WERAM Information


Tag Content
WERAM ID WERAM-Drm-0009
Ensembl Protein ID FBpp0079252
Uniprot Accession P05205; HP1_DROME; A4V0F1; B6UVR4; B6UVS1; B6UVS2; B6UVS3; B6UVT2; B6UVT6; B6UVT7; Q9VLR6
Genbank Protein ID NP_476755.1; NP_723361.1
Protein Name Heterochromatin protein 1
Genbank Nucleotide ID NM_057407.4; NM_164799.2
Gene Name HP1;Su(var)205HP1;CG8409
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0003607 FBtr0079636 FBpp0079252
FBgn0003607 FBtr0079635 FBpp0079251
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader DCD Chromo1 H3K9me2/3 K 21777708
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader Chromodomain 2.40e-19 69.7 24 172
Me_Reader DCD 1.80e-34 104.7 26 70
Organism Drosophila melanogaster
NCBI Taxa ID 7227
Functional Description
(View)
Structural component of heterochromatin, involved in gene repression and the modification of position-effect-variegation. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression.
Domain Profile
  Me_Reader Chromodomain

  Chromodomain.txt  1 FeverivdkkelrkgeveYlVrWkGynksddtWepeenLlckelleefekkkekkkkq 58
++ve+i+ ++++rkg+veY +WkGy+++++tWepe+nL c+ l++++e + ++k+
FBpp0079252 24 YAVEKII-DRRVRKGKVEYYLKWKGYPETENTWEPENNLDCQDLIQQYEASRKDEEKS 80
79*****.9***************************************9887777765 PP
Chromodomain.txt 2 everivdkkelrkgeveYlVrWkGyn 27
e+e+i+ +g+ +l+++kG +
FBpp0079252 148 EAEKIL-GASDNNGRLTFLIQFKGVD 172
678999.6677789999******965 PP

  Me_Reader DCD

  Chromo-2.txt  3 verIinhsvdkkGelhyLikWkdlpYdeaswesatvenkkypqlvqsf 50
ve+Ii+ kG+++y++kWk+ p e +we++ n +++ l+q++
FBpp0079252 26 VEKIIDRR-VRKGKVEYYLKWKGYPETENTWEPE--NNLDCQDLIQQY 70
89****99.89************99999999997..599*******99 PP
Chromo-2.txt 2 mverIinhsvdkkGelhyLikWkdlpYdeaswesatvenkkypqlvqsfyeeresmrgee 61
++e+I+++s d++G+l++Li++k++ d+a++++++v+n+k+p++v++fyeer+s+++++
FBpp0079252 148 EAEKILGAS-DNNGRLTFLIQFKGV--DQAEMVPSSVANEKIPRMVIHFYEERLSWYSDN 204
78*******.***************..******************************987 PP

Protein Sequence
(Fasta)
MGKKIDNPES SAKVSDAEEE EEEYAVEKII DRRVRKGKVE YYLKWKGYPE TENTWEPENN 60
LDCQDLIQQY EASRKDEEKS AASKKDRPSS SAKAKETQGR ASSSTSTASK RKSEEPTAPS 120
GNKSKRTTDA EQDTIPVSGS TGFDRGLEAE KILGASDNNG RLTFLIQFKG VDQAEMVPSS 180
VANEKIPRMV IHFYEERLSW YSDNED 206
Nucleotide Sequence
(Fasta)
CGCACACTGT TCGGCCGGCG TCATTTTAGA ACGCGCATTT TTTTGCAGAT TTTTCATTTT 60
GTGGAAAGTC TTCTAGCGCC AACACACAGG CTTATAAAAA CCAATTTAGC TGCGTGCATA 120
AAGTGTAGAT CTTATTTAAT CTAGGTGAGC CATGAAAGCA AAGAGAGTCG ACTAAAAATC 180
GTACTTTCCT TTCGTACTTT GCGTGTGTGT GCGGTTGTGT GCGGTTGTGC TAATTCTTTC 240
CTTATTTTTT GTCGTGTGAA GTATTTTAAT AAAAACAAAA TGGGCAAGAA AATCGACAAC 300
CCTGAGAGCT CGGCAAAGGT TTCCGATGCC GAAGAGGAGG AGGAGGAGTA CGCCGTGGAA 360
AAGATCATCG ACAGGCGGGT GCGCAAGGGA AAGGTGGAGT ACTATCTGAA ATGGAAGGGC 420
TATCCCGAAA CTGAGAACAC GTGGGAGCCG GAGAACAATC TCGACTGCCA GGATCTTATC 480
CAGCAGTACG AGGCGAGCCG CAAGGATGAG GAGAAGTCAG CCGCCTCCAA GAAGGATCGA 540
CCCAGCAGCA GCGCCAAGGC CAAGGAAACT CAAGGACGCG CCAGCAGTTC GACGTCCACA 600
GCAAGCAAGC GAAAGTCCGA AGAACCAACA GCGCCCTCTG GCAATAAATC AAAACGTACC 660
ACAGATGCGG AGCAGGACAC CATTCCCGTT TCAGGATCTA CCGGATTCGA TCGCGGCCTG 720
GAGGCCGAAA AGATCTTGGG TGCCTCCGAC AATAATGGCC GCCTGACATT CCTCATTCAG 780
TTCAAAGGCG TGGACCAAGC AGAAATGGTG CCCTCCTCAG TGGCCAATGA AAAAATCCCA 840
CGAATGGTAA TCCACTTCTA CGAAGAGCGC CTATCCTGGT ACTCTGATAA TGAAGATTAA 900
ACAGTTGGAT CATCGAAAGC GAAAAAGAAC GATTATACAT TTAACGAAAA ATTACCCACT 960
TAGAATTATA GCTCCTTGCA GGCGCTTTCA AAACCACCCA ACCAACTCTT AAGGCATCGG 1020
ACTTTTTTCC ATAAATGTCC AGAGTCAGTG TCTGTATTTA TGATAACCAT TTTCAATAAA 1080
TAAAAAAAAC CTTTATTCTG CTGGAGCCT
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
--

Interpro

IPR000953--Chromo/shadow_dom
IPR017984--Chromo_dom_subgr
IPR023780--Chromo_domain
IPR008251--Chromo_shadow_dom
IPR016197--Chromodomain-like
IPR023779--Chromodomain_CS

PROSITE

PS00598--CHROMO_1
PS50013--CHROMO_2

Pfam

PF00385--Chromo
PF01393--Chromo_shadow

Gene Ontology

GO:0005694--C:chromosome
GO:0000775--C:chromosome, centromeric region
GO:0000781--C:chromosome, telomeric region
GO:0000793--C:condensed chromosome
GO:0000780--C:condensed nuclear chromosome, centromeric region
GO:0000791--C:euchromatin
GO:0000792--C:heterochromatin
GO:0005720--C:nuclear heterochromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005721--C:pericentric heterochromatin
GO:0005700--C:polytene chromosome
GO:0005704--C:polytene chromosome band
GO:0005701--C:polytene chromosome chromocenter
GO:0005703--C:polytene chromosome puff
GO:0035012--C:polytene chromosome, telomeric region
GO:0003682--F:chromatin binding
GO:0042393--F:histone binding
GO:0035064--F:methylated histone binding
GO:0003729--F:mRNA binding
GO:0000182--F:rDNA binding
GO:0003723--F:RNA binding
GO:0003696--F:satellite DNA binding
GO:0006342--P:chromatin silencing
GO:0030702--P:chromatin silencing at centromere
GO:0051276--P:chromosome organization
GO:0044026--P:DNA hypermethylation
GO:0006343--P:establishment of chromatin silencing
GO:0016458--P:gene silencing
GO:0031507--P:heterochromatin assembly
GO:0034773--P:histone H4-K20 trimethylation
GO:0007067--P:mitotic nuclear division
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0022008--P:neurogenesis
GO:0033697--P:positive regulation of extent of heterochromatin assembly
GO:1900111--P:positive regulation of histone H3-K9 dimethylation
GO:0090309--P:positive regulation of methylation-dependent chromatin silencing
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0042981--P:regulation of apoptotic process
GO:0031060--P:regulation of histone methylation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0000723--P:telomere maintenance
GO:0006351--P:transcription, DNA-templated

Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Asm-0048 ENSAMXP00000006467.1 Astyanax mexicanus 44 7e-26 114
WERAM-Xim-0087 ENSXMAP00000008088.1 Xiphophorus maculatus 42 2e-25 112
WERAM-Pof-0027 ENSPFOP00000001788.2 Poecilia formosa 42 2e-25 112
WERAM-Lac-0097 ENSLACP00000012217.1 Latimeria chalumnae 42 1e-24 110
WERAM-Tar-0197 ENSTRUP00000040634.1 Takifugu rubripes 41 1e-24 110
WERAM-Xet-0140 ENSXETP00000047517.3 Xenopus tropicalis 42 2e-24 109
WERAM-Dar-0009 ENSDARP00000118656.1 Danio rerio 43 2e-24 109
WERAM-Leo-0134 ENSLOCP00000016544.1 Lepisosteus oculatus 42 4e-24 108
WERAM-Anc-0067 ENSACAP00000006455.3 Anolis carolinensis 42 5e-24 107
WERAM-Pem-0070 ENSPMAP00000007598.1 Petromyzon marinus 43 3e-23 105
WERAM-Orn-0147 ENSONIP00000015421.1 Oreochromis niloticus 43 3e-23 105
WERAM-Cap-0101 ENSCPOP00000007559.2 Cavia porcellus 40 5e-23 104
WERAM-Caj-0232 ENSCJAP00000051811.1 Callithrix jacchus 42 8e-23 103
WERAM-Prc-0021 ENSPCAP00000001721.1 Procavia capensis 41 1e-22 103
WERAM-Loa-0021 ENSLAFP00000001314.1 Loxodonta africana 41 1e-22 103
WERAM-Sah-0103 ENSSHAP00000011342.1 Sarcophilus harrisii 41 1e-22 103
WERAM-Poa-0134 ENSPPYP00000016983.1 Pongo abelii 41 2e-22 102
WERAM-Ptv-0001 ENSPVAP00000000296.1 Pteropus vampyrus 41 2e-22 102
WERAM-Orc-0135 ENSOCUP00000011485.2 Oryctolagus cuniculus 41 3e-22 102
WERAM-Anp-0066 ENSAPLP00000007544.1 Anas platyrhynchos 40 3e-22 102
WERAM-Gaga-0002 ENSGALP00000029248.3 Gallus gallus 40 3e-22 102
WERAM-Tub-0057 ENSTBEP00000007000.1 Tupaia belangeri 41 3e-22 102
WERAM-Sus-0006 ENSSSCP00000000298.2 Sus scrofa 41 3e-22 102
WERAM-Paa-0083 ENSPANP00000000701.1 Papio anubis 41 3e-22 102
WERAM-Pat-0042 ENSPTRP00000008567.2 Pan troglodytes 41 3e-22 102
WERAM-Nol-0192 ENSNLEP00000021446.1 Nomascus leucogenys 41 3e-22 102
WERAM-Mim-0051 ENSMICP00000004948.1 Microcebus murinus 41 3e-22 102
WERAM-Mam-0033 ENSMMUP00000006559.1 Macaca mulatta 41 3e-22 102
WERAM-Ict-0128 ENSSTOP00000013142.2 Ictidomys tridecemlineatus 41 3e-22 102
WERAM-Hos-0048 ENSP00000449207.1 Homo sapiens 41 3e-22 102
WERAM-Gog-0001 ENSGGOP00000000040.2 Gorilla gorilla 41 3e-22 102
WERAM-Eqc-0044 ENSECAP00000006177.1 Equus caballus 41 3e-22 102
WERAM-Dio-0098 ENSDORP00000009987.1 Dipodomys ordii 41 3e-22 102
WERAM-Chs-0059 ENSCSAP00000001750.1 Chlorocebus sabaeus 41 3e-22 102
WERAM-Bot-0066 ENSBTAP00000008198.4 Bos taurus 41 3e-22 102
WERAM-Ten-0119 ENSTNIP00000002974.1 Tetraodon nigroviridis 40 3e-22 102
WERAM-Pes-0067 ENSPSIP00000008496.1 Pelodiscus sinensis 40 3e-22 102
WERAM-Ova-0173 ENSOARP00000017451.1 Ovis aries 41 4e-22 102
WERAM-Otg-0140 ENSOGAP00000012061.2 Otolemur garnettii 41 4e-22 102
WERAM-Myl-0056 ENSMLUP00000004587.1 Myotis lucifugus 38 4e-22 101
WERAM-Dan-0069 ENSDNOP00000007127.2 Dasypus novemcinctus 40 4e-22 101
WERAM-Soa-0047 ENSSARP00000004394.1 Sorex araneus 38 4e-22 101
WERAM-Ect-0014 ENSETEP00000000985.1 Echinops telfairi 41 4e-22 101
WERAM-Gam-0030 ENSGMOP00000003256.1 Gadus morhua 40 5e-22 101
WERAM-Mup-0068 ENSMPUP00000005777.1 Mustela putorius furo 41 5e-22 101
WERAM-Fec-0110 ENSFCAP00000009423.3 Felis catus 41 5e-22 101
WERAM-Caf-0078 ENSCAFP00000009868.3 Canis familiaris 41 5e-22 101
WERAM-Aim-0059 ENSAMEP00000005159.1 Ailuropoda melanoleuca 39 6e-22 101
WERAM-Ocp-0040 ENSOPRP00000003390.1 Ochotona princeps 38 6e-22 101
WERAM-Chh-0093 ENSCHOP00000010569.1 Choloepus hoffmanni 38 6e-22 101
WERAM-Ere-0053 ENSEEUP00000004419.1 Erinaceus europaeus 38 6e-22 101
WERAM-Mod-0103 ENSMODP00000015491.2 Monodelphis domestica 40 6e-22 101
WERAM-Ran-0054 ENSRNOP00000011665.2 Rattus norvegicus 38 7e-22 100
WERAM-Tut-0053 ENSTTRP00000004253.1 Tursiops truncatus 42 7e-22 100
WERAM-Ora-0043 ENSOANP00000006668.1 Ornithorhynchus anatinus 39 8e-22 100
WERAM-Gaa-0070 ENSGACP00000009362.1 Gasterosteus aculeatus 38 1e-21 100
WERAM-Cii-0080 ENSCINP00000030026.1 Ciona intestinalis 38 1e-21 100
WERAM-Mum-0020 ENSMUSP00000104441.3 Mus musculus 42 1e-21 99.8
WERAM-Orla-0079 ENSORLP00000009999.1 Oryzias latipes 37 2e-21 99.8
WERAM-Meg-0009 ENSMGAP00000000674.1 Meleagris gallopavo 40 6e-21 97.8
WERAM-Tas-0030 ENSTSYP00000003062.1 Tarsius syrichta 41 9e-21 97.4
WERAM-Tag-0045 ENSTGUP00000002967.1 Taeniopygia guttata 39 2e-20 95.9
WERAM-Fia-0115 ENSFALP00000009927.1 Ficedula albicollis 39 3e-20 95.5
WERAM-Vip-0116 ENSVPAP00000010686.1 Vicugna pacos 38 5e-20 94.7
WERAM-Mae-0074 ENSMEUP00000007510.1 Macropus eugenii 37 5e-17 84.7
WERAM-Cis-0006 ENSCSAVP00000000838.1 Ciona savignyi 55 4e-16 82.0
Created Date 25-Jun-2016