WERAM Information

Tag Content
WERAM ID WERAM-Thc-0049
Ensembl Protein ID EOY04373
Gene Name TCM_019641
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
TCM_019641 EOY04373 EOY04373
Status Unreviewed
Classification
Type Family E-value Score Start End
Ac_Reader Bromodomain 1.80e-21 77.1 151 217
Organism Theobroma cacao
Domain Profile
  Ac_Reader Bromodomain
  BROMO.txt   2 ehevsepFrepvdpqleipdYydiikePmdLstikerleegnYsspeefvkDvrlifnNakaynenks 69 
                +++  e+F epvd+  e+ dYydiikePmd+ t++++l eg+Y+s+++f +Dv li +Na+ +n+  +
   EOY04373 151 RRDTYEIFAEPVDR-EEVEDYYDIIKEPMDFGTMRAKLHEGMYTSLQQFEHDVYLISKNAMHFNSSAT 217
                678899********.6************************************************9865 PP
Protein Sequence
(Fasta)		MARKVRMSKW KEGQRRSPRI SASHPCEAQR SRRVGRTALA PPPQAMGLQV QHSRPQDQGP 60
ASRTRARKKR KLRPVDDVAA TSLSPFAQQG SDLQSHDEDH RISCDPPTAQ GGNSPKFDDK 120
AVSPDQLSSV PSTRWMPEKR ILELVLDILQ RRDTYEIFAE PVDREEVEDY YDIIKEPMDF 180
GTMRAKLHEG MYTSLQQFEH DVYLISKNAM HFNSSATIYF RQARAIDELA KKVFHSLKTD 240
PENFELEFSE TRRRTSRRLM SEARAPSYSS SSKLATNLRR NSKTNVSSKP MPSFLPNSSN 300
LRKGVRGICG LAGATTDCNA RDHVVHSGAL NGRGNNFAEV DRRCTYRPWT SLHTDNDSIV 360
STIYSDSKPL IPVNQQDIGY RDSLMFFVKD LGPTAQMIAK QKLIGCSVDA SNCWTPGSKH 420
WFQEPECQNP NAFHSTQRGL PILDSAFTAA SENLFDHLQR GPNILGNANY KVDSSYAGAG 480
EKAYASNKML IPSASVVVVS SSDEKKSPVA FKGDGHFSNA MDIFGLFGCD KLHQDQCSEI 540
QLGSHPSSVG QDIIAQDEVE VRGSVEGGQE LKAGQPNQLG SQFIFDLPFL KKRLDQINSS 600
GKDKLLQQGS SIETPFLNEE VNWKMQLACS RHKKLSTQNI QRSLSLSLCV RKKPTKKKLE 660
EKEMAYRRRQ GISRASTFKE EIHHPPDDND SKTFTSSYSF SSSTSPANSL AAQAIRASAA 720
ARKTDSPAFA AHSDFGPSRS KGFNAYEDAR NDSKGFWGVL ARKAKAILDD DNMSQQFETP 780
GRVGSSYMFD ASTASQQKQQ PGDQGFRRMD NPTIRRGLHK LTSSLNQIGD TFERAFEEGR 840
TIVESKTQDI IQETRKLQIR RKGSGPEEQN LVTGFNSTSQ QPLVQPTQLQ NQTNHETQLK 900
ASRDVAMATA AKAKLLLREL KTVKADLAFA KERCAQLEEE NKLLRESREK GGNPADDDLI 960
RLQLETLLAE KARLAHENSV YARENRFLRE IVEYHQLTMQ DVVYLDEGAE EVTEVYPINF 1020
PFSKMLSEDS PTSPESPPSP SEVTPSTTSP PMTQEILPLP ESDVSPTSSV PDGEDARRPP 1080
PSSV 1084
Nucleotide Sequence
(Fasta)		TTGATCCGTG GGTTAAATAC TGCATAGAAG AGCTCGAAAC ATGCCTTGTG TTTTTACCCC 60
TCAAAACCTC ATGCCCTCAT GGAGTGGATG GTCATGGAAT AGACATTCTT CTAAGCTGTA 120
ATCACACCCA TTTCCCATGA TTTCCTATCT TCGTTCTGAA CCTATTCAGC TCTCGCTTGG 180
GGATTATGAA GAAAGTAAAA CAGTTGTTAG TGATTACCAT TTGAAGCAAA ACAGGATGTG 240
AGGAAGCAAA TGAGGACTAC AGTTTGGGGG TTTTAATCCT TTTTCCTTGT CTGGAAAATT 300
CACCATATCT CTCATAAACA GAAAAACAAT GCCAATCCCT TAGCTGTAAC CTCTTTAATA 360
TAATGTGATC ACAAATCCCC TCTTGAGTTC AAGTTCCTTT TCTCCCATTC CCTTGCCATT 420
GTCTCTGTGT TTGGAATGGC CAGAAAAGTA CGAATGTCCA AGTGGAAAGA AGGGCAGAGG 480
CGGAGCCCGC GAATATCTGC ATCGCATCCT TGCGAGGCCC AGCGATCGAG GCGCGTGGGT 540
CGCACTGCTT TGGCTCCACC TCCACAGGCA ATGGGTTTAC AAGTGCAACA CTCTCGCCCT 600
CAGGATCAAG GACCAGCCTC CCGGACTAGG GCCAGGAAAA AGAGAAAACT CAGACCAGTC 660
GACGATGTGG CTGCTACTTC CCTTTCACCC TTTGCTCAGC AGGGCAGCGA CCTACAAAGC 720
CATGATGAAG ATCATCGAAT TAGTTGCGAT CCACCAACTG CCCAGGGTGG CAATAGCCCA 780
AAATTTGATG ATAAAGCGGT CTCCCCTGAT CAACTATCAA GTGTGCCATC TACCAGATGG 840
ATGCCAGAGA AACGCATACT AGAGCTTGTT CTCGACATAT TACAGAGGAG AGACACCTAT 900
GAAATATTCG CTGAACCTGT TGACCGTGAA GAGGTTGAGG ATTATTATGA TATCATTAAA 960
GAGCCTATGG ATTTTGGCAC AATGAGAGCT AAACTTCATG AAGGGATGTA TACGAGTCTT 1020
CAACAATTTG AGCATGATGT ATATTTAATA TCCAAAAATG CAATGCATTT TAATTCCTCG 1080
GCAACTATAT ACTTCAGACA GGCTCGAGCC ATTGATGAAC TAGCAAAAAA GGTCTTTCAT 1140
TCTCTTAAAA CTGACCCAGA GAATTTTGAG TTGGAATTTT CAGAGACAAG ACGAAGAACT 1200
AGTAGAAGGC TCATGAGTGA AGCTAGGGCT CCATCATATA GCTCAAGTTC TAAGCTTGCA 1260
ACAAATTTAA GACGCAATAG CAAGACCAAT GTATCATCAA AACCTATGCC ATCTTTTCTT 1320
CCTAATTCTT CAAACCTCAG GAAAGGTGTT AGAGGAATTT GTGGACTCGC TGGTGCTACT 1380
ACTGATTGTA ATGCAAGAGA TCATGTAGTG CACTCTGGTG CTTTAAATGG TAGGGGAAAT 1440
AATTTTGCTG AAGTAGATAG ACGTTGTACG TATAGACCCT GGACGTCTCT CCACACTGAC 1500
AATGATTCAA TTGTTTCCAC AATTTATAGT GATTCAAAAC CACTAATTCC TGTGAATCAG 1560
CAGGATATTG GTTACAGAGA TAGTTTAATG TTCTTTGTTA AAGATTTAGG ACCAACAGCC 1620
CAAATGATTG CCAAGCAGAA GTTGATTGGA TGCTCGGTTG ATGCTTCTAA TTGTTGGACT 1680
CCAGGTTCAA AACATTGGTT TCAGGAACCT GAATGTCAAA ATCCTAATGC ATTTCATTCC 1740
ACCCAGAGGG GACTTCCTAT TCTGGATTCT GCATTTACTG CAGCATCTGA AAATTTATTT 1800
GACCATCTTC AAAGGGGTCC AAACATCTTA GGAAATGCCA ATTATAAAGT GGATTCATCT 1860
TATGCTGGTG CAGGAGAGAA GGCTTATGCC TCGAACAAAA TGCTTATCCC TAGTGCTTCA 1920
GTGGTAGTGG TGTCAAGCAG TGATGAAAAG AAAAGTCCAG TTGCCTTCAA AGGGGATGGT 1980
CACTTCAGTA ATGCAATGGA TATTTTTGGC CTTTTTGGTT GTGACAAGTT ACATCAGGAT 2040
CAGTGCTCTG AGATTCAGTT GGGCTCCCAT CCTTCCAGTG TTGGCCAAGA CATAATTGCA 2100
CAAGATGAAG TTGAAGTCCG TGGTTCTGTT GAAGGAGGCC AAGAGTTGAA AGCAGGCCAA 2160
CCTAACCAAC TGGGTTCTCA GTTCATATTT GATTTGCCAT TTCTGAAGAA GCGGCTTGAT 2220
CAGATTAACT CCTCAGGAAA GGATAAACTT TTGCAGCAAG GTTCCAGCAT TGAAACTCCA 2280
TTTCTGAACG AAGAAGTAAA TTGGAAGATG CAATTGGCCT GCAGCCGTCA CAAGAAGCTT 2340
AGCACTCAAA ACATACAAAG ATCTCTCTCT CTCTCTCTCT GTGTTAGGAA AAAACCAACC 2400
AAAAAGAAAT TAGAGGAAAA GGAAATGGCT TATAGGAGAA GGCAGGGGAT AAGCAGAGCC 2460
TCGACGTTCA AGGAAGAAAT TCACCACCCA CCTGATGACA ATGACAGCAA AACGTTTACG 2520
TCCTCGTATT CTTTCTCTTC ATCAACATCG CCGGCCAATT CTCTAGCCGC TCAGGCCATC 2580
CGTGCTTCGG CTGCTGCTCG CAAAACCGAC TCCCCTGCTT TTGCTGCTCA CTCTGATTTC 2640
GGCCCGTCAA GATCTAAGGG ATTCAATGCC TATGAAGATG CAAGAAATGA TTCGAAAGGG 2700
TTCTGGGGTG TTCTTGCTCG AAAAGCCAAA GCCATTCTCG ACGATGATAA TATGTCTCAG 2760
CAATTTGAAA CGCCCGGCAG AGTGGGATCA TCGTATATGT TCGATGCCTC AACGGCTTCC 2820
CAGCAAAAGC AACAGCCAGG TGATCAGGGG TTTAGAAGAA TGGACAATCC TACAATACGA 2880
AGGGGCTTGC ATAAGCTCAC CTCTTCCCTT AATCAAATTG GTGACACATT TGAAAGGGCT 2940
TTCGAGGAAG GTCGAACAAT TGTCGAAAGT AAAACCCAAG ATATCATCCA AGAAACGCGC 3000
AAACTTCAAA TCAGGCGGAA AGGGAGTGGC CCCGAGGAAC AAAACCTGGT CACTGGTTTC 3060
AATAGCACAT CGCAGCAACC TCTGGTGCAA CCAACACAGC TCCAGAATCA AACCAACCAT 3120
GAAACCCAAC TCAAGGCATC TCGCGACGTT GCAATGGCCA CAGCTGCTAA AGCAAAACTT 3180
CTTCTGCGGG AGCTGAAAAC TGTTAAAGCA GATTTGGCTT TTGCAAAGGA ACGATGTGCC 3240
CAACTAGAAG AGGAGAACAA ACTCCTTCGG GAGAGTCGAG AGAAAGGGGG CAATCCGGCA 3300
GATGATGATT TGATTCGGCT TCAACTGGAG ACTCTATTGG CAGAGAAGGC ACGTTTGGCG 3360
CATGAGAATT CAGTATACGC TCGTGAGAAC CGGTTTCTAA GGGAAATTGT GGAGTATCAC 3420
CAGCTGACCA TGCAGGACGT GGTGTACTTA GATGAGGGGG CTGAAGAAGT TACAGAAGTT 3480
TATCCCATCA ACTTCCCATT CTCAAAAATG CTTTCAGAGG ATTCCCCAAC CTCACCTGAG 3540
TCTCCACCAT CACCGTCCGA GGTCACCCCC TCTACTACAA GCCCGCCGAT GACACAGGAA 3600
ATATTACCTC TCCCTGAAAG TGATGTTTCA CCTACTAGTT CAGTACCTGA TGGAGAGGAT 3660
GCAAGAAGAC CTCCACCGTC TTCTGTCTAA ATTTAGTTTT ACCAATATAC TTATTTTGTA 3720
TGTTAAAGAC TTTCTGTAAC ATGGATTGAT ACTCTTTTTC CTTTTTCATT TTTTTTTGGG 3780
TATTTTCTGG GAAGGGTTCC TTTTATTTAT TTATTTATTT ATTTGTTTGT TTGTTTTTTA 3840
ATCTTTGAAG GAGGAAGGAG GAGGCAGATT TTTTTTGTTC TTTTTTTGGG GATTGATAAA 3900
TTTTGATGCG TGTGTAATTG TGCATACCCC TTTTTTGGTC CATGATTAAA TAAGAATGAT 3960
AAAAATTCTT TTCATTTTTC CAGTTACTTT TACCTATCAA CTCTTCTTCA ATCATAGATG 4020
AGCCTCCTTG TTTCAAAATT ACGAGAGCCC TTGTTTTTGC TCAAAAACAG TGTAGCCAAG 4080
GCTAATCGTA ATGACAGGAG CGTAACTCAA CTGAAAGAAG TGCGGTTAGT TATTATCTCT 4140
TGGTGGAATG GTTTGCAGAC TACACCGCAC TGAAATGCAA AAGGGTTTTT ATCAGCTGAA 4200
CGGCATGATC CTCACTGTTG AAGAGACGGA AATGGCATCG ACCTTCCCTT GAAAATCCGT 4260
CTCAATTATG GCTTAACATT CACCGGTTTT TCCCTATTAA GACACGAAGG GCATTCCATG 4320
AATGTCGTCA TCATGCACTC TGGCTGTAGC CAACACCAGC CTGCAATTGC ACTTCAAAGC 4380
ATATTGCTCT AAACCAAAGA CCAGTATCAG ATTTCTTTTG AGACCCAAAA GAAGAAACAG 4440
TACAGGGGGC A 4452
Sequence Source Ensembl
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Pot-0156 POPTR_0016s14820.1 Populus trichocarpa 48 1e-114 412
WERAM-Prp-0101 EMJ07659 Prunus persica 44 3e-81 301
WERAM-Glm-0214 GLYMA16G34785.1 Glycine max 48 9e-78 289
WERAM-Sot-0058 PGSC0003DMT400051031 Solanum tuberosum 44 6e-55 214
WERAM-Viv-0058 VIT_08s0056g00330.t01 Vitis vinifera 71 1e-54 212
WERAM-Sol-0110 Solyc09g055660.1.1 Solanum lycopersicum 49 1e-52 206
WERAM-Amt-0078 ERN04277 Amborella trichopoda 44 2e-51 202
WERAM-Met-0170 AET01108 Medicago truncatula 68 2e-45 182
WERAM-Brd-0038 BRADI1G76370.1 Brachypodium distachyon 33 1e-33 142
WERAM-Art-0029 AT1G76380.2 Arabidopsis thaliana 31 1e-33 142
WERAM-Bro-0125 Bo7g061450.1 Brassica oleracea 35 2e-33 142
WERAM-Ors-0095 OS09T0550000-01 Oryza sativa 53 2e-33 142
WERAM-Orr-0109 ORUFI09G20360.1 Oryza rufipogon 53 2e-33 142
WERAM-Orni-0105 ONIVA09G19920.1 Oryza nivara 53 2e-33 142
WERAM-Orb-0106 OBART09G18790.1 Oryza barthii 53 2e-33 142
WERAM-Arl-0051 fgenesh2_kg.2__ 1923__ AT1G76380.2 Arabidopsis lyrata 34 3e-33 142
WERAM-Sei-0113 Si029325m Setaria italica 58 4e-33 141
WERAM-Orgl-0103 OGLUM09G19290.1 Oryza glumaepatula 58 4e-33 141
WERAM-Org-0099 ORGLA09G0149700.1 Oryza glaberrima 58 4e-33 141
WERAM-Sob-0032 Sb02g032020.1 Sorghum bicolor 59 4e-33 141
WERAM-Zem-0107 GRMZM2G312501_P01 Zea mays 57 6e-33 140
WERAM-Mua-0071 GSMUA_Achr4P11790_001 Musa acuminata 58 6e-33 140
WERAM-Lep-0034 LPERR03G02260.1 Leersia perrieri 32 8e-33 140
WERAM-Orbr-0037 OB03G12430.1 Oryza brachyantha 32 8e-33 140
WERAM-Orl-0064 KN539310.1_FGP014 Oryza longistaminata 59 1e-32 139
WERAM-Orp-0099 OPUNC09G17160.1 Oryza punctata 52 1e-32 139
WERAM-Brr-0126 Bra025837.1-P Brassica rapa 56 4e-32 137
WERAM-Aet-0070 EMT11052 Aegilops tauschii 56 5e-32 137
WERAM-Tra-0201 Traes_5BL_C2FF92AB7.1 Triticum aestivum 32 9e-32 136
WERAM-Ori-0086 BGIOSGA025787-PA Oryza indica 55 4e-31 134
WERAM-Orm-0072 OMERI07G12350.1 Oryza meridionalis 55 4e-31 134
WERAM-Tru-0062 TRIUR3_25198-P1 Triticum urartu 32 3e-30 132
WERAM-Php-0049 PP1S214_29V6.1 Physcomitrella patens 53 2e-28 125
WERAM-Hov-0042 MLOC_4085.1 Hordeum vulgare 53 2e-24 112
WERAM-Sem-0087 EFJ10182 Selaginella moellendorffii 46 2e-20 99.4
WERAM-Cym-0004 CMB029CT Cyanidioschyzon merolae 43 4e-19 95.1
WERAM-Tut-0180 ENSTTRP00000015203.1 Tursiops truncatus 42 4e-19 94.7
WERAM-Eqc-0025 ENSECAP00000004577.1 Equus caballus 43 4e-19 94.7
WERAM-Orc-0083 ENSOCUP00000007454.3 Oryctolagus cuniculus 42 6e-19 94.4
WERAM-Mum-0217 ENSMUSP00000004985.9 Mus musculus 42 6e-19 94.4
WERAM-Drm-0049 FBpp0088092 Drosophila melanogaster 42 6e-19 94.4
WERAM-Chs-0121 ENSCSAP00000006430.1 Chlorocebus sabaeus 42 6e-19 94.4
WERAM-Vip-0098 ENSVPAP00000009227.1 Vicugna pacos 42 6e-19 94.4
WERAM-Paa-0008 ENSPANP00000012515.1 Papio anubis 42 6e-19 94.4
WERAM-Cap-0116 ENSCPOP00000009174.2 Cavia porcellus 42 6e-19 94.4
WERAM-Ova-0135 ENSOARP00000014056.1 Ovis aries 42 6e-19 94.4
WERAM-Hos-0050 ENSP00000350267.6 Homo sapiens 42 6e-19 94.4
WERAM-Dan-0074 ENSDNOP00000007515.3 Dasypus novemcinctus 42 6e-19 94.4
WERAM-Dio-0041 ENSDORP00000004516.1 Dipodomys ordii 42 7e-19 94.4
WERAM-Pat-0201 ENSPTRP00000046383.4 Pan troglodytes 42 7e-19 94.0
WERAM-Mup-0043 ENSMPUP00000004041.1 Mustela putorius furo 42 7e-19 94.0
WERAM-Gog-0148 ENSGGOP00000013085.2 Gorilla gorilla 42 7e-19 94.0
WERAM-Fec-0022 ENSFCAP00000001618.3 Felis catus 42 7e-19 94.0
WERAM-Poa-0149 ENSPPYP00000018502.2 Pongo abelii 42 7e-19 94.0
WERAM-Nol-0094 ENSNLEP00000011003.1 Nomascus leucogenys 42 7e-19 94.0
WERAM-Ict-0068 ENSSTOP00000006036.2 Ictidomys tridecemlineatus 42 7e-19 94.0
WERAM-Aim-0006 ENSAMEP00000000373.1 Ailuropoda melanoleuca 42 7e-19 94.0
WERAM-Caf-0020 ENSCAFP00000001989.4 Canis familiaris 42 7e-19 94.0
WERAM-Myl-0031 ENSMLUP00000002199.2 Myotis lucifugus 42 7e-19 94.0
WERAM-Caj-0165 ENSCJAP00000029416.2 Callithrix jacchus 42 8e-19 94.0
WERAM-Tas-0080 ENSTSYP00000007958.1 Tarsius syrichta 42 1e-18 93.6
WERAM-Ran-0166 ENSRNOP00000041680.3 Rattus norvegicus 42 1e-18 93.6
WERAM-Mae-0048 ENSMEUP00000004688.1 Macropus eugenii 42 1e-18 93.2
WERAM-Otg-0037 ENSOGAP00000002289.2 Otolemur garnettii 41 2e-18 92.8
WERAM-Sah-0064 ENSSHAP00000007688.1 Sarcophilus harrisii 40 2e-18 92.4
WERAM-Gaga-0007 ENSGALP00000001121.4 Gallus gallus 40 3e-18 92.0
WERAM-Meg-0003 ENSMGAP00000000252.2 Meleagris gallopavo 40 3e-18 91.7
WERAM-Ocp-0109 ENSOPRP00000010619.2 Ochotona princeps 43 4e-18 91.7
WERAM-Pes-0055 ENSPSIP00000007495.1 Pelodiscus sinensis 41 4e-18 91.7
WERAM-Mod-0118 ENSMODP00000031361.3 Monodelphis domestica 44 5e-18 91.3
WERAM-Ora-0025 ENSOANP00000003691.2 Ornithorhynchus anatinus 43 7e-18 90.9
WERAM-Tub-0066 ENSTBEP00000008262.1 Tupaia belangeri 41 1e-17 90.1
WERAM-Spr-0041 CBQ70925 Sporisorium reilianum 37 1e-17 89.7
WERAM-Anp-0002 ENSAPLP00000000272.1 Anas platyrhynchos 43 2e-17 89.7
WERAM-Soa-0089 ENSSARP00000008498.1 Sorex araneus 41 2e-17 89.7
WERAM-Usm-0035 UM05887P0 Ustilago maydis 45 2e-17 89.4
WERAM-Ect-0118 ENSETEP00000013907.1 Echinops telfairi 41 3e-17 88.6
WERAM-Fia-0052 ENSFALP00000003674.1 Ficedula albicollis 42 3e-17 88.6
WERAM-Pem-0069 ENSPMAP00000007494.1 Petromyzon marinus 52 5e-17 87.8
WERAM-Tag-0057 ENSTGUP00000003959.1 Taeniopygia guttata 42 5e-17 87.8
WERAM-Anc-0176 ENSACAP00000016633.3 Anolis carolinensis 43 7e-17 87.4
WERAM-Ptv-0134 ENSPVAP00000011359.1 Pteropus vampyrus 48 9e-17 87.0
WERAM-Orn-0045 ENSONIP00000004990.1 Oreochromis niloticus 43 9e-17 87.0
WERAM-Loa-0173 ENSLAFP00000016305.2 Loxodonta africana 41 1e-16 87.0
WERAM-Ere-0049 ENSEEUP00000004249.1 Erinaceus europaeus 43 1e-16 86.7
WERAM-Mam-0004 ENSMMUP00000000744.2 Macaca mulatta 47 2e-16 86.3
WERAM-Ten-0080 ENSTNIP00000009563.1 Tetraodon nigroviridis 49 2e-16 85.9
WERAM-Lac-0016 ENSLACP00000002326.1 Latimeria chalumnae 40 2e-16 85.9
WERAM-Tar-0011 ENSTRUP00000002345.1 Takifugu rubripes 49 3e-16 85.5
WERAM-Mim-0029 ENSMICP00000002767.1 Microcebus murinus 48 3e-16 85.1
WERAM-Orla-0122 ENSORLP00000014580.1 Oryzias latipes 48 4e-16 85.1
WERAM-Leo-0167 ENSLOCP00000019767.1 Lepisosteus oculatus 48 4e-16 85.1
WERAM-Bot-0219 ENSBTAP00000055298.1 Bos taurus 46 4e-16 85.1
WERAM-Xim-0051 ENSXMAP00000004637.1 Xiphophorus maculatus 44 4e-16 84.7
WERAM-Pof-0113 ENSPFOP00000009821.1 Poecilia formosa 44 4e-16 84.7
WERAM-Xet-0184 ENSXETP00000061483.1 Xenopus tropicalis 41 1e-15 83.2
Created Date 25-Jun-2016