| Tag |
Content |
| WERAM ID |
WERAM-Drm-0009 |
| Ensembl Protein ID |
FBpp0079252 |
| Uniprot Accession |
P05205; HP1_DROME; A4V0F1; B6UVR4; B6UVS1; B6UVS2; B6UVS3; B6UVT2; B6UVT6; B6UVT7; Q9VLR6
|
| Genbank Protein ID |
NP_476755.1; NP_723361.1
|
| Protein Name |
Heterochromatin protein 1 |
| Genbank Nucleotide ID |
NM_057407.4; NM_164799.2
|
| Gene Name |
HP1;Su(var)205HP1;CG8409 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| Me_Reader |
DCD |
Chromo1 |
H3K9me2/3 |
K |
21777708
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| Me_Reader |
Chromodomain |
2.40e-19 |
69.7 |
24 |
172 |
| Me_Reader |
DCD |
1.80e-34 |
104.7 |
26 |
70 |
|
| Organism |
Drosophila melanogaster |
| NCBI Taxa ID |
7227 |
Functional Description
(View)Functional Description
Structural component of heterochromatin, involved in gene repression and the modification of position-effect-variegation. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. |
Structural component of heterochromatin, involved in gene repression and the modification of position-effect-variegation. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression.
|
| Domain Profile |
Me_Reader Chromodomain
Chromodomain.txt 1 FeverivdkkelrkgeveYlVrWkGynksddtWepeenLlckelleefekkkekkkkq 58
++ve+i+ ++++rkg+veY +WkGy+++++tWepe+nL c+ l++++e + ++k+
FBpp0079252 24 YAVEKII-DRRVRKGKVEYYLKWKGYPETENTWEPENNLDCQDLIQQYEASRKDEEKS 80
79*****.9***************************************9887777765 PP
Chromodomain.txt 2 everivdkkelrkgeveYlVrWkGyn 27
e+e+i+ +g+ +l+++kG +
FBpp0079252 148 EAEKIL-GASDNNGRLTFLIQFKGVD 172
678999.6677789999******965 PP
Me_Reader DCD
Chromo-2.txt 3 verIinhsvdkkGelhyLikWkdlpYdeaswesatvenkkypqlvqsf 50
ve+Ii+ kG+++y++kWk+ p e +we++ n +++ l+q++
FBpp0079252 26 VEKIIDRR-VRKGKVEYYLKWKGYPETENTWEPE--NNLDCQDLIQQY 70
89****99.89************99999999997..599*******99 PP
Chromo-2.txt 2 mverIinhsvdkkGelhyLikWkdlpYdeaswesatvenkkypqlvqsfyeeresmrgee 61
++e+I+++s d++G+l++Li++k++ d+a++++++v+n+k+p++v++fyeer+s+++++
FBpp0079252 148 EAEKILGAS-DNNGRLTFLIQFKGV--DQAEMVPSSVANEKIPRMVIHFYEERLSWYSDN 204
78*******.***************..******************************987 PP
|
Protein Sequence
(Fasta) | MGKKIDNPES SAKVSDAEEE EEEYAVEKII DRRVRKGKVE YYLKWKGYPE TENTWEPENN 60
LDCQDLIQQY EASRKDEEKS AASKKDRPSS SAKAKETQGR ASSSTSTASK RKSEEPTAPS 120
GNKSKRTTDA EQDTIPVSGS TGFDRGLEAE KILGASDNNG RLTFLIQFKG VDQAEMVPSS 180
VANEKIPRMV IHFYEERLSW YSDNED 206Protein Fasta Sequence
>FBpp0079252|HP1;Su(var)205HP1;CG8409|Drosophila melanogaster
MGKKIDNPESSAKVSDAEEEEEEYAVEKIIDRRVRKGKVEYYLKWKGYPETENTWEPENNLDCQDLIQQYEASRKDEEKSAASKKDRPSSSAKAKETQGRASSSTSTASKRKSEEPTAPSGNKSKRTTDAEQDTIPVSGSTGFDRGLEAEKILGASDNNGRLTFLIQFKGVDQAEMVPSSVANEKIPRMVIHFYEERLSWYSDNED |
Nucleotide Sequence
(Fasta) | CGCACACTGT TCGGCCGGCG TCATTTTAGA ACGCGCATTT TTTTGCAGAT TTTTCATTTT 60
GTGGAAAGTC TTCTAGCGCC AACACACAGG CTTATAAAAA CCAATTTAGC TGCGTGCATA 120
AAGTGTAGAT CTTATTTAAT CTAGGTGAGC CATGAAAGCA AAGAGAGTCG ACTAAAAATC 180
GTACTTTCCT TTCGTACTTT GCGTGTGTGT GCGGTTGTGT GCGGTTGTGC TAATTCTTTC 240
CTTATTTTTT GTCGTGTGAA GTATTTTAAT AAAAACAAAA TGGGCAAGAA AATCGACAAC 300
CCTGAGAGCT CGGCAAAGGT TTCCGATGCC GAAGAGGAGG AGGAGGAGTA CGCCGTGGAA 360
AAGATCATCG ACAGGCGGGT GCGCAAGGGA AAGGTGGAGT ACTATCTGAA ATGGAAGGGC 420
TATCCCGAAA CTGAGAACAC GTGGGAGCCG GAGAACAATC TCGACTGCCA GGATCTTATC 480
CAGCAGTACG AGGCGAGCCG CAAGGATGAG GAGAAGTCAG CCGCCTCCAA GAAGGATCGA 540
CCCAGCAGCA GCGCCAAGGC CAAGGAAACT CAAGGACGCG CCAGCAGTTC GACGTCCACA 600
GCAAGCAAGC GAAAGTCCGA AGAACCAACA GCGCCCTCTG GCAATAAATC AAAACGTACC 660
ACAGATGCGG AGCAGGACAC CATTCCCGTT TCAGGATCTA CCGGATTCGA TCGCGGCCTG 720
GAGGCCGAAA AGATCTTGGG TGCCTCCGAC AATAATGGCC GCCTGACATT CCTCATTCAG 780
TTCAAAGGCG TGGACCAAGC AGAAATGGTG CCCTCCTCAG TGGCCAATGA AAAAATCCCA 840
CGAATGGTAA TCCACTTCTA CGAAGAGCGC CTATCCTGGT ACTCTGATAA TGAAGATTAA 900
ACAGTTGGAT CATCGAAAGC GAAAAAGAAC GATTATACAT TTAACGAAAA ATTACCCACT 960
TAGAATTATA GCTCCTTGCA GGCGCTTTCA AAACCACCCA ACCAACTCTT AAGGCATCGG 1020
ACTTTTTTCC ATAAATGTCC AGAGTCAGTG TCTGTATTTA TGATAACCAT TTTCAATAAA 1080
TAAAAAAAAC CTTTATTCTG CTGGAGCCT
Nucleotide Fasta Sequence
>FBpp0079252|DCD|Drosophila melanogaster
CGCACACTGTTCGGCCGGCGTCATTTTAGAACGCGCATTTTTTTGCAGATTTTTCATTTTGTGGAAAGTCTTCTAGCGCCAACACACAGGCTTATAAAAACCAATTTAGCTGCGTGCATAAAGTGTAGATCTTATTTAATCTAGGTGAGCCATGAAAGCAAAGAGAGTCGACTAAAAATCGTACTTTCCTTTCGTACTTTGCGTGTGTGTGCGGTTGTGTGCGGTTGTGCTAATTCTTTCCTTATTTTTTGTCGTGTGAAGTATTTTAATAAAAACAAAATGGGCAAGAAAATCGACAACCCTGAGAGCTCGGCAAAGGTTTCCGATGCCGAAGAGGAGGAGGAGGAGTACGCCGTGGAAAAGATCATCGACAGGCGGGTGCGCAAGGGAAAGGTGGAGTACTATCTGAAATGGAAGGGCTATCCCGAAACTGAGAACACGTGGGAGCCGGAGAACAATCTCGACTGCCAGGATCTTATCCAGCAGTACGAGGCGAGCCGCAAGGATGAGGAGAAGTCAGCCGCCTCCAAGAAGGATCGACCCAGCAGCAGCGCCAAGGCCAAGGAAACTCAAGGACGCGCCAGCAGTTCGACGTCCACAGCAAGCAAGCGAAAGTCCGAAGAACCAACAGCGCCCTCTGGCAATAAATCAAAACGTACCACAGATGCGGAGCAGGACACCATTCCCGTTTCAGGATCTACCGGATTCGATCGCGGCCTGGAGGCCGAAAAGATCTTGGGTGCCTCCGACAATAATGGCCGCCTGACATTCCTCATTCAGTTCAAAGGCGTGGACCAAGCAGAAATGGTGCCCTCCTCAGTGGCCAATGAAAAAATCCCACGAATGGTAATCCACTTCTACGAAGAGCGCCTATCCTGGTACTCTGATAATGAAGATTAAACAGTTGGATCATCGAAAGCGAAAAAGAACGATTATACATTTAACGAAAAATTACCCACTTAGAATTATAGCTCCTTGCAGGCGCTTTCAAAACCACCCAACCAACTCTTAAGGCATCGGACTTTTTTCCATAAATGTCCAGAGTCAGTGTCTGTATTTATGATAACCATTTTCAATAAATAAAAAAAACCTTTATTCTGCTGGAGCCT
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0002--3D-structure
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
--
|
| Interpro |
IPR000953--Chromo/shadow_dom
IPR017984--Chromo_dom_subgr
IPR023780--Chromo_domain
IPR008251--Chromo_shadow_dom
IPR016197--Chromodomain-like
IPR023779--Chromodomain_CS
|
| PROSITE |
PS00598--CHROMO_1
PS50013--CHROMO_2
|
| Pfam |
PF00385--Chromo
PF01393--Chromo_shadow
|
| Gene Ontology |
GO:0005694--C:chromosome
GO:0000775--C:chromosome, centromeric region
GO:0000781--C:chromosome, telomeric region
GO:0000793--C:condensed chromosome
GO:0000780--C:condensed nuclear chromosome, centromeric region
GO:0000791--C:euchromatin
GO:0000792--C:heterochromatin
GO:0005720--C:nuclear heterochromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005721--C:pericentric heterochromatin
GO:0005700--C:polytene chromosome
GO:0005704--C:polytene chromosome band
GO:0005701--C:polytene chromosome chromocenter
GO:0005703--C:polytene chromosome puff
GO:0035012--C:polytene chromosome, telomeric region
GO:0003682--F:chromatin binding
GO:0042393--F:histone binding
GO:0035064--F:methylated histone binding
GO:0003729--F:mRNA binding
GO:0000182--F:rDNA binding
GO:0003723--F:RNA binding
GO:0003696--F:satellite DNA binding
GO:0006342--P:chromatin silencing
GO:0030702--P:chromatin silencing at centromere
GO:0051276--P:chromosome organization
GO:0044026--P:DNA hypermethylation
GO:0006343--P:establishment of chromatin silencing
GO:0016458--P:gene silencing
GO:0031507--P:heterochromatin assembly
GO:0034773--P:histone H4-K20 trimethylation
GO:0007067--P:mitotic nuclear division
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0022008--P:neurogenesis
GO:0033697--P:positive regulation of extent of heterochromatin assembly
GO:1900111--P:positive regulation of histone H3-K9 dimethylation
GO:0090309--P:positive regulation of methylation-dependent chromatin silencing
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0042981--P:regulation of apoptotic process
GO:0031060--P:regulation of histone methylation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0000723--P:telomere maintenance
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
