WERAM Information

Tag Content
WERAM ID WERAM-Drm-0098
Ensembl Protein ID FBpp0292800
Uniprot Accession Q8INR6; DOT1L_DROME; A4V2H8; Q1RKY0; Q9VI22
Genbank Protein ID NP_649655.1; NP_731083.1; NP_731084.1
Protein Name Histone-lysine N-methyltransferase, H3 lysine-79 specific
Genbank Nucleotide ID NM_141398.4; NM_169142.2; NM_169143.2
Gene Name DOT1L;gppCG10272
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0264495 FBtr0303788 FBpp0292800
FBgn0264495 FBtr0303787 FBpp0292799
FBgn0264495 FBtr0303789 FBpp0292801
FBgn0264495 FBtr0303790 FBpp0292802
FBgn0264495 FBtr0334322 FBpp0306435
Details
Type Family Domain Substrates AA References (PMIDs)
HMT nonSET DOT1 H3K79 K 15371351
Status Reviewed
Classification
Type Family E-value Score Start End
HMT nonSET 9.70e-169 561 19 336
Organism Drosophila melanogaster
NCBI Taxa ID 7227
Functional Description
(View)		 Histone methyltransferase. Methylates 'Lys-79' of histone H3. Required for Polycomb Group (PcG) and trithorax Group (trxG) maintenance of expression. Also involved in telomeric silencing but do not in centric heterochromatin. Probably participates in pairing sensitivity.
Domain Profile
  HMT nonSET
   nonSET.txt   1 dvivfkwplai..ydkkydaaseiielikyvCeelPdlkaafensvlididtksfesmirlvdkynraidsirilekgttlpleklnkiprtsllrdi 96 
                  dvi+f+wpl+i  +++k+d++++ii++ik+vC+elP++++afe+++l++idt+++++m++lvd++n+a+dsi++lekgt+lp+e+lnk++++sllr+i
  FBpp0292800  19 DVISFAWPLQIghGQDKHDNGIDIIDTIKFVCDELPSMSSAFEETNLHQIDTACYKTMTGLVDRFNKAVDSIVALEKGTSLPAERLNKFAHPSLLRHI 116
                  799********9889*********************************************************************************** PP
   nonSET.txt  97 lqlvynrsvtdaeklnnyeafspevyGelsfdlvaqvldevklkkddtfvdlGsGvGqvvlqvaaetncklsfGvekadiaakyaelmdeelrkrmkl 194
                  lqlvyn++v+d++kln+ye+fspevyGe+s++lv+q+l++v+++k+dtf+dlGsGvGqvvlq+a+++++k+++G+ekad++a+yae+md+++r++m++
  FBpp0292800 117 LQLVYNAAVLDPDKLNQYEPFSPEVYGETSYELVQQMLKHVTVSKEDTFIDLGSGVGQVVLQMAGSFPLKTCIGIEKADTPARYAERMDVIFRQYMGW 214
                  ************************************************************************************************** PP
   nonSET.txt 195 yGkrlaeyelekgdflvdenreriaqtdvilvnnfafgeevdkklkerladlkeGarivsskslaplnfrinsrnlsdigtilkvveldllkgsvsWt 292
                  +Gkr++ey+l+kgdflvde+re+i+++++++vnnfafg++vd++lker+adl++Gar+vssks++plnfri++rnlsdigti++v+e+++lkgsvsWt
  FBpp0292800 215 FGKRFCEYKLIKGDFLVDEHRENITSSTLVFVNNFAFGPTVDHQLKERFADLRDGARVVSSKSFCPLNFRITDRNLSDIGTIMHVSEIPPLKGSVSWT 312
                  ************************************************************************************************** PP
   nonSET.txt 293 gkpvsyylhtidrtilesyfsslk 316
                  +kpvsyylh+idrtile+yf++lk
  FBpp0292800 313 CKPVSYYLHVIDRTILERYFQRLK 336
                  *********************997 PP
Protein Sequence
(Fasta)		MATPQVKDLV LRSPAGSSDV ISFAWPLQIG HGQDKHDNGI DIIDTIKFVC DELPSMSSAF 60
EETNLHQIDT ACYKTMTGLV DRFNKAVDSI VALEKGTSLP AERLNKFAHP SLLRHILQLV 120
YNAAVLDPDK LNQYEPFSPE VYGETSYELV QQMLKHVTVS KEDTFIDLGS GVGQVVLQMA 180
GSFPLKTCIG IEKADTPARY AERMDVIFRQ YMGWFGKRFC EYKLIKGDFL VDEHRENITS 240
STLVFVNNFA FGPTVDHQLK ERFADLRDGA RVVSSKSFCP LNFRITDRNL SDIGTIMHVS 300
EIPPLKGSVS WTCKPVSYYL HVIDRTILER YFQRLKTKGG NDHESVGTVR TTRDRAKREA 360
NVGQHHHNNH HSNNHANSNN HQRDREQSNG ATATAAHQQR HQSQSPANVS GAGIVLAASG 420
QQAASKTRQQ LQHQHNQQQR SLDMESSTES DGDATNGNGG NTTTATNTTS ASNGPMTRKV 480
WSDWCSSKGK SSQSDDEENN NSNSNGGSNG GSIGGGSVGR QARATTQKKR KKLTRKAAIA 540
SKSAAAAQRE AEAAAAAAVS VPSKESSSKE DPPRAASAGP GRKGRMKKGA RGRKSLKIVG 600
LEALHKQTVL STSLDTMTKK LPAAPGTVDQ QLTALLTENM SHAELDIPTA PQDTPYALQI 660
LLDVFRSQYT SMIEHMKSSA YVPQVQKQIA QEQERMARLK NRASQLDKQI KVLIDDSVAL 720
LKVRMNELGI HVNSPNDLIA QAKEIVGRHK DLQHTASRMR NEVTFYEGEQ KLLLNKQLKN 780
LPEYQKLCGT VNGKVKLEVP PELSETTAQE LVLKEIANTL SQRKKLYAQV STIEQETSVL 840
QKTAEERSTA ATLLAQGTNM IVSTGSSSSS STTVCASAVT AQSNKLNSVK NSRRNREHRA 900
RSQEWPEVPE VGKIQESNPE VLAQKIVETC RQIEAGKFQG AGAPSSQVNG KNKAIIEVPP 960
PPATAPVSIK SSPGHHYKDT TLMPAPKQQQ QQQMTLSQLP KCELPGLSTS RKQESPKVAN 1020
FEDRLKSIIT TALNEDQEQR SKAVESSPSP SPLHSPAPKR SKQHPAGAIN PAQSLPNNLH 1080
NIITVSTQGL MHLNANTTIS PITPPLPGPG AGATASTAPP PPANLPYGAY GGAVAKTTIS 1140
GKYQAAKEPK YSPVRQAPLP PPPSHMASLY PAGQQTTPAD LGYQRRRSSV SATSYEHYMV 1200
QQQQQLQQQQ LMLAAAAHAA QRQQMRVEEQ QQQQQHQHHH HHHHHHPQHR LPQHVQHQHP 1260
HQHHPNEFKA PPADSHLQRS SSREQLIVEP PQTQPLELLP RASSANSDYS GYRIRPPSRP 1320
SSNSSQPDYT QVSPAKMALR RHLSQEKLSQ HVTPQATPPL PGHGGAPTSG KTIGDLVNGE 1380
IERTLEISHQ SIINAAVNMS TSGASFMERA FLNERSNDRL LINLNAQRPE RVHVRPLSEE 1440
SQDPQPTSYA QERGPGLGAG GAAAGGNSNL ATLAHVAYAQ KAQGGARANA GTAPPATHSS 1500
SARSGRDYQP VALPRAELKG SIEAYFHEEQ QQKQSKGAGS AGSSSLRGPR LNGANPPLEG 1560
LAASLQDHVR ARKYKEETEE RQRRAAAAAS SSAGPPAGME LPTHYAHQAP PAHSYHHHGA 1620
SINGTPHKVE LGIKRSSPLA PHQQPPRPSK LAHYEPPTTQ QQHAHAHLYA NGQVLPPPPA 1680
HDATTPSPTP SSSSSSCGRR SNSNNGKLLV DPPLLMSPEI NSLLGDERPL QLSHHQQQQQ 1740
QMLHHHQSQQ QQHLQLTQQQ LRVAHLGHGL SHGHSTMPTL GGQRNGNGNA ADDVNDLATQ 1800
RTITNYDPRR RLRTTLSGPT KLSAAHSNQN LNGYVMADSS SSCPTIPQ 1848
Nucleotide Sequence
(Fasta)		TTTTTGTTTC TTTCTTTCGC TGGAACATAA CGGACGTGTC GTTGCGTCGT CTTCCTCGTC 60
GCGCGCGTGT GTGTGTGGTG TATGTGTGTA CTGAAACATT TTGGGGTCGT AGCAAATCGG 120
AGAAAAATTC TTAATTATAC AATACAATAC TCGTGCTTGT TCTCGCAGCG AATCGAAGTG 180
ATCCAATTGT GAGATTTGGC TGCAAAGGAA GAATACGAAA AGTTAGCTAA ATTACGTGAG 240
TAGCCAGAGT GTGAGTGTGT GAGCCAGAGC GAGGCGGCAA ATCAGTATGG CGTGAAAGAG 300
CTGCAAAATG TAATTTGCTG TGAATACCTC TGTGTGTTCG TGCCTGTGTT TAGTGTGCAT 360
GTGTGCTAAA ACAAATGCCT AAATTGCAAC AAAGAAAATT GTATGAAATA TACGAAGCGA 420
AGAGCAGAGC GAAAGCGACG ATGAAAAAGA GGCTGCTGCT TGAAAAATAA GAAGAGGTGG 480
AGGAGCAAGA AGAAGAGCAG CAGCAGCCGT CGCGAGTTTT TTACACGCGT GTGTTAGTGT 540
GCATACAATT GTGTATGAAA AAGAATAAAA GCTAATCTAA AGTGTCAAAC GTAATCTTGT 600
ATATCTCCGT GTTTCTTGCA GCGCTTGACA ACGAAATTTA TATTACATAG TAAATGCGAA 660
ATACAACAAA GGTTAATCAT ATTGCTTAAT CAGAGTACTG CGGTTTCAAA CGTCTTCGTC 720
TTCCCCATCT TCTAAACTGG AATGCAACCA ACACCAAACA ACCAAAACCC ACAACAACAA 780
CAACAAGATC GAATGGAGTA AAACAGAAAC CAAGAACCTT TAAAGAGAGC AGTGAGAGAG 840
AGGCGTCGGC TAACGGCTAA TCAATTGACA AAGCGCAAAG AGAGAGGGAG AAGAAGCAGA 900
GCGCTGAGTG CGCGAAATAC TCAAACTAAC AAAACACTTT TAAACTGTAC ATAAATTACG 960
GCGCGCGTGT TGTAAAGGCG TAAAGATAGC AGATTCCACT GAAACACTTG CCAATACTGG 1020
ACAGAGTTGC GTGCAATATG TGCAACGGTT TTCGGCAACG AGCGTGCGCC ACGAAACGCA 1080
CTGAATCGAA ACGGAACGGT GGGAATCTAT AATGCAACAG CAACAGGAAG AATTCGATAC 1140
AGAAACAGAA ACTGTAGGGG GAAAGGAAAA CATTTGGAAA ATGTTGTTCC CGAAAACTGA 1200
AGAAAATGCA TCGTTTTCTT AACATCCAGC AAAATATCAA ACTTCGCAAC TATCATCAGT 1260
TACTTTTGTA TTTTGTCGCT GCTGCTGGAG GAAGAGCGGA AGTGAGAAGA GGAAGACGGA 1320
CCGGAACCGG AAAGAGAAGC CTTCGCAAAG GAAGCAGAAA AGGAAGCAGA GCAGCAGCAG 1380
CAGTAAAAGT AACAGTTAAA GTAACGTTTA GAGCAACGTC GAGAGTAGTT GAAGCATAAT 1440
ATTATTCTAT TAGCCCAATA CGTTAACCCA ACGCTGCCAC TGTTCCTAAG ACACTAAATT 1500
TGACACAAAA AAGAAGAAGA AACCACTTGA AATAAACGTA GACCATAGTC GTAACCGTAA 1560
AACGAAACGC CAACGCCTCT ACACAATATA CGCTACTGAA ACACGAATCC TATGCCAATT 1620
TTTGATCATC AAATCGCTTA GCACCTATCA TAGACTCCCA TAAACGCCTC ATCAAACGTC 1680
AAAATCTCAA ACGACAGTGT CGCAACTAGA CGTTGTTTTC GACAAATACC CAAAACCCCC 1740
ACAAAAACAA CGCCGATCTC GCCCCTTTGT CACGCACACC AAAAACACAA CAAAATAGAC 1800
AAAAATAATA AAAAAAAAGG CTGGCTAAGG CTAAGGAAAG CGGAAAAATA TGGCCACACC 1860
CCAAGTCAAG GACTTGGTGT TGCGCTCGCC CGCTGGCTCC TCCGATGTCA TTTCCTTCGC 1920
CTGGCCCCTG CAGATCGGAC ACGGACAGGA TAAGCACGAC AATGGCATCG ACATCATCGA 1980
CACCATTAAG TTCGTCTGCG ATGAACTGCC ATCGATGTCA TCGGCCTTCG AGGAAACCAA 2040
TCTCCACCAA ATTGACACTG CCTGCTATAA GACTATGACC GGTCTGGTCG ATCGCTTCAA 2100
CAAGGCCGTC GACAGTATCG TTGCATTGGA AAAAGGAACT TCACTGCCCG CCGAGCGCCT 2160
GAACAAGTTC GCTCACCCTA GCCTTCTAAG ACACATATTG CAATTAGTTT ACAATGCCGC 2220
CGTACTCGAT CCGGATAAAC TCAACCAGTA CGAGCCCTTC TCGCCAGAGG TTTACGGCGA 2280
GACGAGCTAT GAGCTGGTGC AGCAGATGCT TAAGCACGTC ACTGTCAGCA AGGAGGACAC 2340
GTTTATCGAT CTCGGCTCGG GGGTGGGCCA GGTGGTTCTG CAGATGGCCG GATCGTTTCC 2400
CCTGAAAACC TGCATCGGCA TCGAGAAGGC CGACACGCCG GCGCGATATG CGGAACGCAT 2460
GGATGTTATC TTCCGCCAGT ATATGGGATG GTTTGGAAAA CGCTTTTGCG AATACAAGCT 2520
GATAAAGGGT GACTTCCTGG TCGATGAGCA TCGTGAAAAC ATCACCTCAT CGACGCTGGT 2580
TTTTGTAAAT AACTTCGCCT TTGGGCCAAC TGTGGACCAT CAGCTCAAGG AACGGTTCGC 2640
AGATCTTCGC GACGGAGCAC GGGTCGTGTC CTCCAAGTCG TTTTGCCCGC TGAACTTTCG 2700
GATCACAGAC AGAAACCTCA GTGACATTGG CACCATTATG CACGTCAGCG AAATTCCGCC 2760
CCTCAAGGGG TCCGTTTCCT GGACCTGCAA GCCCGTTTCG TATTATCTGC ATGTGATCGA 2820
TCGCACCATA TTGGAGCGAT ACTTTCAGCG CCTGAAAACT AAGGGCGGCA ACGATCACGA 2880
GAGCGTGGGA ACTGTTCGCA CCACACGTGA TCGCGCCAAG CGAGAGGCAA ACGTTGGCCA 2940
ACATCATCAC AACAATCATC ATAGCAACAA CCACGCCAAC AGCAACAACC ATCAGAGGGA 3000
TCGGGAGCAG TCGAACGGAG CTACCGCAAC TGCAGCTCAT CAGCAACGGC ATCAGTCCCA 3060
GTCGCCAGCT AATGTAAGCG GTGCGGGAAT AGTACTTGCA GCTAGCGGGC AACAAGCAGC 3120
TTCCAAAACA CGCCAGCAAC TGCAGCATCA GCATAACCAG CAGCAACGCA GCTTGGACAT 3180
GGAAAGCAGC ACGGAAAGCG ATGGCGACGC AACGAATGGC AATGGTGGCA ATACCACCAC 3240
TGCCACCAAT ACCACCTCCG CCTCCAATGG CCCGATGACT AGGAAAGTTT GGTCCGACTG 3300
GTGCAGTTCC AAAGGCAAGA GTTCGCAGTC TGACGACGAG GAGAACAACA ACTCGAACAG 3360
CAATGGCGGC AGTAATGGTG GTAGCATTGG AGGAGGATCA GTTGGCCGAC AGGCTCGGGC 3420
TACAACCCAG AAGAAGCGCA AAAAGTTGAC TAGGAAGGCT GCGATAGCCA GCAAATCTGC 3480
TGCCGCTGCC CAAAGGGAAG CGGAGGCGGC AGCGGCGGCG GCGGTATCCG TACCAAGCAA 3540
GGAGTCCAGT TCCAAAGAGG ATCCACCAAG GGCTGCTAGC GCCGGACCTG GTCGCAAAGG 3600
ACGCATGAAG AAGGGTGCGC GCGGCAGGAA GTCTTTAAAG ATTGTTGGAC TAGAAGCTCT 3660
GCACAAGCAA ACAGTGTTGA GTACCTCCTT GGATACCATG ACCAAGAAGT TGCCTGCAGC 3720
TCCTGGAACC GTGGATCAAC AGCTTACTGC TTTGCTCACG GAAAACATGT CGCATGCAGA 3780
GTTGGATATT CCAACGGCGC CACAAGACAC GCCTTATGCC TTGCAGATCC TTCTAGACGT 3840
GTTCCGTTCG CAGTACACAT CGATGATCGA GCACATGAAG TCAAGTGCCT ATGTGCCTCA 3900
AGTTCAGAAG CAGATTGCCC AAGAGCAGGA GCGGATGGCC AGGCTGAAAA ACAGAGCCAG 3960
CCAGTTGGAT AAGCAGATAA AAGTGCTGAT CGATGACAGT GTGGCTTTAC TTAAAGTGCG 4020
AATGAACGAG CTGGGCATCC ATGTAAACTC ACCAAACGAT TTGATCGCCC AGGCAAAGGA 4080
GATTGTGGGT AGACATAAGG ATCTACAGCA CACTGCAAGT CGAATGCGAA ACGAAGTAAC 4140
CTTCTATGAG GGCGAACAGA AGCTGCTCCT TAACAAACAA CTAAAAAATC TACCCGAGTA 4200
TCAAAAACTC TGTGGTACTG TTAATGGAAA GGTCAAGCTG GAGGTGCCCC CGGAACTTTC 4260
CGAGACCACG GCCCAGGAGC TGGTGCTAAA GGAGATCGCC AACACGCTAA GTCAACGAAA 4320
GAAACTTTAC GCCCAGGTGT CCACCATTGA ACAGGAGACT TCGGTTTTGC AGAAGACAGC 4380
AGAGGAAAGG TCCACGGCAG CGACGCTCTT GGCACAAGGA ACAAATATGA TTGTGTCGAC 4440
CGGATCATCT TCCTCCTCCT CTACCACTGT TTGTGCAAGT GCAGTTACGG CGCAGAGCAA 4500
CAAGTTGAAC TCCGTGAAGA ACTCTCGTCG CAATCGCGAG CACCGAGCGC GTTCCCAGGA 4560
GTGGCCAGAG GTTCCCGAAG TGGGTAAAAT CCAGGAAAGC AATCCCGAAG TGCTGGCACA 4620
GAAAATAGTC GAGACCTGCC GCCAAATCGA AGCTGGCAAG TTCCAAGGAG CAGGTGCGCC 4680
CTCATCGCAA GTGAATGGCA AGAATAAAGC AATTATAGAG GTCCCACCAC CTCCGGCCAC 4740
TGCTCCAGTG AGCATTAAAT CCTCGCCTGG GCACCACTAT AAAGACACAA CACTGATGCC 4800
AGCACCCAAA CAACAACAGC AACAACAGAT GACGCTTTCC CAGCTTCCGA AGTGTGAGCT 4860
GCCCGGACTA TCGACTAGTC GCAAACAGGA ATCTCCCAAG GTTGCCAACT TTGAGGATCG 4920
GTTAAAGAGT ATCATCACCA CGGCCTTAAA CGAAGATCAG GAGCAGCGCA GCAAGGCAGT 4980
GGAGTCGTCA CCCTCTCCCT CACCTCTTCA CAGTCCAGCA CCCAAGCGAT CAAAGCAGCA 5040
TCCGGCTGGA GCGATAAACC CTGCCCAGTC GCTGCCCAAC AATCTGCACA ACATCATCAC 5100
CGTCTCCACG CAGGGTTTGA TGCACCTTAA TGCCAATACA ACAATATCCC CAATAACACC 5160
ACCACTGCCG GGTCCAGGTG CAGGAGCAAC CGCATCCACT GCGCCGCCTC CCCCAGCGAA 5220
TCTTCCTTAT GGGGCTTACG GCGGGGCAGT GGCAAAGACA ACGATATCGG GGAAGTACCA 5280
GGCAGCTAAG GAACCGAAGT ATTCGCCAGT TAGACAGGCA CCATTACCTC CTCCCCCCTC 5340
CCACATGGCA TCTTTGTATC CAGCTGGACA GCAGACTACT CCGGCGGACC TAGGTTACCA 5400
GCGGCGACGC AGCTCTGTTA GTGCCACTAG CTACGAACAC TATATGGTAC AGCAGCAGCA 5460
GCAACTCCAG CAACAACAAC TCATGCTAGC AGCCGCTGCT CATGCGGCCC AGCGTCAACA 5520
GATGCGCGTA GAAGAACAAC AGCAGCAGCA GCAGCACCAA CACCACCACC ACCACCACCA 5580
CCACCATCCC CAACACCGTC TGCCGCAGCA TGTGCAGCAT CAGCATCCGC ATCAGCATCA 5640
TCCCAATGAG TTCAAGGCAC CGCCGGCTGA TAGTCATCTC CAGCGATCGA GCAGTCGTGA 5700
GCAATTAATA GTGGAGCCCC CGCAGACGCA ACCGCTGGAG CTGCTGCCTC GAGCAAGTTC 5760
CGCCAATTCG GATTACAGCG GATATCGCAT CCGTCCGCCA AGCAGGCCAA GCTCCAACTC 5820
CTCGCAACCA GATTACACGC AAGTTTCACC CGCAAAGATG GCTCTGCGGC GGCATCTGTC 5880
GCAGGAGAAG CTGAGCCAAC ATGTCACGCC CCAGGCCACA CCGCCGCTTC CTGGTCACGG 5940
AGGAGCACCC ACATCAGGGA AGACCATTGG CGATTTGGTT AACGGGGAAA TCGAGCGAAC 6000
GCTTGAGATT TCGCATCAGA GCATCATTAA TGCGGCTGTG AATATGAGCA CTAGTGGCGC 6060
TAGCTTCATG GAGCGGGCCT TCCTTAATGA GCGCTCCAAC GATCGTTTGC TGATCAACTT 6120
GAATGCCCAA CGACCAGAGA GAGTTCATGT TCGTCCGCTC TCCGAAGAAT CGCAGGATCC 6180
ACAGCCCACC AGTTATGCTC AGGAGAGAGG ACCTGGTCTA GGTGCTGGTG GAGCAGCAGC 6240
TGGAGGTAAC AGCAATCTGG CCACTTTGGC ACATGTAGCC TACGCCCAAA AGGCACAGGG 6300
CGGCGCTCGA GCCAACGCAG GAACGGCACC ACCCGCAACC CACTCCTCCT CTGCTCGTTC 6360
TGGACGTGAC TATCAGCCTG TGGCTTTGCC CCGTGCTGAG CTTAAGGGCA GCATTGAGGC 6420
CTATTTCCAC GAGGAGCAGC AGCAGAAGCA GTCGAAGGGC GCAGGATCAG CAGGATCGTC 6480
CTCTTTGCGG GGACCGCGTC TTAATGGTGC CAATCCTCCA TTGGAAGGTC TAGCAGCATC 6540
GCTGCAGGAT CATGTCCGTG CCAGAAAGTA CAAGGAGGAG ACCGAGGAGC GTCAACGACG 6600
TGCAGCAGCC GCTGCCTCGT CTTCGGCGGG ACCGCCTGCT GGCATGGAAC TGCCAACGCA 6660
CTATGCTCAT CAGGCGCCTC CAGCCCACAG CTACCACCAC CATGGTGCAA GCATCAATGG 6720
AACACCGCAC AAAGTAGAAC TGGGAATAAA ACGCAGCTCA CCGCTGGCGC CGCATCAGCA 6780
ACCGCCACGT CCCTCGAAAT TGGCACACTA CGAGCCGCCA ACGACGCAGC AGCAGCATGC 6840
CCATGCCCAC CTGTACGCCA ACGGACAAGT GCTACCTCCG CCTCCAGCTC ATGATGCGAC 6900
CACGCCCTCC CCGACGCCCT CGTCATCTTC ATCGTCCTGC GGACGTCGAA GCAACAGCAA 6960
CAATGGAAAG TTGCTCGTGG ATCCACCTTT GCTAATGAGT CCCGAGATCA ATTCACTGTT 7020
GGGCGACGAA AGGCCTTTGC AGCTGTCGCA CCACCAACAG CAGCAGCAGC AAATGCTGCA 7080
TCACCATCAA TCGCAGCAAC AGCAGCATCT GCAGCTGACC CAACAGCAAC TGCGTGTAGC 7140
TCATCTTGGA CATGGTCTTA GTCACGGTCA CAGCACCATG CCCACTTTGG GCGGACAACG 7200
CAATGGCAAT GGCAATGCCG CCGACGATGT TAACGATTTG GCAACGCAAC GTACTATAAC 7260
TAATTACGAT CCCAGACGTC GCCTTCGCAC GACTTTGTCT GGCCCAACGA AACTATCAGC 7320
TGCCCATAGT AATCAAAATC TGAACGGATA TGTTATGGCC GATAGTAGTA GTAGTTGCCC 7380
CACAATACCC CAATAACCAA TGATCGATTG CATTGAATTG ACTTGCATTG AACTGAATTG 7440
AATTGAATTG AATTGATTGA TTGATTGACT TGCATACCTC AAAATTCCTC AAACAAACTA 7500
AACAAAAAGC AAAACCGAAA ACATGTTTGT TGTTGGGCGA AGATACGATC TTGTAATAAC 7560
CATAAATAAT AAGCAGAGTA CAAAAAACCT GATGAAAAAC AAAGATTTCA AATCAGAAAC 7620
AACCTACAAA AGACAACTTT TAATTTTTGC GTTTAATAAT TTACCTACTA AAAGTACAGA 7680
ATTTATATGC C 7692
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
--
Interpro

IPR025789--DOT1_dom
IPR021169--DOT1L/grappa
IPR030445--H3-K79_meTrfase
IPR029063--SAM-dependent_MTases
PROSITE

PS51569--DOT1
Pfam

PF08123--DOT1
Gene Ontology

GO:0000781--C:chromosome, telomeric region
GO:0035097--C:histone methyltransferase complex
GO:0005634--C:nucleus
GO:0031151--F:histone methyltransferase activity (H3-K79 specific)
GO:0006342--P:chromatin silencing
GO:0006348--P:chromatin silencing at telomere
GO:0048096--P:chromatin-mediated maintenance of transcription
GO:0034729--P:histone H3-K79 methylation
GO:0016571--P:histone methylation
GO:0046331--P:lateral inhibition
GO:2000637--P:positive regulation of gene silencing by miRNA
GO:0051726--P:regulation of cell cycle
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Bot-0098 ENSBTAP00000013182.5 Bos taurus 55 4e-113 408
WERAM-Nol-0022 ENSNLEP00000002551.1 Nomascus leucogenys 55 7e-113 407
WERAM-Paa-0089 ENSPANP00000009219.1 Papio anubis 55 7e-113 407
WERAM-Cap-0178 ENSCPOP00000016104.1 Cavia porcellus 55 1e-112 406
WERAM-Gog-0076 ENSGGOP00000006459.2 Gorilla gorilla 58 1e-112 406
WERAM-Otg-0049 ENSOGAP00000003300.2 Otolemur garnettii 58 1e-112 406
WERAM-Mum-0211 ENSMUSP00000100973.2 Mus musculus 58 1e-112 406
WERAM-Myl-0046 ENSMLUP00000004017.2 Myotis lucifugus 58 2e-112 405
WERAM-Xet-0090 ENSXETP00000029898.3 Xenopus tropicalis 55 2e-112 405
WERAM-Pat-0084 ENSPTRP00000059247.2 Pan troglodytes 58 2e-112 405
WERAM-Ran-0179 ENSRNOP00000043691.3 Rattus norvegicus 56 2e-112 405
WERAM-Hos-0067 ENSP00000381657.3 Homo sapiens 58 2e-112 405
WERAM-Dar-0143 ENSDARP00000083509.4 Danio rerio 54 8e-112 403
WERAM-Asm-0190 ENSAMXP00000018246.1 Astyanax mexicanus 53 8e-111 400
WERAM-Xim-0156 ENSXMAP00000012884.1 Xiphophorus maculatus 54 1e-110 399
WERAM-Pof-0009 ENSPFOP00000001322.2 Poecilia formosa 54 2e-110 399
WERAM-Gaga-0008 ENSGALP00000001234.4 Gallus gallus 60 3e-110 398
WERAM-Orn-0052 ENSONIP00000006006.1 Oreochromis niloticus 55 6e-110 397
WERAM-Ten-0051 ENSTNIP00000006986.1 Tetraodon nigroviridis 54 6e-110 397
WERAM-Caf-0201 ENSCAFP00000032181.2 Canis familiaris 57 8e-110 397
WERAM-Ova-0153 ENSOARP00000015227.1 Ovis aries 58 9e-110 396
WERAM-Aim-0067 ENSAMEP00000005765.1 Ailuropoda melanoleuca 60 1e-109 396
WERAM-Poa-0077 ENSPPYP00000010482.2 Pongo abelii 60 1e-109 396
WERAM-Loa-0036 ENSLAFP00000002270.4 Loxodonta africana 60 2e-109 395
WERAM-Fec-0094 ENSFCAP00000007980.3 Felis catus 60 2e-109 395
WERAM-Anp-0075 ENSAPLP00000009183.1 Anas platyrhynchos 60 2e-109 395
WERAM-Fia-0168 ENSFALP00000014375.1 Ficedula albicollis 60 3e-109 395
WERAM-Meg-0021 ENSMGAP00000001612.2 Meleagris gallopavo 60 2e-108 392
WERAM-Leo-0052 ENSLOCP00000007020.1 Lepisosteus oculatus 57 3e-108 391
WERAM-Tar-0217 ENSTRUP00000045719.1 Takifugu rubripes 53 3e-108 391
WERAM-Tag-0004 ENSTGUP00000000304.1 Taeniopygia guttata 56 4e-107 388
WERAM-Dan-0030 ENSDNOP00000002767.3 Dasypus novemcinctus 59 6e-107 387
WERAM-Sah-0123 ENSSHAP00000012830.1 Sarcophilus harrisii 60 4e-106 384
WERAM-Caj-0129 ENSCJAP00000024230.1 Callithrix jacchus 58 2e-103 376
WERAM-Ocp-0012 ENSOPRP00000001490.2 Ochotona princeps 55 1e-101 369
WERAM-Eqc-0099 ENSECAP00000011661.1 Equus caballus 58 2e-101 369
WERAM-Mup-0075 ENSMPUP00000006907.1 Mustela putorius furo 61 3e-101 368
WERAM-Pes-0106 ENSPSIP00000013048.1 Pelodiscus sinensis 59 8e-101 367
WERAM-Lac-0083 ENSLACP00000010704.1 Latimeria chalumnae 58 3e-99 362
WERAM-Prc-0009 ENSPCAP00000000843.1 Procavia capensis 53 6e-99 360
WERAM-Ptv-0109 ENSPVAP00000009648.1 Pteropus vampyrus 54 7e-96 350
WERAM-Mod-0038 ENSMODP00000005746.2 Monodelphis domestica 51 4e-87 321
WERAM-Sac-0010 YDR440W Saccharomyces cerevisiae 26 3e-17 89.7
Created Date 25-Jun-2016