WERAM Information

Tag Content
WERAM ID WERAM-Drm-0008
Ensembl Protein ID FBpp0297150
Uniprot Accession Q9VHA0; SCM_DROME; Q24191
Genbank Protein ID NP_001247006.1; NP_731385.1
Protein Name Polycomb protein Scm
Genbank Nucleotide ID NM_001260077.2; NM_169299.2
Gene Name SCM
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0003334 FBtr0306008 FBpp0297150
FBgn0003334 FBtr0082102 FBpp0081580
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader MBT MBT1 H3K27 K 15280237
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader MBT 1.40e-68 216 175 273
Organism Drosophila melanogaster
NCBI Taxa ID 7227
Functional Description
(View)		 Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility.
Domain Profile
  Me_Reader MBT
    MBT-2.txt   1 sdwkeylrktldgakvapkslseklseskallsfkvgmrlEvvdkknsseirvatveeviggrlkvsfeesededddyWidesspfifpvGwaakqgk 98 
                  +dw++yl +t  g+++ap++ +++ ++ ++ ++fk gm+lE++d +n++++++atv  v g+rl+++ ++s d++ d+W   +s  i+ +G+++k+g 
  FBpp0297150 175 FDWDAYLEET--GSEAAPAKCFKQAQNPPN-NDFKIGMKLEALDPRNVTSTCIATVVGVLGSRLRLRLDGS-DSQNDFWRLVDSTEIHAIGHCEKNGG 268
                  59********..**********88776655.55**************************************.************************** PP
    MBT-2.txt  99 elqpp 103
                   lqpp
  FBpp0297150 269 MLQPP 273
                  **998 PP
    MBT-2.txt   1 sdwkeylrktldgakvapkslseklseskallsfkvgmrlEvvdkknsseirvatveeviggrlkvsfeesededddyWidesspfifpvGwaakqgk 98 
                  s+w+ yl+k+l++a+vap+++++ ++++++++ fkvg++lE+vdkkn+++i++atv+++++++++v+f+++ + ++dyW++++s++ifp+Gw+a++++
  FBpp0297150 281 SSWPGYLCKILNNAMVAPEEIFQPEPPEPEENLFKVGQKLEAVDKKNPQLICCATVDAIKDDQIHVTFDGW-RGAFDYWCNYRSRDIFPAGWCARSCH 377
                  68*********************************************************************.************************** PP
    MBT-2.txt  99 elqpp 103
                  ++qpp
  FBpp0297150 378 PMQPP 382
                  ***98 PP
Protein Sequence
(Fasta)		MSGGRDSSTS SGSNSAAPGA STNATSSASA SASSTSTSAS PGSTTSPAST QRQRGRPAKR 60
ATCTWCGEGK LPLQYVLPTQ TGKKEFCSET CIAEFRKAYS KGACTQCDNV IRDGAPNKEF 120
CSIMCMNKHQ KKNCSTRHSG GSASGKGLAE SERKLLASGA PAPTGPFQYE SFHVFDWDAY 180
LEETGSEAAP AKCFKQAQNP PNNDFKIGMK LEALDPRNVT STCIATVVGV LGSRLRLRLD 240
GSDSQNDFWR LVDSTEIHAI GHCEKNGGML QPPLGFRMNA SSWPGYLCKI LNNAMVAPEE 300
IFQPEPPEPE ENLFKVGQKL EAVDKKNPQL ICCATVDAIK DDQIHVTFDG WRGAFDYWCN 360
YRSRDIFPAG WCARSCHPMQ PPGHKSRMDS SSSKQRCPRP RYTVVAESEA MVPASPATAH 420
FHPNCKGGPF INNSKLPCMV TGPTYQTLAK LCLQEVLAAS TDTQQLSKLL FALEGDVHIV 480
TAAGKNFTVK IPSPMRMKDD ESLAQFIETL CTTCRACANL ISLVHETEEC KKCANSRKRQ 540
LTQSATPPSS PVLADKRNRQ SNSATTSPSE KIIKQELAVK SPVESKSKTS TNNGKEPASQ 600
QNSNHSLNNN NNSASKSSNK VVIKSEPNGA NAQTSSTTQA LRKVRFQHHA NTNTNSSATN 660
GNQDTSQTTH VSTSHCSSSS TSSSTSLAGG SANTSTIGKY LAPLVAEVHP EQANVKPSNS 720
YYKSPTTLSS SASLPTSVST PFTGCQSASS TALAAGGVTA AKAATAPAGA AATAGASPSY 780
TAITSPVSTP TSALANSHLR SQPIDWTIEE VIQYIESNDN SLAVHGDLFR KHEIDGKALL 840
LLNSEMMMKY MGLKLGPALK ICNLVNKVNG RRNNLAL 877
Nucleotide Sequence
(Fasta)		CACCACTAGA AAAACAAATA TGGCGGAACC GAGCGTAAAA GTAAAAAAAG TCTAACATTT 60
TGGAGTTTAA GCGACTCAAA ATCATCTAAT TTCGGATTGA AACCGAGTAA CAAGATCCGC 120
GCAGCGCTCT AAATATAAAG CTCGATATTT GGTGAACCAG AAACTAATTG TGCGGCTCGC 180
GTTTGTTTTC GTTGGGTGAT GCGATGCGAT TTGGCCACCA ATTTGTTATT ACGTGACCTC 240
AAGAACGCCG CAAAATTTCG CCAGGCCAAA TCGAAAGAAA TCGGAAAGTT AGTGCTGCAA 300
AACAAAACTT GCTATTGGTG GCTAATGATT CAAGGCAGCC GCAATGCGAT TTGACCGCCG 360
GATCGGAACA CACGAAATCG AAATCGCCTG AGATGCCAAG GGGCTTGCCG GCGCGAATCA 420
GCAAGTGCGA CTACTAGGAC AGCCACGCGA GAAACCATGT CGGGCGGACG TGATAGCAGT 480
ACCAGTAGCG GGAGCAATTC TGCTGCGCCA GGGGCCAGTA CGAATGCCAC CTCCTCCGCA 540
TCCGCATCCG CCTCCTCCAC ATCCACATCC GCATCCCCTG GAAGTACAAC ATCGCCCGCG 600
TCCACGCAAC GGCAACGAGG TAGACCGGCC AAACGAGCCA CATGCACCTG GTGCGGCGAG 660
GGCAAGCTAC CGCTGCAGTA CGTCCTGCCC ACGCAGACCG GCAAGAAGGA GTTCTGCTCG 720
GAAACATGCA TTGCCGAGTT CCGCAAGGCG TACAGCAAGG GGGCGTGCAC CCAGTGCGAC 780
AACGTCATCC GCGATGGGGC GCCCAACAAG GAGTTCTGCT CGATCATGTG CATGAACAAG 840
CACCAGAAGA AGAACTGCTC GACCAGGCAC AGCGGCGGAT CGGCATCGGG CAAGGGTCTG 900
GCGGAAAGCG AGCGCAAGTT GCTGGCCAGT GGAGCGCCCG CACCAACGGG GCCCTTTCAA 960
TACGAGAGCT TCCACGTCTT CGACTGGGAT GCCTATCTAG AGGAAACGGG TAGCGAAGCT 1020
GCTCCTGCAA AATGTTTCAA ACAGGCTCAG AATCCTCCCA ACAATGATTT TAAAATCGGA 1080
ATGAAGCTGG AGGCTTTGGA TCCGCGCAAC GTCACTTCCA CCTGCATTGC CACCGTGGTC 1140
GGAGTGCTTG GCTCCAGACT GCGGCTACGC CTGGATGGAA GTGACTCCCA GAATGACTTT 1200
TGGCGGCTGG TCGATTCTAC GGAGATCCAT GCTATTGGAC ACTGTGAAAA GAACGGTGGC 1260
ATGCTGCAGC CGCCTCTGGG ATTCCGCATG AACGCATCCA GCTGGCCCGG CTATCTGTGC 1320
AAGATCCTCA ACAATGCCAT GGTGGCGCCA GAAGAGATCT TCCAGCCAGA GCCGCCAGAG 1380
CCAGAAGAAA ACCTGTTCAA GGTGGGCCAG AAACTCGAGG CTGTCGACAA GAAGAACCCG 1440
CAGCTCATCT GCTGTGCAAC AGTAGATGCA ATCAAGGATG ATCAGATCCA TGTAACATTC 1500
GATGGTTGGC GAGGGGCATT CGACTACTGG TGCAATTACC GATCGCGTGA CATTTTTCCC 1560
GCCGGCTGGT GCGCTAGAAG TTGTCATCCC ATGCAGCCAC CGGGCCATAA ATCGCGCATG 1620
GACTCCAGCT CTAGCAAACA GCGATGCCCT CGACCCCGCT ACACTGTTGT AGCTGAGTCC 1680
GAGGCTATGG TTCCCGCTTC CCCTGCCACA GCCCACTTCC ATCCGAACTG CAAGGGCGGT 1740
CCGTTCATCA ACAATTCCAA ACTGCCCTGC ATGGTGACGG GACCCACCTA CCAAACGCTG 1800
GCCAAGCTTT GCCTGCAGGA GGTTTTAGCT GCCAGCACGG ATACGCAACA GCTCTCAAAG 1860
TTGCTGTTTG CCCTGGAAGG AGATGTTCAT ATCGTGACGG CAGCGGGGAA AAATTTCACA 1920
GTAAAAATAC CATCGCCAAT GCGAATGAAG GATGACGAAA GCCTCGCCCA ATTCATCGAA 1980
ACGCTGTGCA CTACATGCCG GGCATGTGCG AATCTCATTT CCTTGGTCCA CGAGACGGAG 2040
GAGTGCAAGA AGTGCGCCAA TAGTCGGAAG CGTCAACTGA CTCAGTCAGC CACACCGCCT 2100
TCCTCGCCAG TGCTCGCCGA CAAGCGAAAC CGTCAATCCA ACTCGGCAAC GACATCACCC 2160
TCTGAGAAGA TTATCAAGCA GGAATTGGCT GTCAAATCGC CAGTGGAGTC CAAGTCGAAA 2220
ACTTCGACGA ACAATGGCAA GGAGCCTGCA AGCCAGCAAA ACAGCAATCA CAGTCTCAAC 2280
AATAACAACA ACAGTGCCAG CAAGTCCAGC AACAAGGTGG TCATCAAATC GGAGCCCAAC 2340
GGAGCGAACG CGCAGACTTC CTCCACAACG CAGGCTCTGC GCAAAGTACG CTTCCAACAC 2400
CACGCAAACA CGAATACGAA TAGCTCTGCG ACAAACGGAA ACCAGGATAC GAGCCAGACC 2460
ACGCACGTAT CTACCAGCCA TTGCAGCAGC TCGTCAACGT CGTCCAGCAC GAGCCTAGCC 2520
GGAGGATCGG CGAACACCAG CACAATTGGC AAATACCTGG CACCTCTTGT GGCAGAAGTT 2580
CATCCAGAGC AGGCCAATGT AAAGCCCTCG AATAGCTACT ACAAGAGTCC GACGACGCTC 2640
TCGTCAAGCG CCTCGTTGCC GACATCCGTG TCCACGCCGT TCACGGGCTG CCAGTCAGCC 2700
TCGTCCACTG CACTGGCTGC AGGTGGAGTT ACAGCGGCTA AGGCGGCCAC CGCGCCGGCT 2760
GGAGCAGCGG CAACTGCGGG AGCTTCTCCG AGCTACACCG CGATTACCTC ACCCGTGAGC 2820
ACGCCCACTT CTGCTTTGGC AAACTCACAT CTGCGGTCGC AGCCGATCGA CTGGACCATC 2880
GAAGAGGTGA TCCAGTACAT CGAGAGCAAC GACAACTCCC TTGCAGTTCA TGGTGATCTC 2940
TTCCGAAAGC ACGAAATCGA TGGTAAAGCT TTATTATTGC TAAATTCAGA GATGATGATG 3000
AAGTACATGG GCCTGAAGCT AGGACCAGCC TTAAAAATCT GCAATTTAGT CAATAAGGTC 3060
AATGGTCGTC GAAATAATCT GGCACTCTAA ACAGAAAAAC ATTAAGTTTC AGGCAGCGGA 3120
CTCGGTTCGG GTTTGACTTA TATAGAAATT GTTAACAAAT TAGTACCTCC CTTTAACGTA 3180
AAGCAAAGCA AACATGAACG ATATTCATAG ATGTGTTATG TGTTGGCCAT TCATGAAGAA 3240
AAAACCCCTA CCCTATTTTA TTATATTGAT AATATAAAAC ACGCTATAAC AAATGTAATC 3300
GCGAAGACAT GAAATTCCCT ATACAAAATC AATCGCATAA CAAATTATAC ACAGTCAAGC 3360
TCCGGTTTTC AAAACCATTA TTATTAATTT TTTTCCAACT GCTCGTGATT CTTTTTTTGG 3420
AATACACATT TACAAATTGA TTTATTTAGA CAAAATTATT ATACTTGAAT TAGGAATTTT 3480
TATAGGTTTA TTCAAATTTA CCCAGTCAAA GGAGTGGAGT ATTCGTACAC ACACAATAAT 3540
TAGTTTATCC ATCTATTTCG AAAAATGTGA AATAGTTCTC AATTGGACAC AAAATGATTC 3600
GACTTTTTCG AAAACTGGAG CTCGGCTACC AAAATCGCAA TGCACATACA TTATATTTAT 3660
TACACATAAA AACACGCACA TTAGACACCA AAATCTATCC GACACAAAAG AAATGATAAT 3720
TAACTTTAGA ATAGGCGAGA AAATAAAAAC CAATATTAAA TGATTGT 3768
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR021987--DUF3588
IPR004092--Mbt
IPR001660--SAM
IPR013761--SAM/pointed
IPR012313--Znf_FCS
IPR010507--Znf_MYM
PROSITE

PS51079--MBT
PS50105--SAM_DOMAIN
PS51024--ZF_FCS
Pfam

PF12140--DUF3588
PF02820--MBT
PF00536--SAM_1
PF06467--zf-FCS
Gene Ontology

GO:0005634--C:nucleus
GO:0005700--C:polytene chromosome
GO:0035102--C:PRC1 complex
GO:0042802--F:identical protein binding
GO:0008270--F:zinc ion binding
GO:0007409--P:axonogenesis
GO:0016568--P:chromatin modification
GO:0048749--P:compound eye development
GO:0016458--P:gene silencing
GO:0030708--P:germarium-derived female germ-line cyst encapsulation
GO:0045926--P:negative regulation of growth
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0022008--P:neurogenesis
GO:0030713--P:ovarian follicle cell stalk formation
GO:0006351--P:transcription, DNA-templated
GO:0007419--P:ventral cord development
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Mod-0153 ENSMODP00000021393.3 Monodelphis domestica 64 2e-74 278
WERAM-Asm-0013 ENSAMXP00000001859.1 Astyanax mexicanus 60 3e-73 274
WERAM-Ora-0093 ENSOANP00000016657.2 Ornithorhynchus anatinus 65 5e-73 273
WERAM-Lac-0026 ENSLACP00000004182.2 Latimeria chalumnae 67 5e-73 273
WERAM-Pes-0115 ENSPSIP00000013723.1 Pelodiscus sinensis 68 6e-73 273
WERAM-Sah-0113 ENSSHAP00000012035.1 Sarcophilus harrisii 68 1e-72 272
WERAM-Anc-0122 ENSACAP00000011431.3 Anolis carolinensis 66 1e-72 272
WERAM-Meg-0149 ENSMGAP00000015548.2 Meleagris gallopavo 65 3e-72 270
WERAM-Gaga-0152 ENSGALP00000026636.4 Gallus gallus 65 4e-72 270
WERAM-Anp-0090 ENSAPLP00000010486.1 Anas platyrhynchos 65 4e-72 270
WERAM-Fia-0061 ENSFALP00000004491.1 Ficedula albicollis 65 5e-72 270
WERAM-Leo-0072 ENSLOCP00000009205.1 Lepisosteus oculatus 66 5e-72 270
WERAM-Tar-0149 ENSTRUP00000032053.1 Takifugu rubripes 64 7e-72 269
WERAM-Gam-0168 ENSGMOP00000016806.1 Gadus morhua 67 1e-71 269
WERAM-Pof-0230 ENSPFOP00000018943.2 Poecilia formosa 66 1e-71 269
WERAM-Xim-0125 ENSXMAP00000010575.1 Xiphophorus maculatus 66 3e-71 268
WERAM-Gaa-0144 ENSGACP00000018461.1 Gasterosteus aculeatus 64 6e-71 266
WERAM-Ran-0177 ENSRNOP00000051099.3 Rattus norvegicus 67 6e-71 266
WERAM-Myl-0083 ENSMLUP00000006723.2 Myotis lucifugus 59 1e-70 266
WERAM-Tag-0107 ENSTGUP00000008015.1 Taeniopygia guttata 59 1e-70 265
WERAM-Xet-0085 ENSXETP00000028407.3 Xenopus tropicalis 67 1e-70 265
WERAM-Orn-0195 ENSONIP00000020379.1 Oreochromis niloticus 66 1e-70 265
WERAM-Fec-0152 ENSFCAP00000014209.3 Felis catus 67 2e-70 265
WERAM-Ten-0073 ENSTNIP00000009135.1 Tetraodon nigroviridis 66 2e-70 265
WERAM-Nol-0133 ENSNLEP00000014903.2 Nomascus leucogenys 67 2e-70 265
WERAM-Ptv-0017 ENSPVAP00000002374.1 Pteropus vampyrus 59 2e-70 264
WERAM-Mup-0163 ENSMPUP00000013977.1 Mustela putorius furo 67 2e-70 264
WERAM-Hos-0063 ENSP00000251900.4 Homo sapiens 63 3e-70 264
WERAM-Chs-0012 ENSCSAP00000016858.1 Chlorocebus sabaeus 67 3e-70 264
WERAM-Pat-0004 ENSPTRP00000056840.2 Pan troglodytes 67 3e-70 264
WERAM-Otg-0163 ENSOGAP00000013791.2 Otolemur garnettii 67 3e-70 264
WERAM-Gog-0194 ENSGGOP00000016776.2 Gorilla gorilla 67 3e-70 264
WERAM-Mum-0002 ENSMUSP00000000087.6 Mus musculus 67 3e-70 264
WERAM-Tub-0010 ENSTBEP00000000916.1 Tupaia belangeri 67 3e-70 264
WERAM-Caf-0032 ENSCAFP00000003780.3 Canis familiaris 67 4e-70 264
WERAM-Ict-0116 ENSSTOP00000011742.2 Ictidomys tridecemlineatus 67 4e-70 263
WERAM-Ova-0214 ENSOARP00000021856.1 Ovis aries 67 4e-70 263
WERAM-Eqc-0192 ENSECAP00000020768.1 Equus caballus 67 4e-70 263
WERAM-Orc-0042 ENSOCUP00000004062.3 Oryctolagus cuniculus 67 4e-70 263
WERAM-Tut-0125 ENSTTRP00000010021.1 Tursiops truncatus 67 5e-70 263
WERAM-Bot-0016 ENSBTAP00000002134.5 Bos taurus 67 6e-70 263
WERAM-Ere-0038 ENSEEUP00000002917.1 Erinaceus europaeus 67 7e-70 263
WERAM-Mam-0036 ENSMMUP00000006741.2 Macaca mulatta 62 7e-70 263
WERAM-Dar-0231 ENSDARP00000131127.1 Danio rerio 65 9e-70 262
WERAM-Loa-0121 ENSLAFP00000011138.3 Loxodonta africana 67 1e-69 262
WERAM-Prc-0071 ENSPCAP00000006551.1 Procavia capensis 67 1e-69 262
WERAM-Vip-0037 ENSVPAP00000003523.1 Vicugna pacos 67 1e-69 262
WERAM-Poa-0193 ENSPPYP00000022558.1 Pongo abelii 62 1e-69 262
WERAM-Paa-0210 ENSPANP00000003375.1 Papio anubis 67 2e-69 261
WERAM-Dan-0018 ENSDNOP00000001856.3 Dasypus novemcinctus 61 4e-69 260
WERAM-Orla-0153 ENSORLP00000017829.1 Oryzias latipes 66 1e-68 258
WERAM-Aim-0191 ENSAMEP00000017807.1 Ailuropoda melanoleuca 62 4e-68 257
WERAM-Sus-0085 ENSSSCP00000012940.2 Sus scrofa 59 6e-68 256
WERAM-Tas-0055 ENSTSYP00000005172.1 Tarsius syrichta 64 2e-67 254
WERAM-Dio-0148 ENSDORP00000013601.1 Dipodomys ordii 62 6e-67 253
WERAM-Mim-0115 ENSMICP00000011266.1 Microcebus murinus 65 5e-65 246
WERAM-Cap-0038 ENSCPOP00000003071.2 Cavia porcellus 62 2e-62 238
WERAM-Mae-0026 ENSMEUP00000001773.1 Macropus eugenii 63 1e-61 235
WERAM-Soa-0090 ENSSARP00000008503.1 Sorex araneus 68 9e-61 233
WERAM-Caj-0063 ENSCJAP00000010784.2 Callithrix jacchus 64 2e-59 228
WERAM-Cis-0067 ENSCSAVP00000015010.1 Ciona savignyi 52 3e-56 217
WERAM-Cii-0016 ENSCINP00000025543.2 Ciona intestinalis 51 6e-52 203
WERAM-Pem-0053 ENSPMAP00000006206.1 Petromyzon marinus 37 7e-37 153
WERAM-Ect-0004 ENSETEP00000000278.1 Echinops telfairi 42 3e-35 147
WERAM-Ocp-0026 ENSOPRP00000002220.1 Ochotona princeps 38 3e-33 141
Created Date 25-Jun-2016