| Tag |
Content |
| WERAM ID |
WERAM-Drm-0095 |
| Ensembl Protein ID |
FBpp0302536 |
| Uniprot Accession |
P45975; SUV39_DROME; Q9VFA6
|
| Genbank Protein ID |
NP_524357.2
|
| Protein Name |
Histone-lysine N-methyltransferase Su(var)3-9 |
| Genbank Nucleotide ID |
NM_079633.3
|
| Gene Name |
SU(VAR)3-9 |
| Ensembl Information |
|
| Details |
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HMT |
SUV39 |
3.10e-39 |
134.9 |
94 |
602 |
|
| Organism |
Drosophila melanogaster |
| NCBI Taxa ID |
7227 |
Functional Description
(View)Functional Description
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting Su(var)205/HP1 to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric regions. Involved in heterochromatic gene silencing including the modification of position-effect-variegation. |
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting Su(var)205/HP1 to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric regions. Involved in heterochromatic gene silencing including the modification of position-effect-variegation.
|
| Domain Profile |
HMT SUV39
SUV39.txt 37 ddeaekegleegdeyladlds 57
+++ +++ +++++l +l +
FBpp0302536 94 SKQQRQQYEIKQRSMLRHLAE 114
333333322222222222222 PP
SUV39.txt 1 vrLqvfktenk.GwGvrclddiakgsFvciyaGeiltddeaekegl...eegdeyladldske 59
v+L +fkt+n GwGvr+ + ++kg+Fvc+y+Gei+t+dea+++g ++g++yl+dld+++
FBpp0302536 477 VPLVLFKTANGsGWGVRAATALRKGEFVCEYIGEIITSDEANERGKaydDNGRTYLFDLDYNT 539
5799******99********************************8778889999*****9975 PP
SUV39.txt 87 keeseyiidakkegnvgrflnHscspNlfvqnvfvdthdlrfprvafFaskrikagtELtwdY 149
++sey+ida+++gn+++f+nHsc+pNl+v ++++++ + +p+++fF+ + ikag+EL++dY
FBpp0302536 540 AQDSEYTIDAANYGNISHFINHSCDPNLAVFPCWIEHLNVALPHLVFFTLRPIKAGEELSFDY 602
6789*********************************************************** PP
|
Protein Sequence
(Fasta) | MATAEAQIGV NRNLQKQDLS NLDVSKLTPL SPEVISRQAT INIGTIGHVA HGKSTVVKAI 60
SGVQTVRFKN ELERNITIKL ERLSEKKIKN LLTSKQQRQQ YEIKQRSMLR HLAELRRHSR 120
FRRLCTKPAS SSMPASTSSV DRRTTRRSTS QTSLSPSNSS GYGSVFGCEE HDVDKIPSLN 180
GFAKLKRRRS SCVGAPTPNS KRSKNNMGVI AKRPPKGEYV VERIECVEMD QYQPVFFVKW 240
LGYHDSENTW ESLANVADCA EMEKFVERHQ QLYEIYIAKI TTELEKQLEA LPLMENITVA 300
EVDAYEPLNL QIDLILLAQY RAAGSRSQRE PQKIGERALK SMQIKRAQFV RRKQLADLAL 360
FEKRMNHVEK PSPPIRVENN IDLDTIDSNF MYIHDNIIGK DVPKPEAGIV GCKCTEDTEE 420
CTASTKCCAR FAGELFAYER STRRLRLRPG SAIYECNSRC SCDSSCSNRL VQHGRQVPLV 480
LFKTANGSGW GVRAATALRK GEFVCEYIGE IITSDEANER GKAYDDNGRT YLFDLDYNTA 540
QDSEYTIDAA NYGNISHFIN HSCDPNLAVF PCWIEHLNVA LPHLVFFTLR PIKAGEELSF 600
DYIRADNEDV PYENLSTAVR VECRCGADNC RKVLF 635Protein Fasta Sequence
>FBpp0302536|SU(VAR)3-9|Drosophila melanogaster
MATAEAQIGVNRNLQKQDLSNLDVSKLTPLSPEVISRQATINIGTIGHVAHGKSTVVKAISGVQTVRFKNELERNITIKLERLSEKKIKNLLTSKQQRQQYEIKQRSMLRHLAELRRHSRFRRLCTKPASSSMPASTSSVDRRTTRRSTSQTSLSPSNSSGYGSVFGCEEHDVDKIPSLNGFAKLKRRRSSCVGAPTPNSKRSKNNMGVIAKRPPKGEYVVERIECVEMDQYQPVFFVKWLGYHDSENTWESLANVADCAEMEKFVERHQQLYEIYIAKITTELEKQLEALPLMENITVAEVDAYEPLNLQIDLILLAQYRAAGSRSQREPQKIGERALKSMQIKRAQFVRRKQLADLALFEKRMNHVEKPSPPIRVENNIDLDTIDSNFMYIHDNIIGKDVPKPEAGIVGCKCTEDTEECTASTKCCARFAGELFAYERSTRRLRLRPGSAIYECNSRCSCDSSCSNRLVQHGRQVPLVLFKTANGSGWGVRAATALRKGEFVCEYIGEIITSDEANERGKAYDDNGRTYLFDLDYNTAQDSEYTIDAANYGNISHFINHSCDPNLAVFPCWIEHLNVALPHLVFFTLRPIKAGEELSFDYIRADNEDVPYENLSTAVRVECRCGADNCRKVLF |
Nucleotide Sequence
(Fasta) | GCATTGTCGG GTCCAATCGT TCTTCGATAT CGAGATTTGA TGCCGAGCTG TAATAGCTGA 60
AAATTATTAT TTTCATTTTG CATACGCATC GTTTTTGAAA ACATCAGCAA CATGGCCACG 120
GCTGAAGCCC AGATCGGTGT GAACAGGAAC TTGCAGAAGC AGGACCTCAG CAACTTGGAC 180
GTCTCTAAAC TAACGCCTCT ATCACCGGAG GTCATCTCCC GACAGGCGAC CATCAACATC 240
GGCACCATCG GTCATGTGGC TCACGGCAAA TCCACGGTGG TCAAAGCCAT ATCCGGCGTG 300
CAGACTGTGC GCTTCAAGAA CGAACTGGAG CGCAACATCA CAATCAAGCT GGAACGCTTG 360
AGCGAAAAAA AAATCAAAAA TCTTTTGACC TCCAAGCAGC AGCGACAGCA GTATGAAATC 420
AAACAGCGTT CAATGCTGCG CCACCTGGCC GAATTGCGGC GACATAGCCG ATTCCGCCGC 480
CTCTGCACCA AGCCAGCTTC GTCTTCCATG CCAGCATCCA CCTCCAGTGT AGATAGACGC 540
ACCACCCGGC GAAGCACCAG TCAGACCTCA CTGAGTCCAA GCAATAGTAG CGGCTATGGC 600
AGCGTTTTTG GCTGCGAGGA ACATGATGTG GACAAAATAC CCAGTCTCAA CGGATTCGCC 660
AAACTGAAGC GTCGACGCAG CAGTTGTGTG GGCGCCCCAA CTCCCAACTC CAAGCGGTCG 720
AAAAATAACA TGGGAGTAAT TGCCAAAAGG CCGCCCAAAG GAGAGTACGT TGTGGAGCGT 780
ATTGAATGCG TCGAGATGGA TCAATATCAG CCAGTCTTCT TCGTCAAATG GCTGGGATAC 840
CATGATAGCG AGAACACCTG GGAAAGTCTT GCCAACGTGG CCGACTGCGC CGAAATGGAG 900
AAGTTTGTGG AGCGGCATCA GCAGCTCTAC GAGATATACA TAGCCAAGAT AACCACTGAG 960
CTTGAGAAGC AGCTGGAGGC ATTGCCACTA ATGGAGAACA TTACGGTGGC CGAAGTAGAC 1020
GCCTATGAGC CACTCAATCT GCAGATCGAT CTTATACTGC TCGCCCAATA TCGCGCTGCT 1080
GGCAGTCGAA GCCAAAGGGA ACCGCAGAAA ATTGGAGAAC GAGCCCTGAA AAGCATGCAA 1140
ATCAAGCGGG CCCAATTTGT ACGACGCAAG CAGTTGGCTG ATCTAGCATT GTTCGAGAAG 1200
CGCATGAATC ATGTGGAGAA ACCGTCACCG CCAATACGTG TTGAGAACAA CATTGATCTG 1260
GACACCATAG ACAGCAATTT CATGTACATA CATGATAACA TAATCGGCAA GGATGTGCCC 1320
AAGCCGGAAG CGGGGATTGT GGGCTGTAAG TGCACTGAAG ACACAGAGGA GTGTACTGCC 1380
TCTACGAAGT GTTGTGCCCG CTTCGCCGGC GAGCTGTTCG CCTACGAGCG AAGCACACGG 1440
CGCTTGCGCC TTCGTCCCGG AAGTGCCATC TATGAGTGCA ATAGCCGCTG CTCGTGCGAT 1500
TCAAGCTGCT CCAACCGTCT GGTGCAGCAC GGACGCCAGG TACCGTTGGT GCTGTTTAAG 1560
ACCGCCAACG GCAGCGGATG GGGGGTGCGA GCCGCAACTG CCTTGCGTAA GGGTGAATTT 1620
GTGTGCGAGT ACATTGGAGA GATCATCACC AGCGATGAGG CAAATGAGCG CGGCAAGGCG 1680
TATGACGACA ATGGGAGGAC ATATCTGTTC GACTTGGATT ACAACACAGC TCAGGATAGC 1740
GAGTACACTA TCGATGCAGC TAACTATGGC AACATCTCGC ACTTTATCAA TCACTCTTGC 1800
GATCCTAATC TCGCCGTGTT CCCCTGTTGG ATCGAGCACC TGAATGTCGC GCTGCCGCAC 1860
CTCGTGTTCT TCACACTGCG TCCAATCAAG GCGGGCGAGG AGTTGAGCTT CGACTACATT 1920
CGCGCGGACA ACGAAGATGT GCCCTACGAG AACCTCTCGA CAGCTGTGCG TGTCGAGTGC 1980
CGCTGCGGAG CTGATAATTG CAGAAAGGTC CTCTTTTGAA TGGACTTGAA GTACTATATT 2040
TAAATGGCAC GCCGTTACCC ACCTGAGACA TCATTGCATT GAACCTTTTT TTTTTTTGTT 2100
AACATATATA TATATTACTA GTTGGATTTT ATATTCCGAC GTTTTAATTA TTTATTTGTT 2160
AATAAATGCT AATATCGATA TATTGGATCT ATATTATGTT TGAGGATCTA TATTACTAGA 2220
GGATAAAACG AGTAATTCTA TATAGTTTGT ACTTGTATAC ATTTCATAAA CTTAAATTTT 2280
AATTTAGTAA TAACTTAGTG TTTTGACAAA CAACCTTGTA ATGTGCTGAA ATTATTACCG 2340
CATTAAGTGC AAATTATTAT TTTACAATAA ATATTTTACG ATTATT
2387Nucleotide Fasta Sequence
>FBpp0302536|SUV39|Drosophila melanogaster
GCATTGTCGGGTCCAATCGTTCTTCGATATCGAGATTTGATGCCGAGCTGTAATAGCTGAAAATTATTATTTTCATTTTGCATACGCATCGTTTTTGAAAACATCAGCAACATGGCCACGGCTGAAGCCCAGATCGGTGTGAACAGGAACTTGCAGAAGCAGGACCTCAGCAACTTGGACGTCTCTAAACTAACGCCTCTATCACCGGAGGTCATCTCCCGACAGGCGACCATCAACATCGGCACCATCGGTCATGTGGCTCACGGCAAATCCACGGTGGTCAAAGCCATATCCGGCGTGCAGACTGTGCGCTTCAAGAACGAACTGGAGCGCAACATCACAATCAAGCTGGAACGCTTGAGCGAAAAAAAAATCAAAAATCTTTTGACCTCCAAGCAGCAGCGACAGCAGTATGAAATCAAACAGCGTTCAATGCTGCGCCACCTGGCCGAATTGCGGCGACATAGCCGATTCCGCCGCCTCTGCACCAAGCCAGCTTCGTCTTCCATGCCAGCATCCACCTCCAGTGTAGATAGACGCACCACCCGGCGAAGCACCAGTCAGACCTCACTGAGTCCAAGCAATAGTAGCGGCTATGGCAGCGTTTTTGGCTGCGAGGAACATGATGTGGACAAAATACCCAGTCTCAACGGATTCGCCAAACTGAAGCGTCGACGCAGCAGTTGTGTGGGCGCCCCAACTCCCAACTCCAAGCGGTCGAAAAATAACATGGGAGTAATTGCCAAAAGGCCGCCCAAAGGAGAGTACGTTGTGGAGCGTATTGAATGCGTCGAGATGGATCAATATCAGCCAGTCTTCTTCGTCAAATGGCTGGGATACCATGATAGCGAGAACACCTGGGAAAGTCTTGCCAACGTGGCCGACTGCGCCGAAATGGAGAAGTTTGTGGAGCGGCATCAGCAGCTCTACGAGATATACATAGCCAAGATAACCACTGAGCTTGAGAAGCAGCTGGAGGCATTGCCACTAATGGAGAACATTACGGTGGCCGAAGTAGACGCCTATGAGCCACTCAATCTGCAGATCGATCTTATACTGCTCGCCCAATATCGCGCTGCTGGCAGTCGAAGCCAAAGGGAACCGCAGAAAATTGGAGAACGAGCCCTGAAAAGCATGCAAATCAAGCGGGCCCAATTTGTACGACGCAAGCAGTTGGCTGATCTAGCATTGTTCGAGAAGCGCATGAATCATGTGGAGAAACCGTCACCGCCAATACGTGTTGAGAACAACATTGATCTGGACACCATAGACAGCAATTTCATGTACATACATGATAACATAATCGGCAAGGATGTGCCCAAGCCGGAAGCGGGGATTGTGGGCTGTAAGTGCACTGAAGACACAGAGGAGTGTACTGCCTCTACGAAGTGTTGTGCCCGCTTCGCCGGCGAGCTGTTCGCCTACGAGCGAAGCACACGGCGCTTGCGCCTTCGTCCCGGAAGTGCCATCTATGAGTGCAATAGCCGCTGCTCGTGCGATTCAAGCTGCTCCAACCGTCTGGTGCAGCACGGACGCCAGGTACCGTTGGTGCTGTTTAAGACCGCCAACGGCAGCGGATGGGGGGTGCGAGCCGCAACTGCCTTGCGTAAGGGTGAATTTGTGTGCGAGTACATTGGAGAGATCATCACCAGCGATGAGGCAAATGAGCGCGGCAAGGCGTATGACGACAATGGGAGGACATATCTGTTCGACTTGGATTACAACACAGCTCAGGATAGCGAGTACACTATCGATGCAGCTAACTATGGCAACATCTCGCACTTTATCAATCACTCTTGCGATCCTAATCTCGCCGTGTTCCCCTGTTGGATCGAGCACCTGAATGTCGCGCTGCCGCACCTCGTGTTCTTCACACTGCGTCCAATCAAGGCGGGCGAGGAGTTGAGCTTCGACTACATTCGCGCGGACAACGAAGATGTGCCCTACGAGAACCTCTCGACAGCTGTGCGTGTCGAGTGCCGCTGCGGAGCTGATAATTGCAGAAAGGTCCTCTTTTGAATGGACTTGAAGTACTATATTTAAATGGCACGCCGTTACCCACCTGAGACATCATTGCATTGAACCTTTTTTTTTTTTGTTAACATATATATATATTACTAGTTGGATTTTATATTCCGACGTTTTAATTATTTATTTGTTAATAAATGCTAATATCGATATATTGGATCTATATTATGTTTGAGGATCTATATTACTAGAGGATAAAACGAGTAATTCTATATAGTTTGTACTTGTATACATTTCATAAACTTAAATTTTAATTTAGTAATAACTTAGTGTTTTGACAAACAACCTTGTAATGTGCTGAAATTATTACCGCATTAAGTGCAAATTATTATTTTACAATAAATATTTTACGATTATT
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0137--Centromere
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0862--Zinc
--
|
| Interpro |
IPR000953--Chromo/shadow_dom
IPR023780--Chromo_domain
IPR016197--Chromodomain-like
IPR023779--Chromodomain_CS
IPR011381--Histone_H3-K9_MeTrfase
IPR027417--P-loop_NTPase
IPR003616--Post-SET_dom
IPR007728--Pre-SET_dom
IPR001214--SET_dom
|
| PROSITE |
PS00598--CHROMO_1
PS50013--CHROMO_2
PS50868--POST_SET
PS50867--PRE_SET
PS50280--SET
|
| Pfam |
PF00385--Chromo
PF05033--Pre-SET
PF00856--SET
|
| Gene Ontology |
GO:0000775--C:chromosome, centromeric region
GO:0000781--C:chromosome, telomeric region
GO:0000792--C:heterochromatin
GO:0005634--C:nucleus
GO:0005701--C:polytene chromosome chromocenter
GO:0003682--F:chromatin binding
GO:0042054--F:histone methyltransferase activity
GO:0046974--F:histone methyltransferase activity (H3-K9 specific)
GO:0008270--F:zinc ion binding
GO:0006325--P:chromatin organization
GO:0006342--P:chromatin silencing
GO:0030702--P:chromatin silencing at centromere
GO:0006348--P:chromatin silencing at telomere
GO:0051276--P:chromosome organization
GO:0006306--P:DNA methylation
GO:0048132--P:female germ-line stem cell asymmetric division
GO:0016458--P:gene silencing
GO:0031507--P:heterochromatin assembly
GO:0070868--P:heterochromatin organization involved in chromatin silencing
GO:0051567--P:histone H3-K9 methylation
GO:0016571--P:histone methylation
GO:0016570--P:histone modification
GO:2001229--P:negative regulation of response to gamma radiation
GO:0048477--P:oogenesis
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
