Tag |
Content |
WERAM ID |
WERAM-Drm-0009 |
Ensembl Protein ID |
FBpp0079252 |
Uniprot Accession |
P05205; HP1_DROME; A4V0F1; B6UVR4; B6UVS1; B6UVS2; B6UVS3; B6UVT2; B6UVT6; B6UVT7; Q9VLR6 |
Genbank Protein ID |
NP_476755.1; NP_723361.1 |
Protein Name |
Heterochromatin protein 1 |
Genbank Nucleotide ID |
NM_057407.4; NM_164799.2 |
Gene Name |
HP1;Su(var)205HP1;CG8409 |
Ensembl Information |
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Details |
Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
Me_Reader |
DCD |
Chromo1 |
H3K9me2/3 |
K |
21777708 |
|
Status |
Reviewed |
Classification |
Type |
Family |
E-value |
Score |
Start |
End |
Me_Reader |
Chromodomain |
2.40e-19 |
69.7 |
24 |
172 |
Me_Reader |
DCD |
1.80e-34 |
104.7 |
26 |
70 |
|
Organism |
Drosophila melanogaster |
NCBI Taxa ID |
7227 |
Functional Description (View)Functional Description
Structural component of heterochromatin, involved in gene repression and the modification of position-effect-variegation. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. |
Structural component of heterochromatin, involved in gene repression and the modification of position-effect-variegation. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression.
|
Domain Profile |
Me_Reader Chromodomain
Chromodomain.txt 1 FeverivdkkelrkgeveYlVrWkGynksddtWepeenLlckelleefekkkekkkkq 58 ++ve+i+ ++++rkg+veY +WkGy+++++tWepe+nL c+ l++++e + ++k+ FBpp0079252 24 YAVEKII-DRRVRKGKVEYYLKWKGYPETENTWEPENNLDCQDLIQQYEASRKDEEKS 80 79*****.9***************************************9887777765 PP Chromodomain.txt 2 everivdkkelrkgeveYlVrWkGyn 27 e+e+i+ +g+ +l+++kG + FBpp0079252 148 EAEKIL-GASDNNGRLTFLIQFKGVD 172 678999.6677789999******965 PP
Me_Reader DCD
Chromo-2.txt 3 verIinhsvdkkGelhyLikWkdlpYdeaswesatvenkkypqlvqsf 50 ve+Ii+ kG+++y++kWk+ p e +we++ n +++ l+q++ FBpp0079252 26 VEKIIDRR-VRKGKVEYYLKWKGYPETENTWEPE--NNLDCQDLIQQY 70 89****99.89************99999999997..599*******99 PP Chromo-2.txt 2 mverIinhsvdkkGelhyLikWkdlpYdeaswesatvenkkypqlvqsfyeeresmrgee 61 ++e+I+++s d++G+l++Li++k++ d+a++++++v+n+k+p++v++fyeer+s+++++ FBpp0079252 148 EAEKILGAS-DNNGRLTFLIQFKGV--DQAEMVPSSVANEKIPRMVIHFYEERLSWYSDN 204 78*******.***************..******************************987 PP
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Protein Sequence (Fasta) | MGKKIDNPES SAKVSDAEEE EEEYAVEKII DRRVRKGKVE YYLKWKGYPE TENTWEPENN 60 LDCQDLIQQY EASRKDEEKS AASKKDRPSS SAKAKETQGR ASSSTSTASK RKSEEPTAPS 120 GNKSKRTTDA EQDTIPVSGS TGFDRGLEAE KILGASDNNG RLTFLIQFKG VDQAEMVPSS 180 VANEKIPRMV IHFYEERLSW YSDNED 206Protein Fasta Sequence
>FBpp0079252|HP1;Su(var)205HP1;CG8409|Drosophila melanogaster MGKKIDNPESSAKVSDAEEEEEEYAVEKIIDRRVRKGKVEYYLKWKGYPETENTWEPENNLDCQDLIQQYEASRKDEEKSAASKKDRPSSSAKAKETQGRASSSTSTASKRKSEEPTAPSGNKSKRTTDAEQDTIPVSGSTGFDRGLEAEKILGASDNNGRLTFLIQFKGVDQAEMVPSSVANEKIPRMVIHFYEERLSWYSDNED
|
Nucleotide Sequence (Fasta) | CGCACACTGT TCGGCCGGCG TCATTTTAGA ACGCGCATTT TTTTGCAGAT TTTTCATTTT 60 GTGGAAAGTC TTCTAGCGCC AACACACAGG CTTATAAAAA CCAATTTAGC TGCGTGCATA 120 AAGTGTAGAT CTTATTTAAT CTAGGTGAGC CATGAAAGCA AAGAGAGTCG ACTAAAAATC 180 GTACTTTCCT TTCGTACTTT GCGTGTGTGT GCGGTTGTGT GCGGTTGTGC TAATTCTTTC 240 CTTATTTTTT GTCGTGTGAA GTATTTTAAT AAAAACAAAA TGGGCAAGAA AATCGACAAC 300 CCTGAGAGCT CGGCAAAGGT TTCCGATGCC GAAGAGGAGG AGGAGGAGTA CGCCGTGGAA 360 AAGATCATCG ACAGGCGGGT GCGCAAGGGA AAGGTGGAGT ACTATCTGAA ATGGAAGGGC 420 TATCCCGAAA CTGAGAACAC GTGGGAGCCG GAGAACAATC TCGACTGCCA GGATCTTATC 480 CAGCAGTACG AGGCGAGCCG CAAGGATGAG GAGAAGTCAG CCGCCTCCAA GAAGGATCGA 540 CCCAGCAGCA GCGCCAAGGC CAAGGAAACT CAAGGACGCG CCAGCAGTTC GACGTCCACA 600 GCAAGCAAGC GAAAGTCCGA AGAACCAACA GCGCCCTCTG GCAATAAATC AAAACGTACC 660 ACAGATGCGG AGCAGGACAC CATTCCCGTT TCAGGATCTA CCGGATTCGA TCGCGGCCTG 720 GAGGCCGAAA AGATCTTGGG TGCCTCCGAC AATAATGGCC GCCTGACATT CCTCATTCAG 780 TTCAAAGGCG TGGACCAAGC AGAAATGGTG CCCTCCTCAG TGGCCAATGA AAAAATCCCA 840 CGAATGGTAA TCCACTTCTA CGAAGAGCGC CTATCCTGGT ACTCTGATAA TGAAGATTAA 900 ACAGTTGGAT CATCGAAAGC GAAAAAGAAC GATTATACAT TTAACGAAAA ATTACCCACT 960 TAGAATTATA GCTCCTTGCA GGCGCTTTCA AAACCACCCA ACCAACTCTT AAGGCATCGG 1020 ACTTTTTTCC ATAAATGTCC AGAGTCAGTG TCTGTATTTA TGATAACCAT TTTCAATAAA 1080 TAAAAAAAAC CTTTATTCTG CTGGAGCCT
Nucleotide Fasta Sequence
>FBpp0079252|DCD|Drosophila melanogaster CGCACACTGTTCGGCCGGCGTCATTTTAGAACGCGCATTTTTTTGCAGATTTTTCATTTTGTGGAAAGTCTTCTAGCGCCAACACACAGGCTTATAAAAACCAATTTAGCTGCGTGCATAAAGTGTAGATCTTATTTAATCTAGGTGAGCCATGAAAGCAAAGAGAGTCGACTAAAAATCGTACTTTCCTTTCGTACTTTGCGTGTGTGTGCGGTTGTGTGCGGTTGTGCTAATTCTTTCCTTATTTTTTGTCGTGTGAAGTATTTTAATAAAAACAAAATGGGCAAGAAAATCGACAACCCTGAGAGCTCGGCAAAGGTTTCCGATGCCGAAGAGGAGGAGGAGGAGTACGCCGTGGAAAAGATCATCGACAGGCGGGTGCGCAAGGGAAAGGTGGAGTACTATCTGAAATGGAAGGGCTATCCCGAAACTGAGAACACGTGGGAGCCGGAGAACAATCTCGACTGCCAGGATCTTATCCAGCAGTACGAGGCGAGCCGCAAGGATGAGGAGAAGTCAGCCGCCTCCAAGAAGGATCGACCCAGCAGCAGCGCCAAGGCCAAGGAAACTCAAGGACGCGCCAGCAGTTCGACGTCCACAGCAAGCAAGCGAAAGTCCGAAGAACCAACAGCGCCCTCTGGCAATAAATCAAAACGTACCACAGATGCGGAGCAGGACACCATTCCCGTTTCAGGATCTACCGGATTCGATCGCGGCCTGGAGGCCGAAAAGATCTTGGGTGCCTCCGACAATAATGGCCGCCTGACATTCCTCATTCAGTTCAAAGGCGTGGACCAAGCAGAAATGGTGCCCTCCTCAGTGGCCAATGAAAAAATCCCACGAATGGTAATCCACTTCTACGAAGAGCGCCTATCCTGGTACTCTGATAATGAAGATTAAACAGTTGGATCATCGAAAGCGAAAAAGAACGATTATACATTTAACGAAAAATTACCCACTTAGAATTATAGCTCCTTGCAGGCGCTTTCAAAACCACCCAACCAACTCTTAAGGCATCGGACTTTTTTCCATAAATGTCCAGAGTCAGTGTCTGTATTTATGATAACCATTTTCAATAAATAAAAAAAACCTTTATTCTGCTGGAGCCT
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Sequence Source |
Ensembl |
Keyword |
KW-0002--3D-structure KW-0156--Chromatin regulator KW-0181--Complete proteome KW-0539--Nucleus KW-0597--Phosphoprotein KW-1185--Reference proteome KW-0677--Repeat KW-0678--Repressor KW-0804--Transcription KW-0805--Transcription regulation --
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Interpro |
IPR000953--Chromo/shadow_dom IPR017984--Chromo_dom_subgr IPR023780--Chromo_domain IPR008251--Chromo_shadow_dom IPR016197--Chromodomain-like IPR023779--Chromodomain_CS
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PROSITE |
PS00598--CHROMO_1 PS50013--CHROMO_2
|
Pfam |
PF00385--Chromo PF01393--Chromo_shadow
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Gene Ontology |
GO:0005694--C:chromosome GO:0000775--C:chromosome, centromeric region GO:0000781--C:chromosome, telomeric region GO:0000793--C:condensed chromosome GO:0000780--C:condensed nuclear chromosome, centromeric region GO:0000791--C:euchromatin GO:0000792--C:heterochromatin GO:0005720--C:nuclear heterochromatin GO:0005654--C:nucleoplasm GO:0005634--C:nucleus GO:0005721--C:pericentric heterochromatin GO:0005700--C:polytene chromosome GO:0005704--C:polytene chromosome band GO:0005701--C:polytene chromosome chromocenter GO:0005703--C:polytene chromosome puff GO:0035012--C:polytene chromosome, telomeric region GO:0003682--F:chromatin binding GO:0042393--F:histone binding GO:0035064--F:methylated histone binding GO:0003729--F:mRNA binding GO:0000182--F:rDNA binding GO:0003723--F:RNA binding GO:0003696--F:satellite DNA binding GO:0006342--P:chromatin silencing GO:0030702--P:chromatin silencing at centromere GO:0051276--P:chromosome organization GO:0044026--P:DNA hypermethylation GO:0006343--P:establishment of chromatin silencing GO:0016458--P:gene silencing GO:0031507--P:heterochromatin assembly GO:0034773--P:histone H4-K20 trimethylation GO:0007067--P:mitotic nuclear division GO:0045892--P:negative regulation of transcription, DNA-templated GO:0022008--P:neurogenesis GO:0033697--P:positive regulation of extent of heterochromatin assembly GO:1900111--P:positive regulation of histone H3-K9 dimethylation GO:0090309--P:positive regulation of methylation-dependent chromatin silencing GO:0045893--P:positive regulation of transcription, DNA-templated GO:0042981--P:regulation of apoptotic process GO:0031060--P:regulation of histone methylation GO:0006355--P:regulation of transcription, DNA-templated GO:0000723--P:telomere maintenance GO:0006351--P:transcription, DNA-templated
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Orthology |
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Created Date |
25-Jun-2016 |