WERAM Information

Tag Content
WERAM ID WERAM-Hos-0098
Ensembl Protein ID ENSP00000483946.1
Uniprot Accession Q5T6S3; PHF19_HUMAN; Q32NF2; Q5T6S4; Q6N038; Q8TBL6; Q9UFS9
Genbank Protein ID NP_001009936.1; NP_001273769.1; NP_001273772.1; NP_056466.1; XP_005251963.1; XP_011516811.1; XP_011516812.1
Protein Name PHD finger protein 19
Genbank Nucleotide ID NM_001009936.2; NM_001286840.1; NM_001286843.1; NM_015651.2; XM_005251906.1; XM_011518509.1; XM_011518510.1
Gene Name PHF19;PCL3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000119403.13 ENST00000616568.4 ENSP00000483946.1
ENSG00000119403.13 ENST00000312189.10 ENSP00000310372.6
ENSG00000119403.13 ENST00000373896.7 ENSP00000363003.3
ENSG00000119403.13 ENST00000456291.1 ENSP00000397935.1
ENSG00000119403.13 ENST00000436309.5 ENSP00000408479.1
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader Tudor Tudor H3K36me3 K 23273982
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader Tudor 2.50e-13 52.3 59 110
Me_Reader PHD 2.40e-08 36.3 117 267
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases NO66 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds dimethylated at 'Lys-36' (H3K36me2). Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter.
Domain Profile
  Me_Reader Tudor
          Tudor.txt   2 skvGlrVvakwssdGyfYsgkiVvkghrvesgeeyysikyedqrkwyilsLekgnrlre 60 
                        +++G++V+++w+ dG++Y gki    +rv+s+++ +++++ed++k+++  L+k+++++ 
  ENSP00000483946.1  59 LTEGQYVLCRWT-DGLYYLGKI----KRVSSSKQSCLVTFEDNSKYWV--LWKDIQHAG 110
                        579*********.*********....**********************..9***99875 PP
  Me_Reader PHD
            PHD.txt   3 iClvC.gkddegekemvqCdeCddwfHlkCvklplsslpeg..kswyCpsC 50 
                         C +C gk++   +e++ C +C   +H++C+ +   s+ ++  + w+C++C
  ENSP00000483946.1 117 KCNIClGKTSGPLNEILICGKCGLGYHQQCHIPIAGSADQPllTPWFCRRC 167
                        5999*7788888888****************99977777777677****** PP
            PHD.txt   3 iClvCgkddegekemvqCdeCddwfHlkCvklplsslpeg...kswyCpsCke 52 
                        +C+ Cg ++e    m+qC  C++wfH  C+++  +++  g     ++C  C +
  ENSP00000483946.1 216 YCY-CGGPGEWYLRMLQCYRCRQWFHEACTQCLNEPMMFGdrfYLFFCSVCNQ 267
                        899.9766666666*******************88887663333366999975 PP
Protein Sequence
(Fasta)		MLVLVIRGPY PSAQCQGKLM ENRALDPGTR DSYGATSHLP NKGALAKVKN NFKDLMSKLT 60
EGQYVLCRWT DGLYYLGKIK RVSSSKQSCL VTFEDNSKYW VLWKDIQHAG VPGEEPKCNI 120
CLGKTSGPLN EILICGKCGL GYHQQCHIPI AGSADQPLLT PWFCRRCIFA LAVRKGGALK 180
KGAIARTLQA VKMVLSYQPE ELEWDSPHRT NQQQCYCYCG GPGEWYLRML QCYRCRQWFH 240
EACTQCLNEP MMFGDRFYLF FCSVCNQGPE YIERLPLRWV DVVHLALYNL GVQSKKKYFD 300
FEEILAFVNH HWELLQLGKL TSTPVTDRGP HLLNALNSYK SRFLCGKEIK KKKCIFRLRI 360
RVPPNPPGKL LPDKGLLPNE NSASSELRKR GKSKPGLLPH EFQQQKRRVY RRKRSKFLLE 420
DAIPSSDFTS AWSTNHHLAS IFDFTLDEIQ SLKSASSGQT FFSDVDSTDA ASTSGSASTS 480
LSYDSRWTVG SRKRKLAAKA YMPLRAKRWA AELDGRCPSD SSAEGASVPE RPDEGIDSHT 540
FESISEDDSS LSHLKSSITN YFGAAGRLAC GEKYQVLARR VTPEGKVQYL VEWEGTTPY 599
Nucleotide Sequence
(Fasta)		ACCAGTAAGT CGTGTATTTA GCATTCATTC ATCAAAGCCT CCGGATGCCT CCTACGTGCC 60
CTGCACTATG CTGGTCTTGG TAATCCGTGG TCCCTATCCC AGCGCCCAGT GTCAGGGGAA 120
GCTGATGGAG AATCGAGCTC TGGATCCAGG GACTCGGGAC TCCTATGGTG CCACCAGCCA 180
CCTCCCCAAC AAGGGGGCCC TGGCGAAGGT CAAGAACAAC TTCAAAGACT TGATGTCCAA 240
ACTGACGGAG GGCCAGTATG TGCTGTGCCG GTGGACAGAT GGCCTGTACT ACCTCGGGAA 300
GATCAAGAGG GTCAGCAGCT CTAAGCAAAG CTGCCTCGTG ACTTTCGAAG ATAATTCCAA 360
ATACTGGGTC CTATGGAAGG ACATACAGCA TGCCGGTGTT CCAGGAGAGG AGCCCAAGTG 420
CAACATCTGC CTAGGGAAGA CATCAGGGCC GCTGAATGAG ATCCTCATCT GCGGGAAGTG 480
TGGCCTGGGT TACCACCAGC AGTGCCACAT CCCCATAGCG GGCAGTGCTG ACCAGCCCCT 540
GCTCACACCT TGGTTCTGCC GACGCTGCAT CTTCGCACTG GCTGTGCGGA AAGGCGGCGC 600
GCTGAAGAAG GGCGCCATCG CCAGGACGCT GCAGGCCGTG AAGATGGTGC TGTCCTACCA 660
GCCCGAGGAG CTCGAGTGGG ACTCGCCCCA TCGCACCAAC CAGCAGCAAT GCTACTGCTA 720
CTGCGGCGGG CCCGGAGAAT GGTACCTGCG GATGCTGCAA TGTTACCGGT GCAGGCAGTG 780
GTTCCACGAG GCCTGCACCC AGTGCCTCAA TGAGCCCATG ATGTTTGGAG ACCGGTTTTA 840
CCTGTTCTTC TGCTCCGTGT GTAACCAGGG CCCAGAGTAC ATCGAGAGGC TGCCCCTGCG 900
ATGGGTGGAT GTGGTTCACC TGGCCCTCTA TAATCTGGGG GTACAGAGCA AGAAGAAGTA 960
CTTTGACTTT GAGGAGATTC TGGCCTTTGT CAACCACCAC TGGGAGCTCC TGCAGCTTGG 1020
CAAGCTCACC AGCACCCCAG TGACAGATCG AGGACCACAT CTCCTCAACG CTCTGAACAG 1080
TTATAAAAGC CGGTTCCTCT GCGGCAAGGA GATCAAGAAG AAGAAGTGCA TCTTCCGCCT 1140
GCGCATCCGC GTCCCACCCA ACCCGCCAGG GAAGCTGCTG CCTGACAAAG GACTGCTGCC 1200
AAATGAGAAC AGCGCCTCCT CTGAGCTGCG TAAGAGAGGA AAGAGCAAGC CTGGTTTGTT 1260
GCCTCACGAA TTCCAGCAGC AGAAAAGGCG AGTTTATAGA AGAAAAAGAT CAAAGTTTTT 1320
GCTGGAAGAT GCTATTCCCA GTAGTGACTT CACCTCAGCC TGGAGCACCA ACCACCACCT 1380
GGCTAGCATA TTTGACTTCA CGCTGGATGA AATTCAAAGT TTAAAAAGTG CCAGCTCAGG 1440
CCAGACCTTC TTCTCAGATG TCGACTCCAC CGACGCTGCC AGCACCTCTG GCTCTGCCTC 1500
CACCAGCCTC TCCTATGACT CCAGATGGAC AGTGGGCAGC CGAAAGAGGA AGCTGGCAGC 1560
CAAGGCATAC ATGCCCCTGC GGGCAAAGCG GTGGGCAGCT GAGCTGGATG GACGCTGCCC 1620
CTCGGACAGC AGTGCAGAGG GGGCTTCAGT CCCCGAGCGG CCAGACGAAG GCATTGACAG 1680
CCACACATTT GAGAGCATCA GTGAAGATGA CTCATCCCTG TCCCACCTCA AGTCATCTAT 1740
CACCAACTAC TTTGGTGCAG CTGGGCGGTT GGCCTGTGGG GAGAAGTACC AGGTGTTGGC 1800
TCGGAGGGTC ACACCTGAGG GCAAGGTTCA GTACCTGGTG GAGTGGGAAG GGACCACCCC 1860
TTACTGACTA GCCCCCGGGG GTGCCAGGGG TCCTGAAAAC CAAAGGAGGA GCAGCAGAAG 1920
CCATAGGCTC CCCAGCTTTC TCCAGGCTGG GGTGGGAGAA GGAAGCAGGA CAGAGCTGCA 1980
AGTGCCTGGC AGAATGCCCT GCCTGCCTGC CTGCCAGGCC AAGGCCTGCG TCTCTCTGCT 2040
GTACCAGCTC TGTTCCAGGG CCTCCTCAGG CTCGTTACCC CTGTGCCTGT GTCTCTACAC 2100
ACTCCACACC CCCTCAAACT CTGTTTATCT GTTCTCTGAC CTTGTGTCCC CTGCGCTGGG 2160
ACCCTTCCTC CTGAGGCCCA GGTCTTTGTC CCCAGTTGTG TGCCTTGACC TCTCTCGCCC 2220
CTTTCTGGGT GTGTTCGCAC ATCCTGTGTG TGCACAGCTG TCCCTCCACT GGATCCCCTT 2280
CACACGTGAC CCGTGGGGCA GCCAGTCCTC CCAGGGACTA CATAACAGGC ACCTTTGAGA 2340
GAGCATGGGA GAAGGTGGAT AAGAGGATGC TGCTCAGTGC TTTTCTCTTC CACTTTCCTG 2400
CCACTCCCCA CTACCCTCGG AGAGAGGTGG TGGGATGGGA GAGAGCCCCT GTGAAAGCCT 2460
GTGAGGATCT GAAGAGTAAA GGGCTGGGTC TGCCTCAGAA GGCACCAGCA CCAGGGCCCA 2520
GGTATTAAGG CTGAGAGTGA AGGCTGCCAA TGTCAGCTTT GGAGGTCCCA GAAGTCTTCT 2580
GTTCTCTGGC CTCACCCCCT CAGTCGCCAT AGAGCTGGGC CTGGCCTTGC TGGAATGGAG 2640
GCATCCTTCC AAACCTGGGG GACGGGGGTG GGGGGTGGTA GTGGTGGGAG GGAAACCATG 2700
TCTTGCTAAA CCTGTTTCTG GTGCCTCCCA TCCCCAGACC CACCAGACAC CACACAGCAG 2760
ACAATACACA CCCACTCGCA CAAGCTTCCA TCCACATGTG TTGTACTTTC AGCTCTAGGC 2820
ATGCAGACAA CCCCACACGG CCACACCACC ACATGCCCAA GTGTACACAC ACAGAGCCAC 2880
ACCGTCCCTC TGGGCCTGCT GGCTCCTCCC TTGGCTTTCC CTTGGCCCAC TTCCAGGGCC 2940
CAGGTGCTGC AACTAAATGT GAAAGCTCAG TGGCCGCTCC TTCTTTCAGC CCATCAACCA 3000
GCATTGGTCC CATAGGGAAG CACAGGGGAC TCACCCTCTT TCATATCCCT TGCCCTGCCC 3060
TGAAATGGAC AATCACTTTT TGGGATAGGT TGAAATTTTT AAAGAGCCTG CATCATTTGG 3120
TTCCCTCAAA GGGAAGCCCT TGCCAGTGGG GGTTTGAAAG AGAATTTTTG GAACCAACAT 3180
TCAAATTCTG CCTCATCTGG AGGGAAACCA AAATTGGGAG GGGGAAGAGG ACCCCTGATG 3240
TTTTGCTGCT TCCAGAGATA TTAGAAACTG ACTCACTTGA TTGGAAAATG GACAAAAGTG 3300
CCTTGACGTG GAGGGTGGGC ACCAGATGGG GACCAGCCTT GCCAACTGCT GCTGTGGCCT 3360
CCAGCTTGGC TGGTTTTGCA GGCCGCCAGC AGGAAGGCGA AGGTGGTAGT ACAGCAAGAG 3420
GCACTGGCGG GGCAGCAGGC CTGCAGGAGC TGTTTTTCCA TTGCTAGGCC TGACCCCTCT 3480
CTACCTGTGA GCGTTCAGGG GGTCCCTGAG ATAGTTTAGA TGCCCCCCCA TCTTAGACCT 3540
CAGCTCCCAC AGTGCCTTTT AAGGGGGACC TCACCTCCTG TGCACAGCCC ACCCACTTTC 3600
CTCTGCTTCC CTGGCACAGC CCAGGCATAG ACGAGCTGGC GTTGGACCCA GTTCTTCCCC 3660
CTTTTCAGCC CCACAGCTGC TGCCACAGGG GCCAACTAGG GCCAGGTGGA AGGGGAGCTG 3720
AGAAGCCAAC CCCTAGCCCA GGGGTGCTGT GGGAACTGGG ATCCAATTTG TAGCTTCCTG 3780
CCTGGCTTCA GAGAGCCCAG CAACCTTCTA GGCCTGCTTT CCAGACTTCT GAGATAGCCT 3840
GGGATGAGCA ATCCTGTTAT AGTACATCTG GACCTTCCCT ACCTGGGCTC TGGGGAGGCT 3900
GTGGGCCTGG AGAGGGAAAA GGAGGGAGGG GGTGTCTGCA CCACCTGGGA AGATAGCACA 3960
AGGCCTAATG AGGTCACCCT GACTCCCCAC CCCAGCATTT CATTCATACC AGATAATAGC 4020
TGCATTACTG CCAACTGACC TTATAACCCT CTGCACCTTC AAAAAGATTC ATGGTTTTTA 4080
ATTGCTGCTT TTAATAACAT TTGTTAAAGT TATAATTAAT GTGTCTGATT TATGATTTAA 4140
AACCTCCCTT TGAACAATC
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR025894--Mtf2_C_dom
IPR002999--Tudor
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS01359--ZF_PHD_1
Pfam

PF14061--Mtf2_C
PF00628--PHD
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0035064--F:methylated histone binding
GO:0008270--F:zinc ion binding
GO:0016568--P:chromatin modification
GO:0045814--P:negative regulation of gene expression, epigenetic
GO:0061087--P:positive regulation of histone H3-K27 methylation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Nol-0187 ENSNLEP00000020703.1 Nomascus leucogenys 100 0.0 1078
WERAM-Gog-0023 ENSGGOP00000002247.2 Gorilla gorilla 100 0.0 1078
WERAM-Paa-0212 ENSPANP00000018930.1 Papio anubis 100 0.0 1077
WERAM-Mam-0088 ENSMMUP00000013924.2 Macaca mulatta 100 0.0 1077
WERAM-Chs-0159 ENSCSAP00000009370.1 Chlorocebus sabaeus 100 0.0 1077
WERAM-Poa-0185 ENSPPYP00000021915.2 Pongo abelii 100 0.0 1077
WERAM-Eqc-0194 ENSECAP00000021073.1 Equus caballus 98 0.0 1064
WERAM-Otg-0215 ENSOGAP00000022602.1 Otolemur garnettii 97 0.0 1046
WERAM-Fec-0007 ENSFCAP00000000596.3 Felis catus 97 0.0 1046
WERAM-Loa-0055 ENSLAFP00000004073.3 Loxodonta africana 94 0.0 1046
WERAM-Orc-0051 ENSOCUP00000004910.3 Oryctolagus cuniculus 96 0.0 1045
WERAM-Bot-0152 ENSBTAP00000022557.4 Bos taurus 97 0.0 1044
WERAM-Cap-0025 ENSCPOP00000002036.2 Cavia porcellus 97 0.0 1040
WERAM-Mup-0083 ENSMPUP00000007596.1 Mustela putorius furo 96 0.0 1031
WERAM-Myl-0055 ENSMLUP00000004589.2 Myotis lucifugus 96 0.0 1031
WERAM-Caj-0214 ENSCJAP00000042819.1 Callithrix jacchus 100 0.0 1016
WERAM-Aim-0016 ENSAMEP00000001231.1 Ailuropoda melanoleuca 94 0.0 1001
WERAM-Ran-0120 ENSRNOP00000025528.5 Rattus norvegicus 89 0.0 966
WERAM-Mum-0080 ENSMUSP00000028232.3 Mus musculus 89 0.0 961
WERAM-Dio-0090 ENSDORP00000009372.1 Dipodomys ordii 92 0.0 952
WERAM-Sah-0188 ENSSHAP00000020428.1 Sarcophilus harrisii 89 0.0 945
WERAM-Ptv-0127 ENSPVAP00000011106.1 Pteropus vampyrus 97 0.0 924
WERAM-Tut-0075 ENSTTRP00000006294.1 Tursiops truncatus 92 0.0 908
WERAM-Ect-0026 ENSETEP00000001872.1 Echinops telfairi 84 0.0 853
WERAM-Fia-0031 ENSFALP00000001875.1 Ficedula albicollis 80 0.0 851
WERAM-Meg-0036 ENSMGAP00000003133.1 Meleagris gallopavo 80 0.0 850
WERAM-Mod-0183 ENSMODP00000024495.2 Monodelphis domestica 82 0.0 846
WERAM-Gaga-0017 ENSGALP00000002418.5 Gallus gallus 79 0.0 841
WERAM-Ict-0115 ENSSTOP00000011704.2 Ictidomys tridecemlineatus 98 0.0 838
WERAM-Ova-0055 ENSOARP00000006044.1 Ovis aries 97 0.0 836
WERAM-Lac-0136 ENSLACP00000015753.1 Latimeria chalumnae 76 0.0 816
WERAM-Mae-0050 ENSMEUP00000004804.1 Macropus eugenii 75 0.0 799
WERAM-Caf-0039 ENSCAFP00000005324.3 Canis familiaris 77 0.0 774
WERAM-Leo-0057 ENSLOCP00000007767.1 Lepisosteus oculatus 69 0.0 736
WERAM-Ere-0085 ENSEEUP00000008196.1 Erinaceus europaeus 89 0.0 735
WERAM-Xet-0124 ENSXETP00000042382.3 Xenopus tropicalis 76 0.0 726
WERAM-Anp-0069 ENSAPLP00000008395.1 Anas platyrhynchos 73 0.0 714
WERAM-Dar-0179 ENSDARP00000101389.2 Danio rerio 64 0.0 711
WERAM-Anc-0034 ENSACAP00000018499.2 Anolis carolinensis 81 0.0 664
WERAM-Soa-0088 ENSSARP00000008397.1 Sorex araneus 79 0.0 653
WERAM-Prc-0046 ENSPCAP00000004178.1 Procavia capensis 78 0.0 651
WERAM-Sus-0036 ENSSSCP00000005906.2 Sus scrofa 95 0.0 635
WERAM-Orn-0009 ENSONIP00000001041.1 Oreochromis niloticus 56 3e-171 598
WERAM-Ten-0022 ENSTNIP00000005027.1 Tetraodon nigroviridis 57 2e-168 589
WERAM-Tar-0222 ENSTRUP00000046767.1 Takifugu rubripes 56 4e-166 582
WERAM-Gaa-0109 ENSGACP00000014147.1 Gasterosteus aculeatus 58 5e-165 578
WERAM-Tag-0098 ENSTGUP00000006728.1 Taeniopygia guttata 91 1e-163 573
WERAM-Mim-0032 ENSMICP00000003002.1 Microcebus murinus 80 3e-158 555
WERAM-Xim-0088 ENSXMAP00000008107.1 Xiphophorus maculatus 56 7e-158 555
WERAM-Gam-0002 ENSGMOP00000000180.1 Gadus morhua 59 2e-157 553
WERAM-Pof-0138 ENSPFOP00000011590.2 Poecilia formosa 56 7e-157 551
WERAM-Orla-0194 ENSORLP00000022012.1 Oryzias latipes 54 1e-148 523
WERAM-Ora-0006 ENSOANP00000000893.2 Ornithorhynchus anatinus 88 2e-143 506
WERAM-Ocp-0073 ENSOPRP00000006411.1 Ochotona princeps 88 6e-112 402
WERAM-Asm-0130 ENSAMXP00000012810.1 Astyanax mexicanus 66 9e-112 401
WERAM-Pes-0077 ENSPSIP00000009455.1 Pelodiscus sinensis 58 2e-109 394
WERAM-Pat-0008 ENSPTRP00000052062.2 Pan troglodytes 58 4e-109 392
WERAM-Tas-0127 ENSTSYP00000013465.1 Tarsius syrichta 57 1e-105 381
WERAM-Pem-0006 ENSPMAP00000000578.1 Petromyzon marinus 59 5e-102 369
WERAM-Dan-0184 ENSDNOP00000013781.3 Dasypus novemcinctus 52 9e-92 335
WERAM-Vip-0124 ENSVPAP00000011690.1 Vicugna pacos 98 3e-85 313
WERAM-Chh-0106 ENSCHOP00000011829.1 Choloepus hoffmanni 50 7e-84 308
WERAM-Tub-0048 ENSTBEP00000005679.1 Tupaia belangeri 50 8e-84 308
WERAM-Drm-0007 FBpp0085914 Drosophila melanogaster 31 3e-43 174
WERAM-Cis-0011 ENSCSAVP00000001651.1 Ciona savignyi 44 2e-19 95.1
WERAM-Cii-0087 ENSCINP00000031571.1 Ciona intestinalis 40 1e-18 92.8
WERAM-Gag-0024 GGTG_08466T0 Gaeumannomyces graminis 46 7e-07 53.1
WERAM-Orgl-0003 OGLUM01G08480.1 Oryza glumaepatula 29 4e-06 50.8
WERAM-Orni-0002 ONIVA01G09570.1 Oryza nivara 29 5e-06 50.4
WERAM-Orr-0003 ORUFI01G08070.1 Oryza rufipogon 29 5e-06 50.4
WERAM-Orl-0011 KN538689.1_FGP119 Oryza longistaminata 29 6e-06 50.1
WERAM-Aet-0075 EMT12407 Aegilops tauschii 30 6e-06 50.1
WERAM-Map-0017 MAPG_05228T0 Magnaporthe poae 44 7e-06 50.1
Created Date 25-Jun-2016