WERAM Information

Tag Content
WERAM ID WERAM-Drm-0032
Ensembl Protein ID FBpp0070817
Uniprot Accession Q8IRR5; SIR4_DROME; D0IQB9; Q9W4A1
Genbank Protein ID NP_572241.2; NP_727013.2; NP_727014.2
Protein Name NAD-dependent protein deacylase Sirt4
Genbank Nucleotide ID NM_132013.3; NM_167041.3; NM_167042.3
Gene Name SIRT4;CG3187
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0029783 FBtr0070852 FBpp0070817
Details
Type Family Domain Substrates AA References (PMIDs)
HDAC SIR2 Deacetylase sirtuin-type K 12466527
Status Reviewed
Classification
Type Family E-value Score Start End
HDAC SIR2 1.20e-72 245 38 308
Organism Drosophila melanogaster
NCBI Taxa ID 7227
Functional Description
(View)		 NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues.
Domain Profile
  HDAC SIR2
     SIR2.txt   3 lakllkkskkivvltGAGiStsaGIPDFRs.seGlysklkkeelpspeaifdldffrkdpkv..fyalakelyp.lgsakPtktHyflaelekkgkll 96 
                  l+++l ++ +++vltGAGiSt++GIPD+Rs + Gly++ +++      ++++++f++++  +  ++a++   +p +++++P++tH++la++e++++++
  FBpp0070817  38 LEDFLLSKPNVLVLTGAGISTESGIPDYRSeGVGLYARSNHK------PVQHMEFVKSSAVRkrYWARNFVGWPkFSATQPNATHHALARFEREERVQ 129
                  6677888999****************************9998......9999999999987778********************************** PP
     SIR2.txt  97 rlytQNiDgLerkaglkedklvelHGslatasCtkCkkefpreeikeklkak..........................ekvpkCekCkgvlkpdivff 168
                   ++tQN+D+L++kag++  ++ve+HGs ++++C++C+++++r+e+++ l++                           +++p+C++C+g lkp+ivff
  FBpp0070817 130 AVVTQNVDRLHTKAGSR--NVVEVHGSGYVVKCLSCEYRIDRHEFQSILASLnpafkdapdmirpdgdveipleyienFRIPECTQCGGDLKPEIVFF 225
                  ****************9..****************************999999********************************************* PP
     SIR2.txt 169 genlpeefleeveedlkeadlllvlGtSlkvepvaslvkkavkkkvpvllvnleevkadkladlkllgdcdevveellkllgl 251
                  g+++p+ ++++++  + ++d llvlG+Sl v + +++v+++++ k pv +vn++e++ad+lad+k++++c++v+ +l +  + 
  FBpp0070817 226 GDSVPRPRVDQIAGMVYNSDGLLVLGSSLLVFSGYRVVLQTKDLKLPVGIVNIGETRADHLADIKISAKCGDVIPKLFDFRNS 308
                  ****************************************************************************9987665 PP
Protein Sequence
(Fasta)		MRVGQLLRFR STSLRSSTAR QEYVPHHKPV VEDDIKRLED FLLSKPNVLV LTGAGISTES 60
GIPDYRSEGV GLYARSNHKP VQHMEFVKSS AVRKRYWARN FVGWPKFSAT QPNATHHALA 120
RFEREERVQA VVTQNVDRLH TKAGSRNVVE VHGSGYVVKC LSCEYRIDRH EFQSILASLN 180
PAFKDAPDMI RPDGDVEIPL EYIENFRIPE CTQCGGDLKP EIVFFGDSVP RPRVDQIAGM 240
VYNSDGLLVL GSSLLVFSGY RVVLQTKDLK LPVGIVNIGE TRADHLADIK ISAKCGDVIP 300
KLFDFRNSKS VS 312
Nucleotide Sequence
(Fasta)		TGCGTGCGCT CACCTCTAGT AACGTAACCG AAAAAGAACC AAATATTACT TGCAATAATA 60
CATAACAAAA CAATGCGTGT GGGCCAGCTG CTCCGCTTCC GGAGCACCAG CTTGCGCAGC 120
TCCACCGCCA GGCAGGAGTA CGTGCCGCAT CACAAGCCCG TCGTGGAGGA CGACATCAAA 180
CGGCTGGAGG ACTTTCTCCT GTCCAAACCG AATGTTTTGG TTCTCACGGG CGCTGGCATC 240
TCGACGGAAT CGGGGATTCC CGATTACCGT TCCGAAGGCG TGGGCCTCTA CGCCCGCTCC 300
AACCACAAGC CCGTCCAGCA CATGGAGTTC GTCAAGTCGT CGGCGGTGCG CAAGCGGTAC 360
TGGGCCAGGA ACTTTGTGGG CTGGCCCAAG TTTTCTGCCA CACAGCCCAA TGCCACGCAT 420
CACGCGCTGG CCAGATTCGA GCGGGAGGAG CGGGTCCAGG CGGTGGTCAC CCAGAACGTG 480
GACCGGCTGC ACACGAAGGC GGGCAGCCGA AATGTTGTGG AGGTTCATGG CAGTGGCTAT 540
GTGGTCAAGT GCCTGTCATG CGAGTACCGG ATCGATCGTC ACGAGTTCCA GAGCATACTG 600
GCGTCGCTAA ATCCGGCCTT CAAAGATGCC CCCGACATGA TCCGGCCCGA TGGCGATGTA 660
GAGATACCGC TGGAGTACAT CGAGAACTTC CGGATACCCG AGTGTACGCA GTGCGGCGGC 720
GACTTGAAGC CGGAAATTGT CTTCTTCGGA GATTCTGTGC CTCGGCCACG AGTGGATCAG 780
ATTGCCGGCA TGGTGTACAA TAGCGATGGC CTGCTTGTCC TCGGGTCCAG TCTCCTGGTC 840
TTCTCCGGCT ACCGCGTTGT CCTGCAGACC AAGGACCTCA AGCTACCGGT GGGCATTGTT 900
AATATTGGCG AAACGCGCGC CGATCACCTG GCGGATATCA AGATATCCGC CAAGTGCGGC 960
GATGTCATAC CCAAACTGTT CGACTTTCGC AATTCGAAAA GCGTCAGTTA ATACTCACAG 1020
TTGTTATATG TTGACCCCCA CTAAATTTGT AGTTATGGAA AGCCAGGCTT TCTATTTTAG 1080
CTAAAAAATA AATGTTAATG ATTACTATTT GC 1113
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-0520--NAD
KW-1185--Reference proteome
KW-0809--Transit peptide
KW-0862--Zinc
--
Interpro

IPR029035--DHS-like_NAD/FAD-binding_dom
IPR003000--Sirtuin
IPR026591--Sirtuin_cat_small_dom
IPR026587--Sirtuin_class_II
IPR026590--Ssirtuin_cat_dom
PROSITE

PS50305--SIRTUIN
Pfam

PF02146--SIR2
Gene Ontology

GO:0005759--C:mitochondrial matrix
GO:0005739--C:mitochondrion
GO:0004407--F:histone deacetylase activity
GO:0046872--F:metal ion binding
GO:0070403--F:NAD+ binding
GO:0016575--P:histone deacetylation
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Xet-0032 ENSXETP00000009271.1 Xenopus tropicalis 51 2e-81 299
WERAM-Lac-0179 ENSLACP00000020887.1 Latimeria chalumnae 50 6e-81 298
WERAM-Dar-0026 ENSDARP00000027611.6 Danio rerio 51 1e-79 293
WERAM-Asm-0019 ENSAMXP00000002317.1 Astyanax mexicanus 50 1e-79 293
WERAM-Pes-0110 ENSPSIP00000013404.1 Pelodiscus sinensis 50 4e-79 291
WERAM-Orla-0208 ENSORLP00000024753.1 Oryzias latipes 51 2e-78 290
WERAM-Pem-0012 ENSPMAP00000001780.1 Petromyzon marinus 50 5e-78 288
WERAM-Meg-0094 ENSMGAP00000009092.2 Meleagris gallopavo 49 7e-78 287
WERAM-Tar-0187 ENSTRUP00000038866.1 Takifugu rubripes 49 1e-77 287
WERAM-Cap-0138 ENSCPOP00000011117.2 Cavia porcellus 50 1e-77 286
WERAM-Loa-0028 ENSLAFP00000001879.2 Loxodonta africana 49 1e-77 286
WERAM-Pof-0223 ENSPFOP00000018246.2 Poecilia formosa 50 1e-77 286
WERAM-Fia-0095 ENSFALP00000007922.1 Ficedula albicollis 49 1e-77 286
WERAM-Ova-0127 ENSOARP00000012850.1 Ovis aries 50 2e-77 286
WERAM-Mup-0031 ENSMPUP00000003126.1 Mustela putorius furo 50 2e-77 286
WERAM-Gaga-0078 ENSGALP00000011706.4 Gallus gallus 48 3e-77 285
WERAM-Tag-0120 ENSTGUP00000009802.1 Taeniopygia guttata 49 3e-77 285
WERAM-Tas-0026 ENSTSYP00000002962.1 Tarsius syrichta 50 4e-77 285
WERAM-Caf-0113 ENSCAFP00000015057.3 Canis familiaris 50 5e-77 285
WERAM-Orn-0178 ENSONIP00000018093.1 Oreochromis niloticus 50 5e-77 285
WERAM-Ora-0041 ENSOANP00000006568.2 Ornithorhynchus anatinus 52 6e-77 284
WERAM-Ict-0083 ENSSTOP00000008774.2 Ictidomys tridecemlineatus 50 8e-77 284
WERAM-Caj-0096 ENSCJAP00000015889.2 Callithrix jacchus 50 8e-77 284
WERAM-Mum-0098 ENSMUSP00000107697.1 Mus musculus 50 9e-77 284
WERAM-Anp-0117 ENSAPLP00000013436.1 Anas platyrhynchos 49 9e-77 284
WERAM-Ran-0010 ENSRNOP00000001523.4 Rattus norvegicus 50 1e-76 283
WERAM-Orc-0113 ENSOCUP00000009744.3 Oryctolagus cuniculus 51 2e-76 283
WERAM-Bot-0183 ENSBTAP00000028210.3 Bos taurus 50 2e-76 283
WERAM-Gaa-0017 ENSGACP00000001945.1 Gasterosteus aculeatus 50 2e-76 282
WERAM-Aim-0062 ENSAMEP00000005483.1 Ailuropoda melanoleuca 50 4e-76 281
WERAM-Fec-0171 ENSFCAP00000020847.1 Felis catus 51 4e-76 281
WERAM-Chh-0046 ENSCHOP00000005172.1 Choloepus hoffmanni 49 4e-76 281
WERAM-Gog-0207 ENSGGOP00000025620.1 Gorilla gorilla 50 7e-76 281
WERAM-Sus-0071 ENSSSCP00000010568.2 Sus scrofa 49 7e-76 281
WERAM-Chs-0026 ENSCSAP00000015768.1 Chlorocebus sabaeus 50 9e-76 280
WERAM-Xim-0194 ENSXMAP00000015621.1 Xiphophorus maculatus 49 1e-75 280
WERAM-Paa-0081 ENSPANP00000005490.1 Papio anubis 50 1e-75 280
WERAM-Hos-0046 ENSP00000202967.4 Homo sapiens 50 1e-75 280
WERAM-Gam-0012 ENSGMOP00000001231.1 Gadus morhua 49 1e-75 280
WERAM-Pat-0044 ENSPTRP00000009383.4 Pan troglodytes 50 1e-75 280
WERAM-Poa-0046 ENSPPYP00000005727.2 Pongo abelii 49 1e-75 280
WERAM-Eqc-0095 ENSECAP00000011260.1 Equus caballus 49 2e-75 279
WERAM-Otg-0098 ENSOGAP00000008496.1 Otolemur garnettii 49 2e-75 279
WERAM-Ocp-0148 ENSOPRP00000015399.1 Ochotona princeps 50 3e-75 279
WERAM-Sah-0071 ENSSHAP00000008646.1 Sarcophilus harrisii 47 1e-74 276
WERAM-Anc-0024 ENSACAP00000002561.3 Anolis carolinensis 47 7e-73 271
WERAM-Ptv-0014 ENSPVAP00000002101.1 Pteropus vampyrus 48 3e-72 269
WERAM-Nol-0169 ENSNLEP00000018942.2 Nomascus leucogenys 52 3e-71 265
WERAM-Ect-0086 ENSETEP00000009903.1 Echinops telfairi 48 2e-70 263
WERAM-Cii-0061 ENSCINP00000027422.2 Ciona intestinalis 49 3e-70 262
WERAM-Soa-0051 ENSSARP00000004940.1 Sorex araneus 46 6e-69 258
WERAM-Tub-0044 ENSTBEP00000005291.1 Tupaia belangeri 46 1e-68 257
WERAM-Cae-0023 F46G10.7a Caenorhabditis elegans 45 1e-68 257
WERAM-Viv-0046 VIT_07s0031g02510.t01 Vitis vinifera 46 3e-67 252
WERAM-Orp-0109 OPUNC12G04720.1 Oryza punctata 45 2e-66 249
WERAM-Orl-0007 KN538685.1_FGP039 Oryza longistaminata 45 2e-66 249
WERAM-Amt-0023 ERN08785 Amborella trichopoda 46 2e-66 249
WERAM-Ors-0107 OS12T0179800-01 Oryza sativa 45 3e-66 249
WERAM-Orm-0102 OMERI12G03010.1 Oryza meridionalis 45 5e-66 248
WERAM-Lep-0113 LPERR12G04350.1 Leersia perrieri 45 8e-66 248
WERAM-Ori-0126 BGIOSGA036526-PA Oryza indica 45 9e-66 247
WERAM-Orbr-0122 OB12G14620.1 Oryza brachyantha 45 1e-65 247
WERAM-Orr-0119 ORUFI12G05460.1 Oryza rufipogon 45 1e-65 247
WERAM-Sei-0033 Si009965m Setaria italica 45 2e-65 246
WERAM-Brd-0118 BRADI4G41127.1 Brachypodium distachyon 45 2e-65 246
WERAM-Sob-0114 Sb08g004900.1 Sorghum bicolor 45 4e-65 245
WERAM-Tra-0230 Traes_5DL_84C49FB59.2 Triticum aestivum 45 6e-65 244
WERAM-Php-0025 PP1S15_90V6.1 Physcomitrella patens 44 3e-64 242
WERAM-Orni-0118 ONIVA12G04440.1 Oryza nivara 47 8e-64 241
WERAM-Orgl-0114 OGLUM12G05580.1 Oryza glumaepatula 47 8e-64 241
WERAM-Mua-0095 GSMUA_Achr6P25880_001 Musa acuminata 44 1e-63 240
WERAM-Glm-0062 GLYMA06G16260.1 Glycine max 45 1e-63 240
WERAM-Met-0074 AES72910 Medicago truncatula 44 2e-62 236
WERAM-Tut-0072 ENSTTRP00000005343.1 Tursiops truncatus 50 2e-62 236
WERAM-Thc-0008 EOX92647 Theobroma cacao 44 4e-62 235
WERAM-Pot-0061 POPTR_0005s06930.1 Populus trichocarpa 43 8e-62 234
WERAM-Aet-0050 EMT19694 Aegilops tauschii 41 1e-61 233
WERAM-Sem-0074 EFJ28669 Selaginella moellendorffii 43 4e-61 232
WERAM-Sot-0097 PGSC0003DMT400082473 Solanum tuberosum 42 5e-61 231
WERAM-Sol-0062 Solyc04g009430.2.1 Solanum lycopersicum 41 1e-60 230
WERAM-Chr-0008 EDP00705 Chlamydomonas reinhardtii 50 3e-60 229
WERAM-Art-0118 AT5G09230.7 Arabidopsis thaliana 42 4e-60 229
WERAM-Arl-0027 fgenesh1_pg.C_scaffold_6000741 Arabidopsis lyrata 42 7e-60 228
WERAM-Bro-0024 Bo2g009270.1 Brassica oleracea 44 1e-59 227
WERAM-Brr-0142 Bra028643.1-P Brassica rapa 44 2e-59 226
WERAM-Prp-0069 EMJ12669 Prunus persica 41 2e-59 226
WERAM-Zem-0150 GRMZM5G807054_P01 Zea mays 42 5e-59 225
WERAM-Dan-0155 ENSDNOP00000033669.1 Dasypus novemcinctus 47 1e-58 223
WERAM-Ere-0059 ENSEEUP00000005136.1 Erinaceus europaeus 28 2e-22 103
WERAM-Myl-0161 ENSMLUP00000013308.2 Myotis lucifugus 31 6e-22 102
WERAM-Ten-0147 ENSTNIP00000015282.1 Tetraodon nigroviridis 31 2e-21 100
WERAM-Cis-0081 ENSCSAVP00000017799.1 Ciona savignyi 36 3e-21 99.8
WERAM-Mam-0069 ENSMMUP00000011380.2 Macaca mulatta 32 7e-20 95.1
WERAM-Dio-0050 ENSDORP00000004937.1 Dipodomys ordii 30 8e-20 95.1
WERAM-Crn-0031 AAW44797 Cryptococcus neoformans 33 1e-17 87.8
WERAM-Kll-0027 CAG98291 Kluyveromyces lactis 31 2e-17 87.0
WERAM-Mae-0013 ENSMEUP00000001070.1 Macropus eugenii 31 2e-17 87.0
WERAM-Mao-0040 MGG_17827T0 Magnaporthe oryzae 30 2e-17 87.0
WERAM-Scs-0014 EDN99996 Sclerotinia sclerotiorum 31 5e-17 85.9
WERAM-Fuo-0021 FOXG_06023P0 Fusarium oxysporum 32 5e-17 85.9
WERAM-Gag-0013 GGTG_03219T0 Gaeumannomyces graminis 32 1e-16 84.7
WERAM-Trv-0012 EHK19002 Trichoderma virens 30 2e-16 84.0
WERAM-Leo-0106 ENSLOCP00000013852.1 Lepisosteus oculatus 30 3e-16 83.2
WERAM-Mod-0155 ENSMODP00000021523.3 Monodelphis domestica 29 3e-16 82.8
WERAM-Trr-0018 EGR46788 Trichoderma reesei 32 4e-16 82.8
WERAM-Caa-0033 KGT64755 Candida albicans 28 6e-16 82.4
WERAM-Lab-0008 EDR12994 Laccaria bicolor 27 8e-16 81.6
WERAM-Cag-0026 CAG62123 Candida glabrata 30 1e-15 81.3
WERAM-Miv-0009 MVLG_01362T0 Microbotryum violaceum 28 2e-15 80.9
WERAM-Usm-0036 UM05892P0 Ustilago maydis 33 3e-15 79.7
WERAM-Asg-0028 AAS54472 Ashbya gossypii 29 4e-15 79.7
WERAM-Sac-0046 YPL015C Saccharomyces cerevisiae 31 4e-15 79.7
WERAM-Spr-0042 CBQ70931 Sporisorium reilianum 32 8e-15 78.6
WERAM-Zyt-0001 Mycgr3P100618 Zymoseptoria tritici 32 1e-14 77.8
WERAM-Pyt-0039 EFQ86136 Pyrenophora teres 30 3e-14 76.6
WERAM-Scj-0035 EEB09012 Schizosaccharomyces japonicus 28 6e-14 75.5
Created Date 25-Jun-2016