WERAM Information

Tag Content
WERAM ID WERAM-Scp-0004
Ensembl Protein ID SPAC139.06.1:pep
Uniprot Accession Q9UTM7; HAT1_SCHPO; O13922;
Genbank Protein ID NP_593173.2;
Protein Name Histone acetyltransferase type B catalytic subunit
Genbank Nucleotide ID NM_001018570.2;
Gene Name HAT1;SPAC139.06;SPAC23C4.01
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
SPAC139.06 SPAC139.06.1 SPAC139.06.1:pep
Details
Type Family Domain Substrates AA References (PMIDs)
HAT HAT1 H4K12 K 26223950
Status Reviewed
Classification
Type Family E-value Score Start End
HAT HAT1 3.20e-53 178.3 7 252
Organism Schizosaccharomyces pombe
NCBI Taxa ID 284812
Functional Description
(View)		 Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.
Domain Profile
  HAT HAT1
          HAT1.txt   1 rvveanevielllveakeeidtdistfkpeilyqlfgddetifGYkdlkvtvhylaksldeyidvkYsskinkekgscleaddveskleqkit 93 
                       +v++ane+ie+++v++k+e+d   ++++p+++y++fgd+e i+GYkdl+vt++y+++ + ++++++Ys+++++++g  +e++d+e++l+++++
  SPAC139.06.1:pep   7 WVHNANECIEIVQVNEKHEKD---CQYHPSNTYAIFGDAEVIYGYKDLNVTITYECPLMVPKLEISYSERLAPDSG--VEPTDIEGTLNTYLK 94 
                       79*******************...99**************************************************..*************** PP
          HAT1.txt  94 eetivdnkeeFlqlldkqddFkpfgelihkyrklgkdfeiykaedlsdeflellerlqtlelfFie 159
                       +++i+++ ++F+         ++++++ih+y+++gk+f+i++a++l  e++e++++lq+++lfFie
  SPAC139.06.1:pep  95 DRSIKVEGNSFD---------VHSANSIHNYSFNGKTFKILQATVL--EASEIMQHLQIFSLFFIE 149
                       ************.........899**********************..*****************8 PP
          HAT1.txt  20 id.tdistfkpeilyqlfgddetifGYkdlkvtvhyl.aksldeyidvkYsski......nkekgscleaddveskleqk.iteetivdnkee 103
                       id +d++ +    ly+  +dd  + GY +++++   +  k ++  i+   s+ +       +++gs l++++v   l+++ i + t++d  e+
  SPAC139.06.1:pep 154 IDlNDPR-WMVYLLYETTEDDYCLRGYCTVYKYY--KwDKLIHDGIRARISQFVilppfqHQGHGSQLYNAIVSTFLKNPkILDFTVEDASEA 243
                       7889999.55555677777777888999988864..446999999*999999999************************99************ PP
          HAT1.txt 104 Flqlldkqd 112
                       F++l+d+ d
  SPAC139.06.1:pep 244 FDSLRDHCD 252
                       ****99765 PP
Protein Sequence
(Fasta)		MSAVDEWVHN ANECIEIVQV NEKHEKDCQY HPSNTYAIFG DAEVIYGYKD LNVTITYECP 60
LMVPKLEISY SERLAPDSGV EPTDIEGTLN TYLKDRSIKV EGNSFDVHSA NSIHNYSFNG 120
KTFKILQATV LEASEIMQHL QIFSLFFIEG GSFIDLNDPR WMVYLLYETT EDDYCLRGYC 180
TVYKYYKWDK LIHDGIRARI SQFVILPPFQ HQGHGSQLYN AIVSTFLKNP KILDFTVEDA 240
SEAFDSLRDH CDYKRLLSMG IFSEPDFHPS LSRQWINSKI AETKLTQRQF SRCCELAFTT 300
KLKKLSLLER KSVRLGIKER IFRQNLDVLL QLDKSERIEK IHNAYENQFD EYKQIVKKLP 360
KLKEDSPRKR QKLAQSSS 378
Nucleotide Sequence
(Fasta)		TGAAATTTTG CGTCGCCTTG TAGTTTGTTA CTTCCAACTA GACACATGTA TTTTTTGTTG 60
TTTGACTTGA AATAGGGTCA GGTATTCAAT TTTCCGTATG CAGTGATGAG TGCTGTTGAT 120
GAATGGGTAC ATAATGCCAA TGAATGCATA GAAATTGTAC AAGTAAACGA AAAGCATGAA 180
AAAGATTGTC AATACCATCC TAGCAATACA TATGCAATAT TTGGAGATGC TGAGGTTATT 240
TATGGATATA AAGATCTAAA TGTCACTATA ACCTATGAAT GCCCATTGAT GGTCCCAAAA 300
CTGGAAATCT CATATTCAGA GCGCCTAGCA CCAGATTCAG GAGTGGAACC AACTGATATT 360
GAAGGAACAT TAAACACTTA TCTAAAAGAT CGTTCCATTA AGGTTGAAGG AAACTCATTT 420
GACGTTCATT CGGCAAATAG TATTCATAAC TATTCCTTTA ATGGAAAAAC ATTCAAGATT 480
TTACAAGCAA CGGTTCTTGA AGCTAGTGAG ATTATGCAGC ATTTGCAAAT ATTTTCCTTA 540
TTTTTTATTG AAGGGGGCTC TTTTATTGAC CTTAATGATC CAAGATGGAT GGTATATTTA 600
CTTTACGAGA CTACTGAAGA TGATTATTGC TTACGTGGTT ATTGTACTGT ATACAAATAT 660
TATAAATGGG ACAAATTAAT TCACGATGGT ATTCGAGCTC GTATCTCACA ATTCGTGATT 720
TTACCCCCTT TTCAACATCA AGGACACGGT TCGCAATTGT ACAATGCTAT TGTTAGTACC 780
TTTTTGAAAA ATCCTAAAAT TTTAGACTTC ACAGTTGAGG ATGCATCGGA AGCGTTTGAT 840
AGCCTTAGAG ACCATTGCGA CTATAAAAGA TTATTATCAA TGGGAATATT TTCAGAACCT 900
GACTTTCATC CCTCTCTTTC TAGGCAGTGG ATAAACTCGA AAATAGCTGA AACAAAGTTA 960
ACCCAGCGTC AATTCTCACG CTGTTGTGAA TTAGCATTTA CAACGAAACT AAAAAAGCTT 1020
TCATTATTGG AGCGGAAATC TGTTAGACTA GGAATAAAGG AAAGGATTTT TCGTCAAAAT 1080
CTTGATGTGT TGCTACAGTT GGATAAGTCC GAACGTATTG AAAAAATTCA TAACGCCTAT 1140
GAAAATCAGT TTGATGAGTA TAAACAGATT GTCAAAAAGC TACCCAAGCT TAAGGAAGAT 1200
TCGCCTCGAA AACGCCAAAA ACTTGCTCAA TCTTCTTCCT AAATGAAAAC ACTTTTAGAG 1260
ATCTGAAATA CTTTGAGAAT ATTGAAGGCA TATTAGCATA AAAAGTTATG AGAATCGACT 1320
AAATTACACT ATTGGACGCA ATTACTTTTT ATATAATTTG CTTTTGAAAG CTTTCGCTTG 1380
AAATGATTAA AGACATTTGA AACAGTGATC ATTTTAATAA TATAAATTTT GTATATATTT 1440
TGCAAATTTA GTGTGATATC TAGTTTAATA AAATCTATAA AGGCACCTTA 1491
Sequence Source Ensembl
Keyword

KW-0012--Acyltransferase
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0234--DNA repair
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
--
Interpro

IPR016181--Acyl_CoA_acyltransferase
IPR019467--Hat1_N
IPR017380--Hist_AcTrfase_B-typ_cat-su
IPR013523--Hist_AcTrfase_HAT1_C
PROSITE
Pfam

PF10394--Hat1_N
Gene Ontology

GO:0000781--C:chromosome, telomeric region
GO:0005737--C:cytoplasm
GO:0000123--C:histone acetyltransferase complex
GO:0000790--C:nuclear chromatin
GO:0005634--C:nucleus
GO:0004402--F:histone acetyltransferase activity
GO:0006348--P:chromatin silencing at telomere
GO:0006281--P:DNA repair
GO:0016573--P:histone acetylation
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Sac-0045 YPL001W Saccharomyces cerevisiae 34 9e-51 198
WERAM-Orn-0101 ENSONIP00000010967.1 Oreochromis niloticus 27 4e-33 139
WERAM-Mod-0069 ENSMODP00000011048.3 Monodelphis domestica 29 7e-33 139
WERAM-Lac-0041 ENSLACP00000006166.2 Latimeria chalumnae 28 8e-33 138
WERAM-Orla-0189 ENSORLP00000021710.1 Oryzias latipes 27 2e-32 137
WERAM-Ten-0201 ENSTNIP00000002170.1 Tetraodon nigroviridis 29 3e-32 136
WERAM-Caj-0083 ENSCJAP00000013707.2 Callithrix jacchus 29 1e-31 134
WERAM-Anp-0011 ENSAPLP00000002164.1 Anas platyrhynchos 28 1e-31 134
WERAM-Sah-0179 ENSSHAP00000018728.1 Sarcophilus harrisii 29 2e-31 133
WERAM-Gaga-0098 ENSGALP00000015492.3 Gallus gallus 28 2e-31 133
WERAM-Eqc-0073 ENSECAP00000009282.1 Equus caballus 28 3e-31 133
WERAM-Caf-0137 ENSCAFP00000018999.3 Canis familiaris 29 3e-31 133
WERAM-Soa-0052 ENSSARP00000005106.1 Sorex araneus 29 3e-31 133
WERAM-Aim-0094 ENSAMEP00000008940.1 Ailuropoda melanoleuca 29 3e-31 133
WERAM-Fia-0035 ENSFALP00000002091.1 Ficedula albicollis 27 4e-31 133
WERAM-Fec-0026 ENSFCAP00000002278.3 Felis catus 28 5e-31 132
WERAM-Pes-0131 ENSPSIP00000015233.1 Pelodiscus sinensis 27 5e-31 132
WERAM-Otg-0107 ENSOGAP00000009328.2 Otolemur garnettii 28 6e-31 132
WERAM-Ova-0012 ENSOARP00000001849.1 Ovis aries 29 9e-31 131
WERAM-Bot-0100 ENSBTAP00000013355.2 Bos taurus 29 9e-31 131
WERAM-Vip-0017 ENSVPAP00000001693.1 Vicugna pacos 29 1e-30 131
WERAM-Hos-0115 ENSP00000264108.4 Homo sapiens 28 1e-30 131
WERAM-Tag-0111 ENSTGUP00000008605.1 Taeniopygia guttata 27 1e-30 131
WERAM-Dan-0092 ENSDNOP00000009190.3 Dasypus novemcinctus 28 2e-30 130
WERAM-Cap-0017 ENSCPOP00000001664.2 Cavia porcellus 29 2e-30 130
WERAM-Meg-0104 ENSMGAP00000010389.2 Meleagris gallopavo 27 2e-30 130
WERAM-Sus-0118 ENSSSCP00000016904.2 Sus scrofa 29 2e-30 130
WERAM-Ptv-0121 ENSPVAP00000010680.1 Pteropus vampyrus 28 3e-30 130
WERAM-Pat-0100 ENSPTRP00000021597.3 Pan troglodytes 28 4e-30 129
WERAM-Gog-0106 ENSGGOP00000009140.2 Gorilla gorilla 28 4e-30 129
WERAM-Chs-0180 ENSCSAP00000010905.1 Chlorocebus sabaeus 28 4e-30 129
WERAM-Myl-0187 ENSMLUP00000015650.2 Myotis lucifugus 28 4e-30 129
WERAM-Poa-0112 ENSPPYP00000014436.2 Pongo abelii 28 4e-30 129
WERAM-Nol-0056 ENSNLEP00000006694.2 Nomascus leucogenys 28 4e-30 129
WERAM-Paa-0093 ENSPANP00000018512.1 Papio anubis 28 8e-30 128
WERAM-Mum-0084 ENSMUSP00000028408.2 Mus musculus 30 2e-29 127
WERAM-Orc-0047 ENSOCUP00000004608.2 Oryctolagus cuniculus 28 2e-29 127
WERAM-Ran-0015 ENSRNOP00000002085.5 Rattus norvegicus 28 3e-29 127
WERAM-Drm-0060 FBpp0078318 Drosophila melanogaster 28 3e-29 126
WERAM-Mup-0007 ENSMPUP00000000831.1 Mustela putorius furo 32 4e-29 126
WERAM-Mam-0057 ENSMMUP00000009587.2 Macaca mulatta 32 7e-29 125
WERAM-Ocp-0137 ENSOPRP00000014189.1 Ochotona princeps 31 8e-29 125
WERAM-Loa-0101 ENSLAFP00000008558.3 Loxodonta africana 28 3e-28 123
WERAM-Cae-0071 M03C11.4.2 Caenorhabditis elegans 26 4e-26 116
WERAM-Art-0144 AT5G56740.1 Arabidopsis thaliana 26 8e-21 98.6
Created Date 25-Jun-2016