WERAM Information

Tag Content
WERAM ID WERAM-Drm-0006
Ensembl Protein ID FBpp0076635
Uniprot Accession P50536; MSL3_DROME; A8BP72; A8BP74; A8BP87; A8BP92; A8IL14; A8IL17; A8IL22; A8IL25; A8IL30; A8IL33; A8IL37; A8IL41; A8IL46; Q8IQ74; Q9VS18
Genbank Protein ID NP_523951.1
Protein Name Protein male-specific lethal-3
Genbank Nucleotide ID NM_079227.3
Gene Name MSL3;CG8631
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0002775 FBtr0076926 FBpp0076635
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader Chromo-Barrel Chromo H3K36me3 K 17936709
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader Chromo-Barrel 2.70e-151 489.8 196 500
Organism Drosophila melanogaster
NCBI Taxa ID 7227
Functional Description
(View)		 The MSL proteins are essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation). Mle, msl-1 and msl-3 are colocalized on the X chromosome. Each of the MSL proteins requires all the other MSLs for wild-type X-chromosome binding.
Domain Profile
  Me_Reader Chromo-Barrel
      MRG.txt   1 eerkitlkipekLkklledDrelikrrkklvkLPakvnivtilesyvkevavelaisikedsr..rekksrgarmnkeYirveknvdllkEvvdGlri 96 
                  +e++i+++++e+L++l+e+Dr++ik+ +k+++LPa+v+ivti+e++vk++avelaisik+ds+  r+++sr+arm++eY+rv+++v++lkEvvdGlri
  FBpp0076635 196 QEDRIMMRVSERLRELIEYDRNMIKVLGKQHALPARVPIVTIMENFVKQQAVELAISIKQDSSraRNTQSRNARMEREYDRVMSTVCMLKEVVDGLRI 293
                  699***********************************************************9899******************************** PP
      MRG.txt  97 yFdvtlddvLLYklEr......lqydelrssklilnikeeaistsrdqeelsldgtllvessgdstesigvigegatekrkklekellqslkkstkns 188
                  yF++++dd+LLY++E+      l++d++r+++liln+++e+i++s+d+e+++ldgt++ve+sgd++++igvi++g++e++k+l+k+ll+++++s+kn+
  FBpp0076635 294 YFEFHVDDHLLYTEEKeyvhnyLTDDNMRNCSLILNKSYEYINPSGDTELIGLDGTPVVEGSGDTNGQIGVINIGGPEYEKQLQKCLLYIVTASGKNT 391
                  ************************************************************************************************** PP
      MRG.txt 189 analekksPvtsrsksPvelrgslnevlkwklvsadkPpepsrvyGAqHLlRLlvklpellsktslsekslklLlkhlddFlkyLaenhdefFdesdy 286
                  a+a+e++sP+t+++k+Pve+rg+lne++kw+l+sa++Ppe+s+v+GA+HL+RL++k+p++l+++++s+k+l++Ll+hld+F++yL enh+e+Fd++++
  FBpp0076635 392 AQAYERTSPYTAAYKLPVEMRGFLNETFKWRLLSAESPPEKSMVFGAPHLVRLMIKMPMFLNASPISNKKLEDLLPHLDAFINYL-ENHREWFDRENF 488
                  *************************************************************************************.************ PP
      MRG.txt 287 vnateleyetka 298
                  vn+t+l++e+++
  FBpp0076635 489 VNSTALPQEDLQ 500
                  *********987 PP
Protein Sequence
(Fasta)		MTELRDETPL FHKGEIVLCY EPDKSKARVL YTSKVLNVFE RRNEHGLRFY EYKIHFQGWR 60
PSYDRCVRAT VLLKDTEENR QLQRELAEAA KLQIRGDYSY KGTPDKPSAK KKRGGKAAHV 120
EEPIVVPMDT GHLEAEHEMA PTPRAAGNRT RDNSGGKRKE KPPSGDGRLK GNRGRQTETF 180
YNNAINDVSV YNHVPQEDRI MMRVSERLRE LIEYDRNMIK VLGKQHALPA RVPIVTIMEN 240
FVKQQAVELA ISIKQDSSRA RNTQSRNARM EREYDRVMST VCMLKEVVDG LRIYFEFHVD 300
DHLLYTEEKE YVHNYLTDDN MRNCSLILNK SYEYINPSGD TELIGLDGTP VVEGSGDTNG 360
QIGVINIGGP EYEKQLQKCL LYIVTASGKN TAQAYERTSP YTAAYKLPVE MRGFLNETFK 420
WRLLSAESPP EKSMVFGAPH LVRLMIKMPM FLNASPISNK KLEDLLPHLD AFINYLENHR 480
EWFDRENFVN STALPQEDLQ RELLDSLDGI AA 512
Nucleotide Sequence
(Fasta)		CGCAAAAAAC ATTCGTTATA AATATCATCT CAGCGACGCC AGCAGTTGAA TTCAATATTT 60
AACATTTTGT ATACATAAGT GACTGACTAC GGCCCTATTT AACTGCAAGT AATGACGGAG 120
CTAAGGGACG AGACACCGCT CTTTCACAAG GGCGAGATAG TCCTTTGCTA CGAGCCGGAT 180
AAATCGAAGG CCCGTGTTCT TTACACCAGC AAGGTGCTAA ACGTCTTTGA GCGCCGGAAC 240
GAGCATGGCC TGAGGTTCTA CGAGTACAAG ATTCACTTCC AGGGCTGGCG TCCATCCTAC 300
GATCGCTGTG TGCGCGCCAC CGTTCTATTG AAAGACACCG AGGAGAATCG CCAGTTGCAA 360
AGGGAGCTGG CCGAAGCTGC CAAGCTGCAA ATTCGTGGTG ACTACTCCTA CAAGGGCACA 420
CCCGATAAGC CATCGGCCAA GAAGAAACGC GGCGGAAAAG CGGCCCACGT TGAGGAGCCA 480
ATAGTGGTTC CAATGGACAC GGGACATCTT GAGGCGGAGC ACGAAATGGC GCCCACTCCA 540
CGAGCAGCGG GCAACCGGAC GCGGGACAAC AGCGGTGGCA AGCGAAAGGA AAAACCCCCG 600
TCCGGAGATG GCCGATTAAA GGGAAACCGG GGCAGACAAA CAGAGACCTT TTATAACAAT 660
GCCATAAATG ATGTATCGGT CTATAACCAT GTGCCACAGG AGGATCGCAT TATGATGCGA 720
GTCAGCGAGC GATTGCGAGA GCTTATAGAG TACGATCGGA ATATGATCAA GGTACTAGGC 780
AAACAGCACG CACTGCCCGC CCGCGTGCCC ATCGTGACCA TCATGGAAAA CTTCGTCAAG 840
CAGCAGGCCG TGGAGCTAGC CATTAGCATT AAACAGGACA GCTCGAGGGC CAGGAACACG 900
CAGAGTCGCA ATGCCAGAAT GGAGCGGGAA TACGATCGCG TTATGTCCAC TGTCTGCATG 960
CTGAAGGAGG TGGTAGACGG ATTGCGTATC TACTTTGAGT TCCACGTGGA TGACCACTTG 1020
CTGTATACGG AGGAGAAGGA GTATGTCCAC AACTACCTCA CAGACGACAA CATGCGCAAC 1080
TGCAGCCTAA TATTGAACAA GTCGTACGAG TATATCAATC CCAGCGGTGA CACGGAACTG 1140
ATCGGTCTGG ACGGCACGCC AGTGGTAGAA GGGTCGGGCG ACACCAATGG ACAGATCGGA 1200
GTTATTAATA TCGGCGGTCC GGAGTACGAG AAGCAGTTGC AAAAATGCCT GCTCTACATT 1260
GTTACCGCCA GCGGGAAAAA CACTGCGCAG GCCTATGAGA GGACTTCCCC ATATACGGCT 1320
GCCTACAAAC TGCCCGTGGA GATGCGTGGA TTTCTGAACG AAACATTCAA GTGGCGGCTT 1380
TTGTCAGCGG AATCGCCGCC AGAAAAGTCC ATGGTCTTTG GCGCTCCCCA CCTGGTTAGG 1440
CTAATGATTA AAATGCCCAT GTTCTTAAAC GCATCGCCGA TCAGCAACAA GAAGCTAGAA 1500
GATCTACTTC CCCACCTCGA CGCCTTCATC AACTACTTGG AGAACCACAG GGAGTGGTTC 1560
GACAGGGAAA ACTTTGTTAA CTCCACTGCC CTGCCCCAGG AAGATCTGCA GCGGGAGCTG 1620
TTGGACTCCC TGGATGGGAT TGCTGCTTAG CTTTAGTTGA TCGTAGTTAT CTAGTTTATT 1680
TATTATTACG ATTAAAGCTT ATGCTCTTTT ATTTAAAGAT TTGTAATTGT CGTTTTGGTT 1740
TCTTCAACTA CACACTTTGT AAACAACGCA CTTCTATAAA AAAGTTTCCT AATGTGATCG 1800
TATAATCGAA TAATGCCTAT AACTATATAT GTTAAATATT GAAAATACGA TTTTAACATT 1860
TTTTTTTGTT TTTTTTTTTT TTTTTGCTTA ACCTAAGTTT TAGTTGAGTA GTACATGCTA 1920
GTATTTTTGT CATGCCTTGT TTTTTGTGCT CAAATATATT TAAGAGTTGG 1971
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
--
Interpro

IPR016197--Chromodomain-like
IPR008676--MRG
IPR026541--MRG_dom
PROSITE

PS51640--MRG
Pfam

PF05712--MRG
Gene Ontology

GO:0010369--C:chromocenter
GO:0005694--C:chromosome
GO:0072487--C:MSL complex
GO:0000228--C:nuclear chromosome
GO:0005634--C:nucleus
GO:0005700--C:polytene chromosome
GO:0000805--C:X chromosome
GO:0016456--C:X chromosome located dosage compensation complex, transcription activating
GO:0003682--F:chromatin binding
GO:0035064--F:methylated histone binding
GO:0003729--F:mRNA binding
GO:0003723--F:RNA binding
GO:0016568--P:chromatin modification
GO:0007549--P:dosage compensation
GO:0009047--P:dosage compensation by hyperactivation of X chromosome
GO:0031936--P:negative regulation of chromatin silencing
GO:0035206--P:regulation of hemocyte proliferation
GO:0019233--P:sensory perception of pain
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Mum-0118 ENSMUSP00000033725.9 Mus musculus 27 1e-35 148
WERAM-Cap-0048 ENSCPOP00000004224.2 Cavia porcellus 26 2e-33 141
WERAM-Bot-0087 ENSBTAP00000030520.4 Bos taurus 26 4e-32 136
WERAM-Dio-0030 ENSDORP00000003216.1 Dipodomys ordii 26 5e-31 133
WERAM-Leo-0090 ENSLOCP00000012145.1 Lepisosteus oculatus 26 2e-27 121
WERAM-Pof-0198 ENSPFOP00000016396.2 Poecilia formosa 31 6e-26 116
WERAM-Xim-0103 ENSXMAP00000009086.1 Xiphophorus maculatus 31 1e-25 115
WERAM-Tar-0147 ENSTRUP00000031948.1 Takifugu rubripes 30 7e-25 112
WERAM-Myl-0037 ENSMLUP00000003509.2 Myotis lucifugus 30 1e-23 108
WERAM-Ten-0177 ENSTNIP00000017573.1 Tetraodon nigroviridis 30 1e-22 105
WERAM-Gaa-0153 ENSGACP00000019849.1 Gasterosteus aculeatus 30 9e-22 102
WERAM-Anc-0008 ENSACAP00000001400.2 Anolis carolinensis 23 1e-21 102
WERAM-Caj-0007 ENSCJAP00000001822.2 Callithrix jacchus 25 1e-21 102
WERAM-Orn-0144 ENSONIP00000015236.1 Oreochromis niloticus 58 2e-20 97.8
WERAM-Otg-0062 ENSOGAP00000004494.2 Otolemur garnettii 51 7e-20 96.3
WERAM-Cis-0071 ENSCSAVP00000015365.1 Ciona savignyi 56 1e-19 95.5
WERAM-Chs-0183 ENSCSAP00000011299.1 Chlorocebus sabaeus 50 3e-19 94.0
WERAM-Mup-0027 ENSMPUP00000002516.1 Mustela putorius furo 50 3e-19 94.0
WERAM-Nol-0096 ENSNLEP00000011055.1 Nomascus leucogenys 50 4e-19 94.0
WERAM-Tub-0102 ENSTBEP00000011858.1 Tupaia belangeri 50 4e-19 94.0
WERAM-Tut-0098 ENSTTRP00000008231.1 Tursiops truncatus 50 4e-19 94.0
WERAM-Gog-0075 ENSGGOP00000006441.2 Gorilla gorilla 50 4e-19 94.0
WERAM-Hos-0002 ENSP00000312244.4 Homo sapiens 50 4e-19 94.0
WERAM-Poa-0192 ENSPPYP00000022509.2 Pongo abelii 50 4e-19 93.6
WERAM-Ict-0063 ENSSTOP00000005572.2 Ictidomys tridecemlineatus 50 4e-19 93.6
WERAM-Sus-0084 ENSSSCP00000012895.2 Sus scrofa 50 4e-19 93.6
WERAM-Caf-0129 ENSCAFP00000017070.3 Canis familiaris 50 4e-19 93.6
WERAM-Ran-0026 ENSRNOP00000061187.1 Rattus norvegicus 25 8e-19 92.8
WERAM-Prc-0054 ENSPCAP00000005002.1 Procavia capensis 53 9e-19 92.4
WERAM-Meg-0150 ENSMGAP00000015584.1 Meleagris gallopavo 50 4e-18 90.5
WERAM-Gam-0172 ENSGMOP00000017086.1 Gadus morhua 29 8e-18 89.4
WERAM-Mod-0158 ENSMODP00000021652.2 Monodelphis domestica 51 1e-17 88.6
WERAM-Pat-0182 ENSPTRP00000038929.3 Pan troglodytes 49 4e-17 87.0
WERAM-Asm-0079 ENSAMXP00000008117.1 Astyanax mexicanus 50 7e-17 86.3
WERAM-Mam-0020 ENSMMUP00000003621.2 Macaca mulatta 25 1e-13 75.9
WERAM-Paa-0011 ENSPANP00000006015.1 Papio anubis 25 1e-13 75.5
WERAM-Ova-0120 ENSOARP00000011804.1 Ovis aries 25 2e-13 75.1
WERAM-Lac-0005 ENSLACP00000000561.1 Latimeria chalumnae 24 4e-13 73.9
WERAM-Fec-0036 ENSFCAP00000002569.3 Felis catus 25 5e-13 73.2
WERAM-Coi-0009 EAS36116 Coccidioides immitis 24 6e-13 73.2
WERAM-Aim-0110 ENSAMEP00000010677.1 Ailuropoda melanoleuca 26 8e-13 72.8
WERAM-Dan-0167 ENSDNOP00000019977.1 Dasypus novemcinctus 26 9e-13 72.4
WERAM-Orla-0047 ENSORLP00000005915.1 Oryzias latipes 45 1e-12 72.4
WERAM-Vip-0085 ENSVPAP00000007970.1 Vicugna pacos 25 3e-12 70.9
WERAM-Eqc-0128 ENSECAP00000014407.1 Equus caballus 25 3e-12 70.9
WERAM-Ere-0122 ENSEEUP00000012841.1 Erinaceus europaeus 25 9e-12 69.3
WERAM-Asni-0012 CADANGAP00004222 Aspergillus niger 25 1e-10 65.9
WERAM-Asc-0018 CADACLAP00004414 Aspergillus clavatus 24 9e-10 62.4
WERAM-Soa-0080 ENSSARP00000007667.1 Sorex araneus 24 5e-09 60.1
WERAM-Aso-0013 CADAORAP00001673 Aspergillus oryzae 24 5e-09 60.1
WERAM-Asfu-0038 CADAFUAP00008363 Aspergillus fumigatus 24 6e-09 60.1
WERAM-Mim-0132 ENSMICP00000013129.1 Microcebus murinus 37 2e-08 57.8
WERAM-Tas-0115 ENSTSYP00000011734.1 Tarsius syrichta 42 7e-08 56.6
WERAM-Asn-0032 CADANIAP00008637 Aspergillus nidulans 26 1e-07 55.8
WERAM-Ect-0117 ENSETEP00000013513.1 Echinops telfairi 46 1e-07 55.5
WERAM-Anp-0072 ENSAPLP00000008755.1 Anas platyrhynchos 36 1e-07 55.5
WERAM-Ptv-0044 ENSPVAP00000004729.1 Pteropus vampyrus 42 2e-07 55.1
WERAM-Ora-0027 ENSOANP00000004172.2 Ornithorhynchus anatinus 32 2e-07 55.1
WERAM-Xet-0174 ENSXETP00000062098.1 Xenopus tropicalis 35 2e-07 54.7
WERAM-Pes-0062 ENSPSIP00000008402.1 Pelodiscus sinensis 31 6e-07 53.1
WERAM-Gaga-0153 ENSGALP00000026739.4 Gallus gallus 34 7e-07 52.8
WERAM-Orc-0185 ENSOCUP00000016187.1 Oryctolagus cuniculus 21 9e-07 52.8
WERAM-Tag-0109 ENSTGUP00000008550.1 Taeniopygia guttata 40 9e-07 52.8
WERAM-Tum-0023 CAZ84135 Tuber melanosporum 39 2e-06 52.0
WERAM-Fia-0064 ENSFALP00000004670.1 Ficedula albicollis 33 2e-06 51.6
WERAM-Loa-0174 ENSLAFP00000016634.2 Loxodonta africana 29 7e-06 49.7
WERAM-Dar-0092 ENSDARP00000112985.1 Danio rerio 23 8e-06 49.7
Created Date 25-Jun-2016