064--P:mitotic sister chromatid cohesion
GO:0000070--P:mitotic sister chromatid segregation
GO:0071459--P:protein localization to chromosome, centromeric region
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Scj-0011 EEB06559 Schizosaccharomyces japonicus 73 3e-32 136
Created Date 25-Jun-2016