WERAM Information

Tag Content
WERAM ID WERAM-Hos-0187
Ensembl Protein ID ENSP00000483345.1
Uniprot Accession Q7Z4V5; HDGR2_HUMAN; I3L080; K7EQZ6; Q96GI5; Q9BW08
Genbank Protein ID NP_001001520.1; NP_116020.1
Protein Name Hepatoma-derived growth factor-related protein 2
Genbank Nucleotide ID NM_001001520.2; NM_032631.3
Gene Name HDGF2;UNQ785/PRO1604
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000167674.14 ENST00000616600.4 ENSP00000483345.1
ENSG00000167674.14 ENST00000601353.5 ENSP00000471276.1
ENSG00000167674.14 ENST00000621835.4 ENSP00000483702.1
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader PWWP PWWP H3K79me3; H4K20me3 K 21720545
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader PWWP 2.20e-21 78 7 63
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Involved in cellular growth control, through the regulation of cyclin D1 expression.
Domain Profile
  Me_Reader PWWP
           PWWP.txt  1 agdLVwaKlkgYpwWPalvisppleakklktqeaeenkylVlFFgnkherawvkrkklvpyse 63
                       +gdLV+aK+kgYp+WPa++++  ++a+k+     + nky+++FFg +he+a++++k+l+py++
  ENSP00000483345.1  7 PGDLVFAKMKGYPHWPARIDDIADGAVKP-----PPNKYPIFFFG-THETAFLGPKDLFPYDK 63
                       69***************************.....***********.***************86 PP
Protein Sequence
(Fasta)		MPHAFKPGDL VFAKMKGYPH WPARIDDIAD GAVKPPPNKY PIFFFGTHET AFLGPKDLFP 60
YDKCKDKYGK PNKRKGFNEG LWEIQNNPHA SYSAPPPVSS SDSEAPEANP ADGSDADEDD 120
EDRGVMAVTA VTATAASDRM ESDSDSDKSS DNSGLKRKTP ALKMSVSKRA RKASSDLDQA 180
SVSPSEEENS ESSSESEKTS DQDFTPEKKA AVRAPRRGPL GGRKKKKAPS ASDSDSKADS 240
DGAKPEPVAM ARSASSSSSS SSSSDSDVSV KKPPRGRKPA EKPLPKPRGR KPKPERPPSS 300
SSSDSDSDEV DRISEWKRRD EARRRELEAR RRREQEEELR RLREQEKEEK ERRRERADRG 360
EAERGSGGSS GDELREDDEP VKKRGRKGRG RGPPSSSDSE PEAELEREAK KSAKKPQSSS 420
TEPARKPGQK EKRVRPEEKQ QAKPVKVERT RKRSEGFSMD RKVEKKKEPS VEEKLQKLHS 480
EIKFALKVDS PDVKRCLNAL EELGTLQVTS QILQKNTDVV ATLKKIRRYK ANKDVMEKAA 540
EVYTRLKSRV LGPKIEAVQK VNKAGMEKEK AEEKLAGEEL AGEEAPQEKA EDKPSTDLSA 600
PVNGEATSQK GESAEDKEHE EGRDSEEGPR CGSSEDLHDS VREGPDLDRP GSDRQERERA 660
RGDSEALDEE S 671
Nucleotide Sequence
(Fasta)		CCGCCGCCGC AGCCGCTACC GCCGCTGCAG CCGCTTTCCG CGGCCTGGGC CTCTCGCCGT 60
CAGCATGCCA CACGCCTTCA AGCCCGGGGA CTTGGTGTTC GCTAAGATGA AGGGCTACCC 120
TCACTGGCCT GCCAGGATCG ACGACATCGC GGATGGCGCC GTGAAGCCCC CACCCAACAA 180
GTACCCCATC TTTTTCTTTG GCACACACGA AACAGCCTTC CTGGGACCCA AGGACCTGTT 240
CCCCTACGAC AAATGTAAAG ACAAGTACGG GAAGCCCAAC AAGAGGAAAG GCTTCAATGA 300
AGGGCTGTGG GAGATCCAGA ACAACCCCCA CGCCAGCTAC AGCGCCCCTC CGCCAGTGAG 360
CTCCTCCGAC AGCGAGGCCC CCGAGGCCAA CCCCGCCGAC GGCAGTGACG CTGACGAGGA 420
CGATGAGGAC CGGGGGGTCA TGGCCGTCAC AGCGGTAACC GCCACAGCTG CCAGCGACAG 480
GATGGAGAGC GACTCAGACT CAGACAAGAG TAGCGACAAC AGTGGCCTGA AGAGGAAGAC 540
GCCTGCGCTA AAGATGTCGG TCTCGAAACG AGCCCGAAAG GCCTCCAGCG ACCTGGATCA 600
GGCCAGCGTG TCCCCATCCG AAGAGGAGAA CTCGGAAAGC TCATCTGAGT CGGAGAAGAC 660
CAGCGACCAG GACTTCACAC CTGAGAAGAA AGCAGCGGTC CGGGCGCCAC GGAGGGGCCC 720
TCTGGGGGGA CGGAAAAAAA AGAAGGCGCC ATCAGCCTCC GACTCCGACT CCAAGGCCGA 780
TTCGGACGGG GCCAAGCCTG AGCCGGTGGC CATGGCGCGG TCGGCGTCCT CCTCCTCCTC 840
TTCCTCCTCC TCCTCCGACT CCGATGTGTC TGTGAAGAAG CCTCCGAGGG GCAGGAAGCC 900
AGCGGAGAAG CCTCTCCCGA AGCCGCGAGG GCGGAAACCG AAGCCTGAAC GGCCTCCGTC 960
CAGCTCCAGC AGTGACAGTG ACAGCGACGA GGTGGACCGC ATCAGTGAGT GGAAGCGGCG 1020
GGACGAGGCG CGGAGGCGCG AGCTGGAGGC CCGGCGGCGG CGAGAGCAGG AGGAGGAGCT 1080
GCGGCGCCTG CGGGAGCAGG AGAAGGAGGA GAAGGAGCGG AGGCGCGAGC GGGCCGACCG 1140
CGGGGAGGCT GAGCGGGGCA GCGGCGGCAG CAGCGGGGAC GAGCTCAGGG AGGACGATGA 1200
GCCCGTCAAG AAGCGGGGAC GCAAGGGCCG GGGCCGGGGT CCCCCGTCCT CCTCTGACTC 1260
CGAGCCCGAG GCCGAGCTGG AGAGAGAGGC CAAGAAATCA GCGAAGAAGC CGCAGTCCTC 1320
AAGCACAGAG CCCGCCAGGA AACCTGGCCA GAAGGAGAAG AGAGTGCGGC CCGAGGAGAA 1380
GCAACAAGCC AAGCCCGTGA AGGTGGAGCG GACCCGGAAG CGGTCCGAGG GCTTCTCGAT 1440
GGACAGGAAG GTAGAGAAGA AGAAAGAGCC CTCCGTGGAG GAGAAGCTGC AGAAGCTGCA 1500
CAGTGAGATC AAGTTTGCCC TAAAGGTCGA CAGCCCGGAC GTGAAGAGGT GCCTGAATGC 1560
CCTAGAGGAG CTGGGAACCC TGCAGGTGAC CTCTCAGATC CTCCAGAAGA ACACAGACGT 1620
GGTGGCCACC TTGAAGAAGA TTCGCCGTTA CAAAGCGAAC AAGGACGTAA TGGAGAAGGC 1680
AGCAGAAGTC TATACCCGGC TCAAGTCGCG GGTCCTCGGC CCAAAGATCG AGGCGGTGCA 1740
GAAAGTGAAC AAGGCTGGGA TGGAGAAGGA GAAGGCCGAG GAGAAGCTGG CCGGGGAGGA 1800
GCTGGCCGGG GAGGAGGCCC CCCAGGAGAA GGCGGAGGAC AAGCCCAGCA CCGATCTCTC 1860
AGCCCCAGTG AATGGCGAGG CCACATCACA GAAGGGGGAG AGCGCAGAGG ACAAGGAGCA 1920
CGAGGAGGGT CGGGACTCGG AGGAGGGGCC AAGGTGTGGC TCCTCTGAAG ACCTGCACGA 1980
CAGCGTACGG GAGGGTCCCG ACCTGGACAG GCCTGGGAGC GACCGGCAGG AGCGCGAGAG 2040
GGCACGGGGG GACTCGGAGG CCCTGGACGA GGAGAGCTGA GCCGCGGGCA GCCAGGCCCA 2100
GCCCCCGCCC GAGCTCAGGC TGCCCCTCTC CTTCCCCGGC TCGCAGGAGA GCAGAGCAGA 2160
GAACTGTGGG GAACGCTGTG CTGTTTGTAT TTGTTCCCTT GGGTTTTTTT TTCCTGCCTA 2220
ATTTCTGTGA TTTCCAACCA ACATGAAATG ACTATAAATG GTTTTTTAAT GAAAAAAGAA 2280
A 2282
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
--
Interpro

IPR021567--LEDGF
IPR000313--PWWP_dom
IPR017923--TFIIS_N
PROSITE

PS50812--PWWP
Pfam

PF11467--LEDGF
PF00855--PWWP
Gene Ontology

GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0030307--P:positive regulation of cell growth
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Pat-0086 ENSPTRP00000017529.5 Pan troglodytes 98 3e-110 396
WERAM-Paa-0192 ENSPANP00000000624.1 Papio anubis 97 2e-109 394
WERAM-Chs-0127 ENSCSAP00000006765.1 Chlorocebus sabaeus 96 2e-108 390
WERAM-Caj-0189 ENSCJAP00000032346.2 Callithrix jacchus 93 3e-103 373
WERAM-Otg-0084 ENSOGAP00000006606.2 Otolemur garnettii 83 6e-92 336
WERAM-Mim-0004 ENSMICP00000000296.1 Microcebus murinus 82 1e-90 331
WERAM-Ptv-0165 ENSPVAP00000014119.1 Pteropus vampyrus 79 1e-87 322
WERAM-Loa-0210 ENSLAFP00000027986.1 Loxodonta africana 80 3e-87 320
WERAM-Tut-0020 ENSTTRP00000001619.1 Tursiops truncatus 78 2e-85 314
WERAM-Ova-0098 ENSOARP00000010167.1 Ovis aries 80 8e-85 312
WERAM-Fec-0068 ENSFCAP00000005839.3 Felis catus 79 2e-83 307
WERAM-Poa-0079 ENSPPYP00000010549.2 Pongo abelii 78 6e-83 306
WERAM-Sus-0099 ENSSSCP00000014360.2 Sus scrofa 78 6e-83 306
WERAM-Mum-0010 ENSMUSP00000002911.8 Mus musculus 72 4e-81 300
WERAM-Mam-0217 ENSMMUP00000025108.2 Macaca mulatta 79 9e-81 298
WERAM-Dio-0144 ENSDORP00000013380.1 Dipodomys ordii 74 5e-80 296
WERAM-Ran-0211 ENSRNOP00000064555.1 Rattus norvegicus 74 1e-78 291
WERAM-Cap-0212 ENSCPOP00000015151.1 Cavia porcellus 71 1e-76 285
WERAM-Prc-0103 ENSPCAP00000009426.1 Procavia capensis 73 1e-75 281
WERAM-Ict-0074 ENSSTOP00000006607.2 Ictidomys tridecemlineatus 81 8e-75 279
WERAM-Ocp-0129 ENSOPRP00000013680.1 Ochotona princeps 80 2e-67 254
WERAM-Tag-0015 ENSTGUP00000000828.1 Taeniopygia guttata 75 4e-60 230
WERAM-Gaga-0172 ENSGALP00000042553.1 Gallus gallus 61 5e-60 229
WERAM-Lac-0001 ENSLACP00000000113.1 Latimeria chalumnae 96 2e-51 201
WERAM-Soa-0134 ENSSARP00000013183.1 Sorex araneus 97 2e-51 201
WERAM-Myl-0128 ENSMLUP00000010400.2 Myotis lucifugus 99 3e-51 201
WERAM-Xet-0161 ENSXETP00000052142.3 Xenopus tropicalis 91 2e-49 195
WERAM-Leo-0062 ENSLOCP00000008070.1 Lepisosteus oculatus 88 2e-48 191
WERAM-Ten-0189 ENSTNIP00000000055.1 Tetraodon nigroviridis 88 1e-47 189
WERAM-Tar-0048 ENSTRUP00000011223.1 Takifugu rubripes 88 1e-47 188
WERAM-Gam-0158 ENSGMOP00000015537.1 Gadus morhua 88 2e-47 188
WERAM-Dar-0051 ENSDARP00000103259.2 Danio rerio 85 5e-47 186
WERAM-Orn-0023 ENSONIP00000002883.1 Oreochromis niloticus 87 5e-47 186
WERAM-Orla-0183 ENSORLP00000021203.2 Oryzias latipes 87 6e-47 186
WERAM-Xim-0036 ENSXMAP00000003516.1 Xiphophorus maculatus 85 2e-46 184
WERAM-Pof-0082 ENSPFOP00000007270.2 Poecilia formosa 85 2e-46 184
WERAM-Gaa-0117 ENSGACP00000015088.2 Gasterosteus aculeatus 87 2e-46 184
WERAM-Asm-0194 ENSAMXP00000018465.1 Astyanax mexicanus 85 5e-46 183
WERAM-Pes-0177 ENSPSIP00000020643.1 Pelodiscus sinensis 83 8e-45 179
WERAM-Sah-0196 ENSSHAP00000021263.1 Sarcophilus harrisii 83 9e-45 179
WERAM-Mod-0133 ENSMODP00000018686.2 Monodelphis domestica 83 1e-44 179
WERAM-Fia-0084 ENSFALP00000006824.1 Ficedula albicollis 83 2e-44 178
WERAM-Eqc-0084 ENSECAP00000010935.1 Equus caballus 82 2e-44 177
WERAM-Mup-0042 ENSMPUP00000004024.1 Mustela putorius furo 82 3e-44 177
WERAM-Anc-0181 ENSACAP00000017487.3 Anolis carolinensis 82 3e-44 177
WERAM-Tub-0006 ENSTBEP00000000628.1 Tupaia belangeri 82 3e-44 177
WERAM-Orc-0087 ENSOCUP00000008046.2 Oryctolagus cuniculus 82 3e-44 177
WERAM-Nol-0190 ENSNLEP00000021346.2 Nomascus leucogenys 82 3e-44 177
WERAM-Gog-0178 ENSGGOP00000015764.2 Gorilla gorilla 82 3e-44 177
WERAM-Vip-0058 ENSVPAP00000005409.1 Vicugna pacos 82 3e-44 177
WERAM-Aim-0030 ENSAMEP00000002180.1 Ailuropoda melanoleuca 82 4e-44 177
WERAM-Caf-0022 ENSCAFP00000002245.3 Canis familiaris 82 5e-44 176
WERAM-Bot-0081 ENSBTAP00000010356.5 Bos taurus 82 7e-44 176
WERAM-Chh-0048 ENSCHOP00000005452.1 Choloepus hoffmanni 81 4e-43 173
WERAM-Pem-0101 ENSPMAP00000010356.1 Petromyzon marinus 79 3e-41 167
WERAM-Dan-0080 ENSDNOP00000007922.2 Dasypus novemcinctus 77 2e-37 154
WERAM-Cii-0068 ENSCINP00000030018.1 Ciona intestinalis 67 8e-33 139
WERAM-Php-0123 PP1S81_182V6.1 Physcomitrella patens 37 2e-07 55.5
WERAM-Miv-0038 MVLG_05412T0 Microbotryum violaceum 43 2e-07 55.1
Created Date 25-Jun-2016