WERAM Information

Tag Content
WERAM ID WERAM-Scp-0007
Ensembl Protein ID SPAC17G8.13c.1:pep
Uniprot Accession Q10325; MST2_SCHPO
Genbank Protein ID NP_593736.1
Protein Name Histone acetyltransferase mst2
Genbank Nucleotide ID NM_001019167.2
Gene Name MST2;SPAC17G8.13c
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
SPAC17G8.13c SPAC17G8.13c.1 SPAC17G8.13c.1:pep
Details
Type Family Domain Substrates AA References (PMIDs)
HAT MYST MYST-type HAT H3K14 K 26223950
Status Reviewed
Classification
Type Family E-value Score Start End
HAT MYST 7.50e-117 387.5 101 372
Organism Schizosaccharomyces pombe
NCBI Taxa ID 284812
Functional Description
(View)		 Component of the mst2 complex which is a highly specific H3 lysine 14 (H3K14) acetyltransferase that functions together with gcn5 to regulate global levels of H3K14 acetylation (H3K14ac), critical for DNA damage checkpoint activation. Negatively regulates telomere silencing. Telomere silencing is increased due to histone hypoacetylation and/or an increase in the ratio of methylated histones to acetylated histones. Telomeric histone acetylation contributes to normal meiotic progression.
Domain Profile
  HAT MYST
            MYST.txt   4 kniekielgkyeiktwysspfpeelkklkklyicefclkytkskeslkrhlkkCklrkpPgneiyrkdklsvfevdGkkqklycqnlClla 94 
                         ++i+++ +g+y+ik+wy+sp+pee++ +k+lyice clky++s++ l+rh  kC++++pPg+eiyr++++s+fevdG++q +ycqnlClla
  SPAC17G8.13c.1:pep 101 TSIRYLYFGTYRIKPWYTSPYPEEYSCAKNLYICESCLKYMNSDHVLQRHKMKCSWSYPPGDEIYRDKNISIFEVDGQRQPIYCQNLCLLA 191
                         67999************************************************************************************** PP
            MYST.txt  95 klfldhktlyydvepflFYvltetdekgahlvGyFskekesaekynlaCilvlPpyqrkGyGklLiefsYelsrkegkigsPekPLsdlgl 185
                         k+fl++k+lyydvepflFYvlte d ++++++GyFskek+sa++yn++Cil+lP+yqr+GyG +Li+fsY+l+++egk+gsPekPLsdlgl
  SPAC17G8.13c.1:pep 192 KMFLHSKMLYYDVEPFLFYVLTEFDGQECKVIGYFSKEKRSASDYNVSCILTLPIYQRRGYGVFLIDFSYLLTQVEGKLGSPEKPLSDLGL 282
                         ******************************************************************************************* PP
            MYST.txt 186 lsYrsyWkevllellkekeekkkitikelskatgiaveDivstleslnlike..kkgqyil.lksekiveellklakskkkklkvdeeklk 273
                         ++YrsyWk++++++l   e ++ i+i++++k+t++ ++D++stlesl+++k+   k++y+l lk++++++ +  +a++ k+ ++v+++ l+
  SPAC17G8.13c.1:pep 283 VTYRSYWKMRVAKAL--LEITTPISINAIAKSTSMVCDDVISTLESLSVFKYdpLKKKYVLqLKRDELENVY--KAWNIKHPQRVNPKLLR 369
                         ***************..9999*****************************9954578999966666777776..778899*********** PP
            MYST.txt 274 wkp 276
                         w+p
  SPAC17G8.13c.1:pep 370 WTP 372
                         *97 PP
Protein Sequence
(Fasta)		MPATILKSTA SSKTLLIIKF DTNSSRYPFY KKHLLELNSE STFLGLLTKG QADTSITRLN 60
QDDVRLFEKA KTVADRTKDV AYSFSDPILS TQLRTPPPQP TSIRYLYFGT YRIKPWYTSP 120
YPEEYSCAKN LYICESCLKY MNSDHVLQRH KMKCSWSYPP GDEIYRDKNI SIFEVDGQRQ 180
PIYCQNLCLL AKMFLHSKML YYDVEPFLFY VLTEFDGQEC KVIGYFSKEK RSASDYNVSC 240
ILTLPIYQRR GYGVFLIDFS YLLTQVEGKL GSPEKPLSDL GLVTYRSYWK MRVAKALLEI 300
TTPISINAIA KSTSMVCDDV ISTLESLSVF KYDPLKKKYV LQLKRDELEN VYKAWNIKHP 360
QRVNPKLLRW TPYLGEEQIS NLLLKENILI PLPQKRLLDN SHHLDSV 407
Nucleotide Sequence
(Fasta)		GTTTGTAATG GCATTCAATC AAAAAGCTAA CAGTGAAGTT ATGAATGGTT ACTGTTTCAG 60
AATACAAAAG TAAAAAATAT GAGTAGTTTT TTATTTAACA AGAGTGAAAG GGTTATCTTT 120
GCAGAGATCG GATGGAGGTG GAAGTAAAGC AAGAACTAAG AAGAGAATGA GGGCACTACC 180
ACCAACTCAA TTATATTGAC CAAAGGATTA AATGGGGCCA TTAGGAAAAC TATGAACGAT 240
CTGTAAATAT AAACAATCTT TTTTTTTTAT GTATAATGCC GGCGACTATT TTGAAATCCA 300
CAGCCAGTTC AAAGACTTTG TTAATAATAA AGTTTGATAC AAACTCCTCC AGATATCCAT 360
TTTATAAGAA ACATTTATTA GAGTTAAATT CGGAAAGTAC TTTTTTGGGT CTATTAACTA 420
AAGGGCAAGC TGACACATCG ATTACGAGAC TCAACCAAGA CGATGTGAGG CTGTTTGAAA 480
AAGCAAAGAC AGTAGCAGAT AGGACAAAGG ATGTGGCTTA TTCATTTTCC GATCCTATTT 540
TATCTACACA GTTGCGAACG CCTCCACCAC AACCAACCTC CATTCGATAC CTCTATTTTG 600
GTACTTACCG GATAAAACCA TGGTATACAT CACCGTATCC AGAGGAGTAT AGCTGTGCAA 660
AAAATTTATA TATATGCGAA TCTTGTTTAA AGTATATGAA CAGTGATCAT GTACTACAAA 720
GGCACAAGAT GAAATGCTCA TGGAGTTATC CACCAGGAGA TGAAATATAT CGGGATAAGA 780
ATATATCAAT TTTTGAAGTT GATGGTCAAC GGCAACCGAT ATATTGTCAA AATTTATGTC 840
TTCTAGCAAA GATGTTTCTT CATTCAAAAA TGCTGTACTA TGACGTTGAA CCGTTTCTTT 900
TCTATGTATT GACTGAATTT GATGGCCAAG AATGCAAAGT TATTGGATAT TTCAGTAAAG 960
AGAAACGCTC GGCTTCTGAT TATAACGTTT CCTGTATATT AACATTACCC ATTTACCAAC 1020
GCCGAGGATA TGGTGTCTTT TTGATTGATT TTAGTTATTT ACTTACACAG GTAGAAGGTA 1080
AGCTTGGATC ACCTGAAAAG CCACTTTCAG ATTTAGGCCT CGTTACGTAC CGAAGCTATT 1140
GGAAAATGAG AGTAGCCAAA GCTCTATTGG AAATCACAAC ACCGATTAGC ATAAATGCTA 1200
TCGCCAAATC AACATCTATG GTATGCGACG ATGTTATATC CACATTGGAA TCGTTATCTG 1260
TATTTAAGTA TGATCCGCTC AAAAAGAAAT ATGTATTACA ACTGAAACGG GATGAACTTG 1320
AGAATGTTTA TAAAGCTTGG AATATCAAAC ACCCTCAAAG AGTAAATCCA AAACTTCTAA 1380
GATGGACGCC ATATCTCGGA GAAGAGCAGA TATCTAACCT TTTACTTAAA GAAAATATAC 1440
TTATTCCTCT ACCTCAAAAG CGTCTATTAG ATAACTCTCA TCATCTGGAT TCCGTTTAGT 1500
TCAAATAAAT AAGTATTTTA ATCTTTCGAT ATTTGTCGTG AAGCATTTGT ATCATCTACG 1560
GCTTGGTTGT TGCTCTATAT TAATGACGCC ATTTAATGCA GTAGACAACT CTAGGGAAAA 1620
TAAGTTGATG GTTGAATTGA TAGACTCACA ACCTAAAGCA CAATCTTGAA GTTGGCTCTT 1680
AATGTTTTGC AATTCGATTT CTTCTTCAGC AAGGTTTTCC ACACTGCTTA TGATAGCTCC 1740
ATCAAACGAA AATTCTGTTT GTTTCAATAC ATCTTTTATA GTTGTACCTT CATTCCACTT 1800
CAAAGTGGAA AGACGAGAAA TGCTTTGCTC CGGAATGTTT TTGAGGTTGA TTTTTGAGTT 1860
AAGATCGTAA ACTTTTTCAA CAGAAGCTTG GTGCGGTTTA GTCGGAATGG AAGTAACAAG 1920
AGTTTTCTTG GCTTTTGGCT TGGAAGTGGT TTTTCTATTT TCAAAGCGCA AACTTTCAAA 1980
AAGGGGAAGA AGTTCATTTC CTATAGAAGG CTCGTCGTTT GGTGGTTCGA TTTGTTTACC 2040
AGTCGAAGGA GTTGCCCGAA CAGTTGGCTG ACGGGACGGG TGCTTTGGAG GTAATTTAGG 2100
AATAGCCGGT GCTCCTGTTG GTTTTCGAGA AACAGACTTT GCTGATACTT TAGACGAACT 2160
GGAAGGCTTG TAAGATGACG TTAATACTGA AGGAGTTTCT AAGCTAGAAG ATAAAGCTGC 2220
CTGGGTAGCA TCACGATCCA CTTTACTAAA ATCGCTAGCA AATGTGTTTG ACTCCAAAGA 2280
AGAGCTTAGT TTCACGTCTT TTTGAGACAT ATTATACTTA CCAGCTTCTA GTGCCAAAGC 2340
TGTATTTTTC TCGTAAGAAC CACTGATGCT ATTCTTACCC CTTTCCGAAG AACTCGTTCC 2400
ACTGTTAAAT GAGGGTGCTT GTTCACGACG AGTAGTTTTA CGTAAAGAAG GTTTAGATGG 2460
AAACAATTGA GCTTGTTCTT GAATAAACAT TTCCCGTGTT TGATTATCTC GTCTTTGAGT 2520
TGAAGTATCG AATAAGACAT CATCTTTTCG GTCTCCTGAA GTCCTTGCAA TGGCAGAAGA 2580
ACTTGAAATT TCTATAACAT CACTATGGGC AGATGATGGG GTCCCCCGGG AAACGTTGGA 2640
AGAAGGCTTA TTGTCAGAAA ACCGTCTTTC TTTTTCAACA CTCAACTTCT TTTTGGCTGA 2700
TCGAGAAGAA TCAATAGTGA GCTTCTTCTC GATGCGAGGC TGATCCGTTT CTAAATTGGT 2760
AACAATTGGG CCGTCCGAAA AATTACGGTT ATGTGCGACT CGAGAGTTAA AAGATGAGGA 2820
AACTTGTTCT GAAGAATTTT CAGGTAATGA TGACCTTGCT TTAGGAATAG CTAGGCTCTT 2880
TGCAGGATAG AGATTAGGTT TGTTATCAGC AAAGGAATTA CGATAGGCCC AGTCCACTTT 2940
GCGGCCATCA GTCGTAGTCA CTGAAAGCGG CCTGCCCATA TAGTACATAT AATTTTTAGC 3000
AACAGAAAAA ACAAATCGAT CGCGAGCAGA AGTGTCCTGA GTTCGCAACA AATGTGGCTT 3060
GTTTATTGTC ATAGTAACAT CATGATCATT AATTACAGTA ATATTCTGCA ACTCAAATAA 3120
AGGCCAGGAT TTCACGACTG TCATTCCGCC TTTATCATTT ACTTTCAATC TGTGTATATA 3180
AAAAATACGA GTCACATCAT CACAAGTCAA AGCAATGTAG CGGGGTTTCA TCTTTGAGCC 3240
AACAACATTA ACTCCTCTTT CTTCCTCCAC CGGAAGATAT GCTAATGATT GCTCATGAGC 3300
TTTCCGTTTA TCGGTAGTTT GAGCCGAATT GACAGCTTGT AGAATTTCTT GTTCAACGGC 3360
ATTAGGGTTA GAAGCCATTC GTCTGAAGTG GTGTATTAAA TGAAAAAAAT TGGGTTAAAT 3420
AGATAAATAT TAACAAAAAA AAAACCA 3448
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR016181--Acyl_CoA_acyltransferase
IPR002717--HAT_MYST-type
PROSITE

PS51726--MYST_HAT
Pfam

PF01853--MOZ_SAS
Gene Ontology

GO:0034507--C:chromosome, centromeric outer repeat region
GO:0005829--C:cytosol
GO:0036410--C:Mst2 histone acetyltransferase complex
GO:0000790--C:nuclear chromatin
GO:0005634--C:nucleus
GO:0036408--F:histone acetyltransferase activity (H3-K14 specific)
GO:0046872--F:metal ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:1902368--P:heterochromatin maintenance involved in chromatin silencing at centromere outer repeat region
GO:0044154--P:histone H3-K14 acetylation
GO:0016570--P:histone modification
GO:0031939--P:negative regulation of chromatin silencing at telomere
GO:0033696--P:negative regulation of extent of heterochromatin assembly
GO:0051445--P:regulation of meiotic cell cycle
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Scj-0015 EEB07085 Schizosaccharomyces japonicus 56 4e-127 451
WERAM-Asn-0016 CADANIAP00003430 Aspergillus nidulans 53 3e-105 379
WERAM-Aso-0012 CADAORAP00001649 Aspergillus oryzae 52 4e-105 379
WERAM-Ast-0034 CADATEAP00009194 Aspergillus terreus 53 4e-105 379
WERAM-Asf-0007 CADAFLAP00002066 Aspergillus flavus 54 2e-104 376
WERAM-Asfu-0035 CADAFUAP00007935 Aspergillus fumigatus 53 1e-103 374
WERAM-Asni-0011 CADANGAP00004195 Aspergillus niger 53 1e-103 373
WERAM-Asc-0022 CADACLAP00004828 Aspergillus clavatus 53 4e-103 372
WERAM-Coi-0010 EAS36170 Coccidioides immitis 53 2e-101 367
WERAM-Phn-0016 SNOT_06350 Phaeosphaeria nodorum 51 6e-98 355
WERAM-Pyt-0005 EFQ95284 Pyrenophora teres 52 4e-96 348
WERAM-Pytr-0011 EDU44990 Pyrenophora triticirepentis 52 7e-96 348
WERAM-Nec-0023 EFNCRP00000004537 Neurospora crassa 49 2e-95 346
WERAM-Scs-0002 EDN90912 Sclerotinia sclerotiorum 50 2e-94 343
WERAM-Trr-0025 EGR44494 Trichoderma reesei 45 3e-94 343
WERAM-Lem-0040 CBX94397 Leptosphaeria maculans 50 3e-94 342
WERAM-Chg-0038 EAQ84933 Chaetomium globosum 49 8e-94 341
WERAM-Trv-0006 EHK23684 Trichoderma virens 45 9e-94 341
WERAM-Map-0029 MAPG_08226T0 Magnaporthe poae 45 4e-92 335
WERAM-Mao-0013 MGG_04615T0 Magnaporthe oryzae 47 7e-92 335
WERAM-Fuo-0016 FOXG_03280P0 Fusarium oxysporum 46 7e-91 331
WERAM-Gag-0004 GGTG_01203T0 Gaeumannomyces graminis 45 1e-90 331
WERAM-Ved-0029 EGY16299 Verticillium dahliae 46 1e-89 327
WERAM-Tum-0033 CAZ86542 Tuber melanosporum 52 4e-89 325
WERAM-Yal-0001 CAG83662 Yarrowia lipolytica 49 5e-88 322
WERAM-Tar-0174 ENSTRUP00000036778.1 Takifugu rubripes 52 1e-86 317
WERAM-Orn-0076 ENSONIP00000008231.1 Oreochromis niloticus 56 2e-85 313
WERAM-Zyt-0013 Mycgr3P30000 Zymoseptoria tritici 54 9e-85 311
WERAM-Pof-0033 ENSPFOP00000002754.2 Poecilia formosa 51 1e-84 310
WERAM-Xim-0096 ENSXMAP00000008646.1 Xiphophorus maculatus 55 4e-84 309
WERAM-Gaa-0100 ENSGACP00000013042.1 Gasterosteus aculeatus 55 4e-84 309
WERAM-Orla-0042 ENSORLP00000005128.1 Oryzias latipes 54 8e-84 308
WERAM-Leo-0131 ENSLOCP00000016384.1 Lepisosteus oculatus 55 8e-84 308
WERAM-Dar-0070 ENSDARP00000021648.8 Danio rerio 54 9e-84 308
WERAM-Xet-0138 ENSXETP00000047416.3 Xenopus tropicalis 50 2e-83 306
WERAM-Lac-0093 ENSLACP00000011978.1 Latimeria chalumnae 55 2e-83 306
WERAM-Ten-0155 ENSTNIP00000015833.1 Tetraodon nigroviridis 50 3e-83 306
WERAM-Mae-0040 ENSMEUP00000003756.1 Macropus eugenii 55 3e-83 306
WERAM-Poa-0075 ENSPPYP00000010014.1 Pongo abelii 55 3e-83 306
WERAM-Pat-0076 ENSPTRP00000015934.4 Pan troglodytes 55 3e-83 306
WERAM-Hos-0130 ENSP00000259021.4 Homo sapiens 55 3e-83 306
WERAM-Gog-0085 ENSGGOP00000007314.2 Gorilla gorilla 55 3e-83 306
WERAM-Eqc-0063 ENSECAP00000008441.1 Equus caballus 55 3e-83 306
WERAM-Aim-0136 ENSAMEP00000012925.1 Ailuropoda melanoleuca 55 3e-83 306
WERAM-Gam-0139 ENSGMOP00000014177.1 Gadus morhua 54 3e-83 306
WERAM-Mum-0158 ENSMUSP00000090441.5 Mus musculus 55 3e-83 306
WERAM-Mim-0145 ENSMICP00000015020.1 Microcebus murinus 55 3e-83 306
WERAM-Sus-0134 ENSSSCP00000018601.2 Sus scrofa 55 3e-83 306
WERAM-Orc-0005 ENSOCUP00000000581.3 Oryctolagus cuniculus 55 3e-83 306
WERAM-Chs-0057 ENSCSAP00000001508.1 Chlorocebus sabaeus 55 3e-83 306
WERAM-Ict-0154 ENSSTOP00000015280.1 Ictidomys tridecemlineatus 55 3e-83 306
WERAM-Anp-0058 ENSAPLP00000006419.1 Anas platyrhynchos 55 3e-83 306
WERAM-Tut-0008 ENSTTRP00000000444.1 Tursiops truncatus 55 3e-83 306
WERAM-Loa-0037 ENSLAFP00000002342.3 Loxodonta africana 55 3e-83 306
WERAM-Meg-0019 ENSMGAP00000001561.1 Meleagris gallopavo 55 3e-83 306
WERAM-Ova-0056 ENSOARP00000006067.1 Ovis aries 55 3e-83 306
WERAM-Bot-0165 ENSBTAP00000024887.5 Bos taurus 55 3e-83 306
WERAM-Paa-0175 ENSPANP00000020135.1 Papio anubis 55 3e-83 306
WERAM-Mod-0099 ENSMODP00000015208.2 Monodelphis domestica 55 4e-83 305
WERAM-Caf-0180 ENSCAFP00000024952.2 Canis familiaris 55 4e-83 305
WERAM-Cap-0016 ENSCPOP00000001650.2 Cavia porcellus 55 4e-83 305
WERAM-Asm-0232 ENSAMXP00000025043.1 Astyanax mexicanus 51 4e-83 305
WERAM-Sah-0111 ENSSHAP00000011807.1 Sarcophilus harrisii 55 4e-83 305
WERAM-Fec-0034 ENSFCAP00000002433.3 Felis catus 55 4e-83 305
WERAM-Otg-0020 ENSOGAP00000000937.2 Otolemur garnettii 55 4e-83 305
WERAM-Myl-0126 ENSMLUP00000010098.2 Myotis lucifugus 55 4e-83 305
WERAM-Gaga-0100 ENSGALP00000016147.4 Gallus gallus 55 5e-83 305
WERAM-Pes-0018 ENSPSIP00000004151.1 Pelodiscus sinensis 55 5e-83 305
WERAM-Fia-0073 ENSFALP00000005432.1 Ficedula albicollis 55 7e-83 305
WERAM-Nol-0032 ENSNLEP00000003949.1 Nomascus leucogenys 55 7e-83 305
WERAM-Asg-0008 AAS51462 Ashbya gossypii 49 3e-82 303
WERAM-Caj-0080 ENSCJAP00000013077.2 Callithrix jacchus 55 5e-82 302
WERAM-Tag-0027 ENSTGUP00000001933.1 Taeniopygia guttata 54 1e-81 300
WERAM-Ran-0147 ENSRNOP00000029608.6 Rattus norvegicus 55 1e-81 300
WERAM-Pem-0064 ENSPMAP00000007030.1 Petromyzon marinus 50 2e-81 300
WERAM-Ocp-0075 ENSOPRP00000006602.1 Ochotona princeps 54 2e-81 300
WERAM-Dan-0041 ENSDNOP00000004227.2 Dasypus novemcinctus 54 3e-81 299
WERAM-Mup-0176 ENSMPUP00000015299.1 Mustela putorius furo 60 4e-80 296
WERAM-Tub-0015 ENSTBEP00000001544.1 Tupaia belangeri 48 3e-79 292
WERAM-Ora-0008 ENSOANP00000001123.3 Ornithorhynchus anatinus 48 4e-79 292
WERAM-Ptv-0164 ENSPVAP00000013957.1 Pteropus vampyrus 48 6e-79 291
WERAM-Prc-0040 ENSPCAP00000003620.1 Procavia capensis 51 7e-79 291
WERAM-Dio-0138 ENSDORP00000012841.1 Dipodomys ordii 48 7e-79 291
WERAM-Cii-0017 ENSCINP00000006517.3 Ciona intestinalis 47 8e-79 291
WERAM-Ect-0123 ENSETEP00000014407.1 Echinops telfairi 48 9e-79 291
WERAM-Anc-0133 ENSACAP00000012299.3 Anolis carolinensis 52 3e-78 289
WERAM-Kop-0021 CAY69704 Komagataella pastoris 44 6e-78 288
WERAM-Drm-0026 FBpp0305388 Drosophila melanogaster 46 7e-78 288
WERAM-Cag-0002 CAG57844 Candida glabrata 50 3e-77 286
WERAM-Sac-0001 YBL052C Saccharomyces cerevisiae 47 3e-77 286
WERAM-Cis-0023 ENSCSAVP00000005035.1 Ciona savignyi 46 4e-77 286
WERAM-Tas-0059 ENSTSYP00000005370.1 Tarsius syrichta 50 8e-77 285
WERAM-Mam-0215 ENSMMUP00000030925.2 Macaca mulatta 50 1e-76 284
WERAM-Usm-0022 UM03302P0 Ustilago maydis 55 3e-74 276
WERAM-Crn-0008 AAW41586 Cryptococcus neoformans 50 9e-74 274
Created Date 25-Jun-2016